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1.
1,8-二羟基-9,10-二氢蒽的合成 总被引:1,自引:0,他引:1
以1,8-二羟基蒽醌为原料,经甲醚化,锌粉和金属钠还原,去甲基等4步反应合成1,8-二羟基-9,10-二氢蒽,总产率为37.1,8-二甲氧基蒽醌用NaBH4/CF3COOH还原生成二聚产物,并测定了其单晶结构. 相似文献
2.
Dirk Burdinski 《Tetrahedron》2005,61(6):1587-1594
The synthesis of 1,8-bis(dimethylaminomethylethynyl)-3,6-di(tert-butyl)fluorene-9-yl-acetic acid, a potentially dinucleating ligand containing two N-donor and bridging carboxylate groups, is described. The electronically disfavored 1,8-disubstitution of the fluorene ring system was achieved by using tert-butyl protecting groups in the 3- and 6-positions of the fluorene molecule in combination with mercury(II) as a sterically demanding electrophile. The straightforward synthesis of a 1,8-diiodofluorene derivative provides simple general access to 1,8-disubstituted fluorene molecules. 相似文献
3.
Joseph T. Repine Douglas S. Johnson Timothy Stuk Michael A. Stier Zhixiang Yang 《Tetrahedron letters》2007,48(46):8189-8191
Processes for the synthesis of fluorinated 1,8-naphthyridinone derivatives including 6,7-difluoro-1,8-naphthyridin-2-one are described. 相似文献
4.
《合成通讯》2013,43(12):2269-2275
Abstract Mild and efficient procedures have been developed for synthesis of 1,8‐naphthalide and 1,8‐naphthalenedimethanol. In an ice‐water bath, 1,8‐naphthalide was prepared from 1,8‐naphthlic anhydride using LiAlH4 as reducing agent. 1,8‐Naphthalenedimethanol was obtained with good yield from reduction of 1,8‐naphthalic anhydride by LiAlH4 and Lewis acids at room temperature. The effects of various factors on the reduction of 1,8‐naphthalic anhydride with LiAlH4 were investigated. 相似文献
5.
Ravi D. Ashok K. Rambabu S. Sakram B. Shyam P. 《Russian Journal of General Chemistry》2018,88(6):1232-1237
Russian Journal of General Chemistry - An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under... 相似文献
6.
7.
Mesram Manoj Kumar Dr. Parikibanda Venkataramana Prof. Parikibanda Yadagiri Swamy Dr. Yadaiah Chityala 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(70):17713-17721
A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C−N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C−N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono - amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures. 相似文献
8.
Glaser T Liratzis I Fröhlich R Weyhermüller T 《Chemical communications (Cambridge, England)》2007,(4):356-358
The extension of Robson-type ligands from dinucleating based on 2,6-diformylphenol to trinucleating based on 2,7-diformyl-1,8-naphthalenediol is demonstrated by the synthesis, structural and magnetic characterization of the first trinuclear Cu(II) complex using a 1,8-naphthalenediol derived ligand. 相似文献
9.
Tamara Brider Gary Gellerman 《Tetrahedron letters》2012,53(42):5611-5615
A new approach for a short synthesis of novel medicinally-important mono-, bis- and tris-1,8-naphthalimide peptidyl derivatives is described. The method generates efficiently 1,8-naphthalimides with variable spacer lengths and charged, polar or hydrophobic residues at desired positions, which can increase binding affinity, conformational stability, intracellular transport and/or biological activity. The synthetic routes reported in this work are both general and applicable, and significantly expand the scope of potential 1,8-naphthalimide anticancer candidates. 相似文献
10.
