共查询到20条相似文献,搜索用时 15 毫秒
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Fernando C. Macedo Jr. 《Tetrahedron letters》2004,45(1):53-55
A novel metabolite from Aspergillus terreus, named terreinol, was isolated and its biosynthetic origin was determined by NMR based on the incorporation of [1-13C]-d-glucose. The labeling pattern indicated a predominant polyketide biosynthetic origin for this metabolite. 相似文献
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Masashi TsudaTakao Mugishima Kazusei KomatsuTeruo Sone Michiko TanakaYuzuru Mikami Motoo ShiroManabu Hirai Yasushi OhizumiJun'ichi Kobayashi 《Tetrahedron》2003,59(18):3227-3230
A new pentacyclic oxindole alkaloid, speradine A (1), was isolated from the cultured broth of a fungus Aspergillus tamarii, which was separated from driftwood at a seashore in Okinawa. The structure and relative stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. 相似文献
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Seven new prenylated indole diketopiperazine alkaloids, including compound 1, 3 spirotryprostatins C-E (2-4), 2 derivatives of fumitremorgin B (5 and 6), and 13-oxoverruculogen (7), have been isolated from the holothurian-derived fungus Aspergillus fumigatus, along with 12 known ones (8-19). The structures of the new compounds were determined on the basis of extensive spectroscopic data and amino acid analysis. All new compounds were evaluated for their cytotoxic activities on MOLT-4, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods. 相似文献
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Two antibacterial furano-polyenes, (−)-musanahol (1) and 3-epi-aureonitol (5), and a fatty acid, linoleic acid (8) were isolated from the laboratory cultures of a Chaetomium sp. accessed from tomato fruits, and grown on YMG medium (yeast extract, glucose, malt extract and water) at pH 5.8-6.0. The structure of compound 1, a new furano-polyene, was elucidated by spectroscopic methods that include extensive 2D NMR experiments, double resonance experiments, Mosher's method and PM3 calculations. (−)-Musanahol (1) and 3-epi-aureonitol (5) were present in the culture filtrate of the fungus. 3-epi-Aureonitol (5) completely inhibited the growth of Streptococcus pyogenes at 15.63 μg/mL and Escherichia coli, Staphylococcus aureus, Salmonella choleraesuis and Corynebacterium diphtheriae at 31.25 μg/mL, whereas (−)-musanahol (1) lacked the antimicrobial potency of compound 5 in spite of the similarities in their structures. Linoleic acid (8) was isolated from the mycelia of the fungus; it inhibited the growth of S. aureus and Bacillus subtilis at a minimum concentration of 15.62 μg/mL. 相似文献
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From Klebsiella pneumoniae (+)(11S, 11aS) - 1,2,3,10,11,11a - hexahydro - 9 - hydroxy - 11 - (3′ - indolyl) - 5H - pyrrolo[2,1-c][1,4]benzodiazepin - 5 - one (1) has been isolated for which the name tilivalline is suggested. Structure elucidation and synthesis are reported. 相似文献
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Christian Rank Richard Kerry Phipps Jens Christian Frisvad Thomas Ostenfeld Larsen 《Tetrahedron letters》2006,47(34):6099-6102
Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A. 相似文献
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Studies on the basic fraction from Ipomoeamuricata Jacq. seeds, grown in Senegal, resulted in the isolation of two hexahydroindolizine alkaloids, the previously described ipalbidine and a new alkaloid, ipomine, C30H35NO8, the structure of which is established as 1-β-ipalbidinyl-4-p-coumaroyl-d-glucopyranoside. 相似文献
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P.S. Steyn 《Tetrahedron》1973,29(1):107-120
Evidence is presented which confirms the structures of the five metabolites as shown in 1–5. The absolute configuration of compounds 1 and 2 was established; for compound 5 the absolute configuration was established at position 12 only. 相似文献
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Sang Mi LeeXi Feng Li Hualiang JiangJia Gao Cheng Seeyearl SeongHong Dae Choi Byeng Wha Son 《Tetrahedron letters》2003,44(42):7707-7710
