共查询到20条相似文献,搜索用时 46 毫秒
1.
Alaa A. A. Aljabali Mohammad A. Obeid Hamid A. Bakshi Walhan Alshaer Raed M. Ennab Bahaa Al-Trad Wesam Al Khateeb Khalid M. Al-Batayneh Abdulfattah Al-Kadash Shrouq Alsotari Hamdi Nsairat Murtaza M. Tambuwala 《Molecules (Basel, Switzerland)》2022,27(6)
Advanced innovations for combating variants of aggressive breast cancer and overcoming drug resistance are desired. In cancer treatment, ZnO nanoparticles (NPs) have the capacity to specifically and compellingly activate apoptosis of cancer cells. There is also a pressing need to develop innovative anti-cancer therapeutics, and recent research suggests that ZnO nanoparticles hold great potential. Here, the in vitro chemical effectiveness of ZnO NPs has been tested. Zinc oxide (ZnO) nanoparticles were synthesized using Citrullus colocynthis (L.) Schrad by green methods approach. The generated ZnO was observed to have a hexagonal wurtzite crystal arrangement. The generated nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), UV-visible spectroscopy. The crystallinity of ZnO was reported to be in the range 50–60 nm. The NPs morphology showed a strong absorbance at 374 nm with an estimated gap band of 3.20 eV to 3.32 eV. Microscopy analysis proved the morphology and distribution of the generated nanoparticles to be around 50 nm, with the elemental studies showing the elemental composition of ZnO and further confirming the purity of ZnO NPs. The cytotoxic effect of ZnO NPs was evaluated against wild-type and doxorubicin-resistant MCF-7 and MDA-MB-231 breast cancer cell lines. The results showed the ability of ZnO NPs to inhibit the prefoliation of MCF-7 and MDA-MB-231 prefoliation through the induction of apoptosis without significant differences in both wild-type and resistance to doxorubicin. 相似文献
2.
P. Pachamuthu A. Pricilla Jeyakumari N. Srinivasan R. Chandrasekaran K. Revathi P. Karuppannan 《印度化学会志》2022,99(2):100342
Undoped zinc oxide nanoparticles and Mn (5 atomic % & 10 atomic %) doped zinc oxide nanoparticles were prepared by soft chemical method. Antibacterial, antioxidant and anticancer activities in breast cancer cell line MDAMB231 of prepared nanoparticles were investigated. The nanoparticles were characterized using XRD, SEM, EDAX, UV–Vis, FT-IR, and room temperature PL Analysis. Antimicrobial activity was tested against both gram positive and gram negative human pathogens. The antioxidant potential of prepared nanoparticles was estimated using Phosphomolybdate and DPPH assay. The MTT assay was used for cytotoxicity evaluation of prepared nanoparticles against breast cancer cell line MDAMB231. XRD patterns confirmed the nanoparticles were crystallized hexagonal wurtzite structure with an average size of 38.95 ?nm. The absorption wavelength was observed at 361 ?nm in UV–Vis spectrum of Mn (10 atomic %) doped ZnO nanoparticles. The Mn (5 atomic %) doped ZnO nanoparticles exhibited significant antibacterial activity against the gram negative bacteria Escherichia coli, Klebsiella pneumonia at all concentrations. Undoped zinc oxide nanoparticles and Mn doped zinc oxide nanoparticles were effective against the breast cancer cell line MDAMB231. 相似文献
3.
MK Talari AB Abdul Majeed DK Tripathi M Tripathy 《Chemical & pharmaceutical bulletin》2012,60(7):818-824
The application of nanomaterials has gained considerable momentum in various fields in recent years due to their high reactivity, excellent surface properties and quantum effects in the nanometer range. The properties of zinc oxide (ZnO) vary with its crystallite size or particle size and often nanocrystalline ZnO is seen to exhibit superior physical and chemical properties due to their higher surface area and modified electronic structure. ZnO nanoparticles are reported to exhibit strong bacterial inhibiting activity and silver (Ag) has been extensively used for its antimicrobial properties since ages. In this study, Ag doped ZnO nanoparticles were synthesized by mechanochemical processing in a high energy ball mill and investigated for antimicrobial activity. The nanocrystalline nature of zinc oxide was established by X-ray diffraction (XRD) studies. It is seen from the XRD data obtained from the samples, that crystallite size of the zinc oxide nanoparticles is seen to decrease with increasing Ag addition. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) data also supported the nanoparticle formation during the synthesis. The doped nanoparticles were subjected to antimicrobial investigation and found that both increase in Ag content and decrease in particle size contributed significantly towards antimicrobial efficiency. It was also observed that Ag doped ZnO nanoparticles possess enhanced antimicrobial potential than that of virgin ZnO against the studied microorganisms of Escherichia coli and Staphylococcus aureus. 相似文献
4.
