共查询到20条相似文献,搜索用时 93 毫秒
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采用荧光光谱法和热力学方法研究了3-乙基苯并噻唑螺萘并噁嗪(EBSN)与牛血清白蛋白(BSA)的相互作用.结果表明,在pH为7.46的Tris-HCl及0.01mol·L-1的NaCl介质中,EBSN能强烈猝灭BSA的荧光,猝灭机理为形成复合物的静态猝灭.在298、306和313K时,两者的表观结合常数Kb分别为1.762 0×104,3.396 3×104和6.123 5×104 L·mol-1.与此同时,EBSN与BSA的结合反应是自发的,作用力主要为疏水作用力;BSA和EBSN的工作曲线分别为F0-F=2.439c-8.322和(F0-F)/F=0.061 89c+0.556 6,对BSA和EBSN的检出限分别为0.015mg·L-1和7.61×10-7 mol·L-1. 相似文献
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新型环烷烯并嘧啶并噻唑-3-酮类化合物的合成 总被引:1,自引:0,他引:1
以环戊酮、环庚酮为起始原料合成的环烷烯并[1,2-d]嘧啶-2-硫酮(2)与氯乙酸、芳香醛反应, 合成具有潜在抗癌活性的稠合杂环化合物5-芳基-2,8-二芳亚甲基-2,3,6,7-四氢-5H,8H-环戊烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(3)以及5-芳基-2,10-二芳亚甲基-2,3,6,7,8,9-六氢-5H,10H-环庚烯并[1,2-d]噻唑并[3,2-a]嘧啶-3-酮(4). 3和4的结构经1H NMR, IR, MS分析确认. 相似文献
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噻唑并嘧啶类化合物的合成研究进展 总被引:2,自引:0,他引:2
综述了在医药和农药领域具有广泛用途的噻唑并嘧啶类化合物近二十年来合成方法上的研究进展. 结合本研究组在这一领域的工作介绍了噻唑并嘧啶类化合物的三种主要结构类型: 噻唑并[3,2-a]嘧啶、噻唑并[4,5-d]嘧啶、噻唑并[5,4-d]嘧啶类化合物的相关合成方法及新进展. 相似文献
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6-硝基苯并咪唑杂环衍生物的合成 总被引:1,自引:0,他引:1
以6-硝基苯并咪唑-1-乙酰肼和5-(6-硝基苯并咪唑-1-亚甲基)-3-巯基-4-氨基-1,2,4-三唑为原料,在不同条件下合成了一系列新的均三唑〔3,4-b〕-1,3,4-噻二唑,1,2,4-三唑和1,3,4-恶二唑衍生物。化合物的结构均经元素分析、^1H NMR、IR和MS确证,并对其波谱性质进行了讨论。 相似文献
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The 1,3‐dipolar cycloaddition of azomethine ylides derived from isatin and amino acids viz. sarcosine and proline to 2‐arylmethylidene‐5,6‐dihydroimidazo[2,1‐b]thiazol‐3(2H)‐ones afforded novel spiro pyrrolidines and pyrrolizidines regio‐ and stereoselectively in moderate yields. The products were characterized thoroughly by IR, MS, NMR together with elementary analysis. 相似文献
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Afsaneh Feiz Ghazaleh Imani Shakibaei Zahra Yasaei Hamid Reza Khavasi Ayoob Bazgir 《Helvetica chimica acta》2011,94(9):1628-1637
A new four‐component synthesis of spiro[4H‐indeno[1,2‐b]pyridine‐4,3′‐[3H]indoles] and spiro[acenaphthylene‐1(2H),4′‐[4H‐indeno[1,2‐b]pyridines] by the reaction of indane‐1,3‐dione, 1,3‐dicarbonyl compounds, isatins (=1H‐indole‐2,3‐diones) or acenaphthylene‐1,2‐dione, and AcONH4 in refluxing toluene in the presence of a catalytic amount of pyridine is reported. 相似文献
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Thomas Zimmermann Nikola Pustet Albrecht Mannschreck 《Monatshefte für Chemie / Chemical Monthly》2000,131(10):1083-1090
Summary. The enantiomers of substituted spiro[cyclohexadiene-dihydroacridines] were separated by enantioselective liquid chromatography
with the sorbent/solvent systems triacetylcellulose/methanol, tris-(3,5-dimethylphenylcarbamoyl)-cellulose/silica gel (Chiralcel
ODTM)/n-heptane/2-propanol, and (+)-poly-(trityl methacrylate)/silica gel/n-heptane/2-propanol. Interconversion barriers of the enantiomers were determined for a series of derivatives by thermal racemization.
Electrocyclic ring opening/ring closure in terms of the Woodward-Hoffmann rules is discussed for the enantiomerization mechanism; the interconversion of the enantiomers by enolization is ruled out
by deuterium exchange experiments.
Received April 3, 2000. Accepted April 12, 2000 相似文献
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《Journal of heterocyclic chemistry》2017,54(1):570-574
Reactions of indole‐2,3‐diones with biuret afforded 1,3‐dihydro‐3‐ureidoformimido‐2H‐indol‐2‐ones and spiro[3H‐indole‐3,2′(1′H )‐(1,3,5)triazine]‐2,4′,6′(1H ,3′H ,5′H )‐triones indicated these to be solvent dependent. The chemical structures of the products were elucidated by their comprehensive spectroscopic (IR, 1H‐NMR, 13C‐NMR, 19F‐NMR, and Mass) as well as analytical analysis. 相似文献
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AbstractNovel bis[2-(thiazol-2-yl)acetonitriles], linked to aliphatic cores via ethers, were prepared by the reaction of the appropriate bis(2-bromoethan-1-one) with 2-cyanothioacetamide in dioxane at reflux. Bis[2-(thiazol-2-yl)acetonitriles] were taken as key intermediates for the preparation of a new class of macrocyclic dicarbonitriles bearing two thiazole units and containing two O2-donor sets and fused with two benzene units. The target macrocyclic dicarbonitriles were prepared by the cyclocondensation of bis[2-(thiazol-2-yl)acetonitriles] with the appropriate bis(aldehydes) in N,N-dimethylformamide in the presence of piperidine at reflux. Moreover, a new class of pyrazolo-fused macrocycles containing thiazole subunits were prepared by the reaction of macrocyclic dicarbonitriles with hydrazine hydrate in ethanol at reflux. The structures of the novel macrocycles bearing thiazole subunits were elucidated by considering their elemental analyses as well as their IR, mass, 1H NMR and 13C NMR spectral data. 相似文献
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ZHENG Yue qing * 《高等学校化学研究》1999,(3)
IntroductionPreviously,wereportedthecrystalstructureofK2[Ni(CO3)2(H2O)4][1],whichcrystallizedinthebaylissitetypestructureandwasfoundtobeisostructuralwithK2[Co(CO3)2(H2O)4][2]andK2Mg(CO3)2·4H2O[3].Inordertosystematicallyinvestigatetheoccurrenceoftheco… 相似文献
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4—取代苯基—6—甲基—5—硫代—1,2,4—三嗪—3—酮的合成 总被引:3,自引:0,他引:3
合成了一系列新的4,6-二取代-5-硫代-1,2,4-三嗪-3-酮类化合物,并用元素分析、IR、^1H NMR及MS对其结构进行了表征。 相似文献
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