共查询到20条相似文献,搜索用时 15 毫秒
1.
Pascale Besse Genevive Baziard-Mouysset Kamal Boubekeur Pierre Palvadeau Henri Veschambre Marc Payard Guy Mousset 《Tetrahedron: Asymmetry》1999,10(24):199-4754
From the microbiological reductions of 2-acetyl or 2-benzoylchromen-4-one both enantiomers of the corresponding alcohols were obtained with high enantiomeric excess. The absolute configurations were determined directly by an X-ray structural determination. The results obtained showed that for most of the microorganisms tested, an inversion of the configuration of the alcohol occurred with the change of the substituent (methyl to phenyl group) in position 2, but also with the presence of a bromine atom in position 6 of the aromatic ring, positioned quite far from the prochiral centre. 相似文献
2.
《Arabian Journal of Chemistry》2019,12(5):701-708
DPP-IV inhibitors have been immersed as promising pathway to treat Type 2 diabetes. Here we have reported designing of coumarin derivatives as DPP-IV inhibitors. Designed compounds have been studied for their binding with DPP-IV enzyme through molecular docking followed by synthesis. All synthesized compounds have been fully characterized and screened for DPP-IV inhibition activity. Two compounds showed very good inhibition at 10 μM concentration. 相似文献
3.
Rahim Hekmatshoar Yahya S. Beheshtiha Monire Kheirkhah Farnoosh Faridbod 《Monatshefte für Chemie / Chemical Monthly》2002,133(5):669-672
Summary. Protonation of the highly reactive 1:1-intermediate produced in the reaction between triphenylphosphine and dimethyl acetylenedicarboxylate
by naphthols lead to vinyl triphenylphosphonium salts which undergo an aromatic electrophilic substitution reaction with the
conjugated base to produce the title compounds.
Received August 14, 2001. Accepted November 22, 2001 相似文献
4.
Naohiko Yasuda Tetsuo Yamatani Takashi Ohnuki Masaru Okutsu 《Journal of heterocyclic chemistry》1984,21(6):1845-1848
Novel 1,3-dithiolan-2-one derivatives were prepared starting from α, β- or β, γ-dichlorinated carboxylic esters and potassium O-ethyl dithiocarbonate. The scope and the mechanism of this reaction were investigated. The biological uses of the compounds obtained here were examined. 相似文献
5.
6.
V. S. Moskvina Ya. L. Garazd M. M. Garazd A. V. Turov V. P. Khilya 《Chemistry of Heterocyclic Compounds》2007,43(4):421-429
Syntheses are reported for sulfur-and nitrogen-containing derivatives of 4-arylspiro-2-benzopyranones modified at the exocyclic
oxygen atom. The structure of these products was demonstrated by correlational NMR spectroscopy.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 518–527, April, 2007. 相似文献
7.
N. P. Mustafaev Kh. K. Efendieva T. Kh. Akchurina 《Russian Journal of Organic Chemistry》2017,53(12):1860-1863
Three-component condensation of primary amines with carbon disulfide and dialkyl maleates afforded the corresponding alkyl (3-R-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-yl)acetates whose structure was confirmed by independent synthesis and IR and 1H NMR spectroscopy. 相似文献
8.
Conjugates of ferrocene and 4,5-dichloroisothiazole were synthesized, where the ferrocene and isothiazole moieties are linked through various structural fragments. The acylation of ferrocene with 4,5- dichloroisothiazole-3-carbonyl chloride gave (4,5-dichloroisothiazol-3-yl) ferrocenyl ketone; the acylation of aminomethylferrocene furnished the corresponding amide. The esterification of ferrocene-1,1′-dicarboxylic acid with 4,5-dichloroisothiazol-3-yl-methanol resulted in the formation of the corresponding ester. The condensation of 1,1′-diacetylferrocene with 4,5-dichloroisothiazole-3-carbaldehyde afforded ferrocenophane containing 4,5-dichloroisothiazole moieties. 相似文献
9.
V. N. Yarovenko A. S. Nikitina I. V. Zavarzin M. M. Krayushkin L. V. Kovalenko 《Russian Chemical Bulletin》2007,56(8):1624-1630
A series of new 2-thioxo-1,3-thiazolidin-4-one derivatives containing arylidene, arylazo, and aminomethylene fragments in
position 5 of the rhodanine cycle was synthesized.
Dedicated to Academician V. A. Tartakovsky on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1564–1569, August, 2007. 相似文献
10.
Tietze LF Schuster HJ von Hof JM Hampel SM Colunga JF John M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(42):12678-12682
ortho‐Haloarylcarbamates like 1 – 4 show a high rotational barrier about the N? aryl bond of up to 91.6 kJ mol?1 as found for 1 , which was determined by 2D exchange NMR spectroscopy (EXSY). It was further demonstrated that the height of the barrier not only depends on the substituents at the axis of chirality, but is also influenced by electronic effects. 相似文献
11.
