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1.
Kristina Mickevičienė Aušra Voskienė Vytautas Mickevičius 《Research on Chemical Intermediates》2014,40(4):1619-1631
Mono- and disubstituted benzimidazoles were synthesized during alkaline hydrolysis or reactions with ethyl chloroacetate of 1-phenyl substituted 4-(1H-benzimidazol-2-yl)-2-pyrrolidinones. The properties of the synthesized ethyl-[2-(1-(substituted phenyl)-5-oxopyrrolidinyl-3-yl)-1H-benzimidazolyl]ethanoates have been investigated and their benzimidazolium chlorides, 1-carboxymethylbenzimidazoles, condensation products of 2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetohydrazide with various aromatic aldehydes and aliphatic ketones have been obtained. 相似文献
2.
Thekke V. Sreevidya Badiadka Narayana Hemmige S. Yathirajan 《Central European Journal of Chemistry》2010,8(1):174-181
A series of chalcones and their derivatives have been synthesized. Chalcones, 1-(1,3-benzodioxol-5-yl)-3-(aryl)-prop-2-en-1-ones
were prepared by the aldol condensation of 1-(1,3-benzodioxol-5-yl)ethanones and aryl aldehydes. Based-catalyzed condensation
of 1-(1,3-benzodioxol-5-yl)-3-(aryl)prop-2-en-1-ones with ethyl acetoacetate yields corresponding ethyl 4-(1,3-benzodioxol-5-yl)-6-(aryl)-2-oxocyclohex-3-ene-1-carboxylates.
Some of the synthesized chalcones were reported in the literature; the newly synthesized compounds were characterized by single
crystal X-ray studies, IR, 1H-NMR and LCMS mass spectral analysis. 相似文献
3.
Thirunarayanan G Vanangamudi G 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2011,81(1):390-396
Thirteen ee (αS, βR) 9H-fluorene-2-yl keto-oxiranes (2-(9H)-fluorene-4-yl[3-(substituted phenyl)oxiran-2-yl]methanones) have been synthesized by phase transfer catalysed epoxidation of 9H-fluorene-2-yl chalcones. The yields of oxiranes are more than 95%. The synthesized oxiranes have been characterized by IR, (1)H, (13)C and GC-MS spectral data. The spectral data are correlated with Hammett substituent constants and Swain-Lupton parameters. From the regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial, antioxidant and insect antifeedant activities of all the synthesized oxiranes have been studied. 相似文献
4.
Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity. 相似文献
5.
P. P. Zarin' É. É. Liepin' É. S. Lavrinovich A. K. Aren 《Chemistry of Heterocyclic Compounds》1974,10(1):92-95
New 4- (benzazol-2-yl)pyridinium salts have been synthesized. Their reduction in a neutral medium with sodium tetrahydroborate has given 2-(1,2,5,6-tetrahydropyridin-4-yl)benzazoles. The catalytic hydrogenation of the latter leads to piperidine derivatives which have also been synthesized by an independent route.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 104–107, January, 1974. 相似文献
6.
Urinary metabolites 5-methyl-5-[2-(2,6,6-trimethyl -3-oxo-1-cyclohexen-1-yl)-vinyl]-2-tetrahydrofuranone (1) and 5-[2-(6-hydroxymethyl-2, 6-dimethyl-3-oxo-1- cyclohexen-1-yl)vinyl]-5-methyl-2-tetrahydrofuranone (2) of retinoic acid have been synthesized from 4-[2,2,6-trimethyl-3-(tetrahydro-2 H -pyran-2-yl)oxy-1-cyclohexen-1-yl]-3-buten-2-one (4) and methyl 2-(3,3-ethylenedioxy-1-butenyl)-1, 3-dimethyl-4-oxo-2-cyclohexene-1-carboxylate (5) . 相似文献
7.
