Trimethylphenylammonium Tribromide as a New and Efficient Oxidizing Agent for the Oxidative Coupling of Thiols into Disulfides and Chemoselective Oxidation of Sulfides into Sulfoxides

Abstract

Trimethylphenylammonium tribromide has been introduced as a versatile and new oxidizing agent for the preparation of disulfides and sulfoxides from thiols and sulfides, respectively. The reaction progress is simple, and proceeds under mild and homogenous conditions in ambient temperature.

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Synthesis of Phosphorylated Enaminoketones and Their Application in the Preparation of Trifluoromethyl-Functionalized 2-Phosphonopyrroles

Abstract

New trifluoromethyl-functionalized 2-phosphonopyrroles were obtained by 5-exotrig cyclization of trifluoromethyl and phosphonyl functionalized enaminoketones.

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Efficient Organic Transformations Mediated by ZrOCl2·8H2O in Water

Abstract

Operationally simple and environmentally benign methods for some organic transformations comprising reductive coupling of sulfonyl chlorides, chemoselective deoxygenation of sulfoxides, and halogenation of alcohols mediated by ZrOCl₂·8H₂O/MX in water have been developed.

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Regioselective Syntheses of 1-Aryl-substituted-5H-[1,3]thiazolo[3,2-a]quinazoline-5-ones During Sonogashira Coupling

Abstract

Reaction of 2-mercaptopropargylquinazoline-4-one with various aryliodides catalyzed by Pd–Cu leads to the regioselective formation of 1-arylsubstituted-5H-[1,3]thiazolo-[3,2-a]quinazoline-5-ones.

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New Routes to β-Iminophosphonates,Phosphineoxides, and Sulfides

Abstract

Two synthetic methods leading to β-iminophosphonates, phosphineoxides, and sulfides 2 are reported. The first method involves the reaction of imines with chlorophosphines and phosphites followed by oxidation or sulfurization. The second one utilizes the reaction of imines with diethylchlorophosphate and thiophosphate. The stereochemistry of the obtained products is discussed, and their structure is confirmed by NMR (¹H, ³¹P, ¹³C) and IR spectroscopies, and by mass spectrometry.

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Synthesis of Dialkyl Phosphorylsuccinates from the Reaction of Thiouracil Derivatives with Dialkyl Acetylenedicarboxylates in the Presence of Trialkylphosphites

Abstract

Dialkyl-2-(dialkoxyphosphonyl)-3-(1,6-dihydro-6-oxo-4-propylpyrimidin-2-ylthio) succinates and dialkyl-2-(dialkoxyphosphonyl)-3-(1,6-dihydro-6-oxopyrimidin-2-ylthio) succinates were synthesized in moderate to high yields using a novel, facile, and one-pot condensation of dialkyl acetylenedicarboxylates, trialkylphosphites, and thiouracil derivatives.

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Synthesis and Characterization of Novel Quinazoline-Substituted 1,3,4-Thiadiazolium-5-thiolates

Abstract

Novel 3-[4-(6-bromo-4-oxo-2-phenylquinazolin-3(4H)-yl)benzoyl]-2-substituted-1,3,4-thiazolium-5-thiolate 7(a–j) and 3-{4-[(6-bromo-2-phenylquinazolin-4-yl)amino] benzoyl}-2-substituted-1,3,4-thiadiazolium-5-thiolate 12(a–j) were synthesized from 6-bromo-2-phenyl-4H-3,1-benzoxazin-4-one (1). The structures of the newly synthesized compounds were confirmed by spectral data and elemental analysis.

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Photolysis of 2-(Triorganostannyloxy)-3,6-di-tert-butyl-benzquinone-1,4 in Alkanes Solution

Abstract

Photolysis of 2-(trimethylstannyloxy)-3,6-di-tert-butyl-benzquinone-1,4 (I), 2-(triphenylstannyloxy)-3,6-di-tert-butyl-benzquinone-1,4 (II), and 2-(tribenzylstannyloxy)-3,6-di-tert-butyl-benzquinone-1,4 (III) by light with the wavelength 436 nm leads to the evolution of carbon mono- and dioxide and the formation of hydrocarbon radicals with their consequent recombination.

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A Convenient Synthesis of Thiazolidin-2-ones from Thiazolidine-2-thiones: Antibiotic Activity and Revisiting the Mechanism

Abstract

Various substituted thiazolidin-2-ones were synthesized from the corresponding thiazolidine-2-thiones with bromoethanol in ethanol with sodium ethoxide as a base. The optimal reaction conditions and mechanism were reinvestigated in detail. The bioassay indicated that (S)-4-isobutyl and (S)-4-benzylthiazolidin-2-ones show certain inhibitive activities against Candida albicans and Escherichia coli.

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The Synthesis of Novel S-, S,S-, S,S,S-, and N,S-Substituted Nitrodienes from Polyhalonitrodienes and Thiols

Abstract

The novel S-, S,S-, and S,S,S-substituted nitrobutadienes were synthesized from the reactions of 2-nitrobutadiene compounds with some thiols. The new N,S-substituted nitrobutadienes were obtained from the reaction of the mono-thiosubstituted butadienes with morpholine, thiomorpholine, homopiperazine, and piperazine derivatives. The structures of new compounds were determined by spectroscopic techniques.

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Solvent-Free,Efficient, and High Regioselective Conversion of Epoxides to Symmetrical and Unsymmetrical vic-Dihalides Using Chlorodiphenylphosphine and N-Halosuccinimides

Abstract

A new method is described for the efficient and high regioselective conversion of epoxides to symmetrical and unsymmetrical vic-dihalides in high yields using chlorodiphenylphosphine and N-halosuccinimides under solvent-free and neutral conditions and at room temperature.

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