共查询到19条相似文献,搜索用时 93 毫秒
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寻找抗艾滋病活性的抚导化合物是当前药物化学研究领域中的热点之一. 相似文献
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XueQiangLI XueZhiZHAO PeiNianLIU YongQiangTU 《中国化学快报》2004,15(7):757-758
The stereoselective synthesis of the CI-C7 fragment (3R,4S,6R)-3,4-di[(tert-butyldimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis ofthe HIV-1 protease inhibitive didemnaketals, was developed via 12 steps from the natural ( )-pulegone. 相似文献
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以(S)-3-(2,2-二甲基-5-(3-甲基-1H-吲哚-2-基)-1,3-二氧杂环己烷-5-基)吡咯烷-2-酮为原料,经吡咯烷酮还原开环、串联的氢化脱保护/分子内还原胺化反应等关键步骤,合成了吲哚生物碱actinophyllic acid的A/B/C环手性中间体(S)-3-(2-(2-氯乙酰氨基)-2′,2′-二甲基-1,2,3,4,5,7-六氢螺[氮杂环辛烷并[4,3-b]吲哚-6,5′-[1,3]二氧杂环己烷]-5-基)-3-丙酮酸甲酯(9); 9可在氧化条件下转化为A/B/G环中间体(S)-7-(2-(2-氯乙酰氨基)乙基)-2′,2′-二甲基-8-氧代-7,8-二氢-5-H-螺[环庚烯并[b]吲哚-6,5′-[1,3]二氧杂环己烷]-9-甲酸酯(10)。该合成路线涉及9个新化合物,其结构经1H NMR,13C NMR, 2D NMR和LC-MS(ESI)表征。 相似文献
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综述了1β-Methyl Carbapenem中间体的合成方法,重点强调了如何构筑1位β构型的甲基。参考文献37篇。 相似文献
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手性螺环配体的合成及其在不对称催化反应中的应用研究进展 总被引:2,自引:0,他引:2
手性螺环配体的合成及其在不对称催化反应中的应用是不对称合成和催化研究中重要的研究领域之一, 一些手性螺环配体被合成出来并成功地应用于不对称催化反应中. 综述了近十年来手性螺环配体的合成及在不对称催化反应中的应用研究进展. 相似文献
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Xue Qiang LI Xue Zhi ZHAO Pei Nian LIU Yong Qiang TUDepartment of Chemistry State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Department of Chemistry Ningxia University Yinchuan 《中国化学快报》2004,(7)
The stereoselective synthesis of the C1-C7 fragment (3R,4S,6R)-3,4-di[(tert-butyl-dimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one, which is the crucial intermediate for synthesis of the HIV-1 protease inhibitive didemnaketals, was developed via 12 steps from the natural (+)-pulegone. 相似文献
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A stereocontrolled synthesis of the C1-C8 fragment of reveromycins is presented herein. Key to our strategy was the implementation of Evans' aldol reaction that delivered the desired stereochemistry at the C4 and C5 stereocenters. 相似文献
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An expeditious assembly of a C1-C16 subunit of bryostatin 1 is described. A pyran annulation reaction was utilized to form the B-ring by reaction of a hydroxy-allylsilane with a fully elaborated A-ring subunit. This annulation process proceeded with complete diastereoselectivity and in excellent isolated yield despite the presence of potentially sensitive functionality in the A-ring segment. 相似文献
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The synthesis of C1-C20 and C15-C27 segments of Aplyronine A is described. Oxidative cleavage of cyclic vinyl sulfones has been used to prepare key fragments of Aplyronine A. Key precursors are united by Horner-Wadsworth-Emmons and Julia-Kociensky olefination for the respective elaboration of the C1-C20 and C15-C27 segments. 相似文献
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Described is the construction of a furanyl-cylcobutanone fragment suited for incorporation into a synthesis of the naturally occurring anti-cancer agent Providencin. 相似文献