Mamdouh M. Shawki Alaa El Sadieque Seham Elabd Maisa E. Moustafa 《Molecules (Basel, Switzerland)》2022,27(14)
Cancer remains a leading cause of death worldwide, despite extraordinary progress. So, new cancer treatment modalities are needed. Tumor-treating fields (TTFs) use low-intensity, intermediate-frequency alternating electric fields with reported cancer anti-mitotic properties. Moreover, nanomedicine is a promising therapy option for cancer. Numerous cancer types have been treated with nanoparticles, but zinc oxide nanoparticles (ZnO NPs) exhibit biocompatibility. Here, we investigate the activity of TTFs, a sub-lethal dose of ZnO NPs, and their combination on hepatocellular carcinoma (HepG2), the colorectal cancer cell line (HT-29), and breast cancer cell lines (MCF-7). The lethal effect of different ZnO NPs concentrations was assessed by sulforhodamine B sodium salt assay (SRB). The cell death percent was determined by flow cytometer, the genotoxicity was evaluated by comet assay, and the total antioxidant capacity was chemically measured. Our results show that TTFs alone cause cell death of 14, 8, and 17% of HepG2, HT-29, and MCF-7, respectively; 10 µg/mL ZnO NPs was the sub-lethal dose according to SRB results. The combination between TTFs and sub-lethal ZnO NPs increased the cell death to 29, 20, and 33% for HepG2, HT-29, and MCF-7, respectively, without reactive oxygen species increase. Increasing NPs potency using TTFs can be a novel technique in many biomedical applications. 相似文献
5.
A strategy to fabricate a hydrogen peroxide (HP) sensor is developed by electrodepositing silver nanoparticles (Ag NPs) on a modified glassy carbon electrode (GCE) with a zinc oxide (ZnO) film. The Ag NPs/ZnO/GCE has been characterized by scanning electron microscopy, cyclic voltammetry, and chronoamperometry. It has been found that the Ag NPs synthesized in the presence of ZnO film provide an electrode with enhanced sensitivity and excellent stability. The sensitivity to HP is enhanced 3-fold by using Ag NPs/ZnO/GCE compared to Ag NPs/GCE. The HP sensor exhibits good linear behavior in the concentration range 2 µM to 5.5 mM for the quantitative analysis of HP with a detection limit of 0.42 µM (S/N?=?3). 相似文献
6.
Blassan P. George Naresh K. Rajendran Nicolette N. Houreld Heidi Abrahamse 《Molecules (Basel, Switzerland)》2022,27(20)
Rubus fairholmianus (RF) has widely been used to treat various ailments, including pain, diabetes, and cancer. Zinc oxide nanoparticles (ZnO NPs) have drawn attention in modern healthcare applications. Hence, we designed this study to synthesize zinc oxide (ZnO) nanoparticles using R. fairholmianus root extract to investigate its synergistic cytotoxic effect on MCF-7 cells and explore the possible cell death mechanism. ZnO NPs were synthesized via green synthesis using R. fairholmianus root extract, and the effect on MCF-7 cells was determined by looking at cellular morphology, proliferation, cytotoxicity, apoptosis, and reactive oxygen species (ROS). The results showed that cellular proliferation was reduced following treatment with R. fairholmianus capped zinc oxide nanoparticles (RFZnO NPs), while cytotoxicity and ROS were increased. There was also an increase in apoptosis as indicated by the significant increase in cytoplasmic cytochrome c and caspase 3/7 (markers of apoptosis), as well as increased levels of pro-apoptotic proteins (p53, Bax) and decreased levels of anti-apoptotic protein (Bcl-2). In conclusion, these results showed that RFZnO NPs induce apoptosis in breast cancer cells via a mitochondria-mediated caspase-dependent apoptotic pathway and suggest the use of acetone root extract of R. fairholmianus for the treatment of cancer-related ailments. 相似文献
7.
