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1.
The cyclization of dilithiated nitriles with epibromohydrin afforded 2-cyano-1-(hydroxymethyl)cyclopropanes. 2-Cyanomethylidene-(4-hydroxymethyl)thiazolidines were prepared by one-pot cyclization of dilithiated nitriles with isothiocyanates and epibromohydrin. 相似文献
2.
1,4-Diaza-7-oxabicyclo[4.3.0]non-2-en-6-ones were prepared by cyclization of 1,1-bis(trimethylsiloxy)ketene acetals with pyrazine and quinoxaline. 相似文献
3.
The cyclization of the dianions of diethyl 2-oxopropylphosphonate and of acetone with 1,1-diacylopropanes afforded hydroxyspiro[5.2]cyclooctenones which were transformed, by homo-Michael reactions with tetrabutylammonium halides, into various functionalized phenols or their dimers. 相似文献
4.
6-Alkylidene-2,3-benzo-1,4-diaza-7-oxabicyclo[4.3.0]non-2-enes were prepared by cyclization of 1,3-bis(silyl enol ethers) with quinoxaline. 相似文献
5.
Functionalized 3-hydroxymaleic anhydrides were prepared by cyclization of 1,1-bis(trimethylsilyloxy)ketene acetals with oxalyl chloride. 相似文献
6.
2-(Phenylthio)benzoates containing a remote halide function are regioselectively prepared by ‘[3+3] cyclization/homo-Michael’ reactions of 1-methoxy-1-trimethylsilyloxy-3-phenylthio-1,3-butadienes with 1,1-diacylcyclopropanes. 相似文献
7.
Ehsan Ullah Sven Rotzoll Andreas Schmidt Dirk Michalik Peter Langer 《Tetrahedron letters》2005,46(52):8997-8999
Functionalized 7,8-benzo-9-aza-4-oxabicyclo[3.3.1]nonan-3-ones were prepared by regio- and diastereoselective condensation of 1,1-bis(silyloxy)ketene acetals with isoquinolinium salts and subsequent regioselective and stereospecific iodolactonization. 相似文献
8.
Isotetronic acids were regioselectively prepared by cyclization of 1,3-bis(trimethylsilyloxy)alk-1-enes with oxalyl chloride. 相似文献
9.
Ekaterina A. Anikina Andrey V. Smolobochkin Alexander R. Burilov Michail A. Pudovik 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):766-770
AbstractHerein, we report the successful application of a novel approach to 2-substituted pyrrolidines based on intramolecular cyclization/intermolecular Mannich-type cascade reaction of N-(4,4-diethoxybutyl)sulfonamides to the synthesis of pyrrolidines possessing heterocyclic and polyaromatic moieties. The proposed approach benefits from mild reaction conditions, moderate to high yields of target compounds and provides a convenient route to the previously unknown 1-sulfonyl-2-arylpyrrolidines. 相似文献
10.
Inam Iqbal Nasir Rasool Muhammad A. Rashid Alexander Villinger Peter Langer 《Tetrahedron》2009,65(36):7562-8801
Functionalized 2-(arylthio)benzoates are prepared by formal [3+3] cyclizations of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 3-silyloxy-2-en-1-ones and 1,1-diacylcyclopropanes. 相似文献
11.
7-Arylquinolinones were obtained in two steps from 3-aminobiphenyls through conversion into cinnamic amides. The highly regioselective cyclization under elimination of anisole proceeded in the presence of phosphoric acid and phosphorous pentoxide. 6-Arylindoles were accessible, although in lower yields, from 3-aminobiphenyls via 3-(biphenylamino)acrylates and palladium-catalyzed cyclization reactions. 相似文献
12.
6-(Perfluoroalkyl)salicylates were prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-ethoxy-1-(perfluoroalkyl)prop-2-en-1-ones. 相似文献
13.
Jennifer Hefner 《Tetrahedron letters》2008,49(14):2262-2264
Functionalized diaryl-diazenes (azo-dyes) were regioselectively prepared by formal [3+3] cyclization of 1,3-bis(silyloxy)-1,3-butadienes with 2-aryldiazenyl-3-silyloxy-2-en-1-ones. 相似文献
14.
Jian-Feng Zhou Gui-Xia Gong Kun-Bo Shi Yu-Lan Zhu 《Monatshefte für Chemie / Chemical Monthly》2009,140(6):651-654
Abstract A facile procedure for the synthesis of quinoxalines is being reported starting from 3-(2-bromoacetyl)coumarins or 3-(2-bromobutanoyl)coumarins
and substituted o-phenylenediamines. The reactions were carried out under catalyst-free and microwave irradiation conditions producing the
title compounds in moderate to excellent yields in a short time with easy workup. The structures of all new compounds have
been confirmed on the basis of their IR, 1H NMR, 13C NMR, and HRMS data.
Graphical Abstract
相似文献
15.
Matthias Lau 《Tetrahedron letters》2008,49(39):5618-5619
5-(2-Aryl-2-haloethyl)salicylates are efficiently prepared by the first domino ‘[3+3] cyclization/ring-cleavage’ reactions of 1,3-bis(silyloxy)-1,3-butadienes with 3-acetyl-5-aryl-4,5-dihydrofurans. 相似文献
16.
Functionalized 2,5-dihydrobenzo[b]oxepins and 5,6-dihydro-2H-benzo[b]oxocines were prepared based on a ‘[3+3] cyclization-olefin-metathesis’ strategy. 相似文献
17.
Stefanie Reim Ibrar Hussain Zafar Ahmed Alexander Villinger 《Tetrahedron letters》2008,49(33):4901-4904
The reaction of 2-chloro-1,3-bis(trimethylsilyloxy)-1,3-butadienes with various electrophiles allows a convenient synthesis of chlorinated molecules which are not readily available by other methods. 相似文献
18.
A variety of 2-arylthio-4-methoxybenzoates are regioselectively prepared by TiCl4-mediated [3+3] cyclocondensations of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 3-oxo-orthoesters. Unsubstituted 2-(arylthio)benzoates were prepared by Me3SiOTf-catalyzed cyclization of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 1,1,3,3-tetramethoxypropane. The TiCl4-mediated cyclization of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 1,1-bis(methylthio)-1-en-3-ones results in regioselective formation of 2-arylthio-6-(methylthio)benzoates. 相似文献
19.
Dr. Grant J. Sherborne Dr. Paul Kemmitt Callum Prentice Prof. Dr. Eli Zysman-Colman Prof. Dr. Andrew D. Smith Dr. Charlene Fallan 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(2):e202207829
Condensation of 2-vinylanilines and conjugated aldehydes followed by an efficient light-mediated cyclisation selectively yields either substituted tetrahydroquinolines with typically high dr, or in the presence of an iridium photocatalyst the synthesis of quinoline derivatives is demonstrated. These atom economical processes require mild conditions, with the substrate scope demonstrating excellent site selectivity and functional group tolerance, including azaarene-bearing substrates. A thorough experimental mechanistic investigation explores multiple pathways and the key role that imine and iminium intermediates play in the absorption of visible light to generate reactive excited states. The synthetic utility of the reactions is demonstrated on gram scale quantities in both batch and flow, alongside further manipulation of the medicinally relevant products. 相似文献
20.
Functionalized aryl fluorides were regioselectively prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with 2-fluoro-3-silyloxy-2-en-1-ones. 相似文献