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1.
Aavo Aaviksaar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):47-50
Abstract Structure-activity relationships in inhibition of acetylcholinesterase by organophosphorus compounds (YO)(Z)P(O)SX have been analyzed using the equation log ki = C + ρσ + ?π with Taft σ* for substituent elehtronegativity and Hansch Π for hydrophobicity. The obtained relationships have been used for optimizing the structures of organophosphorus inhibitors for their maximum anticholinesterase activity. 相似文献
2.
以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为原料,经醚化、肼解、成盐、关环和席夫碱反应合成了20个新型的含1,2,4-三唑-5-硫酮席夫碱的1,2,4-三唑并[1,5-a]嘧啶类化合物,通过IR,1H NMR,MS和元素分析对所合成的化合物进行了结构表征.初步生物活性测试结果表明,部分化合物表现出一定的抑菌或较好的抗烟草花叶病毒(TMV)活性.在500μg/mL浓度下,化合物6b,6f和6p对TMV的抑制率分别为41%,43%和40%. 相似文献
3.
Ali A. El-Emam Jochen Lehmann 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):473-474
ABSTRACT -The reaction of 3-(1-adamantyl)-4-methyl-1,2,4-triazole-5-thiol 1 with certain 2-aminoethyl chlorides in alkaline medium yielded a separable mixture of the S-(2-aminoethyl) derivatives 2 and the N-(2-aminoethyl) derivatives 3. Meanwhile, alkylation of 2-(1-adamantyl)-1,3,4-oxadiazole-5-thiol 4 with 2-aminoethyl chlorides under the same conditions yielded only the S-alkyl derivatives 5. Interaction of 4 with primary or secondary amines and formaldehyde solution yielded the corresponding N-aminomethyl derivatives in high yields. 相似文献
4.
M. Mikołajczyk Piotr Bałczewski P. Graczyk 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-2):225-228
Abstract Synthesis, reactivity and conformation of cyclic S,S-thioacetals of formylphosphonates are described. The chemistry of α-trimethylsilyl-α-methylthiometanephosphonate is briefly discussed. 相似文献
5.
E. Niecke O. Altmeyer D. Barion R. Detsch C. Gåtner J. Hein 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):321-324
Abstract Novel iminophosphane derivatives are synthesized by nucleophilic displacement from Cl-P=NMes*. Structures, spectroscopic data, and novel chemical reactions of these compounds are discussed. Furthermore, synthesis of stable cis- and trans isomers of a diphos phene, as well as their mutual interconversion, is reported. 相似文献
6.
Sewara J. Mohammed Akam K. Salih Mohammad Amin M. Rashid Khalid M. Omer Karzan A. Abdalkarim 《Molecules (Basel, Switzerland)》2020,25(22)
In this study, a novel 1,3,4-thiadiazole derivative containing 3-mercaptobutan-2-one and quinazolin-4-one moieties (Compound 3) is synthesized by the coupling of 2-amino-1,3,4-thiadiazole-5-(3-mercaptobutan-2-one) (Compound 1) with 2-Phenyl-4H-3,1-benzoxazin-4-one (Compound 2) in one molecule moiety. Compound 3 is found to exist as two types of intra-molecular hydrogen bonding with keto-enol tautomerism characters, which is further confirmed using FTIR, 1H-NMR, 13C-NMR, mass spectrometer, and UV-Visible spectra. The 1H-NMR and UV-Visible spectra of Compound 3 are investigated in different solvents such as methanol, chloroform, and DMSO. Compound 3 exhibits keto-enol tautomeric forms in solvents with different percentage ratios depending on the solvent polarity. The 1H-NMR and UV-Visible spectral results show that Compound 3 favors the keto over the enol form in polar aprotic solvents such as DMSO and the enol over the keto form in non-polar solvents such as chloroform. The 13C-NMR spectrum gives two singles at δ 204.5 ppm, due to ketonic carbon, and δ 155.5 ppm, due to enolic carbon, confirming the keto-enol tautomerism of Compound 3. Furthermore, the molecular ion at m/z 43 and m/z 407 in the mass spectrum of Compound 3 and fragmentation mechanisms proposed reveal the existence of the keto and enol forms, respectively. 相似文献