A novel chiral dipyrrolobenzoquinone derivative, terreusinone (1), has been isolated as a potent UV-A protectant from the marine algicolous fungus Aspergillus terreus. The structure and absolute stereochemistry of the new compound was established by spectral interpretation, Horeau's method and quantum chemistry calculations as 2,6-bis[(1R)-1-hydroxyisobutyl]-1H,5H-pyrrolo[2,3-b]indole-4,8-dione (1). Compound 1 exhibited a UV-A absorbing activity with ED50 value of 70 μg/mL. 相似文献
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A novel metabolite, mycoediketopiperazine, was isolated from a fungi culture (M-204036). Its structure and absolute stereochemistry was established by spectroscopic studies, including single-crystal X-ray diffraction analysis. 相似文献
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Bidyut Biswas 《Tetrahedron》2008,64(14):3212-3216
A synthesis of the phytotoxic metabolite alboatrin 1 is described. An intramolecular ketene-olefin cycloaddition followed by an oxidative ring enlargement was employed to generate the tricyclic ring system. 相似文献
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Yibin ZhuangXiancun Teng Yi WangPeipei Liu Hui WangJing Li Guoqiang LiWeiming Zhu 《Tetrahedron》2011,67(37):7085-7089
Three new cyclopentapeptides, versicoloritides A-C (1-3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1-4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM. 相似文献
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Jiang-Bo He Yan-Nan Ji Dong-Bao Hu Shen Zhang Hui Yan Xin-Chun Liu Huai-Rong Luo Hua-Jie Zhu 《Tetrahedron letters》2014
Penicilliumine (1), a new structure was isolated from the fermentation Penicillium commune 366606, a marine-derived fungus isolated from the sea water collected at Qingdao, China. HPLC chiral separation of 1 afforded two enantiomers (−)-penicilliumine and (+)-penicilliumine, respectively. The structure of 1 was established by comprehensive spectroscopic data, and single-crystal X-ray diffraction. The absolute configuration of enantiomers was determined by quantum mechanical computation of electronic circular dichroism (ECD). 相似文献
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Takahisa OgaminoShigeru Nishiyama 《Tetrahedron》2003,59(47):9419-9423
An improved synthetic methodology of spiroisoxazolines by employing anodic oxidation of the corresponding phenol derivative has been established. An alternative efficient synthesis of aeroplysinin-1 1 has been achieved by employing the ring-opening reaction of spiroisoxazolines 10b, 10c as a key step. 相似文献
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Patima Phainuphong Vatcharin Rukachaisirikul Souwalak Phongpaichit Jariya Sakayaroj Phongthon Kanjanasirirat Suparerk Borwornpinyo Nattaphong Akrimajirachoote Chantapol Yimnual Chatchai Muanprasat 《Tetrahedron》2018,74(39):5691-5699
Three new depsides, aspergisides A-C, and one new depsidone, aspergisidone, were isolated from the soil-derived fungus Aspergillus unguis PSU-RSPG204 together with one phthalide derivative and 11 depsidones including emeguisin A, aspersidone and folipastatin. The structures were determined by spectroscopic evidence. Aspersidone and emeguisin A showed remarkably antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with equal MIC values of 0.5?μg/mL. Emeguisin A, which displayed the highest activity with 87.06% inhibition of human colon carcinoma (HCT-116) cell viability, decreased numbers of live cells/numbers of dead cells in a dose-dependent manner with the IC50 values of 34.8–84.7?μM in a 3D culture model depending on durations of incubation. In addition, folipastatin dose-dependently inhibited forskolin-stimulated chloride secretion in human intestinal epithelial (T84) cells with an IC50 value of 0.5?μM. These depsidones were considered to be inactive against noncancerous Vero Cells with the IC50 values of >10?μM. 相似文献
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Mukulesh Mondal 《Tetrahedron letters》2004,45(29):5693-5695
A six-step, first synthesis of an anti-Helicobacter pylori secondary metabolite, CJ-13,015 (1a), in 65% overall yield, is described, starting from 5-methylfurfural (2), via a Wittig reaction of the ylide generated in situ from (8-hydroxyoctyl)triphenylphosphonium bromide, selective reduction of the newly formed carbon-carbon double bond, conversion of the alcohol to a halide, coupling with the anion of 3,5-dimethoxyphthalide and a chemoselective conversion of the protective furan group to a 1,4-dicarbonyl system as a key reaction. 相似文献