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1.
Otoacoustic emissions (OAEs) evoked by broadband clicks and by single tones are widely regarded as originating via different mechanisms within the cochlea. Whereas the properties of stimulus-frequency OAEs (SFOAEs) evoked by tones are consistent with an origin via linear mechanisms involving coherent wave scattering by preexisting perturbations in the mechanics, OAEs evoked by broadband clicks (CEOAEs) have been suggested to originate via nonlinear interactions among the different frequency components of the stimulus (e.g., intermodulation distortion). The experiments reported here test for bandwidth-dependent differences in mechanisms of OAE generation. Click-evoked and stimulus-frequency OAE input/output transfer functions were obtained and compared as a function of stimulus frequency and intensity. At low and moderate intensities human CEOAE and SFOAE transfer functions are nearly identical. When stimulus intensity is measured in "bandwidth-compensated" sound-pressure level (cSPL), CEOAE and SFOAE transfer functions have equivalent growth functions at fixed frequency and equivalent spectral characteristics at fixed intensity. This equivalence suggests that CEOAEs and SFOAEs are generated by the same mechanism. Although CEOAEs and SFOAEs are known by different names because of the different stimuli used to evoke them, the two OAE "types" are evidently best understood as members of the same emission family. 相似文献
2.
Comparison between changes that occur simultaneously on spontaneous otoacoustic emissions (SOAEs) and on other cochlear origin phenomena can contribute to the understanding of cochlear micromechanical activity. The temporary changes that arise after short noise exposure are investigated in the following paper. The effects of noise exposure on the threshold microstructure near an SOAE and on the amplitude and frequency of the SOAE were measured. These experimental results indicate the following: (1) exposure to wideband noise for a short time causes a temporary reduction in the SOAE frequency and amplitude, and alters reversibly the threshold microstructure in the vicinity of the SOAE. The difference between the minimum and maximum in the threshold microstructure is reduced, and the frequency that yields the minimum threshold decreases; (2) the threshold at the SOAE frequency is most sensitive to noise exposure; (3) intense stimulation causes a relatively small increase, or even a decrease, in threshold at frequencies near the SOAE. The experimental results are interpreted in terms of a nonlinear transmission line model which includes nonlinear amplifiers. The effect of the noise exposure is modeled by reduction in the cochlear partition amplification term. Most of the experimental results are predicted by this model. 相似文献
3.
Puria S 《The Journal of the Acoustical Society of America》2003,113(5):2773-2789
Middle and inner ears from human cadaver temporal bones were stimulated in the forward direction by an ear-canal sound source, and in the reverse direction by an inner-ear sound source. For each stimulus type, three variables were measured: (a) Pec--ear-canal pressure with a probe-tube microphone within 3 mm of the eardrum, (b) Vst--stapes velocity with a laser interferometer, and (c) Pv--vestibule pressure with a hydrophone. From these variables, the forward middle-ear pressure gain (M1), the cochlear input impedance (Zc), the reverse middle-ear pressure gain (M2), and the reverse middle-ear impedance (M3) are directly obtained for the first time from the same preparation. These measurements can be used to fully characterize the middle ear as a two-port system. Presently, the effect of the middle ear on otoacoustic emissions (OAEs) is quantified by calculating the roundtrip middle-ear pressure gain Gme(RT) as the product of M1 and M2. In the 2-6.8 kHz region, absolute value(Gme(RT)) decreases with a slope of -22 dB/oct, while OAEs (both click evoked and distortion products) tend to be independent of frequency; this suggests a steep slope in vestibule pressure from 2 kHz to at least 4 kHz for click evoked OAEs and to at least 6.8 kHz for distortion product OAEs. Contrary to common assumptions, measurements indicate that the emission generator mechanism is frequency dependent. Measurements are also used to estimate the reflectance of basally traveling waves at the stapes, and apically generated nonlinear reflections within the vestibule. 相似文献
4.
