The polybuffer separation of the alkaloids of Vinca erecta

Summary By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (–)-1,2-dehydroaspidospermidine, and kopsanone. This is the first time that these alkaloids have been obtained from this plant. Thin-layer chromatography showed the presence of another 10–12 uncharacterized alkaloids.The region of the passage into the buffer solutions of some alkaloids has also been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 713–717, November–December, 1970.     

Isolation and purification of alkaloids

A literature review is given of methods of isolating and purifying alkaloids. Material is collected on the influence of the nature of the solvent on the isolation of alkaloids and on the interaction of alkaloids with acids and alkalis.All-Union Scientific-Research Institute of Medicinal Plants, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 415–429, July–August, 1983.     

Biosynthesis and metabolism of some matrine alkaloids inGoebelia pachycarpa

Information is given on the biosynthesis, metabolism, and interconversion of a number of matrine alkaloids isolated fromGoebelia pachycarpa. The role of amino acids and other organic acids in the formation of these alkaloids is discussed.V. I. Lenin State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 3–12, January–February, 1984.     

Investigation of the lability of the conformations of some alkaloids of the quinolizidine series

Summary The IR and NMR spectra of lupinine, epilupinine, and a series of other alkaloids of the quinolizidine series have been studied.It has been shown that the inhibition of the inversion processes in the molecules of the alkaloids in the solid phase is revealed in a change in the nature of the absorption in the 500–1200 cm^2–1 region.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 49–54, January, 1971.     

Ungernia alkaloids

The review is devoted to the study of the alkaloids of plants of the genusUngernia (Amaryllidaceae). It gives their characteristic reactions and information on the determination of their structures and stereochemistry and on the dynamics of the accumulation of alkaloids in the plants of the genusUngernia. A dependence of the physiological activity of the alkaloids on their structure is shown.Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbek, SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 749–767, November–December, 1980.     

The distribution of some alkaloids in heterogeneous systems

Summary 1. The distribution of the alkaloids investigated in the heterogeneous systems selected is accompanied by salt formation.2. The distribution coefficients of the 13 alkaloids studied change within wide limits (from 0 to 10 and more) according to the pH of the buffer solution, the heterogeneous system, the basic strengths of the alkaloids, etc.3. In order to characterize the distribution of alkaloids in heterogeneous systems and to differentiate alkaloids with respect to their basic strength, the value of pH_1/2, in addition to pK_a, is proposed.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 25–28, January–February, 1975.     

Alkaloids ofColchicum luteum

The paper gives a review of the alkaloids ofColchium luteum Baker from various growth sites. The structure of luteidine — one of the main alkaloids of the plant — has been established. In addition, two new alkaloids have been isolated from the plant and the structure of one of them has been established as collutine N-oxide.M. I Kalinin Turkmen Agricultural Institute, Ashkhabad, and V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 810–815, November–December, 1985.     

The biosynthesis of the alkaloids of Goebelia pachycarpa

Summary 1. Qualitative and quantitative compositions of the main alkaloids in five development phases of theGoebelia pachycarpa C. A. Mey. have been determined.2. The radioactivities of the alkaloids isolated after feeding the plant with assumed precursors -[2-¹⁴C] lysine and [1,5-¹⁴C] cadaverine — show that vigorous synthesis of alkaloids takes place in the flowering and budding periods.3. The results of an investigation of the oxidation products and of the alkaloids introduced and isolated after the feeding of plants with labelled matrine and labelled sophocarpine show that the alkaloids undergo interconversion without intramolecular changes.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh, Soedinenii, No. 4, pp. 549–552, July–August, 1977.     

Aporphine alkaloids

The review gives information on aporphine alkaloids and their oxo and dehydro derivatives and discusses the characteristic features of the chemical and spectral properties of these alkaloids.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 279–312, May–June, 1980.     

Alkaloids ofRhinopetalum stenantherum. Structure of stenanzidine

Three new alkaloids have been isolated from the combined alkaloids of the epigeal part ofRhinopetalum stenantherum: stenanzidine, stenanzidinine, and stenanzamine.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 341–344, May–June, 1984.     