Marcel Morvan Guy Nadler Richard G. Zimmermann 《Journal of heterocyclic chemistry》1991,28(5):1365-1368
The synthesis of the new heterocycle 1,3,4-selenadiazin-2-one is described, based on the preparation of the analogue heterocycle 1,3,4-thiadiazin-2-one. The related cyclization between an α-haloketone and a thiocarbazate cannot readily be employed within the selenium series. Therefore a new route was developed based upon a diazotization/hydrolysis sequence of the related 2-amino-1,3,4-selenadiazine. 相似文献
12.
Aryl(ethyl-) and propylamines are obtained with good yields by a decarboxylation-alkylation process applied on aluminium trichloride-cyclic carbamate complexes. The coupling of two aromatic units is observed in the case of oxazolidinonetoluene reaction. 相似文献
13.
《Tetrahedron: Asymmetry》2001,12(6):863-867
The enantioselective hydrogenation of prochiral ene carbamates, directly derived from 2-tetralone, was completed using a catalytic ruthenium system generated from Ru(COD)(methallyl)2, an optically pure diphosphine and a strong acid containing a non-coordinating counter anion. 相似文献
14.
Synthesis of a N-Boc-protected piperidin-2-yl phosphine oxide starting from piperidine in three steps, followed by olefination using a variety of α,β-unsaturated aldehydes resulted in tert-butyl 2-(2′-alkenylidene)piperidine-1-carboxylates in high yields. A novel type of intramolecular cyclization of these enamides furnished a new family of 3-alkyl-4,6,7,8-tetrahydro-3H-pyrido[1,2-c][1,3]oxazin-1-ones as useful substrates for further elaboration. Subsequent reduction of these unsaturated bicyclic carbamates using NaCNBH3 or NaBH4 afforded the corresponding 3-alkylhexahydropyrido[1,2-c][1,3]oxazin-1-ones in a highly stereoselective way. Reductive ring opening of two representatives furnished the corresponding Sedum alkaloid derivatives in good yields. 相似文献
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16.
Summary 5H-Indolo[3,2-a]-6H-phenothiazin-6-one and its regioisomer 1H-Indolo[2,3-a]-6H-phenothiazin-6-one were prepared by the condensation of 2-aminobenzenethiol with carbazole-1, 4-dione or with isomeric mixture of bromo-carbazole-1,4-diones.
Synthese von Indolo-Phenothiazin-6-on-Derivaten (Kurze Mitteilung)
Zusammenfassung 5H-Indolo[3,2-a]-6H-phenothiazin-6-on und sein Regioisomer 1H-Indolo[2,3-a]-6H-phenothiazin-6-on wurden mittels Kondensation von 2-Aminobenzolthiol mit Carbazol-1,4-dion oder mit einer isomeren Mischung von Bromcarbazol-1,4-dionen hergestellt.相似文献
17.
A. L. Kurlovich V. A. Tarasevich N. G. Kozlov 《Russian Journal of Organic Chemistry》2010,46(9):1323-1326
The reaction of 5′-[(2-naphthylamino)methyl]-2′-hydroxy[1,1′:3′,1″]terphenyl with paraformaldehyde and 1,3-cyclohexanedione, methyl 2,2-dimethyl-4,6-dioxocyclohexanecarboxylate, dimedone, furan-2,4(3H,5H)-dione, indan-1,3-dione led to the formation of spiro derivatives of azaphenanthrene. 相似文献
18.
TMSOTf-mediated reactions of 1-cyclopropyl-2-arylethanones with allenic esters afford a novel method for the synthesis of dihydrofuro[2,3-h]chromen-2-one derivatives in moderate to good yields. This process is a sequential reaction involving a nucleophilic ring-opening reaction of the cyclopropane by H(2)O, two intermolecular aldol-type reactions and one intramolecular aldol-type reaction, a cyclic transesterification, dehydration, and aromatization mediated by Lewis acid. 相似文献
19.
5,7-Dihydroxy-4,8-dimethylchromen-2-one was synthesized based on methyl phloroglucinol and its spectral and physicochemical characteristics were obtained. Reactions of the newly synthesized coumarin with different diazonium salts were studied, conditions allowing selective obtaining the corresponding monoor bisazo compounds were found. The synthesized azo compounds dye nylon in the yellow-brown colors under standard coloration conditions, providing high stability of obtained colors upon exposure to physicochemical conditions. 相似文献
20.
Nurieva E. V. Zefirov N. A. Zefirov N. S. Kuznetsov S. A. Zefirova O. N. 《Russian Chemical Bulletin》2015,64(9):2248-2252
Russian Chemical Bulletin - The work describes the synthesis of 2-adamantyl 7-[(2-{[(2E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoyl]amino}ethyl)amino]-7-oxoheptanoate and... 相似文献