Modification of spontaneous and evoked otoacoustic emissions and associated psychoacoustic microstructure by aspirin consumption 总被引:1,自引:0,他引:1
The discovery that aspirin consumption can abolish spontaneous otoacoustic emissions [D. McFadden and H.S. Plattsmier, J. Acoust. Soc. Am. 76, 443-448 (1984)] provides a technique for further exploring the relation between otoacoustic emissions (spontaneous and evoked) and psychoacoustic threshold microstructure. Spontaneous emissions, delayed evoked emissions, synchronous evoked emissions, and threshold microstructure in four subjects were monitored before, during, and after consumption of 3.9 g of aspirin per day (three 325-mg tablets every 6 h) for 3 or 4 days. The changes in spontaneous emissions are consistent with the findings of McFadden and Plattsmier except that one spontaneous emission appeared to plateau at a reduced level above the noise floor during the last day and a half of the 3-day period of aspirin consumption. Evoked emissions and threshold microstructure were also reduced by aspirin consumption but persisted longer and recovered sooner. In most instances, the initial change in threshold microstructure was a trend to increased sensitivity (reduced thresholds), with a greater increase near threshold maxima than at threshold minima. Further reduction in the levels of the evoked emissions was accompanied by the eventual decrease in sensitivity (elevation of all thresholds). 相似文献
5.
Observation of the otoacoustic emissions (OAEs) evoked during a continuous single stimulus tone have been made on humans using a nonlinear residual time domain technique. The technique, described in this paper, involved the digital summation of responses to contiguous stimulation intervals, some of which included short bursts of a suppressor, or probe, tone. Stimulus intervals are constructed so that both the stimulus and probe tones summed to zero cyclically, leaving a residual response. This residual is attributable to the nonlinearity of the whole acoustic response, as measured in the ear canal, to the stimulus and probe tone complex. A theoretical treatment of this paradigm is presented examining the relation of this residual to the OAE evoked by the stimulus tone. It is shown experimentally that the residual, found at the stimulus tone frequency, has a latency and saturating input-output growth functions indicative of an OAE. The detailed OAE amplitude-versus-frequency variations, and the general latencies of the OAEs in two human ears were measured using both the constant tone evoked residual method described and the click evoked delayed emission method. The results from both methods are in agreement. The frequency-dependent properties of the suppression of the OAE were investigated using various stimuli to probe frequency ratios. The continuous tone time domain residual method has advantages for the observation of stimulus frequency OAEs and for relating these to any distortion product simultaneously generated. 相似文献
6.
Transient-evoked otoacoustic emissions (TEOAE) are responses generated within the inner ear in response to acoustic stimuli and are indicative of normal cochlear function. They are commonly acquired by averaging post-stimulus acoustic responses recorded near the eardrum in response to brief stimuli such as clicks or tone pips. In this study a new long duration stimulus consisting of a frequency swept tone is introduced for the acquisition of TEOAEs. Like stimulus frequency generated OAEs, swept-tone responses contain embedded OAEs. With swept-tone analysis, OAEs can be recovered by convolving it with a time reversed swept-tone signal resulting in time-compression. In addition, higher order nonlinear OAE responses were removed from the linear TEOAE. The results show comparable phase and time-frequency properties between the click and swept-tone evoked OAEs. Swept-tone acquisition of TEOAEs has beneficial noise properties, improving the signal to noise ratio by 6 dB compared to click evoked responses thus offering testing time savings. Additionally, swept-tone analysis removed synchronized spontaneous OAE activity from the recordings of subjects exhibiting such responses in conventional click TEOAEs. Since swept-tone stimulus consists of a single frequency component at any instantaneous moment, its analysis also provides for direct comparison with stimulus-frequency OAEs and click evoked OAEs. 相似文献
7.
