Preparation of Some Substituted Terephthalic Acids

We report in detail the preparation of two substituted terephthalic acids: 2‐sulfomethylterephthalic acid (1) and 2‐phosphonoterephthalic acid (2). Efficient, short syntheses have been developed for both compounds. They are potentially useful monomers for construction of acid‐pendant polymer chains.     

Synthesis of Phosphonoindoprofen

Two synthetic routes to phosphonic analogues of indoprofen, a nonsteroidal anti-inflammatory drug, were developed by the cyclization of aniline 2 (method A) and by the Arbuzov reaction of corresponding alkylchloride 3 with triethylphosphite (method B).     

Thermal Studies on Some Substituted Aminobenzoic Acids

The thermal behaviour of various substituted aminobenzoic acids(3-aminobenzoic acid (3-ABA), 4-aminobenzoic acid (4-ABA), 3-aminosalicylic acid(3-ASA), 4-aminosalicylic acid (4-ASA), and 5-aminosalicylic acid (5-ASA), as well as the‘parent’ benzoic acid (BA) and salicylic acid (SA) as reference substances, and possible decomposition products: 2-aminophenol (2-AP), 3-aminophenol (3-AP) and 4-aminophenol(4-AP) in the solid state has been examined. The various sets of isomers studied showed considerable and interesting differences. Most sublimed well before melting, generally with an increasing rate of mass loss beyond their very different melting points. The differences in behaviour of 4-ASA and 5-ASA were the most remarkable, with 5-ASA being far more stable and apparently not decarboxylating readily, while 4-ASA sublimed at temperatures below the melting point, becoming less stable and decarboxylating in the liquid form. This revised version was published online in July 2006 with corrections to the Cover Date.     

Guaiacol Substituted AzaPCs: A Novel Synthesis Method and Investigation of Photophysical Properties

AzaPCs containing tetra- and octaguaiacol moieties have not been investigated up to now. In this study, an unusual method is used for the synthesis of metalloAzaPCs (M: Zn, Co, Cu) containing guaiacol moieties. All compounds are characterized by a combination of FT-IR, ¹H NMR, ¹³C NMR, mass and UV/vis spectroscopy techniques. The molecular structure of starting pyrazine compounds 1 and 2 is also determined by the single crystal X-ray diffraction technique. The aggregation behavior of new Zn(II) AzaPCs is investigated in DMSO at different concentrations. The fluorescence properties of Zn(II) AzaPCs are investigated in different solvents. The fluorescence quantum yields of Zn(II) AzaPCs are calculated in DMSO.     

Synthesis of Some Substituted 1,3,2-Oxazaphosphorinanes

Abstract

To study the effect of statistically controlled associate dia-stereoisomerism (SCADA), the optical isomers of some derivatives of 2-amino-2-oxo-1,3,2-oxazaphosphorinane, containing the residues of L-α-aminoacids, were synthesized. The magnitude of chemical shift nonequivalence (Δδ) in ³¹P NMR-spectra of diastereomeric mixtures was maximum for isomeric derivatives of valine; the dependence of Δδ³¹P on their concentration was investigated.     

新型钒取代杂多酸电荷转移盐的合成和表征

以不同钒取代的Danson结构的杂多磷钼酸为电子受体 ,N ,N 二甲苯胺为电子给体合成了两种新型电荷转移盐配合物 8C8H11N·H8P2 Mo16V2 O62 ·3C3 H7NO·5H2 O和 8C8H11N·H10 P2 Mo14 V4O62 ·4C3 H7NO。并用元素分析、红外光谱、固体漫反射电子光谱等进行了表征。结果表明 :有机电子给体与杂多酸阴离子间有强烈的相互作用 ,配合物在光激发下发生分子内的电荷转移 ,导致有机阳离子的氧化和杂多阴离子的还原。ESR测试结果显示 ,杂多阴离子的还原反应处于单电子还原阶段 ,阴离子中VV 还原为VⅣ     

Synthesis of functionalized alkoxyalkylidene gem-bisphosphonates

We report the synthesis of a series of new functionalized bisphosphonates and bisphosphonic acids with an alkoxy group fixed at the geminal carbon, which is proposed to increase their lipophilicity and so their bioavailability. Subsequently, the alkylation of these alkoxy bisphosphonates with allyl bromide is reported. The reactivity of the allyl group has been studied to give access to alkoxy bisphosphonates functionalized by diverse groups including alcohol, aldehyde, carboxylic acid, epoxide and amine.     

