苯骈三唑阴离子选择性电极的研制

本报道了一种以乙基紫－苯骈三唑阴离子缔合物为活性物的ＰＶＣ基质碳棒涂膜式ＢＴＡ阴离子选择性电极的研制及其电位响应特性。在２５℃时，电极的线性响应范围５×１０＾－５－１×１０＾－２ｍｏｌ／Ｌ，检测限１．１×１０＾－５ｍｏｌ／Ｌ，响应斜率５８ｍＶ。     

苄氧基甲基12—冠—3的合成与锂离子选择性电极研究

报道了苄氧基甲基－１２－冠－３－的合成，并以此化合物作载体研制成锂离子选择电极。用苄氧基甲基－１２冠－３－为载体的电极对锂离子响应拇性范围为１．０×１０＾－１－８．３×１０＾－５ｍｏｌ／Ｌ．检测限为４．２×１０＾－５ｍｏｌ／Ｌ，斜率为５７．４ｍＶ／ｐＬｉ。电极具有好的稳定性和重现性。     

聚氯乙烯膜奎宁选择电极的研制与应用

本报道了一种以奎宁溴汞酸盐为电活性物的ＰＶＣ膜奎宁选择电极，其线性响应范围为１．０×１０＾－２－１．０×１０＾－６ｍｏｌ／Ｌ；级差５８±１ｍＶ；检测限为８．２×１０＾－７ｍｏｌ／Ｌ。以此电极测定奎宁的含量，方法简单、快速、结果与药典法相符。     

L—天冬门酰胺微生物电极的研制

以谷氨酸棒状杆菌作为生物催化剂，与基础氨气敏电极结合制成对Ｌ－天冬门酰胺响应的微生物电极，在３０℃时选择ＰＨ＝８．５的硼酸缓冲体系，测得电极的线性范围为７．１×１０＾－５－１．１×１０＾－２ｍｏｌ／Ｌ，斜率为５１．４ｍＶ／ｄｅｃ，检测下限为２．０×１０＾－５ｍｏｌ／Ｌ，响应时间为４－７ｍｉｎ寿命达３０ｄ以上。     

簇合物膜亚硫酸根离子选择性电极的研制

报道了复ＭｏＳ６２－４在铜表面形成不溶性族合物膜的性质，研制了一种簇合物膜亚硫酸根离子选择电极。电极对ＨＳＯ＾－３的线性响应范围为１×１０＾－４－１×１０＾－１ｍｏｌ／Ｌ；检测限为８×１０＾－５ｍｏｌ／Ｌ；响应斜度为５８．５ｍＶ／ｄｅｃ；适宜的ｐＨ范围为９－１０。     

涂碳型PVC膜氧氟沙星选择电极的研制与应用

报道了一种以氧氟沙星碘化物与碘化铋的分子缔合物为电活性物的新型涂碳ＰＶＣ膜氧氟沙星选择电极．电极的能斯特响应范围为１．０×１０－５～３．２×１０－２ｍｏｌ／Ｌ，斜率为３１ｍＶ／ｐＣ，电极响应迅速，重现性好．用此电极对药片中的氧氟沙星进行测定，结果与紫外分光光度法相符．     

全固态林可霉素选择电极的研制及应用

本以石墨棒为导电基体，以硅钨酸，林可霉素为电活性和的制成了全固态林可霉素离子选择电极。所制电极在１．０×１０＾－１－５．０×１０＾－５ｍｏｌ／Ｌ浓度范围内有线性响应，斜率为５８．３ｍＶ／ｐＣ，检测下限为２．５×１０＾－５ｍｏｌ／Ｌ。电极响应迅速，具有良好的稳定性，可用于林可霉素含量的快速测定。     

氧氟沙星的单扫描示波极谱分析

报道了一种灵敏的氧氟沙星测定方法－一阶导数单扫示波极谱分析，同时研究了它的极谱波性质和电极反应机理，在ｐＨ６．０的ＫＨ２ＰＯ４－Ｎａ２ＨＰＯ４（ＰＢＳ）底液中，氧氟沙星产生一个灵敏的还原峰，Ｅｐ＝－１．５５Ｖ（ｖｓ．ＳＣＥ），其导数峰高与浓度在１．０×１０＾－５～４．６×１０＾－７ｍｏｌ／Ｌ范围内呈良好的线性关系，相关系数ｒ＝０．９９９６，检测下限为２．４×１０＾－７ｍｏｌ／Ｌ，可用于氧氟沙星片剂     

