Three New Styrylpyroncs from Goniothalamus leiocarpus

Goniolhalamusleiocarpus(Annonaceaefamily)isatropicalplantdistributedinsouthofYunnanprovinceofChina.Wehaveisolatedanewstyrylpypyrone--leiocarpinAlfromthestembarksofGoniothalamusleiocarpusandfourknownannonaceousacetogenins'fromtheseedsofthesameplant.Inthispaper,wereportedthreenewstyrylpyrones,named7epi-goniodioll,IeiocarpinB2andleiocarpinC3respectively.Theywereisolatedfromtheethanolicextractofstembarksoftheplantbyrepeatedlychromatographyofsilicacolumns.Theirstructureswereelucidatedbymeansofs…     

A Styrylpyrone Dimer from the Bark of Goniothalamus leiocarpus

A dimer of styrylpyrone derivative, leiocarpin E(1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested.     

Two new linear acetogenins from the fruits of Goniothalamus gracilipes

Two new linear acetogenins, gracilipin A (1) and methylsaccopetrin A (2) along with seven known compounds, saccopetrin A (3), 7,3′,4′-trimethylquercetin (4), rhamnazin (5), casticin (6), isokanugin (7), melisimplexin (8) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (9) were isolated from the fruits of Goniothalamus gracilipes Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds 1 and 3 showed cytotoxic activity against KB cell line with IC₅₀ values of 14.6 and 15.3 μM, respectively.     

Two New Styryllactones from Goniothalamus cheliensis

Two new styryllactones,iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone,were isolated from the roots of Goniothalamus cheliensis.Their structure were elucidated on the basis of spectroscopic and chemical evidences.     

Two New Compounds from Goniothalamus Cheliensis Hu

Goniothalamus cheliensis Hu (Annonaceace) is a small tree or shrub in Yunnan Province, southwest of China. Acetogenins, styryllactones and alkaloids1-3 from the genus were reported in the previous literature and many of them showed strong cytotoxic activities against a number of human cancer cell lines4. The titled plant has been the subject of our investigation due to the impressive cytotoxicity of its organic extract against mouse lymphocytic leukemia cells in preliminary pharmacological s…     

New Alkaloids from the Rhizomes of Goniothalamus Griffithii

GoniothalamusgrghthiiHook.F.etThoms(Annonaceae)isatropicalplantdistributedinsouthChina,IndiaandThailand.InwiderangescreeningfOrantitumoragentsfromAnnonaceaeplants,thecthanolicextractofrhizomesofG.grghthiiwasfOundtohc-..activeagainstvarioushumancancercelllines.Furtherpuriflcationoftheextractyieldedthreenewalkaloids,griffithdionel,griffiazanoneA2andgriffiazanoneB3wh()scstructuresweree1ucidatedbyvariousNMRtechniques,includingHMBC,NOEexperiments.(R)-and(S)-MTPAderivativeswerepreparedtod…     

Marcanine G,a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib

The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC₅₀ values of 14.87 and 15.18 μM against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC₅₀ values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively.     

Muricatin A和Muricatin B刺果番荔枝中的两个新番荔枝内酯

从刺果番荔枝(Annonamuricata)的种子分离得到两个新成分,此两成分及其衍生化物经光谱分析,鉴定为两个新番荔枝肉酯,命名为MuricatinA和MuricatinB。它们属无THF环番荔枝内酯。     

Desmosdumotin B: A New Special Flavone from Desmos dumosus

Desmos dumosus (Roxb.) Saff. is a liana-like or straight up shrub of the southern and the southwestern areas of China. The roots and leaves of D. dumosus are used as antimalarial, insect-killing, antirheumatic, antispasmodic and pain-relieving agent in Chinese folk medicine. Several flavonoids have been isolated from the plant1-6. In this paper we report the isolation and structural elucidation of a new compound, 5-hydroxy- 7-one-6,8,8-trimethyl flavone, named desmosdumotin B.Desmosdumotin …     

Clavulazols A and B,Two New Pyrazine Derivatives from Clavularia Viridis

Two new marine pyrazine derivatives, clavulazols A ( 4 ) and B ( 5 ), were isolated from ethyl acetate extract of the soft coral Clavularia viridis collected in Taiwan. The structures were determined on the basis of spectral analysis, especially 2D NMR as well as chemical conversion.     