取代氨乙基膦酸的简便合成

以2-氯乙基膦酸和胺为原料,经一步反应合成了3种取代氨乙基膦酸,合成工艺条件为：2-氯乙基膦酸200mmol,n(2-氯乙基膦酸)：n(胺)=1：1．1,反应温度18℃,反应时间120h,pH8～10,KI作催化剂,收率78．2％～91．0％。用元素分析,IR和^1H NMR表征了标题化合物。     

(口恶)唑环取代的俘精酸酐的合成及其光致变色性能的研究

合成了含噁唑环的俘精酸酐,4-（5-甲基-2-对甲氧苯基-4-乙酰基嘿唑）乙叉（异丙叉）丁二酸酐,研究了该化合物在不同溶剂中的光致变色性能,进行了光成色和光消色过程的动力学研究,并考察了溶剂极性对该化合物吸收光谱的影响。稳态动力学分析结果表明,该化合物呈色体的光消色反应遵循一级动力学规律,俘精酸酐本身的光反应比较复杂,不符合简单的动力学级数。     

唑环取代的俘精酸酐的合成及其光致变色性能的研究

合成了含     

Synthesis and Trapping of Some Substituted 1-Bromocyclopropenes

Summary. Treatment of a number of 2-substituted 1,1,2-tribromocyclopropanes with MeLi at −78°C gave the corresponding 1-bromocyclopropenes, which were reacted with three cyclic dienes to yield the [4 + 2]-cycloadducts. Cycloaddition with 1,3-diphenylisobenzofuran (DPIBF) gave the exo adducts, in most cases in excellent yield, whereas cyclopentadiene afforded endo adducts only, but in moderate yield. In most reactions with furan no adduct was formed, but two 1-bromocyclopropenes derivatives with an aromatic side chain were exceptions and furnished mixtures of exo and endo adducts in moderate yields.     

Synthesis and Properties of Functionally Substituted Unsaturated Polysulfones

High-temperature copolymerization of ethyl esters of vinyl- or isopropenylcyclopropanecarboxylic acids with SO₂ was studied as a route to functionally substituted unsaturated polysulfones. The composition, structure, and some properties of the polysulfones obtained were studied. The copolymerization mechanism was considered.     

Synthesis and Trapping of Some Substituted 1-Bromocyclopropenes

Treatment of a number of 2-substituted 1,1,2-tribromocyclopropanes with MeLi at −78°C gave the corresponding 1-bromocyclopropenes, which were reacted with three cyclic dienes to yield the [4 + 2]-cycloadducts. Cycloaddition with 1,3-diphenylisobenzofuran (DPIBF) gave the exo adducts, in most cases in excellent yield, whereas cyclopentadiene afforded endo adducts only, but in moderate yield. In most reactions with furan no adduct was formed, but two 1-bromocyclopropenes derivatives with an aromatic side chain were exceptions and furnished mixtures of exo and endo adducts in moderate yields.     

全氟烷基芳基酮的合成

本文用8种取代苯基卤化物,在无水四氢呋喃中制成的格氏试剂与全氟羧酸(R_FCO_2H,R_F=CF_3和n-C_3F_7)按 3:1摩尔比反应,合成了9种全氟烷基芳基酮(1～9),其中6、7、8和9是新化合物。它们的结构用IR、UV、NMR(~1H,~(19)F)及MS加以表征。     

The Synthesis of Some New Fused and Substituted Chromenes

Some new chromeno[2,3-b]pyrimidines, chromeno[3,2-c]pyridines, chromeno[2,3-b]pyridines and 3-chromenyl-1,3-thiazines were synthesized via the synthetic studies of the reaction of 2-imino-2H-chromen-3-thiocarboxamide with some aromatic aldehydes, active nitriles, and their ylidene derivatives.     

Synthesis and Some Chemical Behaviour of Certain Substituted Thiosemicarbazides

Three new thiosemicarbazides (1 a-c ) were prepared from N-[4-phenyl-5-(2-thienyl)-1,2,4-triazol-3-yl]mercaptoacetohydrazide. Reaction of (1 a-c) with the appropriate phenacyl bromide afforded thiazoline derivatives (2 a-i) whereas their reaction with chloroacetic acid or maleic anhydride gave the corresponding thiazolidine derivatives (3 a,b) and (4 a,b) . Cyclodesulfurization of (1 a-c) with DCCD in toluene yielded 5-substituted-amino-1,3,4-oxadiazoles (5 a,b) , while their dehydration with PPA gave the corresponding 5-substituted-amino-1,3,4-thiadiazoles (6 a-c) . Six representative compounds were tested for their in-vitro antimicrobial activity against some pathogenic microorganisms, some of them were proved to be active.     

Design,Synthesis, and Properties of Substituted Polyacetylenes

This article reviews recent topics on the polymerization of substituted acetylenes, focusing on the synthesis of poly(diphenylacetylenes) and the living polymerization of phenylacetylenes. Diphenylacetylene (DPA) polymerizes with TaCl_s-n-Bu₄Sn to give a polymer which is thermally very stable but insoluble in any solvents. DPAs with various groups (e.g.,p-Me₃Si,m-Me₃Ge, p-t-Bu,and_p-PhO) polymerize similarly. These polymers are soluble and their M¯_w's reach 1 × 10⁶ to 3 × 10⁶. Some of them are more gas-permeable than poly(dimethylsiloxane). Several acetylenes (e.g., ClC -n-C₆H₁₃ and HCUC-t-Bu) have been found to undergo living polymerization with MoOCl₄-n-Bu₄Sn-EtOH. Whereas phenylacetylene (PA) does not polymerize in a living fashion, ortho-substituents in PA more or less suppress termination and chain transfer. PAs with bulky ortho groups (e.g., CF₃ and Me₃Ge) especially undergo virtually ideal living polymerization.