The dynamic effects of low-frequency biasing on spontaneous otoacoustic emissions (SOAEs) were studied in human subjects under various signal conditions. Results showed a combined suppression and modulation of the SOAE amplitudes at high bias tone levels. Ear-canal acoustic spectra demonstrated a reduction in SOAE amplitude and growths of sidebands while increasing the bias tone level. These effects varied depending on the relative strength of the bias tone to a particular SOAE. The SOAE magnitudes were suppressed when the cochlear partition was biased in both directions. This quasi-static modulation pattern showed a shape consistent with the first derivative of a sigmoid-shaped nonlinear function. In the time domain, the SOAE amplitudes were modulated with the instantaneous phase of the bias tone. For each biasing cycle, the SOAE envelope showed two peaks each corresponded to a zero crossing of the bias tone. The temporal modulation patterns varied systematically with the level and frequency of the bias tone. These dynamic behaviors of the SOAEs are consistent with the shifting of the operating point along the nonlinear transducer function of the cochlea. The results suggest that the nonlinearity in cochlear hair cell transduction may be involved in the generation of SOAEs. 相似文献
8.
Jacobs PG Konrad-Martin D McMillan GP McDermott D Fausti SA Kagen D Wan EA 《The Journal of the Acoustical Society of America》2012,131(2):1296-1306
Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the six subjects were tested twice for a total of 11 trials and three subjects were tested in a control experiment. During the GTT experiment, the subjects' blood glucose was elevated from a euglycemic level below 150 mg/dL to a hyperglycemic level above 160 mg/dL following the consumption of a bolus of 80 g of sugar. A subset of three subjects were tested in a control experiment during which SF OAE and MOC reflex measurements were made while blood sugar levels remained constant within the euglycemic region. Mean SF OAE amplitudes were elevated following glucose consumption. A statistically significant increase in MOC inhibition amplitude was observed during elevated sugar levels for the 11 GTT trials. Maximum inhibition occurred about an hour after glucose consumption when blood glucose levels peaked. Results indicate that acute hyperglycemia influences efferent control of the cochlea in people with type 2 diabetes. 相似文献
9.
Shera CA Tubis A Talmadge CL de Boer E Fahey PF Guinan JJ 《The Journal of the Acoustical Society of America》2007,121(3):1564-1575
Originally proposed as a method for measuring the power gain of the cochlear amplifier, Allen-Fahey experiments compare intracochlear distortion products and ear-canal otoacoustic emissions (OAEs) under tightly controlled conditions. In this paper Allen-Fahey experiments are shown to place significant constraints on the dominant mode of reverse energy propagation within the cochlea. Existing Allen-Fahey experiments are reviewed and shown to contradict the predictions of compression-wave OAE models recently proposed in the literature. In compression-wave models, distortion products propagate from their site of generation to the stapes via longitudinal compression waves in the cochlear fluids (fast waves); in transverse traveling-wave models, by contrast, distortion products propagate primarily via pressure-difference waves whose velocity and other characteristics depend on the mechanical properties of the cochlear partition (slow waves). Compression-wave models predict that the distortion-product OAEs (DPOAEs) measured in the Allen-Fahey paradigm increase at close primary-frequency ratios (or remain constant in the hypothetical absence of tuned suppression). The behavior observed experimentally is just the opposite-a pronounced decrease in DPOAE amplitude at close ratios. Since neither compression-wave nor simple conceptual "hybrid-wave" models can account for the experimental results--whereas slow-wave models can, via systematic changes in distortion-source directionality arising from wave-interference effects--Allen-Fahey and related experiments provide compelling evidence against the predominance of compression-wave OAEs in mammalian cochlear mechanics. 相似文献
10.
