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1.
Two new secoiridoid glycosides, swertiajaposide A (1) and swertiajaposide B (2), a new unsaturated alco-hol glycoside, 3-butenyl 6'-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside (3), and a new lignan glycoside, 7R,7'R,8S,8'S-(+)-neo-olivil-4-O-beta-D-glucopyranoside (4), were isolated together with six known compounds from the whole plants of Swertia japonica Makino. The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence. 相似文献
2.
A new spirostanol sapogenin and two spirostanol saponins, tentatively named reineckiagenin A (1), reineckiagenoside A (2), and reineckiagenoside B (3), were isolated from the whole plant of Reineckia carnea. By detailed analysis of their 1D and 2D NMR spectra, chemical methods, and by comparison with spectra data of known compounds, the structures of the new steroids were determined to be 25(S)-5β-spirostan-1β,3β,17α-triol (1), 25(S)-5β-spirostan-1β,3β,17α-triol 1-O-β-D-xylopyranoside (2), 25(S)-5β-spirostan-1β,3β,17α-triol 1-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (3). Compounds 1, 2, and 3 are the first naturally occurring steroids with unique structural feature of 5β-spirostan-1β,3β,17α-trihydroxyl. 相似文献
3.
Three new phenolics, (1S,2R)-1-(4'-O-beta-D-glucopyranosyl-3'-methoxyphenyl)-2-(4'-hydroxy-3'-methoxyphenyl)-1,3-propanediol, symplolignanoside A, and 3,4-dimethoxyphenol beta-D-apiofuranosyl(1-->6)-beta-D-glucopyranoside, along with eight known compounds were isolated from the roots of Symplocos caudata Wall. Their structures were elucidated by spectroscopic and chemical methods. 相似文献
4.
Yamauchi H Kakuda R Yaoita Y Machida K Kikuchi M 《Chemical & pharmaceutical bulletin》2007,55(2):346-347
Two new glycosides, 7S,7'S,8R,8'R-icariol A(2)-9-O-beta-D-glucopyranoside (1) and 4-allyl-2-hydroxyphenyl 1-O-beta-D-apiosyl-(1-->6)-beta-D-glucopyranoside (2), were isolated from the dried whole plants of Glechoma hederacea L. (Labiatae) together with four known compounds, cistanoside E (3), dihydrodehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside (4), apigenin 7-O-beta-D-glucuronopyranoside (5) and luteolin 7-O-beta-D-glucopyranoside (6). The structures of the new compounds were elucidated on the basis of chemical and spectral analysis. 相似文献
5.
Lu S Draeger S Schulz B Krohn K Ahmed I Hussain H Yi Y Li L Zhang W 《Natural product communications》2011,6(5):661-666
Two new benzyl gamma-butyrolactone analogues, (R)-5-((S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (1) and its 6-acetate (2), and a new naphthalenone derivative (8), together with eight additional known aromatic derivatives, (S)-5-((S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (3), (S)-5-benzyl-dihydrofuran-2(3H)-one (4), 5-phenyl-4-oxopentanoic acid (5), gamma-oxo-benzenepentanoic acid methyl ester (6), 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid (7), (3R)-5-methylmellein (9), integracins A (10) and B (11) were isolated from Cytospora sp., an endophytic fungus isolated from Ilex canariensis from Gomera. The structures of these compounds were elucidated by detailed spectroscopic analysis, comparison with reported data, and chemical interconversion. The absolute configurations of the new compounds (1, 2, 8) were established on the basis of optical rotation or CD spectra analysis. Preliminary studies showed antimicrobial activity of these compounds against the fungi Microbotryum violaceum, Botrytis cinerea and Septoria tritici, the alga Chlorella fusca, and the bacterium Bacillus megaterium. 相似文献
6.
Three new flavonol 3-O-glycosides, rhamnetin 3-O-[(S)-3-hydroxy-3-methyl-glutaroyl(1→6)]-β-D-glucopyranoside (1), rhamnocitrin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-β-D-glucopyranoside (2), and isorhamnetin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside (3), along with 13 known compounds, were isolated from Oxytropis racemosa TURCZ. Their structures were deduced by means of spectroscopic methods and chemical evidence. 2 and 6 showed cytotoxic activities against HCT-8 (IC?? 6.38 μM) and A549 (IC?? 5.20 μM), respectively. 相似文献
7.
