D280大孔弱碱树脂的合成及对柠檬酸吸附性能的研究

通过丙烯酸甲酯与二乙烯苯的悬浮聚合合成了大孔白球,将大孔白球用多乙烯多胺胺解,得到弱碱树脂;该弱碱树脂再与甲酸甲醛进行甲基化反应,获得大孔弱碱树脂D280测定了D280的各种基本性能,并将其应用于柠檬酸提取工艺中,研究了该树脂对柠檬酸的吸附性能。     

大孔吸附树脂合成及从甜叶菊中提取分离甜菊甙的研究

本文合成了一系列用于从甜叶菊提取液中吸附分离甜菊甙的大孔吸附树脂，测定了它们的孔结构参数及吸附量，并比较了吸附量较高的五种树脂的循环使用性能及解吸性能。实验结果表明，Ｍ－３５树脂吸附量大，解吸率高，用树脂法工艺制备的甜菊甙产品纯度高，质量好。     

树脂吸附法回收头孢氨苄工艺研究

为了从头孢氨苄结晶废母液中回收产品,采用大孔树脂吸附法对回收工艺进行了研究,比较了HZ818,HZ832,HZ801,HZ816,D4020,X-5等6种大孔吸附树脂对头孢氨苄的吸附性能,筛选出了高吸附性能的树脂,同时对头孢氨苄在HZ816吸附柱上的动态吸附-解吸过程进行了研究.其结果是:大孔吸附树脂HZ816能更好地分离回收头孢氨苄,其吸附量在45.4mg/mL左右,40％的乙醇(pH 2.0)可以将吸附在树脂柱上的头孢氨苄有效解吸,解吸率达94.5％,解吸液经结晶、干燥等后续处理可得到符合中国药典要求的产品.大孔吸附树脂HZ816是回收头孢氨苄的一种理想的吸附剂,该工艺简捷,具有很好的工业化前景.     

脱色树脂性能研究

本文合成了对色素具有高只附容量，强选择性的大孔阴离子交换树脂，详细讨论了影响树脂脱色性能的各种因素。结果表明：树脂的孔结构，功能基结构对其脱色性能有很大影响，并在此基础上进行了一些理论分析。     

大孔吸附树脂对洋地黄强心甙吸附性能的研究.I.

本文从六种大孔吸附树脂中筛选出ＨＡ－２和ＨＡ－３二种树脂，这二种树脂对洋地黄类强心甙－－地高辛具有较好的吸附性能，测定了吸附树脂的比表面积、孔容及平均孔径，讨论了地高辛溶液的浓度、ｐＨ值等诸条件对大孔吸附树脂吸附性能的影响。     

大孔磷酸树脂吸收镧的研究

本文测定了大孔膦酸树脂对Ｌａ＾３＋的吸附容量，介质ｐＨ、温度、吸附时间等因素对吸附的影响，测得吸附速率常数Ｋ２９８＝７．６４×１０＾－５Ｓ＾－１，树脂功能基与Ｌａ＾３＋的络合比为３：１，用化学及红外光谱等方法，得到大孔膦酸树脂吸附Ｌａ＾３＋的基本参数及其机理。     

大孔树脂分离提取麻黄碱的研究

本文研究了九种大孔吸附树脂对麻黄碱的吸附能力，其中以D151，XAD－4，XAD－7的吸附效果较好，静态吸附容量分别为240.4mg/ml,122.1mg/ml,87.2mg/ml。三种树脂最佳吸附pH值为11，D151和XAD－7采用.08mol/L的HCl洗脱，XAD－4采用0.02mol/L的HCl与甲醇1：1的混合液洗脱。将三种树脂直接用于麻黄草提取液的麻黄碱分离提取，回收均在90％以上，纯度在80％以上，一次吸附提纯倍数为15－19倍。     

吸附树脂分离回收结晶母液中3-甲基黄嘌呤的研究

研究大孔吸附树脂从3-甲基黄嘌呤(3-methylpurine)结晶母液中分离回收产品的工艺条件。比较了HZ818,HZ830,HZ801,HZ832,HZD-2等5种大孔吸附树脂的吸附性能,同时对母液中的3-甲基黄嘌呤在HZ801吸附柱上的动态吸附解吸过程进行了研究。结果表明,大孔吸附树脂HZ801能更好地分离回收3-甲基黄嘌呤,室温下,其静态吸附量在13mg/m L左右,用50%的乙醇(p H 10.0)可以将吸附在树脂柱上的3-甲基黄嘌呤有效解吸,平均解吸率在90%以上。大孔吸附树脂HZ801是从生产母液中分离回收3-甲基黄嘌呤的一种适宜吸附剂。该工艺简单易操作,具有一定工业化参考的价值,为生产企业提供了一条新思路。     

