Crystal Structure of 3－Methyl－9－（O，O－Diethylphosphoryl） Methyl－1，6，12－Trioxa－9－Aza－5－Germaspiro［4，7］Dodecan－2－One

ＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆ３－Ｍｅｔｈｙｌ－９－（Ｏ，Ｏ－Ｄｉｅｔｈｙｌｐｈｏｓｐｈｏｒｙｌ）Ｍｅｔｈｙｌ－１，６，１２－Ｔｒｉｏｘａ－９－Ａｚａ－５－Ｇｅｒｍａｓｐｉｒｏ［４，７］Ｄｏｄｅｃａｎ－２－Ｏｎｅ￥ＣｈｅｎＲｕ－ｙｕ；ＬｉｕＬｕ...     

The Synthesis and Biological Activity of N－Arylamino Carbonyl Methylene 1，2－Benzothiazine 1，1－Dioxides

ＴｈｅＳｙｎｔｈｅｓｉｓａｎｄＢｉｏｌｏｇｉｃａｌＡｃｔｉｖｉｔｙｏｆＮ－ＡｒｙｌａｍｉｎｏＣａｒｂｏｎｙｌＭｅｔｈｙｌｅｎｅ１，２－Ｂｅｎｚｏｔｈｉａｚｉｎｅ１，１－Ｄｉｏｘｉｄｅｓ￥ＧｕｏＦｅｎｇＺＨＡＯ；ＨｕａＺｈｅｎｇＹＡＮＧ（Ｉｎｓｔｉｔｕ...     

Solid State Synthesis and Crystal Structure of 3－Methyl－1－phenyl－4－phenylbenzoylmethylene－5－pyrazolone

ＳｏｌｉｄＳｔａｔｅＳｙｎｔｈｅｓｉｓａｎｄＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆ３－Ｍｅｔｈｙｌ－１－ｐｈｅｎｙｌ－４－ｐｈｅｎｙｌｂｅｎｚｏｙｌｍｅｔｈｙｌｅｎｅ－５－ｐｙｒａｚｏｌｏｎｅＤｕＤａ－Ｍｉｎｇ；ＭｅｎｇＳｈｕａｎｇ－Ｍｉｎｇ；Ｗａｎｇ...     

CharacterizationofHydroxylgroupsinDealuminatedzeoliteHZSM－5bySolid，State1HNMR＊

ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎｏｆＨｙｄｒｏｘｙｌｇｒｏｕｐｓｉｎＤｅａｌｕｍｉｎａｔｅｄｚｅｏｌｉｔｅＨＺＳＭ－５ｂｙＳｏｌｉｄ,Ｓｔａｔｅ１ＨＮＭＲ＊ＤＥＮＧＦｅｎｇ￣ａ,ＤＵＹｏｕ－ｒｕ￣ａ＊＊,ＹＥＣｈａｏ－ｈｕｉ￣ａＷＡＮＧＪｉｎｇ－ｚｈ...     

Crystal and Molecular Structure of 3，4－diphenyl－5－ethyl－5－methyl－1，3，4－diazaphospholidin－2－thione－4－oxide

ＣｒｙｓｔａｌａｎｄＭｏｌｅｃｕｌａｒＳｔｒｕｃｔｕｒｅｏｆ３，４－ｄｉｐｈｅｎｙｌ－５－ｅｔｈｙｌ－５－ｍｅｔｈｙｌ－１，３，４－ｄｉａｚａｐｈｏｓｐｈｏｌｉｄｉｎ－２－ｔｈｉｏｎｅ－４－ｏｘｉｄｅ￥ＦｅｎｇＫｅ－Ｓｈｅｎｇ；ＣｈｅｎＲｕ－Ｙｕ（Ｉ...     

The Synthesis of 1－（4－（N－methylsulfamylmethyl）phenyl－4－ethoxycarbonyl－2－methyl－pyrrole．A New Method of Pyrrole Synthesis

ＴｈｅＳｙｎｔｈｅｓｉｓｏｆ１－（４－（Ｎ－ｍｅｔｈｙｌｓｕｌｆａｍｙｌｍｅｔｈｙｌ）ｐｈｅｎｙｌ－４－ｅｔｈｏｘｙｃａｒｂｏｎｙｌ－２－ｍｅｔｈｙｌ－ｐｙｒｒｏｌｅ．ＡＮｅｗＭｅｔｈｏｄｏｆＰｙｒｒｏｌｅＳｙｎｔｈｅｓｉｓＹａｎＺＨＡＮＧ；ＹｕｎＺ...     