米托蒽醌的吸附行为及其吸附伏安测定法研究

本文研究了米托蒽醌在悬汞电极上的吸附行为，在此基础上建立了米托蒽醌的吸附伏安测定方法。在ｐＨ为２．２的Ｂ．Ｒ缓冲体系中，米托蒽醌浓度在１．１×１０＾－６ｍｏｌ／Ｌ～１．１×１０＾－９ｍｏｌ／Ｌ范围内，浓度与电流呈线性，检出限可达５．５×１０＾－１０ｍｏｌ／Ｌ。若在盐酸－柠檬酸钠（ｐＨ为１．２５）缓冲体系中，检出限可低至１．１×１０＾－１１２ｍｏｌ／Ｌ。方法可用于尿样或血样中米托蒽醌的测定。     

醋酸纤维素为母体的稀体离子选择性电极的研制

醋酸纤维素为母体的稀土离子选择电极，制备容易，使用方便，可以测定混合稀土，电极的线性范围为１．２×１０＾－１～１×１０＾－５ｍｏｌ／Ｌ，适宜的ＰＨ范围较宽，测定结果令人满意。     

邻菲咯啉冠醚衍生物为载体的伯胺药物电极及机理研究

合成了邻菲咯啉-18-冠-6等四种含邻菲咯啉结构的冠醚化合物, 并用作载体制备伯胺电极, 以苄胺为模型化合物, 研究了电极特性, 并制备了测试美西律药物的选择性电极。研究了实验条件对电极性能的影响。用正交多项式回归法优化电极的膜组成。苄胺电极的线性范围1.0×10^-5~0.1mol/L, 斜率55.6mV/pc, 检测下限2.0×10^-6mol/L。美西律电极的线性范围6.0×10^-6~0.1mol/L, 检测下限8.0×10^-7mol, 斜率58.0mV/pc。同时研究了冠醚推动伯胺穿透大块液膜的传输行为。     

纳米Fe_2O_3修饰涂碳型硫酸沙丁胺醇选择电极的研制与应用

制备了以纳米Fe_2O_3为修饰剂的涂碳型硫酸沙丁胺醇选择电极,采用电位分析方法对其各项性能进行测定。结果表明,该纳米Fe_2O_3修饰电极有很好的能斯特响应,其线性范围为1.0×10~(-6)~0.1 mol/L,级差电位为59 mV/pC,与普通电极相比,响应时间较短(10 s),检出限更低(2.8×10~(-7)mol/L)。将修饰电极应用于猪肉样品中硫酸沙丁胺醇含量的测定,结果与标准方法结果相符。     

Direct Electrochemistry and Electrocatalysis of Hemoglobin at PAMAM Dendrimer-MWNTs-Au Nanoparticles Composite Film Modified Glassy Carbon Electrode

The direct electron transfer of hemoglobin at the PAMAM-MWNTs-AuNPs composite film modified glassy carbon electrode was studied. In a phosphate buffer solution(PBS, pH=7.0), the formal potential(E 0' ) of Hb was –0.105 V versus SCE, the electron transfer rate constant was 4.66 s –1 . E 0′ of Hb at the modified electrode was linearly varied in a pH range of 5.0—8.0 with a slope of –49.2 mV/pH. The Hb/PAMAM-MWNTs-AuNPs/GCE gave an ex-cellent electrocatalytic response to the reduction of hydrogen peroxide. The catalytic current increased linearly with H 2 O 2 concentration in a range of 1.0×10 ?6 to 2.2×10 ?3 mol/L. The detection limit was 2.0×10 ?7 mol/L at a signal to noise ratio of 3. The Michaelis-Menten constant(K ma pp ) was 2.95 mmol/L.     

多壁纳米碳管/二氧化硅复合膜中的联吡啶钌电化学发光法测定氧氟沙星的研究与应用

基于氧氟沙星对联吡啶钌(Ru(bpy)_3~(2+))电化学发光的增敏作用,建立了一种以多壁纳米碳管(MWCNTs)/二氧化硅-联吡啶钌复合物修饰的玻碳电极电化学发光检测氧氟沙星的新方法.利用溶胶-凝胶(sol-gel)固定化稳定的优点和纳米碳管的电催化作用,提高了传感器的电流响应.在最佳实验条件下,氧氟沙星浓度在4.0×10~(-6) ～1.0×10~(-4) mol/L范围内与相对发光强度呈线性关系(r~2=0.994 8),检出限(S/N=3)为2.0×10~(-6) mol/L.连续平行测定2.4×10~(-5) mol/L的氧氟沙星溶液 5次,发光强度的RSD为1.8%.     

