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1.
[reaction: see text] Addition of diverse nucleophiles to the unsaturated lactone 2 that results from hetero Diels-Alder reaction of Brassard's diene 1 with aldehydes leads to an efficient and general approach to the synthesis of 2,3-dihydro-4H-pyran-4-ones 3. 相似文献
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3.
L. Gros S. Westerlich A. Wesolowska T. S. Jagodzinski 《Chemistry of Heterocyclic Compounds》2006,42(2):176-179
A novel synthesis of thioamide derivatives of methyl vinyl ketone and their cyclization to 2,3-dihydro-4H-thiopyran-4-ones
were developed.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 201–204, February, 2006. 相似文献
4.
The reaction of ethyl 2-ethynylphenylcarbamate derivative with alkenes in the presence of a palladium(II) catalyst, copper dichloride and tetrabutylammonium fluoride (TBAF) produced 2-substituted 3-ethenylindoles during refluxing. The intramolecular cyclization reaction of ethyl 2-ethynylphenylcarbamates, which have an ethenyl part in the ethynyl group, was also used to produce carbazole derivatives. 相似文献
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Practical and efficient parallel methods have been developed for the synthesis of 7,8-disubstituted 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and 3,7,8-trisubstituted 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones. This benzothiazepin-4(5H)-one skeleton possesses three or four diversity points. Furthermore, three novel tricycles integrating a benzothiazepin-4(5H)-one scaffold with other privileged structures, such as benzimidazole, benzimidazolone, and thio-benzimidazole, were also developed. The synthetic strategy provides an efficient way to access the benzothiazepinone core, starting from commercially available 1,5-difluoro-2,4-dinitrobenzene (DFDNB), and also allows further derivation of the strategically anchored functionalities. 相似文献
7.
Gabriella Pcsfalvi Albert Lvai Zoltn Dinya rpd Somogyi Kroly Vkey 《Journal of mass spectrometry : JMS》1994,29(6):303-308
The electron impact-induced fragmentations of 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and some related compounds were investigated. On the basis of low- and high-resolution measurements, metastable ion studies by means of mass-analysed ion kinetic energy spectroscopy and collision-induced dissociation experiments, the main fragmentation pathways were established. The effect of methyl and phenyl substituents at the C(2) and C(3) positions of the heterocyclic ring on the fragmentations was also studied. The (1,3) ring splitting was investigated in some detail, using semi-empirical molecular orbital calculations. 相似文献
8.
Katritzky AR Odens HH Zhang S Rostek CJ Maender OW 《The Journal of organic chemistry》2001,66(20):6792-6796
Nucleophilic additions of alpha-mercaptoalkanoate esters and beta-mercaptoalkanoate acids to benzoquinone diimines, followed by cyclization with trifluoroacetic acid or 1,3-dicyclohexylcarbodiimide (DCC), provide novel, high-yielding syntheses of 2H-1,4-benzothiazin-3(4H)-ones (3a-f) and 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones (5a-c), respectively. 相似文献
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10.
A. A. Gaponov Z. F. Solomko N. Ya. Bozhanova E. I. Pantyukh 《Chemistry of Heterocyclic Compounds》1989,25(7):836-836
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, p. 997, July, 1989. 相似文献
11.
Harry L. Yale 《Journal of heterocyclic chemistry》1971,8(2):193-204
A series of 2,3-dihydro-1,3,2-benzodiazaborin-4(IH)-ones have been prepared and their ir spectra compared with those of their carbon isosteres. Solvolysis of these boron compounds in ethanol has been followed by uv and reveals a relationship between structure and rates of ethanol-ysis. Unexpectedly, these boron heterocycles, in contrast to their carbon isosteres, dissolve in aqueous alkali to form stable anions and the significance of this is discussed. The 1 :1 adducts of 1 and phosphorus oxychloride has been utilized to prepare two derivatives of the very stable 1,2-dihydro-2-phenyl-1,3,2-benzodiazaborin heterocycle. 相似文献
12.
