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1.
The binding of the ruthenium(II) complexes [Ru(bpy)2(ITAP)](ClO4)2 (bpy = 2,2’-bipyridine) and [Ru(phen)2(ITAP)](ClO4)2 (phen = 1,10-phenanthroline, ITAP = isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated
with UV–visible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The
experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes
in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation. 相似文献
2.
Two series of new complexes, [Ru(phen)2L]2+ and [RuL3]2+, where phen = 1,10-phenanthroline, and L denotes imidazo[4,5-f][1,10]phenanthroline (IP) or 2-(4-R-phenyl)imidazo[4,5-f][1,10]phenanthroline(PIP, R = H; HOP, R = –OH; MOP, R = –OMe; DMNP, R = NMe2; CLP, R = Cl; NOP, R = NO2), were synthesized and characterized. Their binding to calf thymus DNA was investigated using electronic absorption and emission spectroscopy. [Ru(IP)3]2+ and each [Ru(phen)2 L]2+ showed dramatic absorption hypochromism and bathochromicity, as well as steady-state emission intensity and excited-state lifetime enhancements {except nonluminescent [Ru(phen)2NOP]2+} associated with the presence of DNA, inferring that they bind to DNA by intercalation. These phenomena were not observed for [RuL3]2+ type complexes (except L = IP), indicating that they bind to DNA at most through electrostatic interactions. 相似文献
3.
Two novel RuII complexes [Ru(phen)2(PNOPH)]2+ and [Ru(dmp)2 (PNOPH)]2+ (phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PNOPH = 2-(4-nitrophenyl)imidazo-[4,5-f][1,10]phenanthroline) and their deprotoned complexes were synthesized and characterized by ES–MS, 1H - n.m.r, u.v.–vis. and electrochemistry. The crystal structure of the deprotonated complex [Ru(dmp)2 (PNOP)][ClO4] · CH3CN was determined by means of X-ray single crystal diffraction. Nonlinear optical properties of the RuII complexes were investigated by Z-scan techniques in DMF solution, and all of them exhibited both NLO absorption and self-defocusing effect. The corresponding effective NLO susceptibilities |3 | of the complexes are 2.39 × 10-12–5.80 × 10-12 esu. 相似文献
4.
《Journal of Coordination Chemistry》2012,65(20):3676-3687
DNA-binding properties of a number of ruthenium complexes with different polypyridine ligands are reported. The new polypyridine ligand BFIP (=2-benzo[b] furan-2-yl-1H-imidazo[4,5-f][1,10]phenanthroline) and its ruthenium complexes [Ru(bpy)2BFIP]2+ (bpy = 2,2′-bipyridine), [Ru(dmb)2BFIP]2+ (dmb = 4,4′-dimethyl-2,2′-bipyridine), and [Ru(phen)2BFIP]2+ (phen = 1,10-phenanthroline) have been synthesized and characterized by elemental analysis, mass spectra, IR, UV-Vis, 1H- and 13C-NMR, and cyclic voltammetry. The DNA binding of these complexes to calf-thymus DNA (CT-DNA) was investigated by spectrophotometric, fluorescence, and viscosity measurements. The results suggest that ruthenium(II) complexes bind to CT-DNA through intercalation. Photocleavage of pBR 322 DNA by these complexes was also studied, and [Ru(phen)2BFIP]2+ was found to be a much better photocleavage agent than the other two complexes. 相似文献
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Shaomin Ji Wanhua Wu Wenting Wu Huimin Guo Qi Yang Quan Wang Xin Zhang Yubo Wu Jianzhang Zhao 《Frontiers of Chemistry in China》2010,5(2):193-199
Polypyridyl ruthenium (Ru) complexes 1–3 were prepared. Their photophysical properties were investigated by UV-Vis absorption
and luminescence emission spectra. The luminescent lifetimes of these Ruthenium complex were prolonged by more than 5 folds
(τ = 2.50 μs for complex 3) when compared with the parent Ru complex 1 (τ = 0.45 μs). We propose that the extended luminescent
lifetime of complex 3 is due to the equilibrium between 3MLCT state and the pyrene localized 3π-π* triplet state (3IL). The luminescent O2-sensing property of the complexes in solution and the IMPEK-C polymer film were studied, and the O2 sensing was quantified with the two-site model. The oxygen-sensing property of the Ru complexes can be improved by 104-fold
with extension of the luminescent lifetimes. For example, the quenching constant K
SV was improved from 0.0023 Torr−1 of 1 to 0.2393 Torr−1 for 3. Our results demonstrated a versatile approach for the preparation of Ru (II) polypyridine complexes with extended
luminescent lifetimes as functional materials, for example, for luminescent oxygen-sensing applications. 相似文献
7.
