5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物的合成及抑菌活性研究

本文以多个2,3-二芳基噻唑-4-酮为底物,利用微波辅助的方法合成了18个5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物,并测定了它们对7种植物病原菌的抑菌活性。它们的结构经熔点、1H NMR和MS确证。抑菌活性试验显示,化合物4g和4n表现出潜在的抑菌活性。     

5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物的合成及抑菌活性研究（英文）

本文以多个2,3-二芳基噻唑-4-酮为底物,利用微波辅助的方法合成了18个5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物,并测定了它们对7种植物病原菌的抑菌活性。它们的结构经熔点、1H NMR和MS确证。抑菌活性试验显示,化合物4g和4n表现出潜在的抑菌活性。     

微波辅助合成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物

本文报道了一种通过微波辅助合成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物的新型方法。在以K2CO3 为碱、H2O 为溶剂、四丁基溴化铵（TBAB）为催化剂的条件下,2,3-二苯基-4-噻唑酮与取代醛在微波辅助下发生Knoevenagel 反应,生成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物,产率最高可达85%。     

微波辅助合成5-芳亚甲基-2,3-二苯基噻唑-4-酮类衍生物

本文报道了一种通过微波辅助合成5-芳亚甲基-2,3--二苯基噻唑-4-酮类衍生物的新方法。以H2O为溶剂、K2CO3为去氢试剂、四丁基溴化铵为相转移催化剂,2,3-二苯基噻唑-4-酮与取代醛在微波辅助下发生Knoevenagel反应,生成5-芳亚甲基-2,3-二苯基噻唑-4-酮类衍生物,产率最高可达85%。     

噻唑啉-2-硫酮衍生物的合成与生物活性

根据活性亚结构拼接原理,将3-芳基-4-氨基-5-乙氧羰基(氰基)-3H-噻唑啉-2-硫酮与酰氯反应得到目标化合物3-芳基-4-取代苯氧乙酰氨基-5-乙氧羰基(氰基)-3H-噻唑啉-2-硫酮.再以3-苯基-4-氨基-5-乙氧羰基-3H-噻唑啉-2-硫酮为合成原料,经过Aza-Wittig反应得到目标化合物5-芳氧基-3,6-二芳基-2-硫代噻唑并[4,5-d]嘧啶-7-酮.通过IR,1H NMR,EI-MS,元素分析等方法对所合成的化合物进行了结构表征.代表化合物5-对氯苯氧基-3,6-二苯基-2-硫代-2,3-二氢噻唑并[4,5-d]嘧啶-7(6H)-酮(C1)经单晶X衍射证实了结构.除草活性测试结果表明:部分噻唑啉-2-酮类衍生物对稗草和油菜都表现出了较好的抑制活性.     

含噻唑联哌啶烟酰胺类化合物的合成与生物活性研究

噻唑联哌啶结构能够影响生物体内胆固醇类化合物的代谢活动,是氟噻唑吡乙酮抑制病原菌的氧胆固醇结合蛋白(OSBP)的关键药效基团.为了寻找具有生物活性的新型含噻唑联哌啶结构的化合物,设计并合成了14个未见文献报道的新颖含噻唑联哌啶烟酰胺类化生物,其结构经~1H NMR、~(13)C NMR和HRMS确证,生测结果显示:在100μg/m L浓度下,目标化合物普遍具有抑菌活性,其中1个化合物对小麦赤霉病的抑菌活性为60%; 3个化合物对黄瓜灰霉病的抑菌活性为60%;6个化合物对苹果褐斑病的抑菌效果为70%;(4-(5-(2,3-二氯苯基)-4-甲基噻唑-2-基)哌啶-1-基)(5,6-二氯吡啶-3-基)甲酮(6k)对马铃薯晚疫病的抑菌活性为75%.     

