Synthesis of 3-epistrophanthidin and 3-epistrophanthidol

Conclusions 3-Epistrophanthidin and 3-epistrophanthidol have been synthesized from strophanthidin and strophanthidol with yields of 10 and 40%, respectively. The substances synthesized proved to be identical with the new natural aglycones isolated from the seeds ofStrophanthus kombe Oliv.Khimiya Prirodnykh Soedinenii, Vol. 6, No. 1, pp. 57–60, 1970.     

3-Epistrophanthidin and 3-epistrophanthidol

Conclusions The hydrolysis of the total glycosides of the seeds ofStrophanthus kombé Oliv. and the adsorption-chromatographic separation of the mixture of aglycones has given strophanthidin, strophanthidol, 17-H-strophanthidin, and two new cardenolides denoted by the symbols IM-38 and IM-40 in the individual state. On the basis of the investigations carried out, the new cardenolides have been characterized provisionally as 3-epistrophanthidin and 3-epistrophanthidol.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 6, pp. 508–511, 1969     

Synthesis of 3-alkyl- and 3-arylpyridines

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1143–1144, August, 1992.     

Synthesis of derivatives of 3-amino- and 3-aminomethylquinuclidine

Various methods of preparing 3-aminoquinuclidine from quinuclid-3-one oxime and hydrazone are developed. Quinuclidine derivatives with a substituted amino group at position 3 are synthesized.     

Synthesis and Heterocyclization of 3-Arylaminothiocrotonanilides

Reactions of acetylthioacetanilide with arylamines in acetic acid in the presence of sodium acetate give 3-arylaminothiocrotonanilides in good yields. When treated with -bromoacetophenone in acetone, these products are converted to substituted 4-hydroxy-²-thiazolinium bromides, one of which was dehydrated to obtain the corresponding thiazolium bromide. The structure of the heterocyclization products was confirmed by single crystal X-ray diffraction and NMR study of 2-acetonylidene-3,4-diphenyl-2,3-dihydrothiazole formed by dehydration of the corresponding ²-thiazolinium salt with simultaneous hydrolysis.     

Synthesis and properties of 3-nitrosocarbazole

The synthesis of 3-nitrosocarbazole (I) by the Fischer-Hepp rearrangement of 9-nitrosocarbazole has been described. The resistance of I to oxidation provides evidence that it cannot be the intermediate in the conversion of 9-nitrosocarbazole to the C-nitro compounds. It has also been shown that I and its derivatives cannot be synthesized by the action nitrosyl chloride on carbazoles. Methylation of I yields 9-methyl-3-nitrosocarbazole, 9,9′-dimethyl-3-azocarbazole and 9,9′-dimethyl-3-azoxycarbazole as the main products. The mechanism of this disproportionation process has been proposed. The spectral data of I are given.     

Synthesis and Amination of 3-Chloropropylalkyldiethoxysilanes

3-Chloropropylalkyldiethoxysilanes (alkyl: butyl, hexyl and benzyl) were synthesized by the Grignard reaction of 3-chloropropyltriethoxysilane; The amination of the formed 3-chloropropylalkyldiethoxysilanes with ethylenediamine produce 3-(2-amino-ethyl)aminopropylalkyldiethoxysilanes (alkyl: butyl, hexyl).     

Synthesis of 3-Bromo-3-nitroacrylates

Russian Journal of Organic Chemistry -     

3-(3＇-乙酰基-5＇-芳基-1＇,3＇,4＇-二氢噁二唑-2＇-)色酮的微波促进合成

将微波应用于促进有机合成是近年来兴起的新技术,已受到极大注意,我们采用简单的微波反应装置,成功地合成了3－杂环基取代的色酮,杂环基取代的色酮因其显著的生理活性,而成为近年来的研究特点,以3－甲酰基色酮为原料,与芳酰肼反应得到相应的芳酰腙,再用乙酸酐关环,合成了一系列3位为1,3,4－二氢恶二唑基取代的色酮（3）,为在合适的母体上引入杂环提供了一系新思路,合成路线如下。     

Synthesis and photochromism of 3-indylfulgides

Six fulgides of indole series are prepared. Three of them are photochromic. The others in which R¹ is hydrogen atom do not show photochromism. Only Z-E isomerizations occur on irradiation at 365 nm. The effects of molecular structural modifications on photochromic properties are also discussed.     

Synthesis of 3-functionalized 3-methylazetidines

1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel 3-alkoxy-, 3-aryloxy-, 3-hydroxy-, 3-cyano-, 3-carboxy-, 3-(aminomethyl)- and 3-(hydroxymethyl)azetidines.     

Synthesis of 3-geranyl- and 3-prenyl-2,4,6-trihydroxybenzophenone

Biologically active phenyl[3-(3,7-dimethyl-2,6-octadienyl)-2,4,6-trihydroxyphenyl]methanone (2) and phenyl[2,4,6-trihydroxy-3-(3-methyl-2-butenyl)phenyl]methanone (3) were synthesized by an efficient and convenient synthetic sequence. The reaction steps of this synthesis included methylation, Friedel-Crafts acylation, demethylation and geranylation steps.     

An Easy Synthesis of 3-Amino- and 3-Nitrothiophene

3-Amino- and 3-nitrothiophene are readily made by the decarboxylation of the corresponding thiophene-2-carboxylic acids which are easily prepared from the commercially available methyl 3-aminothiophene-2-carboxylate.     

Synthesis of 3-benzoyl- and 3-trichloroacetylimidazolidin-2-ones

Conclusions The reaction of benzoyl and trichloroacetyl isocyanates with ethylenimine was studied and the structure of the obtained adducts was established.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 447–448, February, 1970.