Synthesis,DNA-binding,and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand
《Journal of Coordination Chemistry》2012,65(24):4344-4356
An asymmetric ligand (pdpiq?=?2-(pyridine-2-yl)-6,7-diphenyl-1-H-imidazo[4,5-g]quinoxaline) and its ruthenium complexes with [Ru(L)2pdpiq]2+ (L?=?bpy (2,2′-bipyridine) or phen (1,10-phenanthroline)) have been synthesized and characterized by elemental analysis, ES-MS, and 1H NMR. The DNA-binding behaviors of these complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the complexes can intercalate into DNA base pairs. When irradiated at 365?nm, the two complexes promote the cleavage of plasmid pBR322DNA. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen. 相似文献
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S. Arounaguiri D. Easwaramoorthy A. Ashokkumar Aparna Dattagupta Bhaskar G. Maiya 《Journal of Chemical Sciences》2000,112(1):1-17
DNA binding and photocleavage characteristics of a series of mixed-ligand complexes of the type [M(phen)2LL]n+ (where M = Co(III), Ni(II) or Ru(II), LL = 1,10-phenanthroline (phen), phenanthroline-dione (phen-dione) or dipyridophenazine
(dppz) andn = 3 or 2) have been investigated in detail. Various physico-chemical and biochemical techniques including UV/Visible, fluorescence
and viscometric titration, thermal denaturation, and differential pulse voltammetry have been employed to probe the details
of DNA binding by these complexes; intrinsic binding constants (K
b) have been estimated under a similar set of experimental conditions. Analysis of the results suggests that intercalative
ability of the coordinated ligands varies as dppz>phen>phen-dione in this series of complexes. While the Co(II) and Ru(II)
complexes investigated in this study effect photocleavage of the supercoiled pBR 322 DNA, the corresponding Ni(II) complexes
are found to be inactive under similar experimental conditions. Results of detailed investigations carried out inquiring into
the mechanistic aspects of DNA photocleavage by [Co(phen)2(dppz)]3+ have also been reported. 相似文献
10.
Lei Wang Jian-zhong Wu Guang Yang Tian-xian Zeng Liang-nian Ji 《Transition Metal Chemistry》1996,21(6):487-490
Summary A series of new complexes [RuL2(pdphen)]2+, where pdphen is the planar ligand pyridino[3,2-f] [1,7]phenanthroline and L = 2,2-bipyridine, phenanthroline, 2,9-dimethylphenanthroline or 5-nitrophenanthroline, were prepared and characterized. The binding of [RuL2-(pdphen)] 2+ to calf thymus DNA was investigated using absorption, fluorescence and circular dichroism (c.d.) spectroscopies. All of the complexes show absorption hypochromicity associated with binding to calf thymus DNA. [Ru(bipy)2pdphen]2+ and [Ru(phen)2pdphen]2+ also show fluorescence intensities and excited state life-time increases. The c.d. spectra of dialyzates from solutions of racemic complexes versus calf thymus DNA indicate enantioselectivity associated with binding to DNA. 相似文献
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The structure of the title adduct comprises a phenanthroline derivative 2-phenyl-imidazo[4,5-f]1,10-phenanthroline and a methanol.The composition of the crystalline adduct was characterized as C19H12N4.CH3OH.It belongs to orthorhombic system,space group Pna21 with a=1.3693(4)nm,b=2.2988(7)nm,c=0.51338(15)nm,V=1.6160(8)nm^3.Z=4,and final R1=0.0423.wR2=0.1012 .Crystal structure shows that all the 19 carbon atoms and 4 nitrogen atoms are coplanar.The bond length data indicated that a very extensive conjugation system was formed.This conjugation makes the compound being a potentially excellent energy transformer used for luminescent materials. 相似文献
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Jiang Cai-Wu Chao Hui Li Run-Hua Li Hong Ji Liang-Nian 《Transition Metal Chemistry》2002,27(5):520-525
Three RuII complexes [Ru(bpy)2(PIP)]2+, [Ru(PIP)2(bpy)]2+ and [Ru(PIP)3]2+ (PIP = 2-phenylimidazo[4,5-f][1,10]phenanthroline, bpy = 2,2-bipyridine) were prepared and characterized by electrospray mass spectrometry, 1H-n.m.r, u.v.–vis. and electrochemistry. The nonlinear optical properties (NLO) of the RuII complexes were investigated by Z-scan techniques with 12 ns laser pulses at 540 nm, and all of them exhibit both NLO absorption and self-defocusing effects. The corresponding effective NLO susceptibility |3| of the complexes is in the (4.15 – 4.86) × 10–12 e.s.u. range. 相似文献
16.