Experimental and Theoretical Study of Enhanced Photocatalytic Activity of Mg‐Doped ZnO NPs and ZnO/rGO Nanocomposites
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Dr. Ramin Yousefi Dr. Javad Beheshtian Seyedeh Mozhgan Seyed‐Talebi Dr. H. R. Azimi Dr. Farid Jamali‐Sheini 《化学:亚洲杂志》2018,13(2):194-203
A systematic experimental and theoretical study of the origin of the enhanced photocatalytic performance of Mg‐doped ZnO nanoparticles (NPs) and Mg‐doped ZnO/reduced graphene oxide (rGO) nanocomposites has been performed. In addition to Mg, Cd was chosen as a doping material for the bandgap engineering of ZnO NPs, and its effects were compared with that of Mg in the photocatalytic performance of ZnO nanostructures. The experimental results revealed that Mg, as a doping material, recognizably ameliorates the photocatalytic performance of ZnO NPs and ZnO/graphene nanocomposites. Transmission electron microscopy (TEM) images showed that the Mg‐doped and Cd‐doped ZnO NPs had the same size. The optical properties of the samples indicated that Cd narrowed the bandgap, whereas Mg widened the bandgap of the ZnO NPs and the oxygen vacancy concentration was similar for both samples. Based on the experimental results, the narrowing of the bandgap, the particle size, and the oxygen vacancy did not enhance the photocatalytic performance. However, Brunauer–Emmett–Teller (BET) and Barret–Joyner–Halenda (BJH) models showed that Mg caused increased textural properties of the samples, whereas rGO played an opposite role. A theoretical study, conducted by using DFT methods, showed that the improvement in the photocatalytic performance of Mg‐doped ZnO NPs was due to a higher electron transfer from the Mg‐doped ZnO NPs to the dye molecules compared with pristine ZnO and Cd‐doped ZnO NPs. Moreover, according to the experimental results, along with Mg, graphene also played an important role in the photocatalytic performance of ZnO. 相似文献
8.
Shwetha U. R Maha Abdallah Alnuwaiser Latha M. S Virupaxappa S. Betageri Shilpa V. A M. Ijaz Khan Kamel Guedri 《印度化学会志》2022,99(9):100606
The present research highlights physical significance of green combination of metal oxide nanomaterials utilizing medicinal plant which has widely analyzed in different medical applications i.e., medicinal science, therapeutics. In this paper, we discussed environmentally benign approach for synthesizing silver doped copper oxide nanoparticles (Ag–CuO NPs) utilizing (ACLE). Scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) were utilized to confirm the size, crystalline structure and surface morphology of the obtained nanomaterials. The monoclinic crystalline structure of the Ag–CuO NPs as produced was revealed by XRD patterns. Morphological analysis disclosed the nano-based spherical configuration of Ag–CuO NPs, as well as their morphology and elemental composition. The anti-diabetic effect of Ag–CuO NPs was further investigated utilizing a yeast cell model and amylase inhibition. Here, a decrease in intracellular glucose and a delay in carbohydrate digestion indicate promising antidiabetic action. Furthermore, the prepared nanomaterial showed anticancer potential against the MCF-7 cancer cell line, with an IC 50 value of 11.21 g/ml. 相似文献
9.
Zinc oxide nanoparticles (ZnO NPs) represent a novel type of metal oxide nanoparticles enabling a new horizon for biomedical applications spanning from diagnosis to treatment. ZnO NPs are extensively used in commercial products such as sunscreens and daily-care products. Apart from that, ZnO NPs are used in food packaging and ointments and as an antimicrobial and antifungal agent. They are extensively used for many biomedical applications noticeably in pharmaceutics and theranostics. Its exceptional optical, electrical, and physiochemical properties, notably its incredible surface chemistry, make ZnO NPs a reliable option for bioimaging, biosensors, antimicrobial action, and drug and gene delivery. The present review covers findings and developments in ZnO NPs research in relation to its application and toxicity mechanism. A special emphasis has been given to the neurotoxic potential of the ZnO NPs and glial cell toxicity. Various factors contributing to the toxic potential of ZnO NPs and cell signaling pathways concerning its toxicity are also discussed. Available data point toward the risk of uncontrollable use of zinc nanoformulation. With increasing use, ZnO NPs pose a severe threat both to the ecosystem and human beings. In a nutshell, the review outlines the current state of the art of ZnO NPs. 相似文献
10.
