Two New Steroidal Glycosides from Liriope muscari

Liriope muscari (Decn.) Bailey (Liliaceae) is a folk medicinal plant used as a substitute of Ophiopogon japonicus (Thunb.) Ker-Gawl., mainly distributing in Quanzhou, Fujian Province, China1. Previously, we reported the isolation and identification of two…     

Two New Steroidal Glycosides from Ophiopogon japonicus

The tuber of Ophiopogon japonicus Ker-Gawl. is recorded to have various functions, such as against cardiovascular diseases and anti-bacteria, and used as a potent drug to treat different diseases, especially heart diseases1. Since the first steriodal glycoside was isolated from the plant by Japanese scholars2, much attention has been paid to the studies of the chemical components of O. japonicus in recent decades. Steroidal glycosides as the major glycosides with the aglycones of ruscogenin …     

Two New Steroidal Glycosides from Caryopteris terniflora

Two new steroidal glycosides were isolated from the Chinese medicinal plant Caryopteris terniflora. The spectroscopic and chemical evidences revealed that their structures tobe 6-(β-sitosteroyl-3-O-β-glucopyranosidyl) hexacosanate 1 and 6‘-(stigmasteroyl-3-O-β-glucopy-ranosidyl) linolenate 2, respectively.     

Five New Steroidal Glycosides from Caralluma dalzielii

Five new pregnane glycosides, caradalzielosides A–E ( 1 – 5 ), were isolated from the aerial parts of Caralluma dalzielii. Their structures were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic analysis as well as by HR‐FAB‐MS experiments.     

Five New Steroidal Alkaloid Glycosides from Solanum tuberosum

Five new steroidal alkaloid glycosides, 1 – 5 , along with the known analog 6 , have been isolated from the aerial parts of Solanum tuberosum. The structures of the new compounds were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR and HR‐ESI‐MS techniques, as well as by comparison of the spectral data with those of related compounds. Only compound 6 showed significant cytotoxicity.     

Six New C21 Steroidal Glycosides from Cynanchum bungei Decne

Six new C₂₁ steroidal glycosides 1 – 6 were isolated from the stem parts of Cynanchum bungei Decne . The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D‐ and 2D‐NMR and HR‐ESI‐MS techniques as well as by comparison of their spectral data with those of related compounds.     

Two New Steroidal Glycosides from Fermented Leaves of Agave americana

Two new spirostanol glycosides named agamenoside A and B, ere isolated from the fermented leaves of Agave americana. Their structures were elucidated as (23S,25R)-5α-spirostan-3β,6α，23－triol 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside(1) and (25R)-5α-spiro-stan-3β,6α-diol 3-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyra-nosyl-(1→4)-β-D-galactopyranoside(2) by a combination of chemical and spectral methods.     

Two New C—21 Steroidal Glycosides from Cynanchum aurichulatum

Two new C-21 steroidal glycosides, cynanauriculoside I and cynanauriculoside Ⅱ, were isolated from the roots of Cynanchum aurichulatum. Their structures were established using spectroscopic methods including one and two-dimensional NMR.     

Three New Steroidal Glycosides from the Roots of Cynanchum auriculatum

Three new C₂₁ steroidal glycosides with a cinnamoyl group at C(12) and a 2‐methylbutanoyl group at C(20), and a straight sugar chain at C(3), namely cyanoauriculosides C–E ( 1 – 3 , resp.), together with three known steroidal derivatives, were isolated from the roots of Cynanchum auriculatum (Asclepiadaceae). Their structures were determined by spectroscopic analyses and chemical methods. The known constituents were identified as wilfoside K1N ( 4 ), cynanauriculoside II ( 5 ), and auriculoside IV ( 6 ).     

C21 Steroidal Glycosides from Cynanchum wilfordii

Eight new C₂₁ steroidal glycosides, named wilfosides A–H ( 1 – 8 , resp.), along with one known compound wilfoside KIN ( 9 ), were isolated from the roots of Cynanchum wilfordii. The structures of the new glycosides were determined on the basis of spectroscopic analysis, including 1D‐ and 2D‐NMR, and ESI‐MS techniques, as well as by comparison of the spectral data with those of related compounds.     

Two New C-21 Steroidal Glycosides from the Stems of Stephanotis mucronata

Two new C-21 steroidal glycosides, mucronatosides M（1） and N（2）, were isolated from the stems of Stephanotis mucronata, together with one known compound stephanoside M（3）. On the basis of chemical evidence and extensive spectroscopic methods, including one-dimensional and two-dimensional NMR, the structures of the two new compounds were identified as 12-O-tigloyl-20-O-N-methylanthraniloyl sarcoslin 3-O-β-D-glucopyranosyl-（1→4）-6- deoxy-3-O-methyl-β-D-allopyranosyl-（→4）-β-D-cymaropyranosyl-（1→4）-β-D-cymaropyranoside （1）, and 12-O- cinnamoyl-20-O-nicotinoyl（ 2OS）-pregn-6-ene-3 β,5α,8βm12 β,14β,17β,20-heptanol 3-O-β-D-glucopyranosyl-（1→4）-6- deoxy-3-O-methyl-β-D-allopyranosyl-（1→4）-β-D-cymaropyranosyl-（1→4）-β-D-cymaropyranoside （2）.     

Two New C21 Steroidal Glycosides from the Stems of Marsdenia tenacissima

Two new pregnane glycosides, (3β,5α,12β,14β,17α)‐3‐(β‐cymaropyranosyloxy)‐8,14,17,20‐tetrahydroxypregnan‐12‐yl benzoate ( 1 ) and (3β,5α,12β,14β,17α)‐3‐(β‐cymaropyranosyloxy)‐8,14,17,20‐tetrahydroxypregnan‐12‐yl cinnamate ( 2 ) were isolated from the stems of Marsdenia tenacissima. The structures and relative configurations of the new compounds were elucidated by spectroscopic methods, including mass spectrometry and NMR spectroscopy.     

Three New C21 Steroidal Glycosides from the Stems of Marsdenia tenacissima

Three new glycosides, (3β,5α,8α,11α,12β,14β,17α,20R)‐3‐[(2,6‐dideoxy‐4‐O‐(6‐deoxy‐3‐O‐methyl‐β‐D ‐allopyranosyl)‐3‐O‐methyl‐β‐D ‐arabino‐hexopyranosyl)oxy]‐12‐O‐tigloyl‐8,20 : 11,20‐diepoxypregnane‐12,14‐diol ( 1 ), (3β,5α,8α,11α,12β,14β,17α,20R)‐3‐[(2,6‐dideoxy‐4‐O‐(6‐deoxy‐3‐O‐methyl‐β‐D ‐ allopyranosyl)‐3‐O‐methyl‐β‐D ‐arabino‐hexopyranosyl)oxy]‐12‐O‐(2‐methylbutanoyl)‐8,20 : 11,20‐diepoxypregnane‐12,14‐diol ( 2 ), and (3β,5α,11α,12β,14β,17α)‐12‐acetoxy‐3‐[(2,6‐dideoxy‐4‐O‐(6‐deoxy‐3‐O‐methyl‐β‐D ‐allopyranosyl)‐3‐O‐methyl‐β‐D ‐arabino‐hexopyranosyl)oxy]‐20‐oxo‐8,14‐epoxypregnan‐ 11‐yl isobutyrate ( 3 ) were isolated from the stems of Marsdenia tenacissima. The structures of the new compounds were elucidated by means of spectral data, including HR‐ESI‐MS, and 1D‐ and 2D‐NMR.