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Krystyna Zygo Wanda Wieczorek K. Michał Pietrusiewicz 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1)
Abstract Macrocyclic systems containing phosphine. phosphoryl or thiophosphoryl functions in the ring demonstrate high ability to complex metal ions Complexed structures of this type show interesting Fatalytic properties and can be used in homogenous and heterogenous catalysis[1,2] Macrocyclic compounds containg phosphorus are also useful as complexing agents for ammonlum salts. anions. etc [3,4] Generally three types of reactions are used to synthesize phosphorus containing macrocyclic compounds the cyclocondensation, the ring opening reaction and the reaction with metal as a matrix[5]. We have devoloped a new procedure for the synthesis of the title systems of different sizes and of different P and S contents It is based on a double conjugate addition of dithiolates to divlnyl phosphine oxides and sulfides and makes use of the so-called “cesium effect”. 相似文献
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WEN Li-rong LI Ming WANG Shu-wen ZHANG Shu-sheng ** LI Xue-mei OUYANG Ping-kai . College of Life Science Pharmaceutical Engineering Nanjing University of Technology Nanjing P. R. China . College of Chemistry Molecular Engineering Qingdao University of Science Technology Qingdao P. R. China 《高等学校化学研究》2004,20(6):722-724
The crystal structure of 5-nitro-4-salicylideneamino-3-methyl-1,2,4-triazole-5-thione ([C10H9N5O3S]·HCON(CH3)2, Mr=352.38)(CCDC No. 216094) was determined by the single crystal X-ray diffraction method. The crystal belongs to a triclinic system, the space group is P1 with unit cell constants a=0.6113(2) nm, b=1.0836(4) nm, c=1.3132(5) nm, α=74.523(7)°, β=117.68(3)°, γ= 79.769(7)°, V=0.8245(5) nm3, Z=2, Dc=1.419 g/cm3, μ=0.228 mm-1, F(000)=368, R and wR are 0.0579 and 0.1040, respectively, beasd on 3348 unique reflections of which 1925 reflections were observed[I>2σ(I)]. The results indicate that the title compound can be assigned to the thione tautomeric form rather than the thiol tautomeric form. It contains a five membered triazole ring and a phenyl ring with a dihedral angle of 4.35°. The intermolecular hydrogen bond N3-H3…S1, O1-H1…O4 can be observed. 相似文献
10.
Issa Yavari Abdolali Alizadeh Mohammad Anary-Abbasinejad 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2379-2383
The addition of triphenylphosphine to methyl propiolate, ethyl propiolate, or ethynyl methyl ketone in the presence of a strong NH-acid, such as 5-nitro-2,4-dihydro-3 H -1,2,4-triazol-3-one, leads to stable 1,6-diionic organophosphorus compounds in excellent yields. 相似文献
11.
AGNTO的制备和分子结构 总被引:8,自引:0,他引:8
通过3-硝基-1,2,4-三唑-5-酮(NTO)与氨基胍重碳酸盐反应制备NTO氨基胍盐,并用X射线衍射、元素分析、红外光谱对其进行了表征.晶体属于单斜晶系,空间群为P21/n.晶体学参数为:a=0.67870(10)nm, b=2.7915(4)nm, c=1.2739(2)nm; β =96.930(10) V=2.3959(6)nm3, Z=12, Dc=1.698 g•cm -3, μ( Mo K )=1.47 cm -1, F(000)=1272.晶体结构经全矩阵最小二乘法修正,最终偏离因子R=0.0352, wR =0.0718.该盐是一种具有广泛应用前景的产气剂材料. 相似文献
12.