THE BIRCH REDUCTION OF（1－OXO－CYCLOHEXENYLO）－2＇－［2＇，3＇，b］－6，7－MEHYLENEDIOXYBENZOZEPINE

ＴＨＥＢＩＲＣＨＲＥＤＵＣＴＩＯＮＯＦ（１－ＯＸＯ－ＣＹＣＬＯＨＥＸＥＮＹＬＯ）－２＇－［２＇，３＇，ｂ］－６，７－ＭＥＨＹＬＥＮＥＤＩＯＸＹＢＥＮＺＯＺＥＰＩＮＥＪｉａｎｇＨｏｎｇＷＡＮＧ；ＹｕｎＺｈｅｎＪＩＡＮＧ；ＺｈｉＺｈｏｎｇＺＨＡＯ（Ｉｎｓ...     

CONVERSION OF KETONES INTO1，1－DISUBSTITUTED－2，3，3－TRIFLUORO－2－PROPEN －1－OLSWITH1，1－DIBROMO－1，2，2，2－TETRLUORO ETHANE／MAGNESIUM REAGENT

ＣＯＮＶＥＲＳＩＯＮ　ＯＦ　ＫＥＴＯＮＥＳ　ＩＮＴＯ１，１－ＤＩＳＵＢＳＴＩＴＵＴＥＤ－２，３，３－ＴＲＩＦＬＵＯＲＯ－２－ＰＲＯＰＥＮ　－１－ＯＬＳＷＩＴＨ１，１－ＤＩＢＲＯＭＯ－１，２，２，２－ＴＥＴＲＬＵＯＲＯ　ＥＴＨＡＮＥ／ＭＡＧＮＥＳＩＵＭ...     

Synthesis and Biological Evaluation of Substituted 3＇－N－Benzoyl Taxol Analogs

ＳｙｎｔｈｅｓｉｓａｎｄＢｉｏｌｏｇｉｃａｌＥｖａｌｕａｔｉｏｎｏｆＳｕｂｓｔｉｔｕｔｅｄ３＇－Ｎ－ＢｅｎｚｏｙｌＴａｘｏｌＡｎａｌｏｇｓＱｉｎＹＵＥ；Ｑｉ－ＣｈｅｎｇＦＡＮＧａｎｄＸｉａｏＴｉａｎＵＡＮＧ（ＩｎｓｉｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅ...     

STUDY ON THE REARRANGEMENT REACTION OF 5－AMINO－1－AMINOCARBONYL－1，2，AND ITS ANALOGUES

ＳＴＵＤＹＯＮＴＨＥＲＥＡＲＲＡＮＧＥＭＥＮＴＲＥＡＣＴＩＯＮＯＦ５－ＡＭＩＮＯ－１－ＡＭＩＮＯＣＡＲＢＯＮＹＬ－１，２，ＡＮＤＩＴＳＡＮＡＬＯＧＵＥＳ￥ＲｏｎｇＪｉａｎＬＵ；ＨｕａＺｈｅｎｇＹＡＮＧ；ＢａｏＹｉｎｇＱＩＡＮ；ＨａｉＹａｎＤＥＮＧ（Ｎ...     

对映体纯1-甲基-7-氧杂双环[2.2.1]庚烷-2-酮的制备

1-甲基 - 7-氧杂双环 [2 .2 .1 ]庚烷 - 2 -酮 ( 1 )是萜类天然产物全合成中的重要中间体 ,能被广泛地应用于多种桉烷 ( Eudesmane)、沉香呋喃 ( Agarofuran)和降胡萝卜素 ( Norcarotenoids)等倍半萜天然产物的全合成[1,2 ] .我们以对映体纯化合物 1为原料 ,实现这类天然产物的不对称全合成 [3～ 6 ] .消旋的化合物 (± ) - 1可以 2 -甲基呋喃和 2 -氯丙烯腈为原料 ,经 3步反应得到 [2 ] .但对映体纯化合物 1的制备尚未见报道 .本文用化学拆分方法 ,成功地制备了对映体纯的 ( + ) - 1和 ( - ) - 1 ,并确定了其绝对构型 .1　结果与讨论为减…     

1-甲基-3-丙基吡唑-5-羧酸的新合成方法

以2-戊酮和草酸二乙酯为起始原料,经缩合、与甲基腓环合、水解等三个步骤合成了1-甲基-3-丙基吡唑-5-羧酸。此化合物是合成新型磷酸二酯酶V型抑制剂西地那非枸橼酸盐（Silenafil citrate）的重要中间体。     

Synthesis, structure and biological activity of 3,7-dinitrodibenzobromonium salt

3,7-Dinitrodibenzobromonium bisulfate 3 was prepared directly by the reaction of4,4' -dinitrobiphenyl with sodium bromide and potassium persulfate in the concentrated sulphuric acid. Metathetical reactions of 3 gave 3, T-dinitrodibenzobromonium chloride 4, bromide 5 and iodide 6, respectively. Crystal structure of 3a obtained by crystallization of 3 in formic acid showed that each molecule of 3a consists of two dibenzobromonium ions, two bisulfate anions and a formic acid. The dibenzobromonium ion is nearly coplanar. Compound 3 can dramatically increase mice's immunofunction.     

