共查询到20条相似文献,搜索用时 78 毫秒
1.
Fedoseev S. V. Lipin K. V. Belikov M. Yu. Tafeenko V. A. 《Russian Journal of Organic Chemistry》2019,55(11):1669-1673
Russian Journal of Organic Chemistry - The reaction of 4-halo-3-hydroxyfuro[3,4-c]pyridin-1(3H)-ones with propan-2-ol leads to the formation of 4-halo-3-isopropoxyfuro[3,4-c]pyridin-1(3H)-ones. The... 相似文献
2.
Convenient syntheses of 2-azafluorenones 5a-f and 5H[1]benzopyrano[3,4-c]pyridin-5-ones 6a-b were performed by using intramolecular cyclization of 4-arylnicotinic acids 4a-F. 4a-f were obtained via permanganate oxidation from the corresponding of 4-arylpyridines 3a-f in good yields. 相似文献
3.
Russian Journal of Organic Chemistry - The reaction of 4-halo-3-hydroxyfuro[3,4-c]pyridin-1(3H)-ones with acyclic and alicyclic secondary amines in ethyl acetate afforded the corresponding... 相似文献
4.
Delaine T Bernardes-Génisson V Meunier B Bernadou J 《The Journal of organic chemistry》2007,72(2):675-678
The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one heterocycle and the 3-aminocarbonyl-4-isonicotinoyl-1,4-dihydropyridine framework present in the isoniazid-NAD(P) adducts are described. 相似文献
5.
Kaigorodova Elena А. Gantsgorn Natal’ya M. Konyushkin Leonid D. Krapivin Gennady D. 《Chemistry of Heterocyclic Compounds》2019,55(11):1098-1103
Chemistry of Heterocyclic Compounds - Alkylation of 6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one in an alkaline medium proceeds regioselectively at the sulfur atom to form sulfanyl... 相似文献
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The selective reduction of α,β-unsaturated ketones and CC double bonds of pyrazolo[3,4-c][1]benzothiepins with sodium borohydride was studied. The reduction of 1-methyl-2-phenyl-1,2,3,10-tetrahydro-4H-pyrazolo[3,4-c][1]benzot (1) with sodium borohydride in refluxing methanol gave 1-methyl-2-phenyl-1,2,3,10-tetrahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3-one (2). The mechanism of this unusual reaction in which the heterocyclic ketone was reduced to the corresponding methylene grouping with such a reagent was elucidated by the isolation of the following intermediates: 1-methyl-2-phenyl-1,2,3,3a, 10, 10a-hexahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3,4-dione (6) and 1-methyl-2-phenyl-1,2,3,3a,10,10a-hexahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3-one (4). 相似文献
8.
E. A. Dikusar S. K. Petkevich A. V. Kletskov T. D. Zvereva N. A. Zhukovskaya R. A. Gadzhily A. G. Aliev G. M. Mamedova Sh. F. Nagieva V. I. Potkin 《Russian Journal of Organic Chemistry》2018,54(1):87-94
The condensation of ethyl 4-(chloromethyl)-2,6-dimethylpyridine-3-carboxylate with substituted phenols in ethanol in the presence of potassium carbonate afforded the corresponding aryl pyridin-4-ylmethyl ethers. Analogous condensation with substituted anilines gave 2-aryl-4,6-dimethyl-1,2-dihydropyrrolo[3,4-c]- pyridin-3-ones. Esters containing 1,2-azole fragments were synthesized by acylation of hydroxymethylsubstituted ethers with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides. 相似文献
9.
