Signalling Properties of Inositol Polyphosphates

Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new insights into their cellular production. These studies have revealed that interaction of IPs with several proteins is critical for stabilization of protein complexes and for modulation of enzymatic activity. This has not only revealed their importance in regulation of several cellular processes but it has also highlighted the possibility of new pharmacological interventions in multiple diseases, including cancer. In this review, we describe some of the intracellular roles of IPs and we discuss the pharmacological opportunities that modulation of IPs levels can provide.     

交联聚磷酸酯的合成及其释药性能研究

以（ｉ－Ｂｕ）３Ａｌ为引发剂研究了２－氢－２－氧－１，３，２二氧五环磷酸酯，２－氢－２－氧－１，３，２－二氧六联药物载体，要用单层骨架片、双层骨架片和夹心片 药方式，对抗肿瘤药物５－氟尿嘧啶进行了控制释放，获得了较好的释药效果。     

低酸度淋洗液离子色谱法测定多聚磷酸盐

在国产阴离子分离柱上采用含钙和镁离子的淋洗液，由于Ｃａ＾２＋和Ｍｇ＾２＋与复杂的多聚磷酸根离子形成螯合物而提高了淋洗能力，加快了分析速度，大大降低了淋洗液的酸度和盐浓度，对几种工业三聚磷酸钠样品进行了测定，与化学法相比，相对误差小于１．５％，加入回收率在９９％－１０９％之间。     

Synthetic Polyphosphates with Diectly Attached Nucleic Acid Bases

Abstract

Synthetic polyphosphates were prepared with NA bases attached directly either as the side groups or introduced to the main chain. Properties of these models explored in solution, some of the prepared polymers are tested as potential biologically active polymers.     

A Spectrophotometric Detector for High-Performance Liquid Chromatography of Inorganic Polyphosphates

Abstract

A spectrophotometric detector for high-performance liquid chromatography of inorganic polyphosphates such as orthophosphate, diphosphate and triphosphate is described. This method is based on the employment of an air-segmented technique (AutoAnalyzer II, Technicon) as a detector, in combination with a post-column reaction using a molybdenum reagent.     

电导检测离子色谱法测定多聚磷酸盐

本文探讨用离子色谱电导检测法直接分离测定多磷酸盐，确定在ＡＳ４Ａ－ＳＣ色谱柱上分离正、焦、三聚、六偏磷酸盐混合物的最佳淋洗条件，并测定了浇铸料添加剂中多聚磷酸盐的含量。     

Synthetic Polyphosphonates,Polyphosphates, and Phosphonocarboxylates as Allosteric Effectors of Hemoglobin

Abstract

Synthetic phosphonocarboxylates, diphosphonates, polyphosphates, and some triphosphonic acids were studied as effectors in the binding of dioxygen to human hemoglobin. Ethane-1,2-diphosphonic acid, and triphosphate anion were strong effectors.     

新一代生物医用材料

第一代生物医用材料是生物相容和生物惰性材料;第二代生物医用材料是生物活性或可生物降解吸收材料;第三代生物医用材料是同时具有生物活性和生物降解性的新一代生物医用材料。作为细胞外基质,它们可在分子水平上激活基因、刺激细胞增殖、诱导其组织分化进而构筑成新的组织和器官。     

Rapid and Complete Separation of Inorganic Polyphosphates from Monomer to 35-Mer by Hplc

Abstract

The on-line coupling system of high-performance liquid chromatography (HPLC) and flow injection analysis (FIA) was developed for the rapid separation and sensitive detection of inorganic polyphosphates. Effects of gradient elution conditions on the chromatographic behavior were studied. The column temperature as well as a chloride concentration gradient were found to be very effective for the improvement of resolution(1). To minimize analysis time and to maximize resolution, the gradient elution conditions were optimized by use of a computer-assisted retention prediction system(2). More than 35 kinds of inorganic polyphosphates could be separated completely within 200 min under the optimum conditions as shown in Fig. 1.     

单原子催化剂的生物医学应用

单原子催化剂(SACs)具有100%的原子利用率及充分暴露的原子金属活性位点,其催化活性和选择性更具优势,已广泛应用在化学、能源及环境等领域.近年来, SACs在生物医学领域也引起了广泛关注.本文综述了SACs在肿瘤治疗、抗菌、抗氧化和生物传感等生物医学领域的应用及研究进展,并简要总结了SACs未来应用的挑战和机遇,为合理设计多性能的SACs提供了可行策略.     

