Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability.

Multislice proton magnetic resonance spectroscopic imaging (1H MRSI) at 25 ms echo time was used to measure concentrations of myo-inositol (mI), N-acetylaspartate (NAA), and creatine (Cr) and choline (Cho) in ten normal subjects between 22 and 84 years of age (mean age 44 +/- 18 years). By co-analysis with MRI based tissue segmentation results, metabolite distributions were analyzed for each tissue type and for different brain regions. Measurement reliability was evaluated using intraclass correlation coefficients (ICC). Significant differences in metabolite distributions were found for all metabolites. mI of frontal gray matter was 84% of parietal gray matter and 87% of white matter. NAA of frontal gray matter was 86% of parietal gray matter and 85% of white matter. Cho of frontal gray matter was 125% of parietal gray matter and 59% of white matter and Cho of parietal gray matter was 47% of white matter. Cr of parietal gray matter was 113% of white matter. Reliability was relatively high (ICC from.70 to.93) for all metabolites in white matter and for NAA and Cr in gray matter, though limited (ICC less than.63) for mI and Cho in gray matter. These findings indicate that voxel gray/white matter contributions, regional variations in metabolite concentrations, and reliability limitations must be considered when interpreting 1H MR spectra of the brain.     

Modeling brain tissue volumes over the lifespan: quantitative analysis of postmortem weights and in vivo MR images

Normative measurements of brain gray matter and white matter tissue volumes across the lifespan have not yet been established. The purpose of this article was to use mathematical modeling and analytical functions to demonstrate the growth trajectory of gray matter and white matter from age 0 to age 90. For each gender, brain weight functions were generated by utilizing existing autopsy data from 4400 subjects. Brain gray matter, white matter and lateral ventricular volumes were measured from 39 MR volumes of normal individuals. These were converted to weight by multiplying the tissue volumes by the specific gravity of that tissue. White matter volumes were described by a saturating exponential function, and the gray matter volume function was calculated by subtracting the white matter weight function from the brain weight function. For each gender, equations were generated for white matter and gray matter volumes as a function of age over the lifespan.     

The euclidean vacuum: Justification from quantum cosmology

We evaluate the wave function of the universe for a de Sitter minisuperspace with inhomogeneous matter perturbations from a massive scalar field. From the Wheeler-DeWitt equation, we derive Schrödinger equations for the matter modes. We show that the matter part of the Hartle-Hawking wave function is the euclidean vacuum state of quantum field theory in curved spacetime.     

A minimal model for two-component FIMP dark matter:A basic search

In the multi-component configurations of dark matter phenomenology,we propose a minimal twocomponent configuration which is an extension of the Standard Model with only three new fields;one scalar and one fermion interact with the thermal soup through Higgs portal,mediated by the other scalar in such a way that the stabilities of dark matter candidates are made simultaneously by an explicit Z2 symmetry.Against the most common freeze-out framework,we look for dark matter particle signatures in the freeze-in scenario by evaluating the relic density and detection signals.A simple distinguishing feature of the model is the lack of dark matter conversion,so the dark matter components act individually and the model can be adapted entirely to both singlet scalar and singlet fermionic models,separately.We find dark matter self-interaction as the most promising approach to probe such feeble models.Although the scalar component satisfies this constraint,the fermionic one refuses it even in the resonant region.     

T1 and proton density at 7 T in patients with multiple sclerosis: an initial study

Magnetic resonance imaging of cortical lesions due to multiple sclerosis (MS) has been hampered by the lesions' small size and low contrast to adjacent, normal-appearing tissue. Knowing cortical lesion T1 and proton density (PD) would be highly beneficial for the process of developing and optimizing dedicated magnetic resonance (MR) sequences through computer modeling of MR tissue responses. Eight patients and seven healthy control subjects were scanned at 7 T using a series of inversion recovery turbo field echo scans with varying inversion times. Regions of interest were drawn in white matter, gray matter, cortical lesions, white matter lesions and cerebrospinal fluid. White matter and gray matter T1s were significantly higher in MS patients than in controls. Cortical and white matter lesion T1 and PD are also presented for the first time. The advantages of ultrahigh field MR imaging will be important for future investigations in MS research and sequence optimization for the detection of cortical lesions.     