N-(取代苯氧乙酰基)-N'-(4-苯基噻唑-2-基)硫脲的合成

以取代苯酚和氯乙酸为原料,合成取代苯氧乙酸,然后经过酰氯化,酯化得到取代苯氧乙酰基异硫氰酸酯,再和2-氨基-4-苯基噻唑反应得到4种N-(取代苯氧乙酰基)-N'-(4-苯基噻唑-2-基)硫脲类化合物,其中3种化合物为首次报道。化合物结构经1H NMR、IR和元素分析得到确证。初步室内生测结果表明该类化合物具有一定的抑菌活性。     

4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑的合成与生物活性

呋喃酚经醚化、傅克酰化、α-溴代、噻唑环化和亚胺化等反应合成了16种4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑新化合物.化合物的结构经1H NMR、质谱和元素分析等确证.杀虫活性实验结果表明,化合物2a和2i在500 mg/L对棉红蜘蛛死亡率分别为53.10%和67.71%,杀菌活性实验结果表明,化合物2a和2k在25 mg/L对油菜菌核病菌抑制率分别为57.9%和59.8%,除草活性实验结果表明,2l在2250 g.ai/ha浓度下对苘麻、刺苋、藜具有一定的除草活性.     

6-烷基-7-亚胺基-2-硫代-2,3,6,7-四氢噻唑并[4,5-d]嘧啶的合成、晶体结构与生物活性

通过3-苯基-5-氰基-2-硫代-2,3-二氢-4-乙氧亚甲胺基噻唑(5)与伯胺反应, 经中间体甲脒关环, 合成了10种新的噻唑并[4,5-d]嘧啶类化合物6a～6j. 所有化合物的结构均经1H NMR, IR和元素分析进行了表征, 并且采用X射线单晶衍射分析方法进一步测定了化合物6i的结构. 初步的生物活性试验表明, 部分标题化合物具有一定的杀菌或除草活性.     

2-[4-(2,6-二氟苯基)噻唑-2-基]-3-羟基丙烯腈衍生物的合成及生物活性

为了寻找生物活性良好的噻唑基丙烯腈类化合物, 利用2-[4-(2,6-二氟苯基)噻唑-2-基]乙腈(3)分别与取代氯甲酸酯4和取代苯基异氰酸酯6在碱存在下反应, 合成了8个2-[4-(2,6-二氟苯基)噻唑-2-基]-3-羟基-3-烃氧基丙烯腈化合物5和7个2-[4-(2,6-二氟苯基)噻唑-2-基]-3-羟基-3-取代苯胺基丙烯腈化合物7, 均为首次报道的丙烯腈类化合物. 化合物结构经1H NMR, IR, MS和元素分析表征. 初步生物活性测定结果表明, 在试验浓度下, 目标化合物均具有一定的杀虫和抑菌活性, 其中化合物5f和5h在100 mg/L浓度下对炭疽病菌的抑制率达95%; 化合物5g和7d在250 mg/L浓度下对棉红蜘蛛的致死率达85%.     

应用先进光谱技术研究无机离子的环境界面化学

发生在环境界面的吸附-解吸和氧化-还原等反应对于污染物在环境介质间传输、转化以及归趋起着重要的调控作用。传统的研究方法虽然可以在实验室模拟并进而描述污染物环境界面过程,但是不能揭示界面反应机制,限制了对污染物环境界面行为的认识。近二十年来,各种谱学技术(例如X射线吸收精细结构和傅里叶红外光谱等)应用于环境界面反应的研究,推动了这一领域研究的发展,特别是在分子水平研究污染物的环境界面过程。通过现代光/波谱技术原位分析,可以实时获取界面反应的定量与结构信息,从而更准确地判断反应机制,极大促进了对污染物在多介质环境界面迁移转化规律的认识。本文将在概述环境界面化学反应的基础上,针对无机离子在环境界面的反应过程,重点介绍几种关键光/波谱技术(X射线吸收精细结构光谱、傅里叶红外光谱、拉曼光谱、核磁共振谱和穆斯堡尔谱等)在环境界面化学研究中的应用,并展望其在环境界面过程研究中的应用前景。     