Matsuda H Morikawa T Toguchida I Harima S Yoshikawa M 《Chemical & pharmaceutical bulletin》2002,50(7):972-975
Two new flavanone glycosides, (2S)- and (2R)-eriodictyol 7-O-beta-D-glucopyranosiduronic acids, and a new phenylbutanoid glycoside, (2S, 3S)-1-phenyl-2,3-butanediol 3-O-beta-D-glucopyranoside, were isolated from the flowers of Chrysanthemum indicum L. cultivated in China together with eight flavonoids. The absolute stereostructures of the new compounds were determined on the basis of chemical and physicochemical evidence. Both of the new flavanone glycosides were found to show inhibitory activity for rat lens aldose reductase. 相似文献
8.
Two new acylated flavanone glycosides, (S)-eriodictyol 7-O-(6"-O-trans-p-coumaroyl)-beta-D-glucopyranoside (1) and (S)-eriodictyol 7-O-(6"-O-galloyl)-beta-D-glucopyranoside (2) were isolated from the leaves and branches of Phyllanthus emblica together with a new phenolic glycoside, 2-(2-methylbutyryl)phloroglucinol 1-O-(6"-O-beta-D-apiofuranosyl)-beta-D-glucopyranoside (3), as well as 22 known compounds. Their structures were determined by spectral and chemical methods. 相似文献
9.
A new series of novel (2S)-2-({2-[1,4-dihydro-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridin-1-yl]-2-oxoethyl}amino)-3-(4-hydroxyphenyl) propanoic acid (3a) and its analogues 3b-j has been synthesized. These compounds were evaluated for their in vitro antioxidant activity, anti-inflammatory activity and antiulcer activity. Compounds 3b and f exhibited significant antioxidant action comparable with that of standard. Efficacy against inflammation and ulceration was also found to be significant. The chemical structures of these compounds were confirmed on the basis of spectral data. 相似文献
10.
A study of the chemical constituents of a methanolic extract of the roots of Livistona halongensis (Arecaceae) led to the isolation of two new flavanes, 2S,3S-3,5,7,3'-tetrahydroxy-5'-methoxyflavane (1) and 3,7,3'-trihydroxy-5'-methoxyflavane 5-O-beta-glucopyranoside (2), together with trans-3,5,3',5'-tetrahydroxy-4-methoxystilbene, saccharose and beta-sitosterol-3-O-beta-glucopyranoside. The structures of these compounds were elucidated on the basis of spectroscopic data. 相似文献
11.
Three cycloartane glycosides from Cimicifuga rhizome and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction 总被引:2,自引:0,他引:2
One known (1) and two new cycloartane triglycosides, 20S,22R,23S,24R-16beta,23;22,25-diepoxy-cycloartane-3beta,23,24-triol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranoside (2) and 20S,22R,23S,24R-16beta,23;22,25-diepoxy-cycloartane-3beta,23,24-triol 3-O-(6-O-trans-isoferuloyl-beta-D-glucopyranosyl)-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranoside (3), were isolated from a commercial Cimicifuga Rhizome. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence. These compounds suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction. 相似文献
12.
Two new abietane diterpene lactones (1--2), three new abietane diterpene lactone glycosides (3--5) and a new iridoid glycoside (6), together with five known compounds, were isolated from the aerial parts of Goldfussia yunnanensis. The new compounds were determined to be 18-hydroxyhelioscopinolide A (1), 18-oxohelioscopinolide A (2), 18-hydroxy-3-O-beta-D-glucopyranosylhelioscopinolide A (3), 3-O-beta-D-glucopyranosylhelioscopinolide A (4), 3-O-beta-D-galactopyranosylhelioscopinolide A (5), and 6-O-trans-cinnamoyl E-harpagoside (6) on the basis of spectral data and chemical evidence. 相似文献
13.
A New Cytotoxic Compound from Penicillium auratiogriseum, Symbiotic or Epiphytic Fungus of Sponge Mycale plumose 总被引:1,自引:0,他引:1
Zhi Hong XIN Wei Ming ZHU* Qian Qun GU Yu Chun FANG Lin DUAN Cheng Bin CUI Key Laboratory of Marine Drugs of Chinese Ministry of Education Marine Drugs Food Institute Ocean University of China Qingdao 《中国化学快报》2005,16(9)
To investigate the bioactive metabolites from marine microbes,the fungus Penicillium auratiogriseum was isolated from the sponge Mycale plumose collected in Qingdao,China.The ethyl acetate extract of the fermentation broth of P.auratiogriseum showed significant cytoxicity in the mouse cdc2mutant cell line(tsFT210).Thus5L of liquid medium was inoculated with the purely isolated fungus and incubated at25?C for9days.The cultured broth was extracted three times with the equivalent volume of et… 相似文献
14.
