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1.
Zusammenfassung Tetrahydro-6-brommethyl-2-oxopyrimidin-5-carbonsäureester reagieren mit Ammoniak bzw. Benzylamin zu Tetrahydro-5H-pyrrolo[3,4-d]pyrimidin-2(1H), 5-dionen. Mit 2-Aminopyridin (A) bilden sich Tetrahydro-6-(2-pyridylaminomethyl)-2-oxopyrimidin-5-carbonsäureester, Tetrahydro-5H-pyrrolo[3,4-d]pyrimidin-2(1H), 5-dione sowie 5-Äthoxycarbony]-2,3,5,6-tetrahydro-2-oxospiro(pyrimidin-4(1H), 2(3H)-1H-imidazo[1,2-a]pyridinium)bromide.
Herrn Prof. Dr.O. Hromatka zum 65. Geburtstag gewidmet. 相似文献
Heterocycles XXII: 3.4.6.7-Tetrahydro-5H-pyrrolo [3.4-d]-pyrimidine-2(1H)-5-diones
Tetrahydro-6-bromomethyl-2-oxopyrimidine-5-carboxylates react with ammonia and benzylamine, resp., to give tetrahydro-5H-pyrrolo[3.4-d]pyrimidin-2(1H), 5-diones. With 2-aminopyridine (A) tetrahydro-6-(2-pyridylaminomethyl)-2-oxopyrimidine-5-carboxylates, tetrahydro-5H-pyrrolo[3.4-d]pyrimidine-2(1H). 5-diones as well as 5-ethoxycarbonyl-2.3.5.6-tetrahydro-2-oxospiro(pyrimidin-4(1H)-2(3H)-1H-imidazo[1.2-a]-pyridinium) bromides are formed.
Herrn Prof. Dr.O. Hromatka zum 65. Geburtstag gewidmet. 相似文献
2.
A. I. Markosyan R. A. Kuroyan S. V. Dilanyan L. A. Shirkhanyan 《Chemistry of Heterocyclic Compounds》1996,32(4):462-465
3-p-Methoxyphenyl-4-oxo-2-mercapto-3, 4, 5, 6-tetrahydrospiro(benzo[h]quinazoline-4,1 -cyclohexane) wassynthesized by the reaction of 4-amino-3-ethoxycarbonvl-1, 2-dihydrospiro(naphthalene-2,1 '-cyclohexane) (1) with p-methoxyphenvl isothiocyanate without separation of the thioureido derivative. Amino ester 1 is transformed byacetamide and formamideinto 2-methyl-4-oxo-3, 4, 5, 6-tetrahydrospiro(benzo[h]quinazoline-5,1 -cyclohexane) and 4-oxo-3, 4, 5, 6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexane (11), respectively. Alkylation of quinazoline 11 with methyl iodide results in formation of 3-methyl-4-oxo-3, 4, 5, 6-tetrahydro-spiro (benzo[h]quinazoline-5,1 -cyclohexane). Amino ester 1 reacts with caprolactam with formation of 2, 3 pentamethylene-4-oxo-3, 4, 5, 6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexane). 4-Ethoxymethyleneamino-3-ethoxy-carbonyl-1,2-dihydrospiro(naphthalene-2,1-cyclohexane) was synthesized by the reaction of amino ester 1 with o-formic ester, and was converted into 3-amino-4-oxo-3, 4,5, 6-tetrahydro-spiro(benzo[h]quinazoline-5,1-cyclohexane) (VIII) by hydrazine hydrate. Aminoquinazoline VIII is acylated by acid chlorides with formation of 3-acylamino-4-oxo-3,4,5,6-tetrahydrospiro(benzo[h]quinazoline-5,1-cyclohexanes) and forms 3-benzyl-ideneamino-4-oxo-3,4,5,6-teirahydrospiro(benzo[h]quinazoline-5,1-cyclohexane) with benzaldehyde.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 530–533, April, 1996 相似文献
3.
The reaction of hydrazines with substituted ethyl 4-chloro-1H-pyrazolo[3,4-b]pyridine-3-carboxylates leads to the formation of 1H,6H-dipyrazolo[3,4-b:3,4-d]pyridin-3-ones.
Tricyclische heteroaromatische Ringsysteme, III. Synthese von 1H,6H-Dipyrazolo[3,4,-b:3,4-d]pyridin-3-onen (Kurze Mitteilung)
Zusammenfassung Die im Titel genannten Verbindungen wurden durch die Reaktion von Hydrazinen mit substituierten Ethyl-4-chlor-1H-pyrazolo[3,4-b]pyridin-3-carboxylaten dargestellt.相似文献
4.