Bestenur YALIN Doan AKCAN brahim Erturul YALIN Mehmet Can ALPHAN Kenan ENTÜRK brahim lker
ZYT Lütfi ARDA 《Turkish Journal of Chemistry》2020,44(4):1177
The objective of this study is to synthesize ZnO and Mg doped ZnO (Zn1−xMgxO) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH3COO)2.2H2O) and magnesium acetate tetrahydrate (Mg(CH3COO)2.4H2O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively. Structural and morphological characterizations of Zn1−xMgxO nanoparticles were studied by using XRD and SEM-EDX, respectively. Photocatalytic activities of ZnO and selected Mg-doped ZnO (Zn1−xMgxO) nanoparticles were investigated by degradation of methylene blue (MeB). Results indicated that Mg doping (both 10% and 30%) to the ZnO nanoparticles enhanced the photocatalytic activity and a little amount of Zn0.90 Mg0.10 O photocatalyst (1.0 mg/mL) degraded MeB with 99% efficiency after 24 h of irradiation under ambient visible light. Antibacterial activity of nanoparticles versus Escherichia coli ( E. coli ) was determined by the standard plate count method. Hemolytic activities of the NPs were studied by hemolysis tests using human erythrocytes. XRD data proved that the average particle size of nanoparticles was around 30 nm. Moreover, the XRD results indicatedthat the patterns of Mg doped ZnO nanoparticles related to ZnO hexagonal wurtzite structure had no secondary phase for x ≤ 0.2 concentration. For 0 ≤ x ≤ 0.02, NPs showed a concentration dependent antibacterial activity against E. coli . While Zn0.90Mg0.10 O totally inhibited the growth of E. coli , upper and lower dopant concentrations did not show antibacterial activity. 相似文献
11.
Microbial contaminants such as bacteria and viruses are of great concern in water. As nanotechnology continues to grow, understanding the interactions of nanoparticles with bacteria and viruses is important to protect public health and the environment. In this study, the effect of two commonly used nanoparticles, silver nanoparticles (AgNPs, average particle size=21 nm) and zinc oxide nanoparticles (ZnO NPs, average particle size=39 nm), on the growth of bacteria (Eschericia coli) and bacteriophages (MS2) were evaluated using a standard double agar layer (DAL) method and a turbidimetric microtiter assay. A 1-h prior exposure of MS2 to nanoparticles did not inactivate MS2 at the highest nanoparticle concentrations tested (5mg/L total Ag and 20 mg/L ZnO). No bacteriophage inactivation was observed in the presence of AgNPs, Ag(+)/AgNPs (50:50 in mass ratio) or Ag(+) ions, all at the total Ag concentration of 5mg/L. In a binary (bacteria-phages) system where the E. coli host was exposed to MS2 and nanoparticles simultaneously, the dynamic changes of active bacteria and MS2 phages during incubation demonstrated that exposure of AgNPs (5mg/L Ag) and ZnO NPs (20mg/L ZnO) increased the number of phages by 2-6 orders of magnitude. These results suggested that exposure of nanoparticles could greatly facilitate bacterial viruses like MS2 to infect the E. coli host. 相似文献
12.
Well-aligned zinc oxide (ZnO) nanorods (NRs) arrays deposited with Ag nanoparticles (NPs) are prepared by a liquid phase epitaxial growth process followed by a reduction of Ag on the surface of the ZnO NRs. Transmission electron microscopy images show that most Ag NPs are deposited on the upper part of the ZnO NRs, and the overall optical absorption in the range of visible light can be enhanced due to the surface plasmon resonance of the Ag NPs. ZnO NRs with and without Ag NPs are used to assemble dye sensitized solar cells. Devices fabricated from the Ag NPs/ZnO NRs composite arrays exhibit a higher open voltage, short circuit current and fill factor than that fabricated from the bare ZnO NRs array, thus, the overall efficiency of the as-fabricated cell is increased from less than 0.5?% to 0.8?%. The main reason for the enhancement of the device performance may be ascribed to that the electron transfer back from ZnO to the dye and electrolyte is blocked by the Schottky barrier at the Ag/ZnO interface, resulting in a great increase of the electron density at the ZnO conduction band. 相似文献
13.