Hemlata Kaur Sunil Kumar Archana Chaudhary Ashok Kumar 《Arabian Journal of Chemistry》2012,5(3):271-283
Various 2-((2-((5-benzylideneamino)-1,3,4-oxa/thiadiazol-2-yl)methyl)hydrazinyl) methyl)benzo[b][1,4]oxa/thiazepin-4(5H)-ones (4a–4l), 2-((2-((5-(4-oxo-2-substitutedphenyl thiazolidin-3-yl)-1,3,4-oxa/thiadiazol-2-yl)methyl)hydrazinyl)methyl)benzo [b] [1,4]oxa/thiazepin-4(5H)-ones (5a–5l) and 2-((2-((5-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl)-1,3,4-oxa/thia diazol-2-yl)methyl)hydrazinyl)methyl)benzo[b][1,4]oxa/thiazepin-4(5H)-ones (6a–6l) have been synthesized. The structures of these compounds have been established by elemental (C, H, N) and spectral (IR, 1H-NMR and Mass) analysis. The synthesized compounds were screened for their antipsychotic and anticonvulsant activities. Compound 5l was found to be the most active compound of this series. 相似文献
8.
9.
Bhatti BS Strachan JP Breining SR Miller CH Tahiri P Crooks PA Deo N Day CS Caldwell WS 《The Journal of organic chemistry》2008,73(9):3497-3507
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the alpha4beta2 and alpha7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, and several of their derivatives have been synthesized in both an enantioselective and a racemic manner utilizing the same basic synthetic approach. For the racemic synthesis, alkylation of N-(diphenylmethylene)-1-(pyridin-3-yl)methanamine with the appropriate bromoalkyltetrahydropyran gave intermediates which were readily elaborated into 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane and 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane via a ring opening/aminocyclization sequence. An alternate synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane via the alkylation of N-(1-(pyridin-3-ylethylidene)propan-2-amine has also been achieved. The enantioselective syntheses followed the same general scheme, but utilized imines derived from (+)- and (-)-2-hydroxy-3-pinanone. Chiral HPLC shows that the desired compounds were synthesized in >99.5% ee. X-ray crystallography was subsequently used to unambiguously characterize these stereochemically pure nAChR ligands. All compounds synthesized exhibited high affinity for the alpha4beta2 nAChR subtype ( K i < or = 0.5-15 nM), a subset bound with high affinity for the alpha7 receptor subtype ( K i < or = 110 nM), selectivity over the alpha3beta4 (ganglion) receptor subtype was seen within the 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane series and for the muscle (alpha1betagammadelta) subtype in the 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane series. 相似文献
10.
超声辐射法在新型含双杂环芳酰基硫脲合成中的应用 总被引:2,自引:0,他引:2
以2-苯基-1,2,3-三唑-4-甲酸、氨基硫脲为原料在三氯氧磷中反应得到2-氨基-5-(2-苯基-1,2,3-三唑-4-基)-1,3,4-噻二唑,然后分别采用超声辐射法和常规加热法与芳酰基异硫氰酸酯反应合成了一系列的N-[5-(2-苯基-1,2,3-三唑-4-基) 1,3,4-噻二唑-2-基\]-N′-酰基硫脲。 通过与常规方法比较,采用超声辐射法反应时间只有原来的12.5%,反应产率提高了4%~17%,减少了副反应。 所有化合物的结构经元素分析、MS、IR、1H NMR测试技术确证。 相似文献
11.
The new 2-[2-(6-tert-butyl-2H-1,3-benzoxazin-3(4H)-yl)ethoxy]ethanol 1 and 2-[2-(6-pentyl-2H-1,3-benzoxazin-3(4H)-yl)ethoxy]ethanol 2 have been synthesized. Axially disubstituted silicon phthalocyanines 3 and 4 have been synthesized by introducing 2-[2-(6-tert-butyl-2H-1,3-benzoxazin-3(4H)-yl)ethoxy]ethanol and 2-[2-(6-pentyl-2H-1,3-benzoxazin-3(4H)-yl)ethoxy]ethanol at the axial positions of silicon(IV) phthalocyanine, respectively. The electrochemical properties of silicon phthalocyanines 3 and 4 were also investigated by cyclic voltammetry (CV) and square wave voltammetry. Voltammetric studies show that while 3 showed two reversible reduction and one irreversible oxidation couples, 4 showed two quasi-reversible reduction and one irreversible oxidation couples. 相似文献
12.
