Optimisation de la Synthèse des Apatites Phosphocalciques Vectrices D’antiseptiques Élaborées à Partir du Nitrate de Calcium et de L’Acide Phosphorique

Oxygenated phosphocalcic apatite is an apatite with an excellent biocompatibility, osteoconduction, and having antiseptic properties able to limit the proliferation of the micro-organisms in the site implementation, without using an antibiotic. However, the synthesis of this apatite encounters several difficulties. On one hand, it depends on many factors such as pH of the reaction, atomic ratio Ca/P of the reagents, temperature of the reaction (T), duration of reaction (D), and concentration in ions calcium ([Ca²⁺]). On the other hand, the product to be developed must have a chemical composition allowing it a dissolution speed in compliance with the bone neoformation and having antiseptic properties.

Aiming to control the synthesis of these apatites and to limit the number of experiments necessary to this study, we applied the methodology of the experimental designs. The mathematical models elaborated in this study allowed us to forecast the optimum conditions of the oxygenated phosphocalcic apatite synthesis.

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