Mg-doped zinc oxide and zinc oxide nanoparticles were prepared by using methanolic seed extract from the Eucalyptus grandis plant via a green approach. Phytoconstituents present in seed extract act as capping and stabilizing agents for the biosynthesis of nanoparticles. Doping of Mg to zinc oxide nanoparticles increases the bandgap energy, thus enhancing its chemical, physical and optical properties. Further, it was characterized by various techniques such as scanning electron microscopy giving morphological information about the wurtzite hexagonal structure of bio-synthesized nanoparticles. X-ray diffraction technique tells about the crystalline nature of particles and the average crystallite size for zinc oxide and doped zinc oxide nanoparticles. Mg as a dopant enhances the properties of nanoparticles, thus making it more efficiently applicable as an antibacterial agent against Escherichia coli, gram-negative bacteria. 相似文献
14.
《印度化学会志》2022,99(12):100756
In this paper, we report the successful fabrication of a novel dye-sensitized solar cell (DSSCs) using Mg doped ZnO as photoanode and natural dye Terminalia catappa as sensitizer. We synthesized Mg doped ZnO nanoparticles at different Mg concentrations (2%, 4%, 6%, and 8%) by employing a simple solvothermal route. The structural, morphology, composition and optical investigations of synthesized Mg doped ZnO nanoparticles are carried out using XRD, FE-SEM, EDAX, TEM, SAED, FTIR and UV–visible measurements. The XRD results confirmed the formation of hexagonal-wurtzite structure for the Mg doped ZnO nanoparticles and increase of crystalline size with increasing dopant concentration up to 6% is observed. FESEM analysis indicated a gradual change in the surface morphology with increasing Mg concentration and the size of the nanoparticles are slightly reduced at higher Mg concentration. The HRTEM images and SAED pattern also confirmed the formation of wurtzite hexagonal phase of ZnO. The band gap energies calculated from the UV–visible spectra using Tauc's plots indicated decrease of band gap energy with dopant concentration. The DSSCs fabricated using Mg doped ZnO photo-anodes and Terminalia catappa sensitizer showed higher efficiency at higher Mg concentration and observed increase in efficiency is discussed based on slower charge carrier recombination and higher carrier life time as evidenced from the electrochemical impedance analysis. 相似文献
15.
Subramanian Senthilkumar Annamalai Rajendran 《Research on Chemical Intermediates》2018,44(10):5923-5940
Eco-friendly biosynthesis of polycrystalline titanium dioxide (TiO2) nanoparticles (NPs) was synthesised using Justicia gendarussa (J. gendarussa) leaf extract as oxidizing agents. They were compared with TiO2 NPs synthesized using the glacial acetic acid and also studied was the combined effect of synthesis of TiO2 NPs. The crystalline nature and structural formation of TiO2 NPs synthesized by different methods were confirmed by the X-ray diffraction technique, and functional groups of materials were confirmed by FT-IR spectroscopy. The synthesized materials were investigated for photocatalytic activity for methylene blue under UV irradiation and toxicity activity against MCF-7 and MDA-MB-231 cells. The result indicates that TiO2 NPs synthesised by J. gendarussa showed superior and enhanced activity against MCF-7 and MDA-MB-231. Biosynthesized TiO2 NPs showed higher photodegradation of dyes when compared with other TiO2 NPs synthesized by different methods. This is due to the alterations in band gap; structural changes and surface area in nanoparticles that increased the activity. Also, nanosphere/disc like morphology of TiO2 NPs is confirmed using TEM. 相似文献
16.
Biogenic metal oxide nanoparticles (NPs) have emerged as a useful tool in biology due to their biocompatibility properties with most biological systems. In this study, we report the synthesis of copper oxide (CuO), zinc oxide (ZnO) nanoparticles (NPs), and their nanocomposite (CuO–ZnO) prepared using the phytochemical extracts from the leaves of Dovyalis caffra (kei apple). The physicochemical properties of these nanomaterials were established using some characterization techniques including X-ray diffraction analysis (XRD), ultraviolet-visible spectroscopy (UV-vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). The XRD result confirmed the presence of a monoclinic CuO (Tenorite), and a hexagonal ZnO (Zincite) nanoparticles phase, which were both confirmed in the CuO–ZnO composite. The electron microscopy of the CuO–ZnO, CuO, and ZnO NPs showed a mixture of nano-scale sizes and spherical/short-rod morphologies, with some agglomeration. In the constituent’s analysis (EDX), no unwanted peak was found, which showed the absence of impurities. Antioxidant properties of the nanoparticles was studied, which confirmed that CuO–ZnO nanocomposite exhibited better scavenging potential than the individual metal oxide nanoparticles (CuO, and ZnO), and ascorbic acid with respect to their minimum inhibitory concentration (IC50) values. Similarly, the in vitro anticancer studies using MCF7 breast cancer cell lines indicated a concentration-dependent profile with the CuO–ZnO nanocomposite having the best activity over the respective metal oxides, but slightly lower than the standard 5-Fluorouracil drug. 相似文献
17.