Structure and adiabatic compression of dark matter halos: Simple analytic model

An analytical model is considered for describing the inner regions of dark matter halos. This model is based on the assumption that the density of dark matter varies according to the power law. The model concerns the distribution function in phase space that is expressed in terms of the adiabatic invariants (radial action and angular momentum). Two types, narrow and broad, are suggested for the angular part of the distribution function. The model makes it possible to explicitly describe the adiabatic compression of halos due to a change induced in the gravitational potential by the condensation of baryonic matter at the center. The change in the density of the dark matter halos is calculated and it is shown that the standard algorithm for calculating the adiabatic compression overestimates the halo density, particularly for the case of strong radial anisotropy.     

A technique for single-channel MR brain tissue segmentation: Application to a pediatric sample

A segmentation method is presented for gray matter, white matter, and cerebrospinal fluid (CSF) in thinsliced single-channel brain magnetic resonance (MR) scans. The method is based on probabilistic modeling of intensity distributions and on a region growing technique. Interrater and intrarater reliabilities for the method were high, and comparison with phantom studies and hand-traced results from an experienced rater indicated good validity. The method was designed to account for spatially dependent image intensity inhomogeneities. Segmentation of MR brain scans of 105 (56 male and 49 female) healthy children and adolescents showed that although the total brain volume was stable over age 4–18, white matter increased and gray matter decreased significantly. There were no sex differences in total gray and white matter growth after correction for total brain volume. White matter volume increased the most in superior and posterior regions and laterality effects were seen in hemisphere tissue volumes. These findings are consistent with other reports, and further validate the segmentation technique.     

Dark matter: Theory

The particle physics interpretation of the dark matter problem, which is intimately of cosmological and astrophysical nature, is going to be posed under deep scrutiny in the next years. From the particle physics side, accelerators like the LHC will deeply test theoretical ideas of new physics beyond the Standard Model, where particle candidates of dark matter are predicted to exist. From the astrophysical side, many probes are already providing a great deal of independent information on the foreseen signals which can be produced by the galactic or extra-galactic dark matter. In all this, cosmology plays a central role in determining the relevance and the basic properties of the particle dark matter candidate. The ultimate hope is the emergence of dark matter signals and the rise of a coherent picture of new physics from and at the crossing of particle physics, astrophysics and cosmology. A very ambitious and farreaching project, which will bring to a deeper level our understanding of the fundamental laws which rule the Universe.     

Particle clustering and Mott transitions in nuclear matter at finite temperature: (I). Method and general aspects

The thermodynamic state of nuclear matter as regards dependence on density and temperature is considered. Expressions for the association degree are derived describing the ratio of nuclear matter which is clustered to bound states. The problem of two nucleons imbedded in the surrounding nuclear matter is considered with the help of the Bethe-Goldstone equation for thermodynamic Green functions. The two-particle energy shift due to the effective nuclear matter hamiltonian is considered in a Hartree-Fock approximation, and a Mott density is obtained so that for densities of nuclear matter higher than the Mott density bound states cannot exist. With a simplified effective two-nucleon interaction the association degree is calculated as a function of the nucleon density and the temperature.     

Bianchi type-II cosmological model: some remarks

Within the framework of a Bianchi type-II (BII) cosmological model the behavior of matter distribution has been considered. It is shown that the non-zero off-diagonal component of the Einstein tensor implies some severe restrictions on the choice of matter distribution. In particular, for a locally rotationally symmetric Bianchi type-II (LRS BII) space-time, it is proved that the matter distribution should be strictly isotropic if the corresponding matter field possesses only non-zero diagonal components of the energy-momentum tensor.     