Highly Stereoselective Synthesis of (E, E)-3,7-Dimethyl-2,6-decadiene-1, 10-diol

Thediol1,aqueenbutterflypheromonewasisolatedfromqueenbutterfly(Danausgillippusbelenice).SynthesesofthiscompoundwerereportedfromtheorthoesterClaisenrearrangement2,therearrangementofallylsiloxylinylether3andtheanionic[2,3]-sigmatropicrearrangementofallylicsulfide4.Inlightoftheirbiologicalinterest,itseemeddesirabletodesignamoreefficientroutetothissubstance.Thus,wewishtoreportashort,stereoselectivesynthesisof1utilizingthe1,3-transformationof2,3-epoxyalcoholandtheClaisenrearrangementofallylvinylet…     

芳香醛与3-甲基-1-苯基-5-吡唑啉酮固相缩合反应的研究

芳香醛与３－甲基－１－苯基－５－吡唑啉酮固相缩合反应的研究李晚陆,麻洪,王永梅,孟继本（南开大学化学系,天津,３０００７１;兰州大学应用化学重点实验室）摘要研究了芳香醛与３－甲基－１－苯基－５－吡唑啉酮在室温固相、熔融状态及Ｌｅｗｉｓ酸催化下的缩合反...     

Crystal Structure of 1-Methyl-5-phenylhydantoin

1　INTRODUCTIONInourinvestigationofhemithioacetals,wediscoveredthatα-benzoylhemithioac-etalisquitestableandhastwoelectrophilicsitesthatcanreactwithalkylureastoformahydantoinring[1].Althoughthehydantoinringitselfdoesnotpresentanymedicinalactivity,somedisubstitutedhydantoinshavebeenwidelyusedasmedicineforitsregulareffectonthebioelectricactivityofthenervoussystem.Inordertoim-proveandexpandtheactivityaswellastopreventsideeffects,variouskindsofhy-dantoinderivativeshavebeenpreparedandtested[2].…     

Untersuchung Der Kcmplexbildung Von Thallium(III) Mit 1-Phenyl-3-Methyl-4-Benzoylpyrazolon-5

Abstract

A study has been made of the method used for extracting the complex formed between thallium(III) and PhMBP. It has been demonstrated that thallium(III) can be readily extracted as a complex with PhMBP by organic solvents at low pH. The extraction of thallium(III) has been studied as a function of pH, concentration of reagent, nature of solvent, duration of contact of the phases and concentration of thallium(III). It has been established that thallium(III) forms a complex with PhMBP of the type MA_n, where n=3. The stability constants and distribution constant of the neutral complex has been calculated by the method of Leden-Rydberg.     

Kinetic Study on the Exothermic Decomposition Reaction of 2,4,6,8-Tetranitro-2,4,6,8-tetraazabicyclo[3,3,1]onan-3,7-dione

Introduction 2,4,6,8-Tetranitro-2,4,6,8-tetraazabicyclo[3,3,1]nonan- 3,7-dione (1) is a novel energetic cyclourea nitramine containing four —NO2 groups (Figure 1). The detona-tion velocity corresponding to =1.93 gcm-3 is 9034 ms-1. It is the potential high explosive. Its preparation,1 properties1 and hydrolytic behavior2 have been reported. Thermal behavior is one of the most important aspects of the compound in practical application. However, its kinetic parameters of thermal decomposition…     

以1-甲基-1-甲氧基乙基为保护基的一锅法合成5-芳香二酮-1H-四氮唑

报道了5-芳香二酮-1H-四氮唑(2)的一锅合成法,并且首次报道了1-甲基-1-甲氧基乙基作为四氮唑氮原子的保护基团,保护与脱保护反应条件温和,操作简便,收率高,为该类化合物的合成提供了一条捷径.采用该方法共合成6个未见文献报道的5-芳香二酮-1H-四氮唑类新化合物,以用于药理活性筛选.