ICP-MS的KED模式测定磷酸加王水复溶土壤样品中的二十种金属元素

在研究锗测定时,磷酸先溶解样品,后加入王水复溶,可同时测定锂、铍、钪、钒、铬、钴、镍、铜、锌、锗、钼、镉、钡、镧、铈、钨、铊、铅、钍和铀元素。研究ICP-MS的最佳测量模式、最佳工作状态,以铑为内标校正仪器的漂移。通过选择高、中、低几个国家一级水系沉积物和土壤标准物质随同样品一起实验溶解建立标准曲线,消除消解、分取、定容中带来的不确定误差和基体干扰,选择8个土壤标准物质为实验样本。最终结果表明,该实验方法准确度(ΔlgC)小于0.1,精密度(RSD)小于8%,该方法满足测定要求,适用于地质普通样品的多金属检测。#$NL     

Transition Metal–(μ-Cl)–Aluminum Bonding in α-Olefin and Diene Chemistry

Olefin and diene transformations, catalyzed by organoaluminum-activated metal complexes, are widely used in synthetic organic chemistry and form the basis of major petrochemical processes. However, the role of M–(μ-Cl)–Al bonding, being proven for certain >C=C< functionalization reactions, remains unclear and debated for essentially more important industrial processes such as oligomerization and polymerization of α-olefins and conjugated dienes. Numerous publications indirectly point at the significance of M–(μ-Cl)–Al bonding in Ziegler–Natta and related transformations, but only a few studies contain experimental or at least theoretical evidence of the involvement of M–(μ-Cl)–Al species into catalytic cycles. In the present review, we have compiled data on the formation of M–(μ-Cl)–Al complexes (M = Ti, Zr, V, Cr, Ni), their molecular structure, and reactivity towards olefins and dienes. The possible role of similar complexes in the functionalization, oligomerization and polymerization of α-olefins and dienes is discussed in the present review through the prism of the further development of Ziegler–Natta processes and beyond.     

中文化学名词醇醛酮醚酯之由来

1932年民国教育部颁布的《化学命名原则》为中文化学名词确立了统一的标准,并对于"元素及化合物定名取字"提出"取字应以谐声为主,会意次之,不重象形"的定名总则.它确立的中文化学名词醇、醛、酮、醚、酯是意译名,这似乎与其音译为主的命名原则相悖.本文讨论了醇、醛、酮、醚、酯的各种历史译名,并分析了它们被《原则》采纳的原因.     

Bestimmung von Fe, Co, Cu, Zn, Se, Rb und Cs in NBS-Ochsenleber, Blutplasma und Erythrocyten durch INAA und AAS

Zusammenfassung Der Gehalt von Fe, Co, Cu, Zn, Se, Rb und Cs wurde in Blutplasma und in Erythrocyten von sechs Normalpersonen mittels der instrumentellen Neutronenaktivierungsanalyse und der flammenlosen Absorptionsspektrometrie (Cu) bestimmt. Zur Überprüfung der Richtigkeit wurde der NBS-Standard 1577, Ochsenleber, verwendet. Die erhaltenen Resultate für Elemente mit höheren Gehalten (Fe, Cu, Zn) liegen weitgehend im Bereich der bisher veröffentlichten Daten. Bei Elementen mit kleineren Gehalten (Co, Se, Rb, Cs) liegen unsere Werte in dem unteren Bereich oder darunter. Für diese Elemente wurden in Blutplasma und in Erythrocyten (hier bezogen auf Trockenmasse) die folgenden Mittelwerte ermittelt: Für Co 0,22 ±0,14 ng/ml, 0,59±0,23 ng/g, für Se 103±18 ng/ml, 401±29 ng/g, für Rb 167±36 ng/ml, 12,1±2,5 g/g und für Cs 0,88±0,18 ng/ml, 13,0±5,7 ng/g.