Crystalline structure in the confined-deconfined mixed phase: Neutron stars

We review the differences in first order phase transition of single and multi-component systems, and then discuss the crystalline structure expected to exist in the mixed confined-deconfined phase of hadronic matter. The particular context of neutron stars is chosen for illustration. The qualitative results are general and apply for example to the vapor-liquid transition in subsaturated asymmetric nuclear matter.     

Quark Matter 1987: Concluding remarks

This year marked the beginning of the experimental program at BNL and CERN to probe the properties of ultra dense hadronic matter and to search for the quark-gluon plasma phase of matter. Possible implications of the preliminary findings are discussed. Problems needing further theoretical and experimental study are pointed out.     

White versus gray matter: fMRI hemodynamic responses show similar characteristics, but differ in peak amplitude

ABSTRACT: BACKGROUND: There is growing evidence for the idea of fMRI activation in white matter. In the current study, we compared hemodynamic response functions (HRF) in white matter and gray matter using 4 T fMRI. White matter fMRI activation was elicited in the isthmus of the corpus callosum at both the group and individual levels (using an established interhemispheric transfer task). Callosal HRFs were compared to HRFs from cingulate and parietal activation. RESULTS: Examination of the raw HRF revealed similar overall response characteristics. Finite impulse response modeling confirmed that the WM HRF characteristics were comparable to those of the GM HRF, but had significantly decreased peak response amplitudes. CONCLUSIONS: Overall, the results matched a priori expectations of smaller HRF responses in white matter due to the relative drop in cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the findings demonstrate that despite lower CBF and CBV, white matter fMRI activation remained within detectable ranges at 4 T.     

Searching for quarks: a quantum chemical assisted approach

The evidence for quarks as the basic blocks of matter come only from very expensive experiments, performed in very large particle accelerators. An alternative method of detection is to look for changes in spectroscopic properties that could be influenced by fractionally charged nuclei formed with the ‘wrong’ number of quarks. Although this proposal has already been made by many authors, they were not able to provide feasible and easily interpretable experiments to detect quarks in matter. In this paper, we present the results of configuration interaction (CI) calculations for the transition energies and optical oscillator strengths associated with inner shell electronic spectra of molecular nitrogen made of fractionally charged nuclei. It is shown that these bands can be used as fingerprints characterizing the presence of quarks in matter.     

Finite nuclei to nuclear matter: a leptodermous approach

The liquid drop model (LDM) expansions of energy and incompressibility of finite nuclei are studied in an analytical model using Skyrme-like effective interactions to examine, whether such expansions provide an unambiguous way to go from finite nuclei to nuclear matter, and thereby can yield the saturation properties of the latter, from nuclear masses. We show that the energy expansion is not unique in the sense that, its coefficients do not necessarily correspond to the ground state of nuclear matter and hence, the mass formulas based on it are not equipped to yield saturation properties. The defect is attributed to its use of liquid drop without any reference to particles as its basis, which is classical in nature. It does not possess an essential property of an interacting many-fermion system namely, the single particle property, in particular the Fermi state. It is shown that, the defect is repaired in the infinite nuclear matter model by the use of generalized Hugenholtz–Van Hove theorem of many-body theory. So this model uses infinite nuclear matter with well defined quantum mechanical attributes for its basis. The resulting expansion has the coefficients which are at the ground state of nuclear matter. Thus a well defined path from finite nuclei to nuclear matter is found out. Then using this model, the saturation density 0.1620 fm⁻³ and binding energy per nucleon of nuclear matter 16.108 MeV are determined from the masses of all known nuclei. The corresponding radius constant r₀ equal to 1.138 fm thus determined, agrees quite well with that obtained from electron scattering data, leading to the resolution of the so-called ‘r₀-paradox’. Finally a well defined and stable value of 288±20 MeV for the incompressibility of nuclear matter K_∞ is extracted from the same set of masses and a nuclear equation of state is thus obtained.     

