共查询到20条相似文献,搜索用时 15 毫秒
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Zaitseva Elvira R. Smirnov Alexander Yu. Baleeva Nadezhda S. Baranov Mikhail S. 《Chemistry of Heterocyclic Compounds》2021,57(6):695-699
Chemistry of Heterocyclic Compounds - The treatment of 5-[2-(dimethylamino)benzylidene]-3-methyl-2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-ones with catalytic amounts of scandium triflate... 相似文献
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通过2-(4,6-二甲氧基嘧啶-2-氧基)苯甲醛(1)与芳氧乙酰肼2的缩合反应,合成了10个含嘧啶结构的芳氧乙酰腙化合物3,其结构经1H NMR、IR、EI-MS或ESI-MS和元素分析测试技术确证。 除草活性测试(活体盆栽)结果表明,大部分目标化合物在1.5 kg/hm2浓度下, 无论苗前或苗后处理对苋菜均显示出很强抑制活性,化合物3e和3h的抑制率分别为100%和97.7%,而化合物3a、3b、3d、3e、3f和3h苗后处理对苋菜的抑制率均超过97%,对马唐的除草活性最差。 苯环4-位取代基性质对除草活性有规律性影响。 相似文献
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Daniel B. Moran George O. Morton J. Donald Albright 《Journal of heterocyclic chemistry》1986,23(4):1071-1077
Methods for the synthesis of (pyridinyl)-1,2,4-triazolo[4,3-a]pyridines were developed. The principal route to the required intermediate 2-chloropyridines was based on rearrangements of mono N-oxides of 2,2′-bipyridine, 2,3′-bipyridine, 3,3′-bipyridine, 2,4′-bipyridine and 4,4′-bipyridine with phosphorus oxychloride. Reaction of 3,3′-bipyridine 1-oxide or 2,2′-bipyridine 1-oxide with phosphorus oxychloride gave mixtures of chloro isomers. Reaction with acetic anhydride, 3,3′-bipyridine 1-oxide and 2,2′-bipyridine 1-oxide gave exclusively [3,3′-bipyridine]-2(1H)-one and [2,2′-bipyridine]-6(1H)-one, respectively. 1,2,4-Triazolo[4,3-a]pyridines with pyridinyl groups at the 5,6,7 and 8 positions were synthesized. 相似文献
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Charles Y. Fiakpui Oludotun A. Phillips K. S. Keshava Murthy Edward E. Knaus 《Journal of heterocyclic chemistry》1999,36(2):377-380
A group of 5-(2-chlorophenyl)-10-(substituted)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepines 7a-c were synthesized by the acid catalyzed reaction of 5-(2-chlorophenyl)-2-hydrazino-3H-pyrido[3,4-e]-[1,4]diazepine ( 6 ) with either trimethyl orthoformate, triethyl orthoacetate or triethyl orthobenzoate, respectively. 5-(2-Chlorophenyl)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine ( 7a ) and 5-(2-chlo-rophenyl)-10-methyl-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine ( 7b ) exhibited good anticonvulsant activity in the subcutaneous metrazol anticonvulsant screen which serves as a model for absence (petit mal) epilepsy. 相似文献
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Paronikyan E. G. Dashyan Sh. Sh. Paronikyan R. G. 《Russian Journal of Organic Chemistry》2019,55(6):818-823
Russian Journal of Organic Chemistry - A new method has been developed for the synthesis of 8-hydrazinylpyrano[3,4-c]pyridines via pyridine ring rearrangement. New... 相似文献
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以2-氨基-5-取代苯氧甲基-1,3,4-噻二唑(1)为起始原料, 合成了中间体2-氯乙酰氨基-5-取代苯氧甲基-1,3,4-噻二唑)-2-乙酰亚胺(2)和2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-4-噻唑啉酮(3), 化合物3进一步与取代苯甲醛发生类Knoevenagle缩合反应, 得到了一系列2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-5-(取代苯基亚甲基)-4-噻唑啉酮类化合物4a~4p. 目标化合物4a~4p的结构经IR, 1H NMR和元素分析确证. 相似文献
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Norton P. Peet 《Journal of heterocyclic chemistry》1984,21(5):1389-1392
The reactions of secondary amines (pyrrolidine, piperidine and morpholine) with 3,4,5-trichloropyridazine ( 4 ) was investigated. With 4 and excess amine, disubstitution occurred in good yield and selectively at positions 3 and 5. Treatment of 4 with 2 equivalents of the amine in ethanol afforded high yields of products resulting from monosubstitution at position 5. 3,4-Dichloro-5-(1-pyrrolidinyl)pyridazine ( 6a ), resulting from 4 and 2 equivalents of pyrrolidine, was converted cleanly to 4-chloro-3-hydrazino-5-(1-pyrrolidinyl)pyridazine ( 8 ) with hydrazine hydrate. Pyridazine 8 was cyclized with formic acid to give a 1:1 complex ( 9 ) of formic acid and 8-chloro-7-(1-pyrrolidinyl)-1,2,4-triazolo[4,3-b]pyridazine ( 13 ). Triazolopyridazine 13 also formed a monohydrate ( 12 ) and a monohydrochloride salt ( 14 ). Catalytic hydrogenation of 9 gave 7-(1-pyrrolidinyl)-1,2,4-triazolo[4,3-b]pyridazine ( 3 ), which was a target compound of this investigation. 相似文献