P. M. Kochergin A. M. Tsyganova L. M. Viktorova 《Chemistry of Heterocyclic Compounds》1967,3(1):66-67
A number of derivatives of imidazo [5, 1-b] thiazole, imidazo [5, 1-b] thiazoline, and imidazo [5, 1-b] thiazolid-3-one are synthesized by cyclizing 2-alkyl-4(5)-nitro-5(4)-formylmethyl (-ketoalkyl-,-hydroxyethyl-, and carboxymethyl) mercaptoimidazoles.For Part XXVI see [18]. 相似文献
5.
H. Junek 《Monatshefte für Chemie / Chemical Monthly》1965,96(5):1421-1426
Zusammenfassung 4-Hydroxycumarine addieren in 3-Stellung leicht Tetracyanäthylen unter Bildung der 3-(1,1,2,2-Tetracyan)äthan-4-hydroxycumarine VII–XII. Ebenso reagieren 4-Hydroxycarbostyril und 4-Hydroxy-2,5-diketo-(2H,5H-pyrano-[3,2-c] [1]-benzopyran) zu XIII und XIV. Die entstehenden Produkte sind sehr hydrolyseempfindlich, und aus VII wird unter partieller Verseifung das Furobenzopyran XV gebildet.
4-Hydroxycoumarins add tetracyanoethylene in position 3 forming the 3-(1,1,2,2-tetracyano)ethane-4-hydroxycoumarins VII–XII. 4-Hydroxycarbostyril and 4-hydroxy-2,5-diketo-(2H,5H-pyrano-[3,2-c] [1]benzopyran) react in the same way to XIII and XIV. These products are very easily hydrolyzed, the furobenzopyran XV is obtained from VII. *** DIRECT SUPPORT *** A3615111 00002相似文献
6.
V. A. Artemov L. A. Rodinovskaya A. M. Shestopalov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1994,30(1):110-120
3-Cyanopyridine-2(1H)-thiones and 3-cyano-2(1H)-selenones undergo heteroannelation with N-cyano-chloracetarnidine to give thieno[2, 3-b]pyridines,selenopheno[2, 3-b]pyridines, 2, 4-diantinopyrido-[3, 2:4, 5]thieno[3, 2-d]pyritnidines, and 2, 4-diamittopyrido[3, 2:4, 5]selenopheno[3, 2-d]pyritnidines, which were converted to compounds containing triazine, anzinopyrimidine, and pyrimidinedione rings.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 122–132, January, 1994. 相似文献
7.
M. A. Zahran E. B. Pedersen C. Nielsen 《Monatshefte für Chemie / Chemical Monthly》1995,126(11):1271-1277
Summary 3-Aryl-7-(2-deoxy--D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-imines (4) as well as 4-arylamino-7-(2-deoxy--D-erythro-pentofuranosyl)-2-methyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidines (7) have been synthesized by glycosylation of the sodium salt of the corresponding nucleobases with 2-deoxy-3,5-di-O-p-toluyl--D-erythro-pentofuranosyl chloride (2) followed by subsequent deprotection with sodium methoxide in methanol. The deprotected nucleoside4 undergoes aDimroth rearrangement on reflux for 24 h in water to furnish the 4-arylamino nucleoside7.
Synthese und Reaktionen von 2-Deoxy--D-ribofuranosylderivaten von 3-Aryl-4H-pyrrolo[2,3-d]pyrimidin-4-iminen
Zusammenfassung 3-Aryl-7-(2-deoxy--D-erythro-pentafuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-imine (4) und 4-Arylamino-7-(2-deoxy--D-erythro-pentofuranosyl)-2-methyl-5-phenyl-7H-pyrrolo[2,3,-d]pyrimidine (7) wurden durch Glycosylierung der Natriumsalze der entsprechenden Nucleosidbasen mit 2-Deoxy-3,5-di-O-p-toluyl--D-erythro-pentofuranosylchlorid (2) und anschließende Entfernung der Schutzgruppe mit Natriummethoxid in Methanol hergestellt. Das entschützte Nucleosid4 ergibt bei 24-stündigem Erhitzen in Wasser unter Rückfluß über eineDimroth-Umlagerung das 4-Aminonucleosid7.相似文献
8.
