N－芳基－2－乙基－3－羟基－4－吡啶酮的微波合成

用微波辐射从2－乙基－3－羟基－4－吡喃酮和芳胺合成了系列N－芳基－2－ 乙基－3－羟基－4－吡啶酮，并对产物进行了紫外、红外、氢核磁和质谱表征。     

SYNTHESIS OF 4－S－（1＂－ARYL－TETRAZOLE－5＂－YL）－4－DEOXY－4＇－DEMETHYL－EPIPODOPHYLLOTOXIN ANALOGUES

ＳＹＮＴＨＥＳＩＳ ＯＦ ４－Ｓ－（１＂－ＡＲＹＬ－ＴＥＴＲＡＺＯＬＥ－５＂－ＹＬ）－４－ＤＥＯＸＹ－４＇－ＤＥＭＥＴＨＹＬ－ＥＰＩＰＯＤＯＰＨＹＬＬＯＴＯＸＩＮ ＡＮＡＬＯＧＵＥＳ￥ＫｕａｎＫｅＬＵ；ＦａｎｇＭｉｎＬＩＵａｎｄＹａｏＺｕＣＨＥＮ（Ｄ...     

2－乙基－1－（α－呋喃基）－1－戊烯－4－炔－3醇的合成

２－乙基－１－（α－呋喃基）－１－戊烯－４－炔－３醇的合成肖蓉，孙悦（成都科技大学化学系６１００６５）涂君俐（中国科学院成都有机化学研究所，６１００４１）蚊香和电热片是拟除虫菊醋类药剂，也是家庭卫生用药的代表性剂型。如果能开发出挥发性高，在非加热条件...     

A Highly Stereoselective Synthesis of 2－Carbomethoxy－3－aryl－4－carboethoxy－5－methyl－cis－2，3－dihydrofurans

ＡＨｉｇｈｌｙＳｔｅｒｅｏｓｅｌｅｃｔｉｖｅＳｙｎｔｈｅｓｉｓｏｆ２－Ｃａｒｂｏｍｅｔｈｏｘｙ－３－ａｒｙｌ－４－ｃａｒｂｏｅｔｈｏｘｙ－５－ｍｅｔｈｙｌ－ｃｉｓ－２，３－ｄｉｈｙｄｒｏｆｕｒａｎｓＤＩＮＧＷｅｉ－ｙｕ；ＣＨＥＮＹａ－ｌｉ；ＺＨＡＮＧ...     

SYNTHESIS OF 5－SUBSTITUTED－2－CHLORO－6－METHYL－4， 7－DIOXOBENZOTHIAZOLE DERIVATIVES

ＳＹＮＴＨＥＳＩＳ ＯＦ ５－ＳＵＢＳＴＩＴＵＴＥＤ－２－ＣＨＬＯＲＯ－６－ＭＥＴＨＹＬ－４， ７－ＤＩＯＸＯＢＥＮＺＯＴＨＩＡＺＯＬＥ ＤＥＲＩＶＡＴＩＶＥＳ￥ＣｕｉＨｕａＬＩＵ；ＢｉｎＬＵ；ＪｉｎｇＬｉｎｇＺＨＡＮＧ（Ｉｎｓｔｉｔｕｔｅｏｆｏｒｇ...     

1－芳酰基－3－烷基－6－羟基－6－芳基富烯的合成

１－芳酰基－３－烷基－６－羟基－６－芳基富烯的合成焦纶基,董育斌,马玉道（山东大学应用化学研究所,济南,２５０１００）关键词富烯,二茂铁,芳酰化,合成前文［１］曾报道过甲基锂、苯基锂与６,６－二烷基富烯加成物的芳酰化。为进一步探讨取代环戊二烯负离子的...     