A. N. Gusev V. F. Shul’gin E. A. Ugolkova N. N. Efimov G. G. Aleksandrov V. V. Minin I. L. Eremenko 《Russian Journal of Inorganic Chemistry》2014,59(7):699-705
Copper(II) coordination compounds with 3-(pyridin-2-yl)-5-(2-salicylideniminophenyl)-1H-1,2,4-triazole and 1,3-bis(5-(pyridin-2-yl)-1,2,4-triazole-3-yl)propane have been synthesized. The complexes have been studied by elemental and thermal analysis, IR and electron spectroscopy, electron paramagnetic resonance (EPR), and magnetochemistry. According to X-ray diffraction data, the complexes have binuclear structures in which metal cations are bonded via the nitrogen atoms of two bridging triazole rings. 相似文献
13.
S. V. Gorelov S. P. Bondarenko M. S. Frasinyuk 《Chemistry of Heterocyclic Compounds》2012,48(6):955-962
Substituted 4-[(3-cyanopyridin-2-yl)thiomethyl]coumarins have been synthesized by the alkylation of 2-mercapto-4,6-dimethylnicotinonitrile with 4-chloromethylcoumarins. Substituted 4-(3-amino-thieno[2,3-b]pyridin-2-yl)coumarins have been obtained by a subsequent intramolecular condensation of the methylene and cyano groups. 6H-Chromeno[4,3-d]thieno[3,2-b:5,4-b']dipyridin-6-ones were isolated as a result of the interaction of these compounds with aldehydes, and their aminomethyl derivatives were synthesized. 相似文献
14.
D. Ashok M. Ziauddin B. Vijaya Lakshmi M. Sarasija 《Russian Journal of General Chemistry》2016,86(7):1753-1757
Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains. 相似文献
15.
Nosova E. V. Poteeva A. D. Lipunova G. N. Slepukhin P. A. Charushin V. N. 《Russian Journal of Organic Chemistry》2019,55(3):384-387
Russian Journal of Organic Chemistry - New 2-(1-methyl-1H-pyrrol-2-yl)- and 2-(1-methyl-1H-indol-3-yl)-5-fluoro- and -6,7,8-trifluoro-1,3-benzothiazin-4-ones have been synthesized in high yields by... 相似文献
16.
Agata Siwek Monika Wujec Joanna Stefańska Piotr Paneth 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):3149-3159
Four 4-aryl-3-(2-methyl-furan-3-yl)-Δ2-1,2,4-triazole-5-thiones were synthesized by intramolecular cyclization of 4-aryl-1-[(2-methyl-furan-3-yl)carbonyl]thiosemicarbazides in alkaline medium. The antimicrobial activity of the synthesized triazoles was evaluated. Semiempirical calculations of geometries, energies, and QSAR parameters have been determined in the hope of gaining insight into different biological activities of closely related isomers. New RM1 parameterization has been shown to perform very well for this class of compounds. 相似文献
17.
Ruthenium complexes( 1 – 3 ) have been synthesized using pincer-type ligands L1 = (E)-2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)pyridine, L2 = (E)-2-(1-phenyl-2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)pyridine, L3 = (E)-2-(phenyl(2-phenyl-2-(pyridin-2-yl)hydrazono) methyl)pyridine. The molecular structures of all the complexes 1 , 2 and 3 were determined by using single crystal X-ray diffraction. These complexes showed excellent catalytic activities such as transfer hydrogenation and alcohol oxidation. Theoretical calculations have been performed to understand the electronic properties of all the complexes using B3LYP as a function and LANL2DZ as a basis set. 相似文献
18.
Sh. A. Samsoniya I. Sh. Chikvaidze T. G. Narindoshvili N. N. Suvorov 《Chemistry of Heterocyclic Compounds》2001,37(7):827-833
2-(Diphenylmethan-4-yl)- and 2-(dibenzyl-4-yl)indoles have been synthesized by the Fischer reaction. Reactions carried out included azo coupling, formylation, and nitrosation. The corresponding 3-substituted derivatives were obtained. 相似文献
19.
The synthesis of three novel 5,5-dimethylhydantoin derivatives 2-amino-N-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)acetamide, 2-amino-N-(4,4-dimethyl-2,5-dioxoimidazol idin-1-yl)-3-phenylpropanamide, and 2-amino-4-methyl-N-(4,4-dimethyl-2,5-dioxoimidazol idin-1-yl) pentanamide, is reported. The newly synthesized compounds have been characterized by infrared (IR), MS, and NMR (1H and 13C) spectra. 相似文献