Jan Pawlas Per Veds? Palle Jakobsen Per O Huusfeldt Mikael Begtrup 《The Journal of organic chemistry》2002,67(2):585-586
3-Chloropyrazolo[3,4-c]quinoline 5, 3-chloropyrazolo[3,4-c]isoquinoline 6, 1,2-dihydro-1,2-dimethylpyrazolo[3,4-c]quinolin-3-one 8, and 1,2-dihydro-1,2-dimethylpyrazolo[3,4-c]isoquinolin-3-one 10 were obtained by acid-induced nucleophilic aromatic substitution (S(N)H) of H-3 in N-hydroxypyrazolo[3,4-c]quinoline 1b and in N-hydroxy pyrazolo[3,4-c]isoquinoline 3b. In the acid-induced chlorination, 3b was far more reactive than 1b, whereas the related N-hydroxypyrazolo[4,3-c]quinoline 2b and N-hydroxypyrazolo[4,3-c]isoquinoline 4b were completely unreactive toward S(N)H under identical conditions. 相似文献
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2-Amino or 2-hydrazino derivatives of pyridine or pyridinopyrazole were obtained by amination or hydrazination of 2-chloro-3-cyano-4-methoxy-6-methylpyridine. Acid hydrolysis of these derivatives leads to heterocyclization with formation of 4-amino-1H-furo[3,4-c]pyridines or pyrazolo[3,4-b]pyridine. The possibility to synthesize 4-arylamino-1H-furo[3,4-c]-pyridines from 4-chloro-6-methyl-1H-furo[3,4-c]-pyridine has been shown.V. S. Pustovoit All-Russian Oil-Bearing Crops Research Institute, Krasnodar 350038, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–66, January, 1999. 相似文献
12.
G. A. Reynolds J. A. Vanallan C. C. Petropoulos 《Journal of heterocyclic chemistry》1970,7(5):1061-1069
4-Dicyanomethylene-2-phenyl-4H-1-benzopyran (1) reacts with primary amines under mild conditions to give 4-imino-3-alkyl-5-alkylimino-2-phenyl-3,4-dihydro-5H-[1]benzopyrano[3,4-c]-pyridine derivatives which, in turn, are hydrolyzed with acid to 4-imino-3-alkyl-2-phenyl-3,4-dihydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones. When more vigorous conditions are employed for the reactions of 1 with primary amines, Dimroth rearrangements take place and the products are derivatives of 4-alkyl- (or aryl)amino-5-alkyl- (or aryl)imino-2-phenyl-5H-[1]benzopyrano-[3,4-c]pyridine. The latter compounds are hydrolyzed by acid to the corresponding 5-pyridone derivatives. The reaction of 1 with piperidine gives 2-phenyl-4-piperidyl-5H-[1]benzopyrano-[3,4-c]pyridin-5-one. Sodium methoxide reacts with 1 to give 3-cyano-2-methoxy-4-(2-hydroxyphenyl)-6-phenylpyridine. Two benzologs of 1 have been allowed to react with primary and secondary amines and the products are analogous to those obtained from 1 . 相似文献
13.
Costa M Areias F Abrunhosa L Venâncio A Proença F 《The Journal of organic chemistry》2008,73(5):1954-1962
The reaction of salicylic aldehydes with malononitrile was reinvestigated, and the reaction pathway was followed by 1H NMR spectroscopy. A delicate control of the experimental conditions allowed the synthesis of 2-imino-2H-chromene-3-carbonitriles 1, (2-amino-3-cyano-4H-chromen-4-yl)malononitriles 2, 4-amino-5-imino-2,7-dimethoxy-5H-chromeno[3,4-c]pyridine-1-carbonitrile 12, and (4,5-diamino-1-cyano-1,10b-dihydro-2H-chromeno[3,4-c]pyridin-2-ylidene)malononitrile 13. Two novel 2-iminochromene dimers, with structures 8 and 9, were isolated and fully characterized. The activity of compound 8a on Aspergillus spp. growth and on ochratoxin A production was evaluated. The results of the bioassays indicate that compound 8a, applied at concentrations of 2 mM, totally inhibited the growth of the fungi tested. Ochratoxin A production by Aspergillus alliaceus was reduced by about 93% with a 200 microM solution of this compound. A moderate inhibitory effect was observed for the analogous structure 8b, and no inhibition was registered for compounds 2 and 1, used as synthetic precursors of the dimeric species 8. 相似文献
14.
The reaction of 5-benzenesulfonyl-3,4-dihydro-1 H-pyridin-2-one derivatives with azides or isocyanides provided two new classes of compounds, triazolo[4,5-b]pyridin-5-ones 3 or pyrrolo[3,4-b]pyridin-2-ones 4, respectively, in good yields and regioselectivity. A representative set of 20 compound 3 and 12 compound 4 was prepared. 相似文献
15.
