共查询到20条相似文献,搜索用时 15 毫秒
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L. J. Ottendorfer 《Fresenius' Journal of Analytical Chemistry》1963,198(2):198
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Klaus rodersen 《Fresenius' Journal of Analytical Chemistry》1960,173(3):259
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R. Hönigschmid-Grossich 《Fresenius' Journal of Analytical Chemistry》1963,198(4):375-376
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L. J. Ottendorfer 《Fresenius' Journal of Analytical Chemistry》1962,189(4):369-370
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《Coordination chemistry reviews》2003,236(1-2):209-233
The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and imine ligands, provides for many approaches to innovative new metallopharmaceuticals. Advantages of utilizing ruthenium am(m)ine complexes in drug development include, (1) reliable preparations of stable complexes with predictable structures; (2) the ability to tune ligand affinities, electron transfer and substitution rates, and reduction potentials; and (3) an increasing knowledge of the biological effects of ruthenium complexes. Many Ru(II) and Ru(III) am(m)ine complexes selectively bind to imine sites in biomolecules. Collectively, these lend ruthenium complexes to redox-activation and photodynamic approaches to therapy as well as the development of radiopharmaceuticals containing one of several radionuclides of ruthenium. Ruthenium red and the related Ru360 strongly inhibit calcium ion uptake in the mitochondria. A number of ruthenium compounds with anticancer activity appear to penetrate tumors through a transferrin-mediated process and bind to cellular DNA following intracellular activation by reduction. Ruthenium complexes exhibit both nitric oxide release and scavenging functions that can affect vasodilation and synapse firing. Simple ruthenium complexes are unusually effective in suppressing the immune response by inhibiting T cell proliferation. 相似文献
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建立了氢还原重量法测定三氯化钌产品大样中钌含量的新方法,研究并优化了测定条件,结合原子吸收光谱法(AAS)、电感耦合等离子体原子发射光谱法(ICP-AES)和氯化铵纯度考察了杂质元素对了分析结果的误差影响。结果表明,钌含量为0.3~0.6g的三氯化钌与5~7g氯化铵能完全形成(NH4)2RuCl6配合物,于约100℃烘干水分、350℃分解铵盐、750℃氢还原为海绵钌和105℃干燥水气的条件下,测定3.94%,5.88%,7.32%,9.47%,10.84%和12.93%含量的钌,极差、标准偏差(S)、相对标准偏差(RSD,n=22)和重复性限(r)分别为±0.01%,0.0030%~0.0050%,0.0369%~0.0761%和0.008%~0.014%。样品加标回收率99.96%~99.98%。方法的结果准确,精密度好,且与YS/T562—2009标准分析方法的吻合。 相似文献
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采用分光光度法测定活性炭负载钌系氨合成催化剂中的钌含量.在强酸和乙醇体系中,Ru(Ⅲ)与硫脲生成蓝色物,于最大吸收波长λ=620am处测定催化剂中的钌含量.测试结果表明,该方法操作简单、干扰小,相对标准偏差为1%~3%,加标回收率在97.5%~102.0%之间,适用于活性炭负载钌系氨合成催化剂中钌含量的准确测定. 相似文献
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Ruthenium complexes of phosphinoferrocenylaminophosphine ligands (BoPhoz™ ligands) have been prepared by combining the ligands with tris(triphenylphosphine)ruthenium dichloride and precipitating the complexes. The optimal species exhibit high enantioselectivities for the asymmetric hydrogenation of functionalized ketones, particularly β-ketoesters. 相似文献
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[RuCl(H)(CO)(PPh3)3] (2) was found to catalyze, in the presence of H2C=CHSiMe3 (3), the trimerisation of aldehydes RCHO [R=Et (4a), i-Bu (4b)] yielding 1,3,5-trioxanes (5) and the aldol condensation yielding α,β-unsaturated aldehydes (6). When (4a) was used as a reactant, from these reaction mixtures, the ruthenium complex [RuCl2(CO)(PPh3)2(i-BuCHO-κO)] (7) having the aldol condensation product as the ligand crystallized. In the analogous reaction with (4b), the complex [RuCl2(CO)(PPh3)2(i-BuCHO-κO)] (8) with the aldehyde as ligand was obtained. The constitution of these complexes was established by single-crystal X-ray diffraction measurements. The ruthenium centers are octahedrally coordinated having the aldehyde and the carbonyl ligand in mutually trans positions (coordination index: OC-6-12). The aldehydes are monodentately coordinated via the carbonyl oxygen atom (κO). The coordination induced elongations of the C=O double bonds [1.242(4) Å (7), 1.234(4) Å (8)] indicate an activation of the aldehydes. Furthermore, the Ru-CO bond lengths [1.842(4) Å (7), 1.823(4) Å (8)] exhibit a relatively low trans influence of the aldehyde ligands. The formation of the complexes (7) and (8) give an indication that the Lewis acidity of the ruthenium center is of importance for aldehyde activation in the catalytic process. 相似文献
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Alejandro Gutiérrez-González Fernando López José L. Mascareñas 《Helvetica chimica acta》2023,106(4):e202300001
Recent years have witnessed a considerable progress in research aimed at merging transition metal catalysis with chemical and cell biology. Therefore, a crescent number of metal-catalyzed transformations have been shown compatible with biological media and even with living settings. Of the different transition metals used to build these biocompatible catalysts, ruthenium has demonstrated to be particularly powerful, in part because the resulting complexes exhibit a very good balance between reactivity and biological stability. Indeed, ruthenium complexes have demonstrated utility to promote a great variety of reactions in biologically relevant contexts, from deprotection and redox processes to cycloadditions or photocatalytic transformations. Many of these reactions may enable the development of new type of biological tools and pharmacological strategies. 相似文献