An investigation of the alkaloids of Lolium cuneatum

Summary In addition to three known alkaloids, the seeds ofL. cuneatum have yielded N-formylloline, N-acetylnorloline, and the new alkaloids N-methylloline and N-formylloline methiodide.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 60–63, January–February, 1976.     

Synthesis of protoberberine alkaloids

In this review an analysis is made of literature information on the synthesis of protoberberine alkaloids during 1980–1990.Institute of Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 449–468, September–October, 1992.     

Chromatographic investigation of the alkaloids of the opium poppy and their acetyl derivatives

The composition of the alkaloids in narcotic agents of domestic production (khanke) has been investigated by thin-layer and gas chromatographies. The retention times in GLC and the retention indices in TLC of the initial alkaloids and their acetylated derivatives have been determined. The rates of acetylation of the alkaloids have been evaluated with the aid of the GLC method.V. I. Nikitin Institute of Chemistry, Tadzhikistan Republic Academy of Sciences, Dushanbe. Translated from Khimiya Prirodnykh Soedeninii, No. 1, pp. 109–111, January–February, 1993.     

Alkaloids ofAndrachne rotundifolia

Summary 1. The content of total alkaloids in the hypogeal parts ofAndrachne rotundifolia C. A. Mey. (family Euphorbicease) is 0.2–0.3% and in the epigeal parts 0.06–0.08%.The total alkaloids in both the hypogeal and the epigeal parts ofAndrachne rotundifolia consist of five or six non-phenolic bases.2. Three individual substances have been isolated: andrachnine C₁₁H₁₇NO₂, which is a new alkaloid; base (II), giving a perchlorate with mp 139°–140° C; and base (III) with mp 135°–136° C.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 257–260, 1966     

Electrochemical extraction of alkaloids of the tropane group from plant raw material

Summary 1. The possibility has been shown of studying the isolation of alkaloids from model systems with a quantitative yield of salt of up to 92%.2. The alkaloids of the tropane group have been isolated from acid extracts of belladonna by the electrochemical method. The conditions ensuring the maximum yield of alkaloids into the catholyte as a function of the time of electrodialvsis have been determined.Zaporozh'e State Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 497–500, July–August, 1976.     

Berberis alkaloids. XXII. Interbrinine and intebrimine — New alkaloids from Berberis integerrima

The known alkaloids reticuline, isoboldine, isocorydine, glaucine, armepavine, oxyacanthine, and heliamine and the new alkaloids intebrinine and intebrimine have been isolated from the total alkaloids of the leaves ofBerberis integerrima, and structures have been proposed for the latter two on the basis of spectral characteristics and independent synthesis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedeninii, No. 1, pp. 70–73, January–February, 1993.     

Alkaloids of the epigeal part ofAconitum karakolicum

The dynamics of the accumulation of alkaloids in the epigeal part ofAconitum karakolicum according to vegetation periods has been studied. It has been established that the highest content of alkaloids is found in the early period. On separating the combined alkaloids, the aporphine alkaloid isoboldine has been isolated from this plant for the first time and a new base has been obtained — napelline N-oxide, the structure of which has been shown on the basis of the results of a study of spectral characteristics and direct transition to napelline.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 826–829, November–December, 1979.     

Biosynthesis of the alkaloids ofAnabasis aphylla

The dynamics of the accumulation of free amino acids and the main alkaloids have been determined, and 15 free amino acids have been detected and identified, 11 having been determined quantitatively. The amounts of the main alkaloids have also been determined. An interrelationship of the amino acid lysine with the alkaloids has been shown. The interconversion of pachycarpine into aphylline and aphyllidine with the formation of a lactam group has been demonstrated experimentally.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 56–60, January–February, 1980.     

Quantitative determination of the alkaloids ofAnabasis aphylla by thin-layer chromatography

Summary A chromatographic method has been developed for the quantitative determination of the alkaloids ofAnabasis aphylla — anabasine, aphylline, lupinine, aphyllidine, and anabasamine — and also pachycarpine in the mixture of reduction products of the high-boiling fraction of alkaloids, in a thin layer of alumina.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 772–776, November–December, 1976.