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Dehydrogenative N‐Incorporation: A Direct Approach to Quinoxaline N‐Oxides under Mild Conditions 下载免费PDF全文
Feng Chen Xiaoqiang Huang Xinyao Li Tao Shen Miancheng Zou Prof. Dr. Ning Jiao 《Angewandte Chemie (International ed. in English)》2014,53(39):10495-10499
An efficient method for the synthesis of quinoxaline N‐oxides proceeds by the dehydrogenative N‐incorporation of simple imines by C(sp2)? H and C(sp3)? H bond functionalization. The overall transformation involves the cleavage of three C? H bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert‐butyl nitrite (TBN) was employed as the NO source. 相似文献
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Dr. Ali Abd‐Elaal Dr. Francesco Parrino Dr. Rosaria Ciriminna Prof. Vittorio Loddo Prof. Leonardo Palmisano Prof. Mario Pagliaro 《ChemistryOpen》2015,4(6):779-785
The oxidation of alcohols to carbonyl compounds in a clean fashion (i.e., with water as a solvent or under solvent‐free conditions, and using O2 or H2O2 as the primary oxidant) is the subject of considerable research efforts. A new approach for the selective oxidation of soluble aromatic alcohols in water under mild conditions via a novel composite photocatalyst has been developed. The catalyst is synthesized by grafting 4‐(4‐(4‐hydroxyphenylimino)cyclohexa‐2,5dienylideneamino)phenol and silver nanoparticles onto the surface of moderately crystalline titanium dioxide. The titanium dioxide‐based composite was first extensively characterized and then employed in the catalytic oxidation of 4‐methoxybenzyl alcohol to 4‐methoxybenzaldehyde under UV irradiation in water at room temperature. The corresponding aldehyde was obtained with unprecedented high selectivity (up to 86 %). The method is general and opens the route to fabrication of photocatalytic composites based on titanium dioxide functionalized with shuttle organic molecules and metal nanoparticles for a variety of oxidative conversions. 相似文献
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a-Bromo benzoylmethylene triphenylphosphorane 3 has been synthesized by the reaction of benzoylmethylene triphenylphosphorane 1 with N-bromosuccinimide in the yield of 87% and can react with aromatic aldehydes 4 to giveα-bromochalcones 5 in good yields. 相似文献
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Klaus Burger Michael Kluge Susanna Fehn Beate Koksch Lothar Hennig Gerhard Müller 《Angewandte Chemie (International ed. in English)》1999,38(10):1414-1416
In only three or four steps glycosylated dipeptide and tripeptide fragments, respectively (see scheme), can be obtained from hydroxy amino acids by using a novel protecting group/activation concept. The method presented is even superior to the pentafluorophenyl ester method. 相似文献
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M. E. Brik 《合成通讯》2013,43(21):3283-3287
This work reports a new mild reducing agents of 2,2,6,6-tetramethylpiperidine-1-oxyl (1) to hydroxylamine with a good yield. These compounds are: tetrahydroxy-1, 4-quinone (3), 2,5-dihydroxy- 4-benzoquinone (4) and rhodizonic acid (5). 相似文献
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The Thorpe-Ziegler reaction has been used in the preparation of enaminonitriles and cyclic ketones for many years. A wide variety of bases1 have been employed to acomplish this reaction, the most effective being the alkali metal salts of aralkyl amines. The reaction conditions vary from room temperature to toluene reflux temperature for long periods of time1. 相似文献
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A new synthetic approach to elvucitabine started from L-xylose via the reactions of 10 steps in an overall yield of 20% was developed. The key steps included trimethylsilyl trifluoromethanesulfonate(TMSOTf)-mediated stereocontrolled β-glycosidation and exquisite choice of chloroacetyl group for the protection of hydroxyl groups as well as the corresponding deprotection under notably mild conditions. The structure of elvucitabine, in particular, the stereochemistry thereof, was unambiguously determined by comparison of the physical properties, such as 1H NMR data and the specific rotation, of the synthesized sample with those reported. 相似文献
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In the present work a short and convenient route for the synthesis of salmeterol from salicylaldehyde has been developed. 相似文献
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An uhexpected success involving the rearrangement of N-benzoyl2-pyrrolidone(1)to 2-phenylpyrroline (2)1 provided us with an imaginative heuristic upon which some novel entries into the pyrrolidine and piperdine alkaloids was based. 相似文献
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Sylvestre P. J. T. Bachollet Dean C. Cocker Harry Adams Prof. Joseph P. A. Harrity 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(40):12889-12893
The aza‐Diels–Alder cycloaddition of 1,2,4‐triazines with alkynes offers a rapid and convenient method for the synthesis of highly substituted pyridines, but often requires harsh conditions and long reaction times. The present study offers a solution to these limitations by use of a temporary tether established by a Lewis acid–base complexation of in situ generated alkynylboranes and triazines bearing a Lewis basic donor. The cycloaddition reactions take place within 20 min at 40 °C and provide direct access to a broad range of pyridines with complete and predictable regiocontrol. The carbon?boron bond can be further functionalised by cross‐coupling allowing further functionality to be introduced after cycloaddition. 相似文献