固态碳糊电极电位法测定利多卡因注射液

本文报道了一种以利多卡因与单质碘形成的缔合物为电活性物的全固态碳糊利多卡因电极,电极的线性响应范围5.0×10-2～4.0×10-5mol.L-1,级差电位为30mV/pC,检测下限为3.0×10-5mol.L-1。该电极响应迅速,重现性好,用该电极测定了盐酸利多卡因注射液中利多卡因的含量,结果与药典法相符。     

Direct Electrochemical Oxidation of Dihydronicotiamide AdenineDinucleotide （NADH） at An Ordered Carbon Nanotubes Electrode

With novel structure, extraordinary electronic properties, high chemical stability and extremely high mechanical strength1, carbon nanotubes (CNTs) have found a wide range of potential applications2-6. The subtle electronic properties suggest that CNTs have the ability to promote electron transfer when they are used as an electrode. The disordered CNTs have been used to fabricate electrode7-10. Thus, it is very interesting to fabricate the electrode using the ordered CNTs and to examin…     

盐酸依匹斯汀PVC膜电极的研制及应用

以四苯硼酸钠与盐酸依匹斯汀生成的离子缔合物为电活性物质,研制了盐酸依匹斯汀PVC膜选择性电极。在pH 5的HCl-NaOH溶液中,电极的线性范围为6.3×10-7~1.0×10-1mol/L,斜率为49 mV/pC(10℃),检出限为1.89×10-7mol/L。应用此电极测定药物中盐酸依匹斯汀含量,RSD3%,回收率为97.5%~100.2%。     

Iodide-selective polymeric membrane electrode based on copper(Ⅱ) bis(N-2-bromophenylsalicyldenaminato) complex

A PVC membrane electrode based on copper（Ⅱ） bis（N-2-bromophenylsalicyldenaminato） as ionophor was prepared.The ion selective electrode was tested by inorganic anions and showed a good selectivity for iodide ion.This sensor exhibited Nernstian behavior with a slope of—57.8 mV per decade at 25℃.The proposed electrode showed a linear range from 1.0×10⁵ to 1.0×10^-1 mol/L with a detection limit of 5.0×10^-6 mol/L.The electrode response was independent of pH in the range of 3.0- 10.0.The proposed sensor was applied to determine the iodide in water and antiseptic samples.     

A comparative study of liquid and solid inner contact roxatidine acetate ion-selective electrode membranes

A comparative study was conducted using two designs of a roxatidine acetate (ROX)-selective electrode; a conventional liquid inner contact called electrode A and a graphite-coated solid contact called electrode B. The fabrication of electrodes was based on roxatidine-tetraphenylborate (ROX-TPB) as an ion-association complex in a PVC matrix using different plasticizers. Electrode A has a linear dynamic range of 2.2×10-5 mol/L to 1.0×10-2 mol/L, with a Nernstian slope of 54.7 mV/decade and a detection limit of 1.4×10-6 mol/L. Electrode B shows linearity over the concentration range of 1.0×10-6 mol/L to 1.0×10-2 mol/L, with a Nernstian slope of 51.2 mV/decade and a limit of detection of 1.1×10-7 mol/L which is remarkably improved as a result of diminishing ion fluxes in this solid contact, ion-selective electrode. The proposed sensors display useful analytical characteristics for the determination of ROX in bulk powder and its pharmaceutical formulation. The present electrodes show clear discrimination of ROX from several inorganic, organic ions, sugars, some common drug excipients and the degradation product (3-[3-(1-piperidinyl methyl) phenoxy] propyl amine) of ROX. Furthermore, the proposed electrodes were utilized for the determination of ROX in human plasma, where electrode B covers drug Cmax which indicated its applicability to pharmacokinetic, bioavailability and bioequivalent studies. The results obtained by the proposed electrodes were statistically analyzed and compared with those obtained by a reported HPLC method. No significant difference for either accuracy or precision was observed.     

钳状杯[4]芳烃为探针的固态PVC膜汞离子选择性电极

全固膜选择性电极(All solid-state selective electrode,ASSE)综合晶体电极和膜电极的优点,具有线性范围宽、检测限低,能真实地体现膜性能等特点,ASSE主要有涂线电极(Coated wire electrode,CWE)、填充固体电解质或配合物的膜电极和电沉积型聚合物膜电极等。