《Solid State Sciences》2012,14(4):488-494
Un-doped and doped ZnO nanoparticles (Zn0.97X0.03O-NPs, X = Mn, Co, and Ni) were synthesized from a metal acetate precursor and acetic acid by a modified sol–gel combustion method. The compounds were synthesized at calcination temperatures of 650 °C for 1 h. The synthesized un-doped/doped ZnO-NPs were characterized by X-ray diffraction analysis (XRD) and high-magnification transmission electron microscopy (TEM). The XRD results revealed that the sample product was crystalline with a hexagonal wurtzite phase. The TEM showed ZnO-NPs nearly spherical shapes and a non-uniform shape for doped ZnO-NPs. The crystalline development in the ZnO-NPs was investigated by X-ray peak broadening. The size–strain plot (SSP) method was used to study the individual contributions of crystallite sizes and lattice strain on the peak broadening of the un-doped and doped ZnO-NPs. Physical parameters such as strain, stress and energy density values were calculated more precisely for all reflection peaks of XRD corresponding to the wurtzite hexagonal phase of ZnO lying in the range of 20–80° from the SSP results. The vibrating sample magnetometer (VSM) was also used to study the magnetic behavior of the samples in the ceramic form. The obtained results showed that strain play an important role in peak broadening; moreover, the mean crystalline size of the un-doped and doped ZnO-NPs estimated from the TEM and the SSP method were highly inter-correlated. 相似文献
18.
Teow Y Asharani PV Hande MP Valiyaveettil S 《Chemical communications (Cambridge, England)》2011,47(25):7025-7038
Many engineered nanomaterials (NMs) are being synthesized and explored for potential use in consumer and medical products. Already, nanoparticles (NPs) of titanium dioxide (TiO(2)), zinc oxide (ZnO), silver (Ag) and other metals or their oxides are present in commercial products such as sunscreens, cosmetics, wound dressings, surgical tools, detergents, automotive paints and tires. More recent and advanced FDA-approved use of NMs includes quantum dots (QDs) in live cell imaging, zirconium oxides in bone replacement and prosthetic devices and nanocarriers in drug delivery. The benefits from nanotechnology are aplenty, comprising antimicrobial activities, scratch- and water-resistance, long-lasting shine, improved processor speeds and better display resolution, to name a few. While developers of these products often focus on the exciting beneficial aspects of their products, safety and toxicity issues are often not discussed in detail. Long-term effects such as chronic exposure and environmental pollution are even less documented. Along with widespread manufacture and use of NMs, concerns for occupational hazards, proper handling, disposal, storage, shipping and clean up are expected to rise. This review focus on the possible biological impact of engineered NPs, serving as a reminder that nanomaterials can become a double-edged sword if not properly handled. 相似文献
19.
Research on Chemical Intermediates - The present study reports an eco-friendly green synthesis of zinc oxide nanoparticles (ZnO NPs) using the bioflavonoid rutin. The synthesized ZnO NPs were... 相似文献
20.
《中国科学:化学(英文版)》2017,(3)
Aptamer-functionalized silver nanoclusters(Ag NCs) have been attracting a lot of interest as label-free probes which have been successfully applied to both cell imaging and molecular detection.MUCl aptamer is an ssDNA aptamer that specifically binds to MUCl mucin which is a large transmembrane glycoprotein whose expression level increases at least 10-fold in primary and metastatic breast cancers.Using C4A4C3-linker-MUCl as template,the Ag NCs were synthesized through one-pot process.The fluorescence intensity of Ag NCs was found to be closely related to the length and type(poly adenine or thymine) of the linker,the optimum linker being-AAAAA-.Using the C4A4C3-A5-MUC1 as the scaffold,the synthesized Ag NCs emitted fluorescence with high quantum yield(QY) of 66.5%.Based on the specific interaction between the MUCl aptamer and MUCl mucin,the C4A4C3-A5-MUC1-stabilized Ag NCs could recognize and differentiate the MCF-7 breast cancer cells from MDA-MB-231 breast cancer and A549 human lung cancer cells. 相似文献