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1.
Michelle A. Meierhoefer Matthew J. Walters S. Patrick Dunn Jarrett H. Vella Bonnie J. Grant Carolyn L. Sober Nidhi S. Patel Laela M. Hajiaghamohseni Sara B. Lioi Clyde R. Metz Charles F. Beam William T. Pennington Donald G. Vanderveer N. Dwight Camper 《Journal of heterocyclic chemistry》2006,43(2):307-313
2.
S. Patrick Dunn Matthew J. Walters Clyde R. Metz Charles F. Beam William T. Pennington Mariusz Krawiec 《Journal of heterocyclic chemistry》2004,41(6):1005-1009
Select dilithiated ortho‐toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2‐(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo[1,2‐b][1,2]isoquinolin‐11‐one‐1,1‐dioxides, a new fused‐ring heterocyclic system. 相似文献
3.
A novel facile photoconversion of 4‐hydroxy‐1,2‐bezothiazine 1,1‐dioxides ( 3a‐e ) into 4‐oxo‐1,3‐2H‐benzothiazine 1,1‐dioxides ( 4a‐e ) and 4‐hydroxy‐2‐methyl‐N‐(pyridin‐2‐yl)‐2H‐1,2‐benzothiazine‐3‐carboxamide 1,1‐dioxide (PRX) into N‐methyl saccharin ( 2 ) upon 254 nm irradiation in methanol or acetonitrile is reported. The structures of the products have been elucidated by spectroscopic methods and single crystal X‐ray structure determination for 4a and 4d . 相似文献
4.
A simple method of introducing a sulfamoylmethyl group on carbon‐3 in 1,2‐benzisothiazole‐1,1‐dioxide is described. 相似文献
5.
Salvador Vega María Esther Arranz Vicente J. Arn 《Journal of heterocyclic chemistry》2005,42(5):763-773
A series of 2‐substituted 2H‐thieno[3,4‐e][1,2,4]thiadiazin‐3(4H)‐one 1,1‐dioxides ( 2 ), 2‐substituted 2H‐thieno[2,3‐e][1,2,4]thiadiazin‐3(4H)‐one 1,1‐dioxides ( 3 ), 2‐substituted 4,6‐dihydropyrazolo[4,3‐e]‐[1,2,4]thiadiazin‐3(2H)‐one 1,1‐dioxides ( 4 ), 2‐substituted 2,3‐dihydrooxazolo[3,2‐b]thieno[3,4‐e]‐[1,2,4]thiadiazine 5,5‐dioxides, ( 5 ), 6‐substituted 6,7‐dihydro‐2H‐oxazolo[3,2‐b]pyrazolo[4,3‐e][1,2,4]thia‐diazine 9,9‐dioxides ( 6 ) and 7‐substituted 6,7‐dihydro‐2H‐oxazolo[3,2‐b]pyrazolo[4,3‐e][1,2,4]thiadiazine 9,9‐dioxides ( 7 ) were synthesized as potential psychotropic agents. 相似文献
6.
Michelle A. Meierhoefer S. Patrick Dunn Laela M. Hajiaghamohseni Matthew J. Walters Mildred C. Embree Sally P. Grant Jennifer R. Downs Jessica D. Townsend Clyde R. Metz Charles F. Beam William T. Pennington Donald G. VanDerveer N. Dwight Camper 《Journal of heterocyclic chemistry》2005,42(6):1095-1099
Select C(α), N‐phenylhydrazones were dilithiated in excess lithium diisopropylamide followed by condensation with methyl 2‐(aminosulfonyl)benzoate and acid cyclization to afford new pyrazol‐benzenesul‐fonamides, 2‐(1‐phenyl‐1H‐pyrazol‐5‐yl)benzenesulfonamides. 相似文献
7.
Synthesis of 5‐Amino‐3,3‐dimethyl‐7‐phenyl‐3H‐[1,2]oxathiolo[4,3‐b]pyridine‐6‐carbonitrile 1,1‐Dioxides
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Mourad Chioua Abdelouahid Samadi Denis Postel Jan Balzarini José Marco‐Contelles 《Journal of heterocyclic chemistry》2014,51(5):1452-1456
The reaction of 4‐amino‐5,5‐dimethyl‐5H‐1,2‐oxathiole 2,2‐dioxide ( 1 ) with 2‐(arylidene)malononitriles 2 in ethanol, at reflux, using piperidine as catalyst, afforded 5‐amino‐3,3‐dimethyl‐7‐aryl‐3H‐[1,2]oxathiolo[4,3‐b]pyridine‐6‐carbonitrile 1,1‐dioxides ( 3 ) in moderate chemical yields. 相似文献
8.