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Determination of Fe, Co, Cu, Zn, Se, Rb and Cs in NBS Bovine Liver, blood plasma and erythrocytes by INAA and AAS

Summary The content of the above elements has been determined in blood plasma and in erythrocytes of six normal persons by instrumental neutron activation analysis and flameless atomic absorption spectrometry (Cu). The over-all accuracy of these techniques was checked by using the NBS standard 1577, Bovine Liver. The results obtained for elements of higher content (Fe, Cu, Zn) are essentially in the range of other published data. However, our results for elements occurring with lower contents (Co, Se, Rb, Cs) are in agreement with the lowest values of the published data and in some cases they are even significantly below these. For these elements, the following contents have been determined in blood plasma and in erythrocytes (here related to dry weight): for Co 0.22±0.14 ng/ml and 0.59±0.23 ng/g, for Se 103±18 ng/ml and 401±29 ng/g, for Rb 167 ±36 ng/ml and 12.1±2.5 g/g and for Cs 0.88 ±0.18 ng/ml and 13.0±5.7 ng/g, respectively.

Diese Arbeit wurde durch die Deutsche Forschungsgemeinschaft gefördert.Dem Kernforschungszentrum danken wir für den Erlaß der Bestrahlungskosten.Herrn Dr. med. K. Spenger sind wir für die Mitwirkung bei der Blutentnahme und für wertvolle Diskussion dankbar.     

Phosphorescence of aromatic molecules in complexes with crystalline β-cyclodextrin at room temperature

The rate constants for the quenching by oxygen of triplet states of aromatic molecules (naphthalenes-d₈ and-h₈, phenanthrene) forming inclusion complexes with crystalline β-cyclodextrin in water at 290 K are equal to 900–1300 L mol⁻¹s⁻¹. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1450–1453, August, 1997.     

Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

Alzheimer’s disease is an emerging health disorder associated with cognitive decline and memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for in vitro cholinesterase inhibitory potential. On the basis of promising results, they were further investigated for in vivo analysis using elevated plus maze (EPM), Y-maze, and novel object recognition (NOR) behavioral models. The binding mode of the synthesized compounds with the active sites of cholinesterases, and the involvement of the cholinergic system in brain hippocampus was determined. The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models. A molecular docking study using MOE software was used for validation of the inhibition of cholinesterase(s). It has been indicated from the current research work that the synthesized curcumin analogs enhanced memory functions in mice models and could be used as valuable therapeutic molecules against neurodegenerative disorders. To determine their exact mechanism of action, further studies are suggested.     

Direct benzylic functionalization of pyridines:Palladium-catalyzed mono-α-arylation of α-(2-pyridinyl)acetates with heteroaryl halides

Herein,we report a Pd-catalyzed mono-a-arylation reaction for pyridine benzylic functionalization.This approach serves as an efficient alternative to synthesize di-heteroaryl acetates in good yields and selectivities.Moreover,the method is applicable to heteroa ryl substrate combinations,and exhibits great functional group tolerance.A streamlined protocol also enables the rapid synthesis of diheteroaryl ketones.The synthetic value was also demonstrated by scale-up experiments.     

Unveiling Antimicrobial and Antioxidant Compositional Differences between Dukkah and Za’atar via SPME-GCMS and HPLC-DAD

Interest in plant-based diets has been on the rise in recent years owing to the potential health benefits of their individual components and the notion that plant-based diets might reduce the incidence of several diseases. Egyptian dukkah and Syrian za’atar are two of the most historic and famous Middle Eastern herbal blends used for their anti-inflammatory, hypolipidemic, and antidiabetic effects. Headspace SPME-GCMS and HPLC-DAD were adopted for characterizing the aroma profile and phenolic compounds of both herbal blends, respectively. Further, vapor-phase minimum inhibitory concentration was employed for assessing each blend’s antibacterial potential, while their antioxidant potential was estimated via in vitro antioxidant assays. SPME headspace analysis indicated the abundance of ethers and monoterpene hydrocarbons, while HPLC revealed the presence of several phenolics including rosmarinic acid, ferulic acid, and rutin. Biological investigations affirmed that vapor-phase of the tested blends exhibited antibacterial activities against Gram-positive and Gram-negative pathogens, while the antioxidant potential of the blends was investigated and expressed as Trolox (125.15 ± 5.92 to 337.26 ± 13.84 μM T eq/mg) and EDTA (18.08 ± 1.62 to 51.69 41 ± 5.33 μM EDTA eq/mg) equivalent. The presented study offers the first insight into the chemical profile and biological activities of both dukkah and za’atar.