A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M methanolic or ethanolic HCl solution and proceed in good yields. 相似文献
13.
Novel 2,3-dihydro-4-pyridinones were synthesized via the reaction of curcumin and primary amines or amine acetates under microwave irradiation. Montmorillonite K-10 was used as a catalyst. Reaction times did not exceed 120 s. The structures of the compounds were established by elemental analysis and from their mass, 1H- and 13C-NMR spectra. 相似文献
14.
[reaction: see text] A mixture of cyclopropylideneacetic acids (or esters) and CuBr(2) (or CuI/I(2)) in aqueous acetonitrile afforded 4-substituted 2(5H)-furanones or 3,4-substituted 5,6-dihydro-2H-pyran-2-ones in moderate to good yields. The selectivity of the reaction greatly depended on the reaction temperature. 相似文献
15.
Lee J. Silverberg Carlos Pacheco Debashish Sahu Peter Scholl Hany F. Sobhi Joshua T. Bachert Kaitlyn Bandholz Ryan V. Bendinsky Heather G. Bradley Baylee K. Colburn David J. Coyle Jonathon R. Dahl Megan Felty Ryan F. Fox Kyanna M. Gonzalez Jasra M. Islam Stacy E. Koperna Quentin J. Moyer Duncan J. Noble Melissa E. Ramirez Ziwei Yang 《Journal of heterocyclic chemistry》2020,57(4):1797-1805
A series of 11 novel 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of N-aryl-C-phenyl imines with thiosalicylic acid. This provides simple and ready access to N-aryl compounds in this family, which have been generally difficult to prepare. 相似文献
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17.
Sung Hwan KimSangku Lee Se Hee KimJin Woo Lim Jae Nyoung Kim 《Tetrahedron letters》2012,53(37):4979-4983
An indium-mediated Barbier type mono-allylation of 1,5-dicarbonyl compounds and a subsequent acid-catalyzed dehydrative cyclization afforded 2,3-dihydro-4H-pyran-4-ones and 3,4-dihydro-2H-[1,4]oxazines. 相似文献
18.
Z. F. Solomko V. N. Proshkina V. I. Avramenko I. A. Plastun N. Ya. Bozhanova 《Chemistry of Heterocyclic Compounds》1984,20(9):1035-1038
The formylation of 8-chloro- and 8-methoxy-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-ones with the Vilsmeier reagent leads to 3-dimethylaminomethylene derivatives which, in the case of the 8-chloro derivative, have been converted by hydrolysis in acetic acid into 8-chloro-3-formyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-ones.Translated from Khimiya Geterotsiklicheskaya Soedinenii, No. 9, pp. 1262–1265, September, 1984. 相似文献
19.
Summary 2,6-Dimethyl-4H-pyran-4-thione (DMTP) acts as a sulphur donor towards PtII and PdII halides yielding adducts of general formula [M(DMTP)2X2] (M=Pd or Pt; X=Cl, Br or I). When complex syntheses are performed in benzene, the solvated species [M(DMTP)2X2]·C6H6 (M=Pd or Pt; X=Cl or Br) are obtained. The compounds have been characterized by i.r. and n.m.r. (1H and13C) spectroscopy and by thermogravimetric data. The adduct geometry and the influence of benzene are discussed. 相似文献
20.
4-Pyridyl-2,3-dihydro-1H-1,5-benzodiazepin-2-ones were obtained by the condensation of ethyl nicotinoyl- or isonicotinoylacetates with o-phenylenediamine. Alkylation of the pyridylbenzodiazepinones with ethyl iodide under phase-transfer catalysis conditions occurred at the amide nitrogen of the heterocycle, whereas in nitromethane it occurred at the nitrogen of the pyridine substituent. Bromination with N-bromosuccinimide occurred at position 3 of the heterocycle. Pyridyldibenzodiazepinones underwent thermal rearrangement to derivatives of vinylbenzimidazole. 相似文献