The reactions of phosphorochloridites 5a–c with an equimolar amount of 1,2‐thiazetidine 1,1‐dioxide (2) or L(−)‐3‐carboethoxy‐1,2‐thiazetidine 1,1‐dioxide (7) in the presence of triethylamine, affords the N‐phosphitylated β‐sultams 6a–b and L(−)‐8a,c. Their oxidation by addition of oxygen, sulfur, or selenium results in formation of stable organophosphorus β‐sultams 10a–b, L(−)‐11a,c, 12a, 13a, L(−)‐14c, and L(−)‐15c. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 61–67, 1999 相似文献
9.
Allison M. Bergmann Stanna K. Dorn Kevin B. Smith Kaitlyn M. Logan M. Kevin Brown 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(6):1733-1737
Two methods are reported for the 1,2‐ and 1,1‐arylboration of α‐methyl vinyl arenes. In the case of 1,2‐arylboration, the formation of a quaternary center occurred through a rare cross‐coupling reaction of a tertiary organometallic complex. 1,1‐Arylboration was enabled by catalyst optimization and occurred through a β‐hydride elimination/reinsertion cascade. Enantioselective variants of both processes are presented as well as mechanistic investigations. 相似文献
10.
Bonnie J. Grant Catherine R. Kramp John D. Knight Michelle A. Meierhoefer Jarrett H. Vella Carolyn L. Sober Stephen S. Jones Clyde R. Metz Charles F. Beam William T. Pennington Donald G. Vanderveer N. Dwight Camper 《Journal of heterocyclic chemistry》2007,44(3):627-632
11.
Chai‐Ho Lee Guo Fan Jin Hyun Wha Lim Eun Hye Yang Jong‐Dae Lee Hiroyuki Nakamura Hyun Seung Ban Sang Ook Kang 《Heteroatom Chemistry》2011,22(2):192-197
A new method for the preparation of 4‐substituted 3,4‐dihydro‐1H‐2,1,3‐benzothiadiazine 2,2‐dioxides is described. Treatment of t‐butyl N‐phenylsulfamoylcarbamate derivatives ( 1 ) with different aldehydes afforded the corresponding intramolecular cyclized products 2 under trifluoroacetic acid conditions. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:192–197, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20670 相似文献
12.
Jennifer R. Downs Stefan J. Pastine Jessica D. Townsend Heather A. Greer Wayne Kelley Deborah A. Schady Teresa Lentz Mcconaughy Clyde R. Metz Charles F. Beam Catharine D. Almquist William T. Pennington Rosa D. Bailey Walsch 《Journal of heterocyclic chemistry》2001,38(3):695-701
Several 2′‐phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C‐acylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5‐trisubstituted, 1,2‐dihydro‐3H‐pyrazol‐3‐ones. 相似文献
13.
Artem Cherepakha Vladimir O. Kovtunenko Andrey Tolmachev Oleg Lukin 《Journal of heterocyclic chemistry》2013,50(5):1071-1077
A set of synthetic procedures was developed to yield functionalized pyrido‐, pyrimido‐, and thiazo‐annulated thiadiazine‐1,1‐dioxides on a preparative scale. In all cases the thiadiazine‐1,1‐dioxide ring closure was carried out through a reaction of hetaryl‐sulfonyl chlorides with amidines under mild noncatalytic conditions. In the case of 2‐chloropyridine‐3‐sulfonyl chloride derivatives and 2,4‐dichlorothiazole‐5‐sulfonyl chloride open‐chain sulfonylated amidine intermediates were isolated and then subjected to the cyclization step. The reaction with 2,4‐dichloropyrimidine‐5‐sulfonyl chloride gave rise to the corresponding thiadiazine‐1,1‐dioxides in one‐pot. Similarly, a reaction of 2‐chloropyridine‐3‐sulfonamide with lactime ethers proceeded in one‐pot readily giving the corresponding thiadiazine‐1,1‐dioxides. Remaining chlorine atoms on the prepared hetaryl‐annulated benzothiadiazine‐1,1‐dioxides readily undergo aromatic nucleophilic displacement reactions serving thus as additional variation points for the design of biologically potent compounds. 相似文献
14.
Alexander V. Martynov Vladimir A. Shagun Svetlana V. Amosova 《Heteroatom Chemistry》2016,27(5):253-259
Oxidation of E,E‐bis(3‐bromo‐1‐chloro‐1‐propen‐2‐yl) sulfide and selenide with hydrogen peroxide in chloroform/acetic acid or acetic acid affords previously unknown E,E‐bis(3‐bromo‐1‐chloro‐1‐propen‐2‐yl) sulfoxide, selenoxide, and sulfone. The reaction of E,E‐bis(3‐bromo‐1‐chloro‐1‐propen‐2‐yl) sulfone with primary amines in ethanol in the presence of NaHCO3 or Na2CO3 is found to lead not only to heterocyclization but also to alcoholysis of the chloromethylidene groups in the intermediate bis(chloromethylidene) derivatives of thiomorpholine‐1,1‐dioxides to afford N‐organyl‐2(E),6(E)‐bis(ethoxymethylidene) thiomorpholine‐1,1‐dioxides as final products. 相似文献
15.