Kandzia F Oswald J Janssen T 《The Journal of the Acoustical Society of America》2011,129(3):1464-1474
Transient evoked otoacoustic emissions (TEOAEs) are usually evoked with air conduction (AC) stimuli. Only a few reports exist about OAEs where stimuli have been delivered using bone conduction (BC) by placing a bone conductor on the forehead or the mastoid. The aims of the present study were to improve the test performance of BC-TEOAEs by using a nonlinear stimulation protocol and to find out, whether this technique can be applied in newborn hearing screening. BC-TEOAEs were measured binaurally in ten normal hearing adults and in ten infants. For measurements in infants, miniaturized probes without loudspeakers were constructed to allow a complete insertion of the probe in the infant's ear canal. It could be shown that robust and valid BC-TEOAEs can be elicited using a nonlinear stimulation protocol. Findings in adults indicated that BC-TEOAEs can be measured with properties similar to AC-TEOAEs. However, mean BC-TEOAE levels were reduced by 0.8-3.7 dB depending on frequency. In view of test time, this is compensated by performing binaural recordings. Measurements in infants indicated that the screening performance of BC-TEOAEs and AC-TEOAEs may be comparable. Further studies have to investigate, whether BC-TEOAEs are more robust than AC-TEOAEs against small conductive hearing loss. 相似文献
11.
Moulin A 《The Journal of the Acoustical Society of America》2000,107(3):1471-1486
Distortion product otoacoustic emissions (DPOAEs) are used widely in humans to assess cochlear function. It is well known that 2f1-f2 DPOAE amplitude increases as the f2/f1 ratio increases from 1.0 to about 1.20, and then decreases as the f2/f1 ratio increases above 1.20, showing an amplitude ratio function, which is thought to be related to cochlear filtering properties. Different lower sideband DPOAEs are believed to show the same amplitude ratio functions as the 2f1-f2 DPOAE, with a magnitude peak situated at a constant DPOAE frequency relative to f2. More recently, several studies have suggested the involvement of a DPOAE component coming from its own distortion product place as well as the DPOAE component coming from the f2 place. To investigate DPOAE generation sites and the importance of the DPOAE frequency place, amplitude ratio functions of 2f1-f2, 3f1-2f2, 4f1-3f2 and 2f2-f1, 3f2-2f1, 4f2-3f1 DPOAE components have been systematically studied in 18 normally hearing subjects, using an f2 fixed, f1 sweep method, and an f1 fixed, f2 sweep method, at ten different f2 frequencies. Results show a dependency of the distortion magnitude peak on f2 frequency for each lower sideband DPOAE, and a small frequency shift of the distortion peak for the high order lower sideband DPOAE components. Strong correlation between the different lower sideband DPOAE amplitude were obtained, whether they were recorded with the same f1 (and a different f2) or with the same f2 (and a different f1), suggesting that lower side-band DPOAE amplitude does not depend on small variations in the f2 frequency. Moreover, correlations between DPOAE amplitude and tone-burst evoked otoacoustic emissions (TBOAEs) are highly significant for TBOAEs centered at the f2 frequency and at 1/2 octave below the f2 frequency, suggesting some degree of importance of the cochlear status at frequencies below f2 in DPOAE amplitude. Subjects presenting spontaneous otoacoustic emissions showed a greater lower sideband DPOAE amplitude recorded for low f2/f1 ratios, and a distortion magnitude peak shifted towards higher frequencies. The best correlation between upper sideband DPOAE amplitude and lower sideband DPOAE amplitude occurred for lower sideband DPOAEs generated by an f2 frequency 1/2 octave to 1 octave below the primaries used to generate upper sideband DPOAEs, suggesting a site of generation basal to f2 for the upper sideband DPOAEs. Correlations between TBOAE amplitude and upper sideband DPOAE amplitude agreed with a site of upper sideband DPOAE generation basal to f2, and which would move with the DPOAE frequency itself. 相似文献
12.
自适应信号增强在瞬态诱发耳声发射信号检测中的应用 总被引:3,自引:0,他引:3
耳声发射是近年来耳科学领域的研究热点。它已成为临床听力筛选和诊断耳蜗病变最为有效的手段之一。耳声发射信号的信噪比和相关率是临床诊断的重要依据。文中将自适应信号增强技术引入到对瞬态诱发耳声发射信号的检测中,并提出了一个基于最小均方算法的实用的自适应信号增强器结构。通过对106例受试耳所进行的瞬态诱发耳声发射信号检测,结果表明,自适应信号增强技术与传统的相干平均技术相比有更好的增强信号和抑制噪声的性能。利用自适应信号增强可以提高瞬态诱发耳声发射信号的信噪比增速、减少检测所需叠加次数、检测用时可缩短近一半。 相似文献
13.