A new direct synthesis of benzo(k,1)thioxanthene-3,4-dicarboxylic anhydride from 4-nitro-naphthalene-1,8-dicarboxylic anhydride and 2-aminobenzenethiol is reported; 4-(2-aminophenylthio) naphthalene-1,8-dicarboxylic anhydride and 4-phenylthionaphthalene-1,8-dicarboxylic anhydride are also formed. Similar reaction in presence of amyl nitrite or sodium nitrite results in formation of larger amounts of 4-phenylthionaphthalene-1,8-dicarboxylic anhydride, together with other products arising from the oxidation of 2-aminobenzenethiol; one such product is the new heterocycle 9,10-dithiaphenanthrene. 4-(2-Aminophenylthio)-naphthalene-1,8-dicarboxylic anhydride is rapidly converted by amyl nitrite or sodium nitrite in dimethylformamide into benzo(k,1)thioxanthene-3,4-dicarboxylic anhydride, constituting a novel one-stage intramolecular cyclisation reaction of greater convenience than the conventional two stage Pschorr cyclisation. 相似文献
11.
Edgardo Laborde John S. Kiely Lawrence E. Lesheski Mel C. Schroeder 《Journal of heterocyclic chemistry》1991,28(1):191-198
A convergent synthesis of 1,8-naphthyridine antibacterials bearing a carbon-carbon bonded, acyclic or cyclic vinyl substituent at the C-7 position has been achieved. The synthetic methodology is based upon the palladium-catalyzed cross coupling of a 7-chloro-1,8-naphthyridine with an appropriately substituted organotin reagent. 相似文献
12.
Goswami S Mukherjee R Mukherjee R Jana S Maity AC Adak AK 《Molecules (Basel, Switzerland)》2005,10(8):929-936
The syntheses in good yields of some new difunctionalized 1,8-naphthyridines 4, 6, 8 and 9 and a novel triethylene glycol ether-linked dinaphthyridine, 10a, along with the mononaphthyridine-linked ether alcohol 10b are described. An improved and milder method for the synthesis of 2,7-diamino-1,8-naphthyridine (14) is also reported. 相似文献
13.
Simin Nazari Mosadegh Keshavarz Bahador Karami Nasir Iravani Masoumeh Vafaee-Nezhad 《中国化学快报》2014,25(2):317-320
Imidazol-1-yl-acetic acid is introduced as a new, efficient and recyclable green bifunctional organocatalyst for the synthesis of 1,8-dioxooctahydroxanthenes under solvent-free conditions. This catalyst is water soluble and can be separated from the products by simple filtration. The filtrate can be evaporated to dryness and recrystallized from cool methanol to give the recovered catalyst. This organocatalyst was used for the synthesis of 1,8-dioxooctahydroxanthenes under solvent-flee conditions and recycled up to 8 consecutive runs without any losing of its efficiency. 相似文献
14.
The chemical behavior of 9-R-sym-octahydroxanthene-1,8-diones and salts based on them in recyclization reactions under the
influence of amines was studied. The effect of the basicity of the amines on the direction of recyclization was established.
A method is proposed for the single-stage synthesis of sym-octahydroacridine-1.8-dione oximes based on 1,8-dioxo-sym-octahydroxanthenes.
Conditions were worked out for the oxidation of sym-octahydroxanthene-1,8-diones and N-R-decahydroacridinediones to the corresponding
salts.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 32–38, January, 2006. 相似文献
15.
The synthesis of (1R,2S,7S,8R)-3,5-diaza-2,7-dimethyl-1,8-diphenyloctan-1,8-diol 6 and its enantiomer 7 are described utilising (-)-(1R,2S)- or (+)-(1S,2R)-norephedrine, respectively. 相似文献
16.
I. P. Beletskaya A. D. Averin A. G. Bessmertnykh F. Denat R. Guilard 《Russian Journal of Organic Chemistry》2010,46(7):947-967
The review describes palladium-catalyzed amination of acyclic di- and polyamines with aryl halides with a view to reveal general
relations holding in this process. Conditions for the synthesis of macrocycles via catalytic diamination of 1,2- and 1,3-dibromobenzenes,
1,3-dichloro-2-bromobenzene, 2,6- and 3,5-dibromopyridines, 3,3′- and 4,4′-dibromobiphenyls, 2,7-dibromonaphthalene, 1,8-
and 1,5-dichloroanthracene, 1,8- and 1,5-dichloroanthraquinones, and bis(haloaryl) derivatives of cyclen, cyclam, and cholanediol
are discussed. The possibility for palladium-catalyzed arylation of cyclic polyamines has been demonstrated. Specificity of
macrocyclization processes and relations between the yield of macrocycles and the nature of initial compounds are considered,
and data on the synthesis of cyclic dimers are given. Applications of polyazamacroheterocycles as optical sensors for metal
cations are described using as examples macrocyclic compounds derived from 1,8-disubstituted anthraquinone. 相似文献
17.