Syntheses and photoisomerization of the new sulfone derivatives, 4,4‐di (p‐trifluoromethylphenyl)‐2,6‐diphenyl‐4H‐thiopyran‐1, 1‐dioxide and 4‐(p‐trifluoromethylphenyl)‐2,4,6‐triphenyl‐4H‐thiopyran‐1,1‐dioxide, have been investigated. The relative molar ratios of the photoproducts are compared with those of 2,4,4,6‐tetraphenyl‐4H‐thiopyran‐1,1‐dioxide as well as electron‐donating substituted 4‐methyl‐2,4,6‐triaryl‐4H‐thiopyran‐1,1‐dioxides as model compounds under identical experimental conditions using 1H NMR spectroscopy. The results observed are discussed on the basis of a triplet excited state di‐π‐methane rearrangement. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:557–561, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20455 相似文献
16.
Several pyrido[2,3‐e]pyrimidine fused with other rings have been prepared by intramolecular cyclization of 5‐(4‐chlorophenyl)‐2‐hydrazino‐benzo [6,7]cyclohepta‐[1,2‐b]pyrido[2,3‐e]pyrimidine‐4‐one ( 1 ) with acids, carbon disulfide to form triazole derivatives ( 2,4 ), halo‐ketones to give triazine derivative ( 5 ), β‐ketoesters, β‐cyanoesters, and β‐diketones to yield 2‐(1‐pyrazolyl) derivatives ( 7,9,10 ), and aldehydes to form arylhydrazone derivatives ( 11a,b ) which cyclized to form triazoles ( 12a,b ). Also, acyclic N‐nucleosides are prepared by heating under reflux 2‐hydrazino‐benzo[6,7]cyclohepta[1,2‐b]pyrido[2,3‐e] pyrimidin‐4‐one ( 1 ) with xylose and glucose to give the corresponding acyclic N‐nucleosides ( 13a,b ) which are cyclized to afford the corresponding protected tetra and penta–O‐acetate C‐nucleosides ( 14a,b ). Deacetylating of the latter nucleosides afforded the free acyclic C‐nucleosides ( 15a,b ). © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:34–43, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20248 相似文献
17.
β‐Bromo‐α,β‐unsaturated ketones are condensed with arylhydrazines to form hydrazones, which are in situ intramolecularly cyclized into 3‐substituted 1‐aryl‐1 H‐pyrazoles under a catalytic system of Pd(OAc)2/1,3‐bis(diphenylhosphino)propane (dppp)/NaOtBu. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
18.
Asymmetric [5+3] Formal Cycloadditions with Cyclic Enones through Cascade Dienamine–Dienamine Catalysis
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Xiang Yin Dr. Yi Zheng Xin Feng Dr. Kun Jiang Xue‐Zhen Wei Prof. Dr. Ning Gao Prof. Dr. Ying‐Chun Chen 《Angewandte Chemie (International ed. in English)》2014,53(24):6245-6248
A few aminocatalytic modes, such as iminium ions and different dienamines, have provided versatile tools for the functionalization of cyclic enones at various sites. Described here is a previously unreported cascade dienamine/dienamine catalytic pathway for β‐substituted 2‐cyclopentenones, and even 2‐cyclohexenone. It involves domino α′‐regioselective Michael addition and a γ‐regioselective Mannich reaction with 3‐vinyl‐1,2‐benzoisothiazole‐1,1‐dioxides to give fused or bridged architectures, which incorporate a spirocyclic skeleton, in excellent stereocontrol, thus furnishing unusual [5+3] formal cycloaddition reactions. Moreover, preliminary biological assays showed that some of the chiral products exhibited promising activity against some cancer cell lines, thus indicating that such skeletons might serve as leads in drug discovery. 相似文献
19.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(38):11742-11746
Reported herein is an efficient copper(I)‐catalytic system for the diastereo‐ and enantioselective 1,2‐addition of 1,1‐bis[(pinacolato)boryl]alkanes to protected imines to afford synthetically valuable enantioenriched β‐aminoboron compounds bearing contiguous stereogenic centers. The reaction exhibits a broad scope with respect to protected imines and 1,1‐bis[(pinacolato)boryl]alkanes, thus providing β‐aminoboronate esters with excellent diastereo‐ and enantioselectivity. The synthetic utility of the obtained β‐aminoboronate ester was also demonstrated. 相似文献
20.
The syntheses of three new optically active β-mercaptoalcohols,(R)-1,1-diphenyl-2-mercapto-3-methyl-1-butanol,(R)-1,1-diphenyl-2-mercapto-4-methyl-1-pentanol,and (R)-1,1-diphenyl-2-mercapto-1-benzenepropanol from the corresponding amino acids are described.The enantiomeric excesses of these β-mercaptoalcohols were determined by ^1H NMR as their (S)-mandeloyl derivatives. 相似文献