Keefe DH Zhao F Neely ST Gorga MP Vohr BR 《The Journal of the Acoustical Society of America》2003,113(1):389-406
This report describes the extent to which ear-canal acoustic admittance and energy reflectance (YR) in human neonates (1) predict otoacoustic emission (OAE) levels and auditory brainstem response (ABR) latencies, and (2) classify OAE and ABR responses as present or absent. Analyses are reported on a subset of ears in which hearing screening measurements were obtained previously [Norton et al., Ear. Hear. 21, 348-356 (2000a)]. Tests on 1405 ears included YR, distortion-product OAEs, transient-evoked OAEs, and ABR. Principal components analysis reduced the 33 YR variables to 5-7 factors. OAE levels decreased and ABR latencies increased with increasing high-frequency energy reflectance. Up to 28% of the variance in OAE levels and 12% of the variance in ABR wave-V latencies were explained by these factors. Thus, the YR response indirectly encodes information on inter-ear variations in forward and reverse middle-ear transmission. The YR factors classify OAEs with an area under the relative operating characteristic (ROC) curve as high as 0.79, suggesting that middle-ear dysfunction is partly responsible for the inability to record OAEs in some ears. The YR factors classified ABR responses less well, with ROC areas of 0.64 for predicting wave-V latency and 0.56 for predicting Fsp. 相似文献
14.
The relationship between hearing loss, detected by measuring the audiometric threshold shift, and the presence of long-lasting otoacoustic emissions, has been studied in a population of 66 adult males, by analyzing the cochlear response in the 80 ms following the subministration of a click stimulus. Most long-lasting OAEs are also recognizable as Synchronized Spontaneous OAEs (SSOAEs). The OAE characteristic decay times were evaluated according to the model by Sisto and Moleti [J. Acoust. Soc. Am. 106, 1893 (1999)]. The starting hypothesis, confirmed by the results, is that long decay time and large equilibrium amplitude are both manifestations of the effectiveness of the active feedback mechanism. The prevalence and frequency distribution of long-lasting OAEs, and of their SSOAE subset, have been separately analyzed for normal and impaired ears. No long-lasting OAE was found within the hearing loss frequency range, but several were found in impaired ears outside the hearing loss range, both at lower and higher frequencies. This result suggests that the correlation between the presence of long-lasting OAEs and good cochlear functionality be local in the frequency domain. The monitor of the OAE decay time is proposed as a new possible method for early detecting hearing loss in populations exposed to noise. 相似文献
15.
de Kleine E Wit HP van Dijk P Avan P 《The Journal of the Acoustical Society of America》2000,107(6):3308-3316
Spontaneous otoacoustic emissions (SOAEs) were studied in humans during and after postural changes. The subjects were tilted from upright to a recumbent position (head down 30 degrees) and upright again in a 6-min period. The SOAEs were recorded continuously and analyzed off-line. The tilting caused a change in the SOAE spectrum for all subjects. Frequency shifts of 10 Hz, together with changes of amplitude (5 dB) and width (5 Hz), were typically observed. However, these changes were observed in both directions (including the appearance and disappearance of emission peaks). The most substantial changes occurred in the frequency region below 2 kHz. An increase of the intracranial pressure, and consequently of the intracochlear fluid pressure, is thought to result in an increased stiffness of the cochlear windows, which is probably mainly responsible for the SOAE changes observed after the downward turn. The time for the spectrum to regain stability after a postural change differed between the two maneuvers: 1 min for the downward and less than 10 s for the upward turn. 相似文献
16.
