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1.
A High Yielding, One-Pot, Triton-B Catalyzed Synthesis of Dithiocarbamates Using Alcoholic Tosylates
Summary. A novel process for the one-step chemoselective conversion of alcoholic tosylates into dithiocarbamates as protected amines
was developed using benzyltrimethylammoniumhydroxide (Triton-B) in presence of carbon disulfide. Thus, dithiocarbamates of
different amines were prepared in very good to excellent yields. This protocol is mild, chemoselective, and efficient compared
to other reported methods.
Present address: Institute of Organic and Biomolecular Chemistry, Georg-August University, D-37077, G?ttingen, Germany 相似文献
2.
In asymmetric catalysis, chiral (central chiral, planar chiral, axial chiral) ferrocenylligands is one of the most successful class of auxiliaries in recent years, and some ofthem have reached the stage of industrial applications'. But many challenges remain forthe synthesis of the intermediate. One of them is how to get ferrocenylcyanide I directlyfrom ferrocenecarboxyaldehyde 2, which can be easily prepared according to thecorresponding literature2. As far as known, I is an important interm… 相似文献
3.
Entesar A. Hassan Salem E. Zayed 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):300-323
Abstract Organic dithiocarbamates have received great attention due to their interesting chemistry and wide utility as radical precursors and intermediates in organic synthesis. They also have found many of applications, that is, in agriculture and medicine. They are in use as pesticides, as well as in the rubber industries as vulcanization accelerators; and as antioxidants. Because they exhibit strong metal-binding capacity, they can act as in inhibitors of enzymes and have a profound effect on biological systems. Moreover, they have found application in the treatment of cancer and HIV. 相似文献
4.
Vinod K. Tiwari Desh D. Singh Hakkim A. Hussain Bhuwan B. Mishra Archana Singh 《Monatshefte für Chemie / Chemical Monthly》2008,139(1):43-48
Summary. A simple and convenient method for the synthesis of diverse 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones was developed as one-pot reaction of anthranilic acid esters, primary amines, and bis(benzotriazolyl)methanethione
in presence of the amidine base DBU. 相似文献
5.
Summary. A novel process for the one-step chemoselective conversion of alkyl halides into dithiocarbamates as protected amines was
developed using benzyltrimethylammonium hydroxide (Triton-B) in presence of carbon disulfide. Thus, dithiocarbamates of different
amines were prepared in very good to excellent yields. This protocol is mild, chemoselective, and efficient compared to other
methods.
Present address: Institute of Organic and Biomolecular Chemistry, Georg–August University, D-37077 G?ttingen, Germany 相似文献
6.
7.
The reaction of vicinal dioxime with sodium hydride in dry THF followed by addition of dichlorophosphates or dichlorothiophosphates yields 2-oxo-1,3,4,7-dioxadiazaphosphepines and 2-thioxo-1,3,4,7-dioxodiazaphosphepines in moderate to good overall yields. The products are characterized by elemental analyses, molecular weights and spectral (IR, 1H, 13C and 31P NMR) studies. A salt elimination route is used for the synthesis of titled heterocycles. 相似文献
8.
9.
Jean-Luc Pirat Agnes Coulombeau Arielle Genevois-Borella Henri-Jean Cristau 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6-7):1793-1796
A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1 , in 60-80% overall yield, allowing the variation of the substituents in f and/or g position to the phosphorus atom and also in f position to the nitrogen atom. 相似文献
10.
We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility. 相似文献
11.
Daniel F. Brayton Karen I. Goldberg Werner Kaminsky D. Michael Heinekey 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2534-2540
A convenient one-pot synthesis of (t-Bu)2P(O)Cl (1) from m-chloroperbenzoic acid and (t-Bu)2PCl is described. The byproduct m-chlorobenzoic acid is neutralized by addition of Et3N. Complex 1 crystallizes in the monoclinic space group P21/c (No. 14), with a = 5.9637(2) Å, b = 11.4734(4) Å, c = 16.2400(5) Å and β = 107.7160(14). 相似文献
12.