锆－7－碘－8－羟基喹啉－5－磺酸－EDTA－表面活性剂体系的荧光光度法研究

在ｐＨ６．２的ＨＡｃ－ＮａＡｃ缓冲溶液中，有溴化十六烷基三甲基铵（ＣＴＭＡ８）存在下，Ｚｒ（Ⅳ）与７－碘－８－羟基喹啉－５－磺酸（Ｈ＿２ＱＳＩ）及ＥＤＴＡ形成了四元荧光配合物。其组成为：Ｚｒ：Ｈ＿ＱＳＩ：ＥＤＴＡ：ＣＴＭＡＢ＝１：１：１：３。据此建立了错的选择性好、灵敏度高的荧光测定方法。方法检测限为１．２ｎｇ／ｍＬ。锆的线性范围为１．６ｎｇ～１．０μｇ／ｍＬ。用于铜合金中微量锆的测定，结果令人满意。     

Crystal and Molecular Structure of 3，4－diphenyl－5－ethyl－5－methyl－1，3，4－diazaphospholidin－2－thione－4－oxide

ＣｒｙｓｔａｌａｎｄＭｏｌｅｃｕｌａｒＳｔｒｕｃｔｕｒｅｏｆ３，４－ｄｉｐｈｅｎｙｌ－５－ｅｔｈｙｌ－５－ｍｅｔｈｙｌ－１，３，４－ｄｉａｚａｐｈｏｓｐｈｏｌｉｄｉｎ－２－ｔｈｉｏｎｅ－４－ｏｘｉｄｅ￥ＦｅｎｇＫｅ－Ｓｈｅｎｇ；ＣｈｅｎＲｕ－Ｙｕ（Ｉ...     

4－叔丁基－β－氯－α－甲基肉桂醛的合成

从苯和叔了醇出发，经过３步反应合成得标题化合物，总收率在６８％以上。     

The Synthesis of 1－O－β－D－（5－Aryl－2－furoyl）AcetylatedSugarsbyPhaseTransferCatalysis

以相转移催化法使α－溴代乙酰基葡萄糖，α－溴代乙酰基木糖和α－溴代乙酰基葡萄糖醛酸甲酯与５－芳基－２－呋喃甲酸在水－有机相体系中反应，合成了１４个未见文献报道的糖酯类化合物，其结构经ＩＲ、１ＨＮＭＲ、ＭＳ等证实，生物活性实验正在进行之中     

N—［1－（2－吡咯烷酮基）甲基］丙烯酰胺类的聚合及其水凝胶

Ｎ—［１－（２－吡咯烷酮基）甲基］丙烯酰胺类的聚合及其水凝胶于淑艳，李福绵（北京大学化学系，北京，１００８７１）关键词Ｎ－［１－（２－吡咯烷酮基）甲基］丙烯酸胺、氧化－还原引发体系、超高分子量、平衡吸水率Ｎ一【ｌ一（２一毗咯烷酮基）甲基］丙烯酸胺（Ｐ...     

The reactions between tetrachloroplatinate(II) anion and bidentate sulphur-nitrogen chelating agents: A direct route for the synthesis of the neutral dichloro species

A direct route for the synthesis of the neutral dichloro complexes [Pt(NS)Cl₂], (NS = 2-[(ethylthio)methyl]pyridine and 2-[(phenylthio)methyl]pyridine) in dimethylformamide, which avoids the formation of bis-chelate cations, is reported.     

Syntheses and properties of 2-[(dimethylamino)methyl]-1-hydroxyferrocene and its derivatives

A 1,2-disubstituted ferrocene derivative, 2-[(dimethylamino)methyl]-1-hydroxyferrocene (I), was prepared from 2-[(dimethylamino)methyl]-1-iodoferrocene via 2-[(dimethylamino)methyl]-1-acetoxyferrocene. On complexation, compound I served as a stable monovalent chelate ligand of a 1,2-disubstituted ferrocene derivative. In addition, a dihydroxy derivative, 2-(hydroxymethyl)-1-hydroxyferrocene, was obtained from hydrolysis of the methiodide formed from I.     