Bruno M Rosselli S Maggio A Piozzi F Scaglioni L Arnold NA Simmonds MS 《Chemical & pharmaceutical bulletin》2004,52(12):1497-1500
Two new neoclerodane diterpenoids, 6-deacetyl-teucrolivin A (5) and 8beta-hydroxy-teucrolivin B (6), were isolated from the aerial parts of Teucrium orientale, along with four already known neoclerodane diterpenoids, teucrolivin A (1), teucrolivin B (2), teucrolivin C (3) and teucrolivin H (4), previously isolated from Teucrium oliverianum. Their structures were elucidated on the basis of spectroscopic evidence and chemical transformations. Compounds 1-3 were assayed for antifeedant activity against Spodoptera littoralis, S. frugiperda and Heliocoverpa armigera. Teucrolivin A was the most potent of the three compounds tested. 相似文献
15.
Nakanishi T Inatomi Y Murata H Iida N Inada A Lang FA Murata J 《Chemical & pharmaceutical bulletin》2002,50(10):1358-1361
Two new phenol glucosides termed juniperosides I (1) and II (2) were isolated, together with known two biflavones, cupressuflavone and amentoflavone and a diterpene, 3beta-hydroxy sandaracopimaric acid, from leaves of Juniperus occidentalis HOOK. (Cupressaceae) collected in Oregon, U.S.A., and their structures were established as (1S)- and (1R)-1-(2'-hydroxy-6'-methylphenyl)ethanol 2'-O-beta-D-glucopyranosides (1, 2), respectively, on the basis of spectral, chemical, and synthetic evidence. The glycosides 1 and 2, as well as the corresponding aglycones 1a and 2a, are apparently novel types of naturally occurring compounds; to our knowledge, isolation of these types of natural phenol derivatives has only rarely been reported from the vegetable kingdom. 相似文献
16.
Eight flavonoids were isolated from Sophora flavescens. Among them, three prenylflavanones: (2S)-6[2(3-hydroxyisopropyl)-5-methyl-4-hexenyl]-5-methoxy-7,2', 4'-trihydroxyflavanone (1), (2S)-5, 4'-dimethoxy-8-lavandulyl-7, 2'-dihydroxy flavanone (2) and (2S)-8-(5-hydroxy-2-isopropenyl-5-methylhexyl)-7-methoxy-5,2', 4'-trihydroxyflavanone (3) are new compounds. Their chemical structures were determined by spectral methods including 2D NMR. 相似文献
17.
Two new flavanone glucosides, (2S)-5,7,3',5'-tetrahydroxy-flavanone 7-O-beta-D-allopyranoside (1) and (2S)-5,7,3',5'-tetrahydroxy-flavanone 7-O-beta-D-glucopyranosie (2) were isolated from the stems and leaves of Jasminum lanceolarium, along with five known compounds: Betulinaldehyde (3), betulinic acid (4), betulin (5), syringin (6) and Liriodendrin (7). Their structures were determined on the basis of spectroscopic and chemical methods. The isolated compounds were screened for their in vitro antioxidant activity through DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. Compounds 2 demonstrated significant radical scavenging activity. 相似文献
18.
A new phenylethanoid glycoside,seulponisidc(1) was isolated from the aerial parts of Isodon sculponeatus(Vaniot) Kudo, along with six known compounds martynoside(2),verbascoside(3),(+)-hydroxypinoresinol-8-O- β-D-glucoside(4),cedrusin(5), 7-megastigmene-3S,5R,6R,7E,9S-tetrol(6) and 4-oxo- β-ionol- β-D-glucopyranoside(7).Their chemical structures were elucidated from physieochemical data and by acidic hydrolysis. 相似文献
19.
Rubio E Merino I García AB Cabal MP Ribas C Bayod-Jasanada M 《Magnetic resonance in chemistry : MRC》2005,43(4):269-282
New spiro-piperidylrifamycin derivatives are presented. These compounds were synthesized from the reaction of 3-amino-4-iminorifamycin S and enantiomerically pure 4-piperidones, which generate diasteroisomeric rifabutin analogues with a new stereocentre at the spiranic carbon. The (1)H and (13)C NMR spectra of these new compounds, and also the configuration of the new stereogenic centres, were assigned using 2D NMR spectroscopic techniques. A preliminary study of the (1)H and (13)C NMR spectra of the starting compounds rifamycin S, 3-amino-4-iminorifamycin S and the related rifabutin was also carried out and as a result, their previously published (13)C NMR data were corrected. 相似文献