Transient-evoked otoacoustic emissions (TEOAEs) and derived, noise-evoked otoacoustic emissions (derived-NEOAEs) were measured in seven normally hearing subjects. The evoked OAEs were all recorded at three excitation levels chosen to ensure that the OAE level curve compressive region was reached. The short-time correlation coefficient (STCC) was used to compare the OAE waveforms at different excitation levels, and thus estimate the time over which the response exceeds the noise level. The short-time correlation for TEOAEs is significant for longer than it is for NEOAEs, particularly in some individuals, and the STCC allows this to be quantified. This suggests that derived NEOAEs do not display the highly synchronized dominant frequencies often seen in TEOAEs. This has been confirmed by examining the derived frequency responses for the two types of excitation. Conventional TEOAEs thus appear to measure a combination of two conceptually different processes, while NEOAEs measure just one. 相似文献
17.
When sinusoidal amplitude modulation (SAM) is applied to noise or tone carriers, the stimuli can generate audible distortion products in the region of the modulation frequency. As a result, when bandpass-filtered SAM noise is used to investigate temporal processing, a band of unmodulated noise is typically positioned at the modulation frequency to mask any distortion products. This study was designed to investigate the distortion products for bandpass noise carriers, and so reduce ambiguity about the form of this distortion and its role in perception. The distortion consists of two distortion-noise bands and a distortion tone at the modulation frequency. In the first two experiments, the level and phase of the distortion tone are measured using two different experimental paradigms. In the third experiment, modulation-frequency difference limens are measured for filtered SAM noise and it is shown that performance deteriorates markedly when the distortion tone is canceled. In a fourth experiment, masked threshold is measured at low frequencies for bands of high-frequency, unmodulated noise with the same levels and spectra as the SAM noises in the earlier experiments. The results confirm that unmodulated noise also produces quadratic distortion which may explain some aspects of earlier reports on remote masking. 相似文献
18.
19.
In the guinea pig it has been shown that the nonlinear derived transient evoked otoacoustic emission (TEOAEnl) is comprised of significant amounts of intermodulation distortion energy. It is expected that intermodulation distortion arising from a nonlinear distortion mechanism will contribute to the overall TEOAE in a stimulus-level-dependent manner, being greatest when basilar-membrane vibration in response to a click stimulus is greatest; with decay of vibration of the basilar membrane subsequent to stimulation by a click, nonlinear interaction along the cochlear partition should reduce and so provide for a linear mechanism to dominate TEOAEnl generation, i.e., the contributions of each of these mechanisms should be delay dependent. To examine this delay dependence, TEOAEnl evoked by acoustic clicks of varying bandwidth were time-domain windowed using a recursive exponential filter in an attempt to separate two components with amplitude and phase properties consistent with different mechanisms of OAE generation. It was found that the part of the TEOAEnl occurring first in time can have a relatively constant amplitude and shallow phase slope, consistent with a nonlinear distortion mechanism. The latter part of the TEOAEnl has an amplitude microstructure and a phase response more consistent with a place-fixed mechanism. 相似文献
20.
Distortion product otoacoustic emission (DPOAE) fine structure is due to the interaction of two major components coming from different places in the cochlea. One component is generated from the region of maximal overlap of the traveling waves generated by the two primaries and is attributed to nonlinear distortion (nonlinear component). The other component arises predominantly from the tonotopic region of the distortion product and is attributed to linear coherent reflection (reflection component). Aspirin (salicylate) ototoxicity can cause reversible hearing loss and reduces otoacoustic emission generation in the cochlea. The two components are expected to be affected differentially by cochlear health. Changes in DPOAE fine structure were recorded longitudinally in three subjects before, during, and after aspirin consumption. Full data sets were analyzed for two subjects, but only partial data could be analyzed from the third subject. Resulting changes in the two components of DPOAE fine structure revealed variability among subjects and differential effects on the two components. For low-intensity primaries, both components were reduced with the reflection component being more vulnerable. For high-intensity primaries, the nonlinear component showed little or no change, but the reflection component was always reduced. 相似文献