J. M. Quintela M. C. Veiga R. Alvarez-Sarandés L. González C. Peinador 《Monatshefte für Chemie / Chemical Monthly》1996,127(10):1037-1043
Summary 8,9-Diphenylpyridazino[4,3:4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-one (2), 3-substituted 8,9-diphenylpyridazino[4,3:4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-ones (3a–c), 3,4-diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazin-8(7H)-one (4), 8-chloro-3,4-diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazine (5), 8-substituted 3,4-diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazines (6a–h) and 7-substituted 3,4-diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazin-8(7H)-ones(7a–c) were synthesized from 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide (1).
Synthese neuer Pyridazino[4,3:4,5]thieno[3,2-d]-1,2,3-triazin-und Pyrimido[4,5:4,5]thieno[2,3-c]pyridazin-Derivate
Zusammenfassung Folgende Verbindungen wurden ausgehend von 5-Amino-3,4-diphenylthieno[2,3-c]pyridazin-6-carboxamid (1) synthetisiert: 8,9-Diphenylpyridazino[4,3:4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-on (2), 3-substituierte 8,9-Diphenylpyridazino[4,3:4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-one (3a–c), 3,4-Diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazin-8[7H]-on (4), 8-Chlor-3,4-diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazin (5), 8-substituierte 3,4-Diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazine (6a–h) und 7-substituierte 3,4-Diphenylpyrimido[4,5:4,5]thieno[2,3-c]pyridazin-8(7H)-one (7a–c).相似文献
9.
B. P. Fabrichnyi I. F. Shalavina S. M. Kostrova Ya. L. Gol'dfarb 《Chemistry of Heterocyclic Compounds》1971,7(10):1270-1272
The synthesis of 1-chloro-4,5,6,7-tetrahydrobenzo[c]-4-thiophenone and 1-chloro-5,6,7,8-tetrahydro-4H-cyclohepta[c]-4-thiophenone was accomplished by the cyclization of the acid chlorides of -(2,5-dichloro-3-thienyl)butyric acid and -(2,5-dichloro-3-thienyl)valeric acid, respectively, to 1,3-dichloro-4,5,6,7-tetrahydrobenzo[c]-4-thiophenone and 1,3-dichloro-5,6,7,8-tetrahydro-4H-cyclohepta[c]-4-thiophenone and by partial dehalogenation of the latter by heating with copper metal in propionic acid.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1358–1360, October, 1971. 相似文献
10.
I. Ya. Postovskii N. N. Vereshchagina S. L. Mertsalov 《Chemistry of Heterocyclic Compounds》1966,2(1):94-97
2-R-Quinazolones have been synthesized (R=Me, Ph,-pyridyl,-furyl), and subsequently the 4-chlorides and the corresponding 2-R-4-hydrazinoquinazolines were obtained. By the reaction of orthoformic ester and nitric acid on the hydrazines, 5-R- [3, 4-c]-s-triazoloquinazolines and 5-R- [1, 5-c] tetrazoloquinazolines were prepared, respectively. The compounds in which R=Me differ considerably from compounds with other groups, both in color and stability of intermediate reaction products. 5-R- [1, 5-c] tetrazoloquinazolines are hydrolyzed by HCl into quinazol-4-ones.For Part IV see [1]. 相似文献
11.
Giuseppina Faraglia Livia Sindellari Valeria Cherchi Sergio Sitran 《Transition Metal Chemistry》1986,11(3):98-102
Summary Thecis-[PtPra2I2],trans-[PtPra2I2], [PtPra3I]I, [PtPra4]I2 and [PtPra4]I2 · 2H2O (Pra = propan-1-amine) complexes have been prepared and characterized by elemental analyses, i.r. and1H n.m.r. spectra and t.g., d.t.g. and d.t.a. measurements. Thermal degradation of the 13 and 14 complexes yieldstrans-[PtPra2I2] as an intermediate, whereascis-[PtPra2I2] isomerizes totrans without decomposition. The1H n.m.r. spectra of the 12 and 14 species in deuteriated solvents are characteristic of the stoichiometry and geometry, whereas the spectra of [PtPra3I]I indicate a general instability of this complex in solution, owing to easy decomposition to give trans-[PtPra2I2]. 相似文献
12.
