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1.
4个新型有机磷缩合试剂的合成及其在生物活性肽合成中的应用 总被引:2,自引:0,他引:2
报道了4个新型有机磷化合物:N-二乙氧基磷酰苯并唑酮(DEPBO)、N-(2-氧-1,3,2-二氧杂磷杂环乙烷基)-苯并唑酮(DOPBO)、3-(2'-氧-1',3',2'-二氧杂磷杂环己烷基)-氧-1,2,3-苯共三嗪-4(3H)-酮(DOPBT)和3-(二乙氧基磷酰基)-氧-1,2,3-苯并三嗪-4(3H)-酮(DEPBT)的合成,并研究了它们作为缩会试剂在多肽合成中的应用. 研究结果表明,它们可以成功地用于固相法和溶液法合成多肽,其中DEPBT还可用于环肽的合成. 应用DEPBO和DEPBT合成了促睡眠肽的类似物及从云南中草药繁缕中分离鉴定的一个环七肽等生物活性肽. 相似文献
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Masaaki Yoshifuji 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6-7):1827-1831
Low-coordinate organophosphorus compounds can be prepared by steric protection. They are diphosphenes, phosphaethenes, phosphaallenes, phosphabutatrienes, phosphaalkynes, and so on, of coordination number 2 and 1 . 相似文献
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XU Liang-zhong XU Zhong-jie ZHANG Gong-sheng ZHOU Kai ZHAI Zhi-wei College of Chemistry Molecule Engineering Qingdao University of Science Technology Qingdao P. R. China 《高等学校化学研究》2008,24(5):575-578
With dimethomorph and flumorph as the leading compounds, four novel acrylamide compounds with two types of structure were designed and synthesized by means of the method of "me too chemistry". The target compounds were characterized by 1H NMR, IR, MS, and elemental analysis. The influences of solvent and raw material on the yield were investigated and optimum processing conditions were determined. The results of preliminary biological tests show that all those compounds exhibit certain antifungal activities. 相似文献
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IntroductionOrganophosphoruscompoundsarewidelyusedasin secticides ,herbicidesandfungicides .Inviewofthepos sibleinfluenceoffluorinesubstitutiononthebiologicalactivityoforganophosphoruscompoundswehaveturnedourattentiontothestudyofthesynthesisandbiologica… 相似文献
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以2-[1,2-二(2-羟基苯甲氨基)-2-(吡啶基)乙基]苯酚和2-[1,2-二(2-羟基苯甲氨基)-4-(吡啶基)乙基]苯酚为原料,分别与乙二醛经缩合反应,合成了两个新型的哌嗪化合物--2-【{12-(2-吡啶基)-3,20-二氧-11,21-二氮杂五环[11.7.1.O2,11.O4,9.O14,19]二十一-4,6,8,14,16,18-六环-21-基}甲基】苯酚(2a)和2-【{12-(4-吡啶基)-3,20-二氧-11,21-二氮杂五环[11.7.1.O2,11.O4,9.O14,19]二十一-4,6,8,14,16,18-六环-21-基}甲基】苯酚(2b),其结构经1H NMR, 13C NMR, FT-IR, ESI-MS和X-射线单晶衍射表征。2a(CCDC: 1 439 422)属单斜晶系,空间群P21/n,晶胞参数a=12.250 2(16) , b=10.299 6(13) , c=18.296(2) , β=95.798(2)°, V=2 296.6(5) 3, Dc=1.341 mg·cm-3,Z=4, F(000)=976, μ=0.088 mm-1。 相似文献
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John J. Morelli Somayajula K. Viswanadham Andrew. G. Sharkey JR. David M. Hercules 《International journal of environmental analytical chemistry》2013,93(2-4):295-323
Abstract Laser mass spectra obtained for 20 organophosphorus (OP) compounds were systematically evaluated for groups containing analogous structural features. Variations in fragmentation can be understood based on simple organic reactions. While detailed mechanistic interpretations of the laser mass spectra (LMS) were not possible, the qualitative features in the LMS obtained from five compounds, not in the original set, could be predicted based on the characteristics of the other OP compounds studied. The success of the prediction lends credence to the qualitative models developed for rationalizing the LMS. A specific feature in the LMS of aromatic thionophosphates is a thiono-thiolo rearrangement. Detailed investigation into the phenomena involved comparison of LMS obtained from aromatic thionophosphates with spectra from electron impact, chemical ionization, field desorption, and secondary ion mass spectrometry. These results led to the conclusion that the rearrangement in laser mass spectrometry must occur during volatilization while the molecule/ion is in the “cloud” present immediately above the laser impact area. 相似文献
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Erika Bálint Eszter Fazekas Judit Takács Ádám Tajti Amadej Juranovič Marijan Kočevar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-3):48-50
Abstract Kabachnik-Fields reactions of a variety of amines, phospha-Michael additions to maleimide derivatives and alcoholysis of dialkyl phosphites were studied under microwave conditions. 相似文献
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利用Vilsmeier-Haak反应得到活性中间体,取代-4-甲酰基吡唑;将其与芳氧乙酰肼反应,合成5个吡唑腙类化合物3,再经关环反应,制得5个吡唑类双杂环化合物4。所有新化合物的结构均经IR,1H NMR,MS和元素分析确证了结构。对新化合物3,4分别进行了棉花枯萎病菌、棉花黄萎病菌、棉花立枯病菌、瓜果腐霉病菌、番茄早疫病菌、向日葵菌核病菌等初步的抑菌活性测试,结果表明,吡唑类双杂环化合物4的抑菌效果明显高于吡唑腙化合物3。在质量浓度为50mg/L时,3d、3e对番茄早疫病菌、向日葵菌核病菌有较好的抑制效果(﹥80%);双杂环化合物4对6种病菌均有明显的抑制效果(﹥70%),其中4d、4e对棉花立枯病菌的抑制率大于95%。 相似文献
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本文设计合成了四核环金属化钯-偶氮配合物(MOP)作为有机磷农药的分辨性光学分子探针, 应用于硫磷类农药组分的分辨性光谱识别. 相似文献