The corresponding 2-(2-furyl)- and 2-[-(2-furyl)vinyl]imida zo[4,5-f]quinolines were obtained by condensation of 5,6-diaminoquinoline and 5-amino-6-rnethylaminoquinoline with furfural, furylacrolein, and their 5-bromo and 5-nitro derivatives and also with the hydrochlorides of imino esters of furancarboxylic and furylacrylic acids. Alkylation, acetylation, nitration, and substitution of the halogen in the furan ring by a nitro group were studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 440–442, April, 1973. 相似文献
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[structure: see text] Two podands, 4,4'-[(ethylenedioxy)bis(ethyleneoxy)]bis[1-(2-imidazo[4,5-f]-1,10-phenanthroline)benzene] (1) and [Ru(phen)(2)](2)(1)(PF(6))(4) (2) complex, were synthesized from 1,10-phenanthroline. The photophysical behavior and the binding ability of 1 and 2 with some alkali metal and alkaline earth cations were investigated by UV-vis and fluorescence spectrometry and (1)H NMR experiments as well as fluorescence lifetime measurements. The complex stability constants (K(S)) and Gibbs free energy changes (DeltaG degrees ) for the stoichiometric 1:1 complexation of 1 and 2 with the cations were obtained by the fluorimetric titrations. The podands 1 and 2 exhibit different fluorescent behavior in the cations examined, i.e., fluorescence quenching for 1, and fluorescence enhancement for 2. In particular, 1 showed responses specific for Mg(2+), resulting in readily distinguishable by eye. 相似文献
19.
Mono-, di-, and tetranuclear Ru(II) polypyridine complexes based on the bridging ligand pdtp, where pdtp is 3-(pyridin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline, have been synthesized and characterizated. This asymmetric bridging ligand is composed of two nonequivalent coordinating sites: one involves the phenanthroline moiety, and the other one involves the pyridyltriazine moiety. Electrochemical data show that the first redox process in these complexes is pdtp based and the metal-metal interaction in di- and tetranuclear complexes is very weak. The two oxidations (+1.41 and +1.56 V vs SCE) observed in dinuclear complex 2 are mainly ascribed to the different coordination environments of two metal centers. Absorption spectra are essentially the sum of the spectra of the component monometallic species. The emission spectra are measured both at room temperature and at 80 K in a 4:1 (v/v) EtOH/MeOH matrix. The complexes all display luminescence properties which are close to that featured by the parent [Ru(phen)(3)](2+) species. It is also noted that center-to-periphery energy transfer occurs in the dendritic tetranuclear complex 3. 相似文献
20.
Geoffrey A. Lawrance 《Polyhedron》1985,4(5):817-820
The redox properties of a series of [Ru(phen)2(py)X]n+ cations (X = pyridine, NH3, Cl, Br, I, CN, SCN, N3 and NO2) have been investigated in acctonitrile. Two reversible reduction steps are seen at ? 1.35 and ? 1.6 V vs Ag/AgCl; the invariance of these processes with X-group is indicative of electron addition to molecular orbitals mainly of phenanthroline ligand π* origin. Irreversible multi-electron reductions follow below ? 2.20 V. The Ru(II)/Ru(III) couple is seen as a reversible wave near + 0.8 V vs the normal hydrogen electrode, from calibration with ferrocene, except in the cases of the NO2 and SCN complexes, where rapid reactions involving these ligands occur. 相似文献