Attempted synthesis of 1,8-dicyclooctatetraenylnaphthalene (1) by the palladium(0)-catalyzed coupling of 1,8-dibromonaphthalene with cyclooctatetraenyltrimethylstannane afforded a single unsymmetrical isomer of 1 in 88% yield. Two-dimensional NMR methods and spectral synthesis were employed to assign the structure of the isomer (2). AM1 geometry-optimized structures of 2 and its isomers showed that the unexpected unsymmetrical structure of 2 results from the minimization of repulsive inter-ring H-H interactions. Compound 2 is postulated to arise via tandem [2 + 2] cycloaddition and 6 pi --> 4 pi + 2 sigma electrocyclization reactions of 1. 相似文献
18.
Eva Eichler Clarence Stanley Rooney Haydn Windsor Richard Williams 《Journal of heterocyclic chemistry》1976,13(1):41-42
The synthesis of some 2-amino-1,8-naphthyridine derivatives substituted in the 5- and/or 7-positions with trifluoromethyl is described along with their conversions to the corresponding 1,8-naphthyridin-2(1H)ones. A modified procedure for oxidizing electron-deficient heterocyclic compounds to their N-oxides is presented. 相似文献
19.
Shohre Rouhani Kamaladin Gharanjig Mozhgan Hossein Nezhad 《Green Chemistry Letters and Reviews》2014,7(2):174-178
This study describes the ultrasound-assisted synthesis of 4-nitro-N-substituted-1,8-naphthalimide derivatives from 4-nitro-1,8-naphthalic anhydride and related amines by irradiating at 35 KHz in a sonic bath in aqueous media at room temperature. The results obtained by this method are comparable to those obtained by a common reflux method. The imidation reaction under ultrasound irradiation preceded 8 and 20 times faster than the common method and produced higher yields. 相似文献
20.
Eldrup AB Christensen C Haaima G Nielsen PE 《Journal of the American Chemical Society》2002,124(13):3254-3262
The synthesis and evaluation of a series of novel nucleobases based on substituted 1,8-naphthyridin-2(1H)-ones are reported. The nucleobases were designed to meet the requirements for incorporation into peptide nucleic acids (PNAs) and were evaluated as part of PNA duplex and triplex nucleic acid recognition systems. Of the various nucleobases tested, only the 7-chloro-1,8-naphthyridin-2(1H)-one (7-Cl-bT) nucleobase led to consistently increased affinity in all recognition systems, duplex (Watson-Crick) as well as triplex (Hoogsteen). For multiply modified systems, the increase in thermal stability per modification was dependent on the sequence context, ranging from 2.0 degrees C (in separate positions) to 3.5 degrees C (in adjacent positions) in PNA-DNA duplexes and from 1.2 degrees C (in separate positions) to 3.2 degrees C (in adjacent positions) in PNA-RNA duplexes. Singly mismatched oligonucleotide targets were employed to demonstrate uncompromised sequence discrimination. When part of multiply modified triplex (Hoogsteen) recognition systems, the 7-Cl-bT unit gave rise to increases in the thermal stability ranging from 2.7 to 3.5 degrees C when incorporated into separated and adjacent positions, respectively. Our results furthermore indicate that the duplex stabilization is predominantly enthalpic and therefore most likely not a consequence of single-strand preorganization. Finally, and most surprisingly, we find no direct correlation between the end-stacking efficiency of this type of nucleobase and its helix stabilization when involved in Watson-Crick base pairing within a helix. 相似文献