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Nosova E. V. Kopotilova A. E. Ivan’kina M. A. Moshkina T. N. Kopchuk D. S. 《Russian Chemical Bulletin》2022,71(7):1483-1487
Russian Chemical Bulletin - A series of [1,2,4]triazolo[4,3-c]quinazolines, bearing 3-positioned p-bromophenyl or 5-bromothiophen-2-yl fragment, was synthesized by oxidative cyclization of the... 相似文献
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1-[4-(二甲氨基)苯亚甲基氨基]-4-苯基硫脲的合成及手性晶体结构 总被引:1,自引:0,他引:1
对二甲氨基苯甲醛和苯基氨基硫脲缩合反应生成对二甲氨基苯甲醛缩氨基苯硫脲{1-[4-(dimethylamino)ben- zylidene]-4-phenylthiosemicarbazide}, 并从溶液中析出手性晶体. 元素分析、红外光谱、紫外光谱、核磁谱、质谱和X射线衍射测定其组成和结构. 晶体属正交晶系, P212121空间群, a=0.77038(14) nm, b=1.1428(2) nm, c=1.6726(3) nm, V=1.4726(5) nm3, Z=4, Dc=1.346 g/cm3, F(000)=632, μ=0.219 mm-1, 可观测点精修最终偏离因子: R=0.0407, wR=0.1157. 化合物的晶体结构和固态圆二色谱表明化合物在结晶过程中发生单一对映体的手性堆积. 相似文献
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1 INTRODUCTION Organic phosphine compounds always attract great interest for their unique properties and extensive uses in biochemistry, pesticide chemistry and synthetic organic chemistry. In the last two decades, much attention has been paid to phosphorus-containing olefin and acetylenic compounds for their applications in transition metal chemistry, asymmetric catalysis and photorearrang- ement [1~7 ]. Previously, we have reported the crystal structure of a novel host compound which … 相似文献
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以对氨基苯腈为起始原料,经胺化反应制得N-(4-氰基苯基)甘氨酸(4);4与N-[3-氨基-4-(甲基氨基)苯甲酰基]-N-2-吡啶-β-丙氨酸乙酯(5)经酰胺化后经闭环反应,合成了达比加群酯的关键中间体——3-【【【2-{[(4-氰基苯基)氨基]甲基}-1-甲基-1H-苯并咪唑-5-基】羰基】(吡啶-2-基)氨基】丙酸乙酯,总收率79.6%,其结构经~1H NMR和ESI-MS确证。 相似文献
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Dabaeva V. V. Baghdasaryan M. R. Barkhudaryants I. M. Paronikyan E. G. Panosyan H. A. Dashyan Sh. Sh. 《Russian Journal of General Chemistry》2022,92(9):1686-1691
Russian Journal of General Chemistry - A method for the synthesis of new fused derivatives of 4-(fur-2-yl)pyrano[4,3-b]pyridines was developed by hydrolysis of... 相似文献
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Treatment of 2-chlorocinchoninic acid with hydrazine gives 2-hydrazinocinchoninic acid and with aroylhydrazines to give 1,2,4-triazolo[4,3-a]quinoline-9-carboxylic acids. These are also prepared by the action of benzoyl chloride or the carboxylic acid on 2-hydrazinocinchoninic acid. With pyruvic acid the latter gives 3-methyl-4-oxo-1,2,4-triazino[4,3-a]quinoline-10-carboxylic acid and with nitrous acid gives 1,2,3,4-tetrazolo[4,3-a]quinoline-9-carboxylic acid.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1227–1229, September, 1991. 相似文献
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A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions. 相似文献
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A synthesis is reported for N1-mono- and N1,N3-disubstituted uracil derivatives containing a terminal carbon-carbon double bond in the side-chain. Alkylation of vinyl 2-chloroethyl ether by uracil potassium salts leads to a mixture of 1-[2-(vinyloxy)ethyl] and 1,3-di[2-(vinyloxy)ethyl] derivatives while treatment of 2,4-bis(trimethylsilyloxy)pyrimidines by vinyl 2-chloroethyl ether leads exclusively to N1-monosubstituted products. Alkylation of cytosine by this chloroether gave 1-[2-(vinyloxy)ethyl]cytosine. The synthesis of 1-[2-(allyloxy)ethyl]uracil derivatives was carried out by treatment of uracil potassium salts by 1-(allyloxy)-2-(p-toluenesulfonyloxy)ethane.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 393–397, March, 1993. 相似文献