New copper(II), nickel(II), and cobalt(II) chelates derived from 2-methyl-3-{[3-methyl-5-oxo-1-phenylpyrazol-4- ylidene)methyl]amino}-quinazolin-4-one

Ligand system derived from pyrazolone-5 and N-aminoquinazolinone was prepared, its structure was studied. Metal chelates ML₂ were prepared by reaction of the obtained ligand with copper(II), nickel(II), and cobalt(II) acetates. The complexes were studied by IR, electronic, and ESR spectroscopy, magnetochemistry, X-ray diffraction. Copper(II) complex was shown to have pseudo-tetrahedral structure, nickel(II) and cobalt(II) complexes are octahedral.     

2-{[3-(Triethoxysilyl)propyl]amino}pyridine and Derivatives

2-{[3-(Triethoxysilyl)propyl]amino}pyridine is synthesized by condensation of [3-(triethoxysilyl)propyl]amine with 2-aminopyridine. Its peretherification with triethanolamine leads to 2-[(3-silatranylpropyl)amino]pyridine and hydrolytic copolycondensation with tetraethoxysilane to cross-linked organosilicon copolymer {SiO₂·2[O1.5Si(CH₂)₃NHC₆H₄N]} _n . The latter in the medium of hydrochloric acid behaves as an anionite in respect of anionic chlorocomplexes of gold(III), platinum(IV), palladium(II) and rhodiumIII).     

Crystal structure of 1-(4-chlorophenyl)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propenone

The title compound C₂₄H₂₂ClNO₂ belongs to the orthorhombic system, space group Pca2₁ with a = 12.1771(10) Å, b = 4.9305(4) Å, c = 34.419(3) Å, α = β = γ = 90°, V = 2066.5(3) ų, Z = 4, D_c = 1.260 g/cm³, F(000) = 824, R = 0.0402 and wR = 0.1144, S = 1.034, T = 293 K. The compound is a chalcone with 4-chlorophenyl and [(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl substituents bonded at the opposite ends of a propenone group, the biologically active region. The propenone bridge makes dihedral angles of 10.61(23)° and 62.75(22)° respectively, with 4-chlorophenyl and the [(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl group.     

Synthesis and characterization of tribenzyltin(IV) and dibenzyltin(IV) complexes of 2-{[(2Z)-3-hydroxy-1-methyl- 2-butenylidene]amino}acetic acid: Crystal structure of tribenzyl{2-{[(2Z)-3-hydroxy-1-methyl-2-butenylidene] amino}acetato}tin(IV)

Reactions of equimolar quantities of potassium 2-{[(2Z)-3-hydroxy-1-methyl-2-butenylidene]amino}acetate, with R _n SnX_4?n (R: benzyl– and n=2 or 3) in methanol yielded products of compositions LHSn(PhCH₂)₃ and LSn(PhCH₂)₂, respectively. The complexes were characterized by microanalysis, IR, NMR (¹H, ¹³C, ¹¹⁹Sn) and ^119mSn Mössbauer spectroscopy. A full characterization of the structure of the complex, tribenzyl{2-{[(2Z)-3-hydroxy-1-methyl-2-butenylidene]amino}acetato}tin(IV), was carried out by single crystal X-ray crystallography. The compound exists as centrosymmetric dimers in which two ligand molecules bridge the two tin centres. Each of the tin atoms in the dimeric unit is five coordinate in an approximately trigonal bipyramidal configuration, with carbon atoms in the equatorial positions and oxygen atoms arranged axially.     

Development of electrochemical and optoelectronic performance of new 7-{[1H-indol-3-ylmethylidene]amino}-4-methyl-2H-chromen-2-one dye

Journal of Solid State Electrochemistry - A new 7-{[1H-indol-3-ylmethylidene]amino}-4-methyl-2H-chromen-2-one dye (3) was synthesized by the reaction of 7-amino-4-methyl coumarin with...     

Synthesis of methyl 4-aryl-2-{[4-(carbamimidoylsulfamoyl)- phenyl]amino}-4-oxobut-2-enoates

Methyl aroylpyruvates reacted with 4-amino-N-carbamimidoylbenzene-1-sulfonamide in acetic acid–ethanol (1: 1) to give methyl 4-aryl-2-{[4-(carbamimidoylsulfamoyl)phenyl]amino}-4-oxobut-2-enoates which were found to exist in solution as mixtures of Z and E isomers.     

Synthesis and Crystal Structure of 3-{[（1E） 1-（2- Hydroxyphenyl） methylidene]amino}-4-cyanopyrazole

The title Schiff base compound （C11H8N4O）, a derivative of pyrazole, has been synthesized by the reaction of salicylaldehyde and 3-amino-4-cyanopyrazole in absolute ethanol and characterized by elemental analyses, IR, ^1H NMR and X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P21/n, with a = 7.5594（7）, b = 18.3342（19）, c = 22.461（2） A^°, β = 98.419（2）°, V = 3079.5（5） A^°3, Mr = 212.21, Z = 12, F（000） = 1320, Dc = 1.373 g/cm^3, T = 298（2） K, 2 = 0.71073 A^°, the final R = 0.0571 and wR = 0.0493. A total of 5412 unique reflections were collected, of which 1612 with I 〉 2σ（I） were observed. The molecular structure adopts a trans configuration about the C=N double bond. The preliminary biological tests show that the compound has high antibacterial activities.     

(R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}- 1H-苯并咪唑的合成

以2,3-二甲基吡啶为起始原料, 经过11步反应, 不对称合成了质子泵抑制剂的关键中间体: (R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}-1H-苯并咪唑. 研究了用手性高效液相色谱拆分对映体、测定产品光学纯度的方法, 结果表明目标产品的ee值达到99%. 通过IR, UV, MS以及1H NMR分析对重要中间体和目标产品进行了结构鉴定.     

Synthesis and structure of 1,10-phenanthroline bis{[2-(2-pyrrole)-methylimino]4-methylphenolato}nickel(II)

Summary Electrochemical oxidation of nickel in an acetonitrile solution containing 2-pyrrole-[N-(2-hydroxy-4-methyl-phenyl)methylimine] (H₂L) and 1,10-phenanthroline (phen) yielded Ni(HL)₂·phen, whose crystal structure was determined by XRD. The nickel atom has a distorted octahedral geometry, and is coordinated to the phenolic oxygen and imino nitrogen atoms of two Schiff base ligands. The i.r. and u.v.-vis. spectra of the complex are discussed and related to the structure.     

~(18)F标记前体3'-甲氧基-7-对甲苯磺酰氧丙氧基槲皮素的合成

以槲皮素为起始原料,经酰化、醚化、苄醚化、脱苄、甲基化、水解6步反应合成了18F标记前体3'-甲氧基-7-对甲苯磺酰氧丙氧基槲皮素,其结构经1H NMR,13C NMR和HR-MS(ESI)确证。