沸水阻断多聚磷酸盐分解离子色谱法检测水产品中的多聚磷酸盐

多聚磷酸盐在水产品中的快速分解影响其准确测定.用沸水破坏使多聚磷酸盐分解的物质,并用三氯甲烷去除水产品中蛋白质等杂质,离子色谱准确测定多聚磷酸盐各组分的量.实验中采用淋洗液自动发生器产生的KOH溶液作为流动相,保护柱和分离柱采用Ionpac AG11-HC和Ionpac AS11-HC抑制电导检测,可以较好地分离所检测焦磷酸根和三偏磷酸根.该方法操作简单,检出限为10 mg/kg,当水产品中添加多聚磷酸盐标准物质浓度达到10～1000 mg/kg范围时,回收率在70%～110%之间,相对标准偏差小于12% .     

The Structure and the Properties of Polyphosphates Recieved by Gasophase Method on Polyoxides Surface

Abstract

The gasophase method of polyphosphate (PPh) synthesis through the reaction between gaseous P₄O₁₀ or mixture P₄O₁₀-activator and surface of polyoxides was developed. The methods of investigation were: IR- and Laser-mass-spectro-scopy, photocolorimetry, X-ray analyse, gravimetry, gel-sol-fraction, and others. The synthesis characteristics of the mono- or polyoxide (MgO, Al₂O₃, CaO, SiO₂, TiO₂, MnO₂ and other ceramics) systems have been investigated. The structure and physical properties of synthesis products, possibility of their modification by thermo- and photochemical influences, and surface anisotropy of composition have been evaluated. The reaction has diffusion nature. Anisotropy determines the peculiarities of the products properties and modification possibility. The results of the investigations allow us to consider the macromolecular structure of glasslike polyphosphates as chains, which consist of various regularly placed components (ROC), e.g. for Mg-, Al-, Mn- or Ti-PPh tetracyclophosphate is ROC as to Si-PPH-it is copolymer with structure ROC in the form of Si-pyropnosphate. PPh structure and the degree of PPh sewing synthesized on polyoxide ceramic surface have been determined mostly by the composition of ceramics. Thus PPh is presented by polytetracyclophosphate of aluminium and by pyrophosphate, of silicon on “Al₂O₃-ceramic” surface (Al₂0₃ + SiO₂). The chains sewing takes place by the mechanism of substitution (by atoms of Mg, Al, Si) or introduction (Ca, zn). The present method has been applied for protection of ceramics by thin films and other coatings, soldering and obtaining composite materials.     

Spectroscopic and Morphological Study of Irradiated PVC Films Doped with Polyphosphates Containing 4,4'-Methylenedianiline

Russian Journal of Applied Chemistry - Polyphosphates containing 4,4'-methylenedianiline moiety were synthesized and their use as polyvinyl chloride (PVC) additives to enhance PVC...     

Biomedical applications of derivative spectroscopy

The value of spectroscopic data can be enhanced by transformation to the second or higher derivative. The impact of this new computer-aided approach in analytical spectroscopy on the biomedical sciences is assessed.     

Biomedical Investigations of Biodegradable PHAs

This work is a review of the results of biomedical studies of polymer devices (films, fibers, microparticles, 3D implants) made from resorbable PHAs synthesized by the bacterium Wautersia (Ralstonia) eutropha B5786, using the technology developed at the Institute of Biophysics of the Siberian Branch of the Russian Academy of Sciences. Two types of PHAs – polyhydroxybutyrate (PHB) and a hydroxybutyrate/hydroxyvalerate copolymer (PHB/PHV) – have been proven to be biocompatible in vitro in cultures of fibroblasts, endothelial cells, hepatocytes, and osteoblasts, and in short- and long-duration experiments on animals. Polymer films and membranes have been found to be usable as scaffolds for functioning cells and monofilament suture fibers – for stitching muscular-fascial wounds and in abdominal surgery. Ectopic bone formation assay and experiments with the model of segmental osteotomy showed that 3D PHB and PHB/HA implants can be used for reparative osteogenesis. The paper reports beneficial results of using polymers to repair bone defects in oral surgery.