Summary. A novel process for the one-step chemoselective conversion of alkyl halides into carbamates as protected amines was developed
using benzyltrimethylammonium hydroxide (Triton-B) in presence of gaseous carbon dioxide. Thus, carbamate esters of different
amines were prepared in very good to excellent yields.
Present address: Institute of Organic and Biomolecular Chemistry, George–August University, 37077, G?ttingen, Germany 相似文献
13.
Zhi-Wei Miao Hua Fu Bo Han Yi Chen Yu-Fen Zhao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):641-646
N-thiophosphonylamino groups have been greatly overlooked as potentially potent, transition-state analogues, or tetrahedral--intermediate inhibitors of metalloproteases. Alkylthiophosphoramidates derivatives were synthesized y reaction of O-isopropyl phosphorodichloridothioate with an amino acid este followed by hydrolysis in 2M NH 4 OH. The reaction was monitored by 31 P NMR spectroscopy. 相似文献
14.
Mohammad M. Mojtahedi M. Saeed Abaee Majid M. Heravi Farahnaz K. Behbahani 《Monatshefte für Chemie / Chemical Monthly》2007,138(1):95-99
Summary. Amines with different stereoelectronic nature were efficiently acylated at room temperature using acetic anhydride in the
presence of no solvent or additive. Various thiols also react equally well under the same conditions. Chemoselective protection
of amines in the presence of thiols, alcohols, and phenols and of thiols in the presence of alcohols, and phenols were achieved
using competitive experiments. 相似文献
15.
Abbas Shockravi Hassan Valizadeh Majid M. Heravi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):501-504
An efficient and facile preparation of simple coumarins via in situ Wittig reaction of salicylaldehydes, triphenylphosphine, and chloroethylacetate supported on MgO in satisfactory yields in solvent-free condition. 相似文献
16.
三丁基锡二硫代氨基甲酸酯的合成及表征 总被引:2,自引:0,他引:2
通过三丁基氯化锡与二硫代氨基甲酸盐反应,合成了10个 三丁基锡二硫代氨基甲酸酯,利用元素分析,IR、HNMR、UV和TG-DTA表征了这些化合物结构,测定了部分化合物的生物活性。 相似文献
17.
采用氯化亚砜-无水乙醇为催化剂,以苯乙酮为原料一步合成了1,3,5-三苯基苯。研究了最佳反应配比和反应条件:反应时间为45~60min时,n(苯乙酮)/n(氯化亚砜)/n(乙醇)=3/15/5时反应产率达到最高,产率80%~85%,并对反应机理进行了讨论。 相似文献
18.
Charles F. Nutaitis 《合成通讯》2013,43(7):1081-1085
A convenient one-pot synthesis of symmetric vicinal diamines utilizing sodium borohydride/trifluoroacetic acid reduction methodology is described . 相似文献
19.
Victor V. Dotsenko Konstantin A. Frolov Sergey G. Krivokolysko Alexander N. Chernega Victor P. Litvinov 《Monatshefte für Chemie / Chemical Monthly》2006,137(8):1089-1098
Summary. 3-(Het)aryl-2-cyanoprop-2-enethioamides easily reacted with primary amines and excessive formaldehyde under mild conditions
to afford pyrimido[6,1-b][1,3,5]thiadiazine derivatives in moderate yields. Furthermore, 2-cyano-2-cyclohexylideneethanethioamide reacted in the similar
Mannich-type manner to give spiro-conjugated pyrimido-1,3,5-thiadiazines. The structure of 3,7-dibenzyl-8-(fur-2-yl)-3,4,7,8-tetrahydro-2H,6H-pyrimido[6,1-b][1,3,5]thiadiazine-9-carbonitrile was determined by X-ray diffraction analysis. 相似文献
20.
Russian Journal of Organic Chemistry - Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized... 相似文献