Anticancer effect of three pyrazole derivatives

The evaluation of the cytotoxic properties in vitro of three synthetic tripods containing pyrazole: N,N-bis[(3,5-dimethylpyrazol-1-yl)methyl]aniline (1); N,N-tetrakis[(3,5-dimethylpyrazol-1-yl)methyl]-para-phenylenediamine (2); and N,N-tetrakis-[(1,5-dimethylpyrazol-3-yl)methyl]-para-phenylenediamine (3), was examined for their cytotoxic activity on two tumor cell lines: P815 (murin mastocytoma) and Hep (human laryngeal carcinome). While the compound 2 shows a small cytotoxic activity, compounds 1 and 3 are more cytotoxic against both cell lines. However, this cytotoxicity is more pronounced against Hep cell line (IC50: 3.25 microg mL(-1) for compound 1 and 6.92 microg mL(-1) for compound 3) than P815 cell line (IC50: 17.82 microg mL(-1) for compound 1 and 37.21 microg mL(-1) for compound 3). Statistical analysis shows that the compound 1 is two- to threefold more cytotoxic than compound 3 (P < 0.05). Interestingly, the cytotoxicity induced by compound 1 against Hep cell line is more important than that induced by adriamycin used as a positive control.     

Hydrogen Bonding Influenced Coordination Mode of Azide Ligand in Schiff base Copper(II) Complexes: Synthesis,Crystal Structures,and Antibacterial Activity

Russian Journal of Coordination Chemistry - Two copper(II) complexes, [CuL1N3] (I) and [CuL2(μ1,?1-N3)] (II), where L1 = 2-[(2-diethylaminoethylimino)methyl]-4,6-difluorophenolate, L2 =...     

Preparation and characterization of dinuclear Pd(II) complexes of binucleating tetraaza-thiophenolate ligands

The thioethers 4-tert-butyl-2,6-bis((2-(dimethylamino)ethylimino)methyl)phenyl(tert-butyl)sulfane (tBu-L3) and 4-tert-butyl-2,6-bis((2-(dimethylamino)ethylimino)methyl)phenyl(tert-butyl)sulfane (tBu-L4) react with PdCl2(NCMe)2 to give the dinuclear palladium thiophenolate complexes [(L3)Pd2Cl2]+ (2) and [(L4Pd2(mu-Cl)]2+ (3) (HL3= 2,6-bis((2-(dimethylamino)ethylimino)methyl)-4-tert-butylbenzenethiol, HL4 = 2,6-bis((2-(dimethylamino)ethylamino)methyl)-4-tert-butylbenzenethiol). The chloride ligands in could be replaced by neutral (NCMe) and anionic ligands (NCS-, N3-, CN-, OAc-) to give the diamagnetic Pd(II) complexes [(L3)Pd2(NCMe)2]3+ (4), [(L3)Pd2(NCS)2]+ (5), [(L3)Pd2(N3)2]+ (6), [{(L3)Pd2(mu-CN)}2]4+ (7) and [(L3)Pd2(OAc)]2+ (9). The nitrile ligands in and in [(L3)Pd2(NCCH2Cl)2]3+ are readily hydrated to give the corresponding amidato complexes [(L3)Pd2(CH3CONH)]2+ (8) and [(L3)Pd2(CH2ClCONH)]2+ (10). The reaction of [(L3)Pd2(NCMe)2]3+ with NaBPh4 gave the diphenyl complex [(L3)Pd2(Ph)2]+ (11). All complexes were either isolated as perchlorate or tetraphenylborate salts and studied by IR, 1H and 13C NMR spectroscopy. In addition, complexes 2[ClO4], 3[ClO4]2, 5[BPh4], 6[BPh4], 7[ClO4]4, 9[ClO4]2, 10[ClO4]2 and 11[BPh4] have been characterized by X-ray crystallography.     