Synthesis of 1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones. I. 3-unsubstituted compounds
David T. Connor Paul C. Unangst Charles F. Schwender Roderick J. Sorenson Mary E. Carethers Chester Puchalski Richard E. Brown 《Journal of heterocyclic chemistry》1984,21(5):1557-1559
Synthesis of 1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones via a Pechmann condensation of 3-carbethoxy-1-methyl-4-piperidone with various phenols is described. The limitations of this method are discussed. Synthesis of the parent ring system 3a via reduction of 1,2,3,4-tetrahydro-3-(phenylmethyl)-8-[(1-phenyl-1H-tetrazol-5-yl)oxy]-5H-[1]benzopyrano[3,4-c]pyridin-5-one ( 5 ) is also described. 相似文献
16.
V. L. Savel'ev O. L. Samsonova V. S. Troitskaya V. P. Lezina 《Chemistry of Heterocyclic Compounds》1991,27(1):108-112
4H-[1]benzopyrano[3,4-c][1,2,5]selenodiazol-4-one has been synthesized by the reaction of 3,4-diaminocoumarin with selenous acid and its reaction with several nucleophiles (alkali, ammonia, amines, hydrazine hydrate) and its nitration have been studied. Using PMR spectroscopy, a comparative kinetic study of the opening of the lactone ring in 6,8-dinitro-4H-[1]benzopyrano[3,4-c][1,2,5]seleno- and thiadiazol-4-ones has been carried out.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 128–133, January, 1991. 相似文献
17.
以4-氯烟酸和芳基乙腈为原料,经取代和环合反应合成了3个新型的氮杂异香豆素化合物(3a~3c),收率32.1%~89.0%,其结构经1H NMR, IR, ESI-MS和元素分析表征。用X-单晶衍射研究了3a的亚甲基衍生物(4a)的晶体结构。4a(CCDC: 935 919)属三斜晶系,空间群P ī, 晶胞参数a=6.881(2) , b=9.768(2) , c=11.809(2) , β=104.125(10)°, V=732.13, Dc=1.331 mg·cm-3 , Z=2, F(000)=308, μ=0.090 mm-1。并对环合反应机理进行了研究。 相似文献
18.
A series of new 1- and 2-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives were synthesized and examined for their antiplatelet activities. Some of these compounds showed significant inhibitory activities. Among them, 1-phenylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (4a), 2-(2'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(2H)- one (3e) and 2-(3'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-(2H) - one (3f) were the most effective. These inhibitors acted in a concentration-dependent manner. The antiplatelet effect of compound 3f is due to the inhibition of thromboxane A2 formation and the blockade of thromboxane A2/prostaglandin endoperoxide receptor in washed rabbit platelets. 相似文献
19.
Two New Antibacterial Chromeno[3,2-c]Pyridine Alkaloids from Whole Plants of Thalictrum scabrifolium
Yin Geng-Yun Zhu Ya-Ning Wu Fan Mi Qi-Li Shi Jian-Quan Gao Qian Zhu Ling-Chao Zhou Tao Li Jing Liu Xin Yang Guang-Yu Hu Qiu-Fen Kong Wei-Song 《Chemistry of Natural Compounds》2022,58(3):506-510
Chemistry of Natural Compounds - Two new chromeno[3,2-c]pyridine alkaloids, 9-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin- 10-one (1) and... 相似文献
20.
Vishnu J. Ram Hrishi Kesh Pandey Arnold J. Vlietinck 《Journal of heterocyclic chemistry》1980,17(6):1305-1308
The synthesis of several pyrimido[4,5-c]pyridazine (4-deazafervenulin) ( 1 ), pyrazolo[3,4-d]-pyrimidine ( 2 ) and 6-(pyrazino-1-yl)pyrimidine ( 9 ) analogs has been accomplished from 6-hydrazinouracil ( 3 ). This compound could not be used as starting material for the preparation of indolo[3,2-c]pyridazino[3,4-d]pyrimidine derivatives ( 8 ) because it yielded the corresponding hydrazones ( 7 ). 相似文献