Ahmad O. Baghlaf Khalid Banaser Hussain Y. Hashem Ahmed Albishry Muhammad Ishaq 《Transition Metal Chemistry》1996,21(1):16-18
Summary [RuCl2(CO)2]
n
reacts with the Schiff base 1-acetylferrocenethiosemicarbazone, [Fe(-Cp)(-C5H4MeC=NN-HCSNH2)] to give [Fe(-Cp)(-C5H4MeC=NN-HCSNH2)RuCl2(CO)2] and with 1-acetylferrocenesemicarbazone [Fe(-Cp)(-C5H4MeC=NN-HCSNH2)] to give [Fe(-Cp)(-C5H4MeC=NN-HCSNH2)RuCl2-(CO) 2]. Spectroscopic data indicate that the Schiff bases act as bidentate ligands and coordinate to ruthenium via the hydrazinic N and either the S or O atoms, respectively, giving stable heterobimetallic complexes, which have been characterized by i.r. and 1H-n.m.r. spectroscopies, and elemental analyses.Part of this work was presented at the First International Conference in Chemistry and its applications in Doha, Qatar, 1993. 相似文献
13.
Marijan Kočevar Branko Stanovnik Miha Tišler 《Monatshefte für Chemie / Chemical Monthly》1988,119(5):597-603
Pyrido[2,3:3,4]pyrazolo[5,1-c][1,2,4]benzotriazin-4(1H)ones were transformed via their oximes in aSemmler-Wolff aromatization process in the tetracyclic heteroaromatic amines4 or bySchmidt reaction into a mixture of the same amine4 and a ring enlarged lactam3. Syntheses of some halo pyrazolo[3,4-b]pyridines and a photochemical transformation of 3-azidopyrazolo[3,4-b]pyridine are also described.
Über dieSemmler-Wolff- undSchmidt-Reaktion einiger Pyrido[2,3:3,4]pyrazolo[5,1-c][1,2,4]benzotriazine
Zusammenfassung Pyrido[23:3,4]pyrazolo[5,1-c][1,2,4]benzotriazin-4(1H)one werden über Oxime in einerSemmler-Wolff-Reaktion in die tetracyklischen aromatischen Amine4 umgewandelt. In einerSchmidt-Reaktion wurden dieselben Ketone in ein Gemisch aus Amin4 und Lactam3 übergeführt. Synthesen von halogensubstituierten Pyrazolo[3,4-b]pyridinen und photochemische Umwandlung von 3-Azidopyrazolo[3,4-b]pyridin werden beschrieben.相似文献
14.
Syntheses within the system CuO-SeO2-H2O revealed four copper(II)-oxo-selenites. The crystal structures of these compounds were determined by single crystal X-ray techniques. Chemical formulae, lattice parameters and space groups are: Cu2O(SeO3)-I [a=8.925 (1) Å, P213], Cu2O(SeO3)-II [a=6.987 (5) Å,b=5.953 (4) Å,c=8.429 (6) Å, =92.17 (3)°, P21/n], Cu4O(SeO3)3-I [a=15.990 (8) Å,b=13.518 (8) Å,c=17.745 (12) Å, =90.49 (5)°, P21/a], and Cu4O(SeO3)3-II [a=7.992 (6) Å,b=8.141 (6) Å,c=8.391 (6) Å, =77.34 (3)°, =65.56 (3)°, =81.36 (3)°,
].All the Cu atoms are-with one exception-[4], [4+1], and [4+2] coordinated by O atoms. The four nearest O atoms are more or less distorted square planar arranged. Within the CuO4 squares the Cu-O bond lengths are significantly shorter for the [4] coordinated O atoms as compared with those of the [4+1] and [4+2] coordinated Cu atoms. The exception in the coordination of the Cu atoms is the Cu(1) atom in Cu2O(SeO3)-I with the site symmetry 3, which is trigonal dipyramidal [5] coordinated. A common feature of these four crystal structures is, that O atoms outside the SeO3 groups are tetrahedrally coordinated by four Cu(II) atoms. The Se atoms are as usual [3] coordinated, building up SeO3 pyramids. In all these four compounds the copper-oxygen polyhedra are combined to a three-dimensional network. 相似文献
15.