An ionic 2D inorganic–organic hybrid of tris[((1H-tetrazol-5-yl)methyl) morpholine] dodecatungstophosphate(V) pentahydrate: Synthesis X-ray crystal structure, and spectroscopic characterizations

A unique ionic hybrid material [C6H12N5O]3[(PO4)W12O36]•5H2O has been synthesized from the reaction of ((1H-tetrazole-5-yl)methyl)morpholine and α-H3[(PO4)W12O36].21H2O. It has successfully been characterized by elemental analysis, IR and 1H NMR spectroscopies, TGA and single-crystal X-ray diffraction method. The title compound is constructed from the three [C6H12N5O]+ cations and α-Keggin [(PO4)W12O36]3- polyoxoanion. The most remarkable structural feature of this hybrid can be described as two-dimensional inorganic infinite plane-like (2D/∞[(PO4)W12O36]3-) which forming via van der Waals interactions along the x axis.     

Coordination chemistry of dinucleating P2N2S ligands: preparation and characterization of cationic palladium complexes

The thioethers (4-tert-butyl-2,6-bis((2-(diphenylphosphino)ethylimino)methyl)phenyl)(tert-butyl)sulfane (tBuL3) and (4-tert-butyl-2,6-bis((2-(diphenylphosphino)ethylamino)methyl)phenyl)(tert-butyl)sulfane (tBuL4) react readily with [Pd(NCMe)2Cl2] to give the dinuclear palladium thiophenolate complexes [(L3)Pd2(Cl)2]+ and [(L4)Pd2(micro-Cl)]2+ (HL3=2,6-bis((2-(diphenylphosphino)ethylimino)methyl)-4-tert-butylbenzenethiol, HL4=2,6-bis((2-(diphenylphosphino)ethylamino)methyl)-4-tert-butylbenzenethiol). The chlorides in could be replaced by neutral (MeCN) and anionic ligands (NCS-, N3-, I-, CN-) to give the dinuclear PdII complexes [(L3)Pd2(NCMe)2]3+, [(L3)Pd2(SCN)2]+, [(L3)Pd2(N3)2]+, [(L3)Pd2(I)2]+, and [(L3)Pd2(CN)2]+. The acetonitrile ligands in are readily hydrated to give the corresponding amidato complex [(L3)Pd2(NHCOMe)]2+. All complexes were isolated as perchlorate salts and studied by infrared, 1H, and 31P NMR spectroscopy. In addition, complexes [ClO4].EtOH, [ClO4]2, [ClO4], [ClO4].EtOH, and [ClO4]2.MeCN.MeOH have been characterized by X-ray crystallography. The dipalladium complex was found to catalyse the vinyl-addition polymerization of norbornene in the presence of MAO (methylalumoxane) and B(C6F5)3/AlEt3.     

Synthesis and characterization of novel bis-triazolyl quinazolinones

Russian Journal of General Chemistry - A series of 2-methyl-1-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]-2-(4-{[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl}amino]phenyl)-2,3-dihydroquinazolin-4(1H)-ones...     

Exogenous bridging and nonbridging in Cu(II) complexes of Mannich base ligands: Synthesis and physical properties

Preparation of pentadentate ligands L¹, L², L³ and L⁴, where L¹ = 4-chloro-3-methyl-2[(prolin-1-yl)methyl]-6-[N-phenyl piperazin-1-yl)methyl]phenol, L² = 4-ethyl-2-[(prolin-1-yl)methyl]-6-[(N-phenyl piperazin-1-yl)methyl]phenol, L³ = 4-chloro-3-methyl-2-[(prolin-1-yl)methyl]-6-[N-methyl piperazin-1-yl]methyl phenol, L⁴ = 4-methoxy-2-[(prolin-1-yl)methyl]-6-[(N-phenyl piperazin-1-yl)methyl]phenol is described together with that of the corresponding Cu(II) complexes with various bridging motifs like OH, OAc and NO₂. The complexes are characterized by elemental analysis, electrochemical and electron paramagnetic spectral studies. Redox properties of the complexes in acetonitrile are highly quasireversible due to the chemical or/and stereochemical changes subsequent to electron transfer. The complexes show resolved copper hyperfine EPR at room temperature, indicating the presence of weak antiferromagnetic coupling between the copper atoms. Strengths of the antiferromagnetic interactions are in the order NO₂>OAc>OH.