Diaion HP–20大孔吸附树脂分离纯化含羞草种子中的黄酮类物质

研究Diaion HP–20大孔吸附树脂分离纯化含羞草种子中黄酮类物质的工艺条件。用海南含羞草种子为原料,以含羞草种子中总黄酮吸附量和解吸率为评价指标,考察上样流量、洗脱液种类、柱径比、洗脱液流量等影响因素。Diaion HP–20大孔吸附树脂分离纯化含羞草种子中黄酮类物质的最佳工艺条件:上样流量3 m L/min,洗脱液为40%乙醇溶液,柱径比为1∶10,洗脱液流量为4 m L/min。该方法简单,可行,能够有效分离纯化含羞草种子中黄酮类物质,且大孔吸附树脂可重生,利用率高。     

大孔吸附树脂法柚皮果胶脱色工艺研究

比较了AB-8、S-8、X-5、聚酰胺、NKA-Ⅱ、NPD-600等6种大孔吸附树脂对柚皮果胶的脱色效果.在静态吸附试验研究的基础上,筛选出效果较好的树脂进行动态试验研究.实验表明:AB-8型大孔吸附树脂对柚皮果胶提取液具有较好的吸附脱色效果和较低的果胶损失率,该树脂对柚皮果胶脱色的适宜工艺参数为:室温(约20℃),流速3BV/h,溶液处理量为5BV,上柱液pH值为4～6.此工艺对果胶提取液中色素的吸附率约80%.树脂吸附后可用70%乙醇进行洗涤再生,果胶提取液脱色后经喷雾干燥所得的果胶成品质量符合QB2484-2000标准.     

THE SEPARATION,PURIFICATION AND DECOLORIZATION OF NEW ANTIBIOTICS-MILUPEINAN USING ADSORPTION RESIN

1. INTRODUCTION Fig.1 The Chemical Structure of Milupeinan As a new type of antibiotics Milupeinan, not only possesses antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, but also higgh stability under th…     

THE SEPARATION，PURIFICATION AND DECOLORIZATION OF NEW ANTIBIOTICS—MILUPEINAN USING ADSORPTION RESIN

Adsorption resin AAS was used for the separation and purification of milupeinan (M-13)from its mother liquor. The good adsorption property of AAS adsorption resin was found formilupeinan (M-13) compared with the Diaion CHP 20p. When acetone and water (2:1 in volume)were used as desorption reagents, it was found that 3 times of bed volume of the desorption reagentswould make the AAS resin which was saturately adsorpted M-13 desorption completely.Also a macroporous anion exchange resin (Poly-4-vinylpyridine type) D-280 was used for thedecolourization from M-13 solution. Good results was given when the sr=1～2.     

大孔吸附树脂分离纯化异甘草素的研究

研究大孔吸附树脂分离纯化异甘草素的工艺条件及参数。通过研究HPD-600、D4020、D101、AB-8、NKA-II、AL-2和NKA-9树脂对异甘草素的吸附和解吸附能力,筛选最佳树脂为AB-8,并研究了其对异甘草素的吸附和解吸附性能,确定了最佳的吸附与解吸附工艺参数,吸附:pH=5,室温,流速1.5BV/h,溶液处理量为5BV;脱附:洗脱剂为70%的乙醇溶液,流速1BV/h,洗脱剂用量4.5BV。异甘草素样品溶液经AB-8树脂吸附与脱附后回收率为76.7%,纯度由2.02%提高到29.1%,提高了14.4倍。实验结果表明,AB-8树脂对异甘草素的吸附量大,脱附容易,可以应用于异甘草素的分离纯化。     

酚醛型吸附树脂对VB_(12)的吸附性能研究

研究了酚醛型吸附树脂JDW 1、JDW 2 (自制 )和DuoliteS 76 1对VB12 的静态和动态吸附 .结果表明 ,JDW 1对VB12 的吸附量达 84mg g ,明显优于DuoliteS 76 1;吸附VB12 的初始阶段 ,即达到 4 3%～6 9%平衡吸附时 ,吸附速率数据和半经验速率方程很吻合 ;酚醛型吸附树脂等温吸附VB12 的平衡吸附数据符合Langmuir方程 ,相关系数在 0 99以上 ,因此 ,酚醛型吸附树脂吸附VB12 属单分子层吸附 ;在动态条件下 ,用含甲醇 80 %溶液以 1 1BV h来洗脱吸附VB12 的JDW 2 ,在 4 2、6 4个床体积的洗脱率分别是 92 2 0 %、95 93% ,这表明酚醛型吸附树脂具有良好的洗脱性能 ,用含甲醇为 80 %溶液作洗脱剂从JDW 2洗脱VB12 ,效果很好     