Jesús M. Arsuaga Mercedes Taravillo Mercedes Cáceres 《Journal of solution chemistry》2001,30(12):1091-1100
The enthalpies of dilution for aqueous solutions of [Co(en)3]Br3, [Co(pn)3]Cl3, and [Co(tn)3]Cl3 (where en = 1,2-diaminoethane, pn = 1,2-diaminopropane, and tn = 1,3-diaminopropane) have been measured at 25°C, and up to m = 1 mol-kg–1, using an isoperibol calorimeter by the long-jump method. Relative apparent molar enthalpies L
have been extracted as an empirical equation relating L
and m. Previously reported experimental data and theoretical predictions in the restricted primitive model (RPM) for 3:1 and 1:3 aqueous electrolytes are shown together with the new experimental material. 相似文献
16.
Tonson Abraham 《Monatshefte für Chemie / Chemical Monthly》1982,113(11):1275-1282
When dibenzo[b,f]-1-azapentalene dianion (3) was allowed to react with either iron (III) chloride or ethylene bromide, a one-electron transfer from3 took place readily to give the radical anion11. Further electron transfer from11 did not occur presumably due to the antiaromatic character of dibenzo[b,f]-1-azapentalene (1) that would have resulted. The radical anion11 underwent further transformation by hydrogen abstraction from the solvent to give 5,10-dihydroindeno[1,2-b]indole (2) and by dimerization to themeso and (R,S) isomers of 5,5,10,10-tetrahydro-10,10-biindeno[1,2-b]indole (4 a and4 b) respectively.
Elektronentransfer von Dibenzo[b,f]-1-azapentalen-Dianion: Ein Versuch zur Synthese von Dibenzo[b,f]-1-azapentalen
Zusammenfassung Die Reaktion von Dibenzo[b,f]-1-azapentalen-Dianion (3) mit Eisen (III) oder Ethylenbromid ergab einen Ein-Elektronentransfer zum Radikalanion11. Ein weiterer Elektronentransfer fand nicht statt, vermutlich wegen des antiaromatischen Charakters von Dibenzo[b,f]-1-azapentalen (1), das dabei entstehen müßte. Das Radikalanion11 ergab unter Wasserstoffentzug aus dem Lösungsmittel 5,10-Dihydroindeno[1,2-b]indol (2), das weiter zummeso- bzw. (R,S)-5,5,10,10-tetrahydro-10,10-biindeno[1,2-b]indol (4 a bzw.4 b) dimerisierte.相似文献
17.
18.
Giuseppina Faraglia Livia Sindellari Valeria Cherchi Ariella Furlani Aristotelis Papaioannou Vito Scarcia 《Transition Metal Chemistry》1993,18(1):45-50
Summary The thiocarbamic esters (L)ETC(EtOSCNHEt) and PTC (EtOSCNHPr) act as sulphur donors towards platinum halides, yielding the cis-[Pt(L)2Cl2], trans-[Pt(L)2Br2], [Pt(L)3X]X (X = Cl or Br) and [Pt(L)4]X2 (X = Cl, Br or I) complexes. By addition of n-hexane to platinum chloride solutions in pure ligands the 16 adducts [Pt(L)4]-Cl2·2L have been isolated. The non-bonded ligand molecules are easily released to give the corresponding 14 complexes. The compounds have been characterized by elemental analysis and spectroscopy. The 14 and 16 complexes decompose in benzene to form the 13 species, except for [Pt(ETC)4]I2, which releases two ligand molecules to give trans-[Pt(ETC)2I2]. The 12 and 13 complexes have been tested for in vitro cytostatic activity against KB cells. 相似文献
19.
Summary The complextrans-[ReCl(N2)(dppe)2], (1) reacts with the thiolate salts Li[SC6H4Me-4], Tl[SC6H4Me-4] and [Pb(SBu-t)2] to yield [ReCl(SC6H4Me-4)(dppe)2], [Re(SC6H4Me-4) (dppe)2] and [{ReO(dppe)}2(-Cl)(-S)(-SBu-t)] (tentative formulation), respectively. The [ReCl(2-CS2)(dppe)2] complex appears to be formed by reaction of (1) with CS2. 相似文献
20.
V. A. Artemov V. L. Ivanov L. A. Rodinovskaya A. M. Shestopalov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1996,32(4):483-486
1,4-Dihydro-3-cyano-2-pyridinethiolates react with 2-bromo-l-(4-bromophenyl)ethylidenemalononitrile or N-cyanochloracetanudine to give 6, 9-dihydropyrido[3, 2': 4, 5]thieno[3. 2-b]pyridines or 6, 9-dihydropyrido-[3.2:4.5Jthieno(3,2-d]pyrimidines, respectively.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 553–556, April, 1996. 相似文献