Two New Iridoid Alkaloids,Daphmacropodosidines A and B,from Daphniphyllum macropodum

Two new iridoid alkaloids, daphmacropodosidines A ( 1 ) and B ( 2 ), together with two known ones, daphcalycinosidine B and caldaphnidine F, were isolated from the fruits of Daphniphyllum maropodum. Their structures were established by spectral methods, especially 2D NMR spectra (¹H,¹H‐COSY, HMQC, HMBC, and NOESY), as well as chemical means.     

Macrorhynines A and B,Two Novel Norditerpenoid Alkaloids from Aconitum macrorhynchum

Two novel norditerpenoid alkaloids, macrorhynines A and B ( 1 and 2 ), together with seven known compounds, were isolated from Aconitum macrorhynchum. The structures of the new compounds were elucidated as (1α,6α,14α)‐8‐acetoxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)aconitan‐14‐yl 4‐methoxybenzoate ( 1 ) and (1α,6α,14α)‐8‐acetoxy‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)aconitan‐14‐yl 4‐methoxybenzoate ( 2 ) on the basis of spectral analyses. The novel compounds were found to contain the rare C(19)?N, azomethine, group.     

Flabelliformides A and B,Two Novel Indole Alkaloids from Ervatamia flabelliformis

Flabelliformides A ( 1 ) and B ( 2 ), containing a novel C₂₀ indole core, have been isolated from the stems of Ervatamia flabelliformis. The structures of 1 and 2 were elucidated on the basis of spectral analysis and X‐ray crystallography.     

Intercedenol A and B, Two New Triterpenoids from the Sea Cucumber Mensamaria intercedens

Two new triterpenoids named intercedenol A and B were isolated from the acid hydrolysate of the crude glycoside fraction. The structures were elucidated by ESI-MS and NMR spectrum.     

Goniodilactone and gomoheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI₅₀S in the range of 1.29-4.56μg/mL.     

Nepethalates A and B: Two New Phthalate Derivatives from Nepeta clarkei

The structure elucidation of two new phthalate derivatives named nepethalates A ( 1 ) and B ( 2 ) is reported. Both of these secondary metabolites were isolated from the MeOH extract of Nepeta clarkei. HR‐EI‐MS, IR and UV absorption spectrometry, and NMR experiments including COSY, HMQC, and HMBC were used for the determination of the structures and complete ¹H‐ and ¹³C‐NMR assignments.     

Habaenines A and B,Two New Norditerpenoid Alkaloids from Aconitum habaense

Two new norditerpenoid alkaloids, habaenine A and B ( 1 and 2 ), together with two known compounds, were isolated from Aconitum habaense. The structures of the new compounds were elucidated on the basis of spectral analyses as (1α,6α,16β)‐8‐(acetyloxy)‐20‐ethyl‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐19‐oxoaconitan‐14‐yl 4‐methoxybenzoate ( 1 ) and (1α,6α,16β)‐8‐(acetyloxy)‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐aconitan‐14‐yl 4‐methoxybenzoate ( 2 ).     

Bisyinshanic Acids A and B,Two Novel Diterpene Dimers from the Roots of Euphorbia yinshanica

Two novel diterpene dimers with a bismagdalenic acid skeleton, bisyinshanic acids A and B ( 1 and 2 , resp.), along with eight known diterpenoids ( 3 – 10 ), were isolated from the roots of Euphorbia yinshanica. Their structures were elucidated on the basis of spectroscopic evidence.     

A New Cyclic Peptide from Schnabelia tetradonta

A new cyclic octapeptide (schnabepeptide B) was isolated from the aerial part of Schnabelia tetradonta (Sun) C. Y. Wu et C. Chert (Lamiaceae). Its structure was elucidated as cyclo-(NH-Trp-Gly1-Leu1-Gly2-Pro1-Pro2-Leu2-Pr03-CO) on the basis of extensive 2D NMR and MS spectra.