Study on Adsorption and Separation of Naringin with Macroporous Resin

X-5 resin, with higher adsorption and easier desorption of naringin, was selected from five kinds of macroporous resins through static adsorption and desorption experiments. Effects of concentration, pH value, and flow rate of naringin extract on the adsorption of naringin by X-5 resin were studied. Meanwhile, the effect of these factors on the desorption of naringin from X-5 resin was also investigated. The experimental results show that the adsorption isotherm of naringin by X-5 resin can be described by the Langmuir isotherm equation. The static maximum adsorption capacity of naringin is 32.6 mg/g with naringin concentration at 2.7 g/L, while the dynamic adsorption capacity of naringin is 23.8 mg/g with naringin extract flow rate at two times that of resin volume per hour. The optimal eluant is 60% (v/v) ethanol-water with pH value of 10. The desorption ratio will rise to more than 85% when the flow rate of this optimal eluant is one to two times that of resin volume per hour. Translated from Journal of Central South University (Science and Technology)     

Separation and purification of flavonoid from Taxus remainder extracts free of taxoids using polystyrene and polyamide resin

An efficient separation process of flavonoid from Taxus wallichiana var. mairei remainder extracts free of taxoids was developed in this study. AB‐8 macroporous resin and polyamide resin offered the fine adsorption capacity, and its adsorption rate at 30°C fitted well to the Langmuir and Freundich isotherms. Resin dynamic adsorption and desorption experiments were conducted to optimize the separation process of total flavonoids from T. wallichiana var. mairei remainder extracts free of taxoids. The optimum parameters for adsorption by AB‐8 resin were as follows: (1) the concentration of flavonoids in a sample solution of 5.61 mg/mL with a processing volume of 2 bed volume (BV) (60 mL); (2) for desorption, ethanol–water (80:20, v/v), with 6 BV as an eluent at a flow rate of 2 BV/h. After a one‐run treatment with AB‐8 resin, the content of flavonoids was increased 5.10‐fold from 4.05 to 20.65%. The optimum parameters for adsorption by polyamide resin were as follows: processing volume of 2 BV (30 mL); for desorption, ethanol–water (70:30, v/v), with 8 BV as an eluent at a flow rate of 2 BV/h. After one‐run treatment with polyamide resin, the content of total flavonoids increased from 20.65 to 65.21%. The method will provide a potential approach for large‐scale separation and purification of flavonoid for its wide pharmaceutical use.     

大孔阳离子交换树脂对奈替米星的吸附研究

通过正交实验合成了9种大孔弱酸性阳离子交换树脂,筛选出具有最大动态饱和吸附量的FB-1树脂.采用红外光谱和热重分析的方法对其表征,并研究其对奈替米星的吸附及解吸性能,结果表明:该树脂对奈替米星的吸附符合Langrnuir吸附:用氨水做洗脱剂,0.3mol/L和0.4mol/L的氨水解吸率均达95%以上.FB-1与HD-2树脂比较:动态吸附量FB-1为398.0mg/mL湿树脂、HD-2为232.1mg/mL湿树脂;0.3mol/L氨水解吸,前者解吸率较后者高约15%.     

Zn2＋型磺酸树脂对维生素B12的配位吸附及洗脱性能

原位吸附;分离;Zn2＋型磺酸树脂对维生素B12的配位吸附及洗脱性能     

ADSORPTION AND DESORPTION OF DSD ACID MANUFACTURING WASTEWATER ON MACROPOROUS RESIN

4,4‘-diaminostilbene-2,2‘-disulfonic acid (DSD acid) manufacturing wastewater was treated by a macroporous resin in a fixed-bed column.The results showed that this method was suitable for removal of chemical oxygen demands(COD) and color,About 91% COD and 99.5% color removal were obtained under the optimum adsorption conditions.i.e.temperature 20℃,flow rate lbed volume/hour(BV/hr)and pH1-2.The resin was efficiently regenerated with aqueous sodium hydroxide and water.Furthermore,65.5% of 4,4‘-dinitrostilbene-2,2‘-disulfonic acid(DNS) could be recovered from wastewater for possible recycling to the manufactureing process.The adsorption capacity of resin remained constant during the repetition process of adsorption and desorption.     

大孔树脂-高速逆流色谱法分离纯化地黄中毛蕊花糖苷

该文建立了大孔树脂-高速逆流色谱分离中药材地黄中有效成分毛蕊花糖苷的方法。考察了4种大孔树脂对地黄粗提物中毛蕊花糖苷的静态吸附与解吸情况,其中D101大孔树脂对目标成分的吸附率与解吸率最理想,实验结果表明体积分数为10%的乙醇洗脱得到的毛蕊花糖苷含量最高,目标成分含量从4.9%提高到32.6%。最后,部分纯化的样品（165 mg）采用高速逆流色谱进一步纯化,两相溶剂系统由乙酸乙酯-正丁醇-水（1：4：5,v/v/v）组成,分离得到45 mg纯度为96%的毛蕊花糖苷。