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Dr. Zhongliang Wang Dr. Zhe Wang Dr. Dingbin Liu Dr. Xuefeng Yan Prof. Fu Wang Prof. Gang Niu Prof. Min Yang Prof. Xiaoyuan Chen 《Angewandte Chemie (International ed. in English)》2014,53(7):1997-2001
RNA interference (RNAi) is an RNA‐dependent gene silencing approach controlled by an RNA‐induced silencing complex (RISC). Herein, we present a synthetic RISC‐mimic nanocomplex, which can actively cleave its target RNA in a sequence‐specific manner. With high enzymatic stability and efficient self‐delivery to target cells, the designed nanocomplex can selectively and potently induce gene silencing without cytokine activation. These nanocomplexes, which target multidrug resistance, are not only able to bypass the P‐glycoprotein (Pgp) transporter, due to their nano‐size effect, but also effectively suppress Pgp expression, thus resulting in successful restoration of drug sensitivity of OVCAR8/ADR cells to Pgp‐transportable cytotoxic agents. This nanocomplex approach has the potential for both functional genomics and cancer therapy. 相似文献
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Back Cover: Nanosized Heterostructures of Au@Prussian Blue Analogues: Towards Multifunctionality at the Nanoscale (Angew. Chem. Int. Ed. 15/2014) 下载免费PDF全文
Guillaume Maurin‐Pasturel Dr. Jérôme Long Dr. Yannick Guari Franck Godiard Dr. Marc‐Georg Willinger Prof. Dr. Christian Guerin Prof. Dr. Joulia Larionova 《Angewandte Chemie (International ed. in English)》2014,53(15):4008-4008
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Back Cover: A High‐Pressure NMR Probe for Aqueous Geochemistry (Angew. Chem. Int. Ed. 37/2014) 下载免费PDF全文
Dr. Brent G. Pautler Christopher A. Colla Dr. Rene L. Johnson Peter Klavins Dr. Stephen J. Harley Dr. C. André Ohlin Prof. Dimitri A. Sverjensky Dr. Jeffrey H. Walton Prof. William H. Casey 《Angewandte Chemie (International ed. in English)》2014,53(37):9962-9962
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Back Cover: Maximum Noble‐Metal Efficiency in Catalytic Materials: Atomically Dispersed Surface Platinum (Angew. Chem. Int. Ed. 39/2014) 下载免费PDF全文
Dr. Albert Bruix Dr. Yaroslava Lykhach Dr. Iva Matolínová M. Sc. Armin Neitzel Dr. Tomáš Skála Dr. Nataliya Tsud Dr. Mykhailo Vorokhta M. Sc. Vitalii Stetsovych M. Sc. Klára Ševčíková Dr. Josef Mysliveček M. Sc. Roman Fiala M. Sc. Michal Václavů Dr. Kevin C. Prince Dr. Stéphanie Bruyère Dr. Valérie Potin Prof. Dr. Francesc Illas Prof. Dr. Vladimír Matolín Prof. Dr. Jörg Libuda Prof. Dr. Konstantin M. Neyman 《Angewandte Chemie (International ed. in English)》2014,53(39):10546-10546
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Back Cover: Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration (Angew. Chem. Int. Ed. 24/2014) 下载免费PDF全文
Dr. Caoyun Ju Dr. Ran Mo Jingwei Xue Lei Zhang Zekai Zhao Dr. Lingjing Xue Prof. Qineng Ping Dr. Can Zhang 《Angewandte Chemie (International ed. in English)》2014,53(24):6278-6278