Elvira Batyeva Lidiya Kursheva Liliya Frolova Victor Dunaev 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):373-375
Abstract New sulfur- and phosphorus containing metal complexes have been obtained by means of reactions of trialkyl- and triaryltrithiophosphites with transition metal halides. Their reactions with proton containing and carbonyl compounds have been studied. 相似文献
13.
D. V. Kryl'sky Kh. S. Shikhaliev V. V. Pigarev A. S. Solovyev 《Chemistry of Heterocyclic Compounds》2002,38(8):992-993
We have established that when acetone cyanohydrin is heated with thiosemicarbazide in aqueous medium, 3-mercapto-6,6-dimethyl-1,2,4-triazin-5-one and 2-methyl-2-thiosemicarbazidopropanoic acid are formed. Cyclization of the latter in dioxane in the presence of H3BO3 leads to 2-amino-5,5-dimethyl-1,3,4-thiadiazin-6-one. 相似文献
14.
Hıkmet Ağirbaş Yeşim Kara 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1435-1443
13C chemical shifts of C═N, C═O and C═S carbons of 3,4-disubstituted-1,2,4-oxadiazole-5-ones(thiones) and 3,4-disubstituted-1,2,4-thiadiazole-5-ones have been determined in CDCl3 solution. Exceptionally good Hammett correlations of 13C NMR chemical shifts of these carbons with σ were obtained. The negative ρ values observed (inverse substituent effects) indicate π-polarization of the C═N, C═O and C═S bonds. As expected, the long distance C═O and C═S 13C chemical shifts were found less susceptible to substituent-induced electronic changes. 相似文献
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在常压、298.15 K条件下, 用RD496-2000微量热仪开展了3-硝基-1,3,4-三唑-5-酮(NTO)金属(Li, Na,Pb, Cu)盐制备反应的热动力学研究, 得到了反应过程中的热力学参数(活化焓、活化熵和活化自由能), 速率常数和动力学参数(活化能、指前因子和反应级数), 还得到了在25-40℃范围内NTO金属(Li, Na, Pb, Cu)盐制备反应过程的反应焓. 结果表明, NTO金属(Li, Na, Pb, Cu)盐的制备反应较容易发生. 基于Hess定律, 得到了ΔfHm0 (Li(NTO)·2H2O, aq, 298.15 K)和ΔfHm0 (Na(NTO)·H2O, aq, 298.15 K)的值. 相似文献
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G. T. Sukhanov G. V. Sakovich A. G. Sukhanova A. Yu. Lukin 《Chemistry of Heterocyclic Compounds》2005,41(8):994-998
The reaction of 3-nitro-1,2,4-triazole and 5-methyl-3-nitro-1,2,4-triazole with dimethyl sulfate leads to mixtures of N-mono-
and N,N-dimethylnitrotriazolium compounds and products of the subsequent conversion of the latter, namely, N,N-dimethyl-1,2,4-triazol-5-ones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1168–1173, August, 2005. 相似文献
20.
Xie Yi Hu Rongzu Zhang Tonglai Li Fuping 《Journal of Thermal Analysis and Calorimetry》1993,39(1):41-51
Three new rare-earth metal (Pr, Nd and Sm) salt hydrates of 3-nitro-1,2,4-triazol-5-one (NTO) were prepared and characterized. The thermal behaviour of the three salt hydrates, M(NTO)3·nH2O (M=Pr and Nd,n=9;M=Sm,n=8) were studied by means of TG and DSC under conditions of linear temperature increase. The thermal decomposition intermediates were determined by means of IR, MS and X-ray diffraction spectrometry. The thermal decomposition mechanisms of these hydrates were proposed as follows:
We express our thanks to Professor Zhu Chunhua, Associate Professor Fu Xiayun, and Lecturers Fan Tao and Liang Yanjun for their help in this work. 相似文献