Editorial: An Interesting Comparison Study

While we all know that large-scale facilities such as neutron sources play an important role in condensed matter research, little quantitative characterization of this role is commonly available. As a matter of fact, it could be the subject of a major study-and certain controversy-to define ways and criteria for such a characterization. In discussions between the neutron groups at FZJ (Jülich, Germany), GKSS (Geesthacht, Germany), and HMI (Berlin, Germany), the idea emerged that Physical Review Letters could be used as a reasonable guinea pig for such a study. This high impact journal is familiar to everyone in condensed matter research, so that most people who read such a study could have an opinion on the meaning of statistical data about PRL.     

Magnetic resonance of brain tumors: considerations of imaging contrast on the basis of relaxation measurements

Proton spin-lattice and spin-spin relaxation times have been measured in surgically-removed normal CNS tissues and a variety of tumors of the brain. All measurements were made at 20 MHz and 37 degrees C. Between grey and white matter from autopsy human or canine specimens significant differences in T1 or T2 were observed, with greater differences seen in T1. Such discrimination was reduced in samples obtained from live brain-tumor patients due to lengthening in T1 and T2 of white matter near tumorous lesions. Edematous white matter showed T1 and T2 values higher than those of autopsy disease-free white matter. Compared to normal CNS tissues, most brain tumors examined in this study demonstrated elevated T1 and T2 values. Exceptions, however, did exist. No definitive correlation was indicated on a T1 or T2 basis which allowed a distinction to be made between benign and malignant states. Furthermore, considerable variation in relaxation times occurred from tumor to tumor of the same type, suggesting that within a tumor type there are important differences in physiology, biology, and/or pathologic state. Such variation caused partial overlap in relaxation times among certain tumor types and hence may limit the capability of magnetic resonance imaging (MR) alone for the diagnosis of specific disease. Nonetheless, this study predicts that on the basis of T1 or T2 differences most brain tumors are readily detectable by MR via saturation recovery or inversion recovery with appropriate selections of pulse-spacing parameters. In general, tumors can be discriminated against white matter better than grey matter and contrast between glioma and grey matter is usually superior to that between meningioma and grey matter. This work did not consider tissue-associated proton density which should be addressed together with T1 and T2 for a complete treatment of MR contrast.     

Fuzzy cold dark matter: the wave properties of ultralight particles

Cold dark matter (CDM) models predict small-scale structure in excess of observations of the cores and abundance of dwarf galaxies. These problems might be solved, and the virtues of CDM models retained, even without postulating ad hoc dark matter particle or field interactions, if the dark matter is composed of ultralight scalar particles (m approximately 10(-22) eV), initially in a (cold) Bose-Einstein condensate, similar to axion dark matter models. The wave properties of the dark matter stabilize gravitational collapse, providing halo cores and sharply suppressing small-scale linear power.     

Bianchi cosmologies with anisotropic matter: Locally rotationally symmetric models

The dynamics of cosmological models with isotropic matter sources (perfect fluids) is extensively studied in the literature; in comparison, the dynamics of cosmological models with anisotropic matter sources is not. In this paper we consider spatially homogeneous locally rotationally symmetric solutions of the Einstein equations with a large class of anisotropic matter models including collisionless matter (Vlasov), elastic matter, and magnetic fields. The dynamics of models of Bianchi types I, II, and IX are completely described; the two most striking results are the following. (i) There exist matter models, compatible with the standard energy conditions, such that solutions of Bianchi type IX (closed cosmologies) need not necessarily recollapse; there is an open set of forever expanding solutions. (ii) Generic type IX solutions associated with a matter model like Vlasov matter exhibit oscillatory behavior toward the initial singularity. This behavior differs significantly from that of vacuum/perfect fluid cosmologies; hence “matter matters”. Finally, we indicate that our methods can probably be extended to treat a number of open problems—in particular, the dynamics of Bianchi type VIII and Kantowski-Sachs solutions.