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Zn(NCS)2‐3‐cyanopyridine Coordination Compounds: Synthesis,Crystal Structures,and Thermal Properties
The reaction of different stoichiometric amounts of Zn(NCS)2 with 3‐cyanopyridine in different solvents leads to the formation of several new coordination compounds, which were structurally characterized and investigated for their thermal behavior. In Zn(NCS)2(3‐cyanopyridine)4 ( 1 ) and Zn(NCS)2(3‐cyanopyridine)2(H2O)2 · (3‐cyanopyridine)2 ( 2 ) the zinc cations are octahedrally coordinated by two terminally N‐bonded thiocyanate anions and four 3‐cyanopyridine ( 1 ) or two 3‐cyanopyridine and two water molecules ( 2 ) within slightly distorted octahedra. Zn(NCS)2(3‐cyanopyridine)2 ( 3 ) and Zn(NCS)2(3‐cyanopyridine)2 · (H2O)0.5 ( 3‐H2O ) also form discrete complexes but with tetrahedrally coordinated Zn cations. Upon heating compound 1 decomposes without the formation of any intermediate compound. In contrast, compound 2 loses the water molecules in the first step and transforms into compound 1 . Surprisingly, upon further heating a second TG step is observed, in which compound 3 is formed as an intermediate, which is not observed if compound 1 is heated directly. The tetrahedral complex 3 melts leading to the formation of an amorphous phase. If the hemihydrate 3‐H2O is heated, it transforms into 3 via melting and crystallization but there are hints that a metastable phase might form as intermediate on water removal. 相似文献
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Marijana Jukić Antonija Hergold-Brundić Mario Cetina Ante Nagl Jasna Vorkapić-Furač 《Structural chemistry》2003,14(6):597-604
Novel pyridoxal oxime derivatives were prepared and characterized by means of IR, 1H and 13C NMR spectroscopy. The crystal structures of the 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-1,2-dimethylpyridinium iodide 1 and 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-1,2-dimethylpyridinium chloride monohydrate 2 were determined by X-ray analysis. The both compounds crystallize in the triclinic crystal system, space group P
. Crystal data: 1
a = 6.286(2) Å, b = 8.748(4) Å, c = 11.736(4) Å, = 104.02(3)°, = 94.70(3)°, = 107.44(6)°, V = 589.0(4) Å3, Z = 2, R = 0.0526; 2
a = 6.8980(5) Å, b = 8.6409(6) Å, c = 11.1777(6) Å, = 111.138(5)°, = 93.114(6)°, = 105.158(5)°, V = 591.57(7) Å3, Z = 2, R = 0.0492. The bond distances and angles in both structures agree very well. The main difference between these structures was observed in the orientation of the hydroxymethyl group with respect to the pyridinium ring. In the both structures intramolecular hydrogen bond forming six-membered ring were observed. The intermolecular OsI hydrogen bonds in the crystal structure of the compound 1 form dimers. In the crystal structure of compound 2, the water molecules and chlorines build eight-membered rings, which are also connected to pyridinium cations by OsCl and OsO intermolecular hydrogen bonds forming a three-dimensional network. 相似文献
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Nickolay I. Tyryshkin Alexander I. Konovalov Viktor V. Gavrilov Nina A. Polezhaeva 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):553-556
Abstract Synthesis of functionally substituted organophosphorus compounds on the basis of reactions of the tri-n-butylphosphine/carbon disulfide, tri-n-butylphosphine/phenylisothiocyanate, tris(dimethylamino)phosphine/phenylisothiocyanate adducts with a wide range of different dipolarophiles are reported. The development of application of S-Li tri-n-butylphosphonio-dithioformiate derivatives to the synthesis of new types of organophosphorus compounds are reported. 相似文献
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Łukasz Albrecht Dr. Anna Albrecht Dr. Henryk Krawczyk Prof. Dr. Karl Anker Jørgensen Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(1):28-48
240 Years have passed since the discovery of elemental phosphorus. During that time organophosphorus chemistry has emerged as an interesting and exciting field of research. Recently organophosphorus chemistry has been raised to a new level. Organophosphorus compounds have found applications in asymmetric organocatalysis for the synthesis of optically active compounds of synthetic or biological importance. The aim of this review article is to present recent contributions to this developing field of chemistry and to point out synthetic advantages of methodologies developed so far. 相似文献
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以苯并噻唑、苯乙酰基和吡啶阳离子为电子受体,二乙烯基苯为共轭桥,合成了两个新的A-π-A′型苯并噻唑衍生物:4-(2-苯并噻唑)-乙烯基查尔酮(1)和4-{4-[2-(苯并噻唑)乙烯基]苯乙烯基}-N-甲基吡啶碘盐(2).研究了它们在溶液和固体基质中的光物理性质.研究发现:染料2由于具有较强的极性和较好的平面性,从而具有较长的吸收、发射峰和较强的荧光发射.有机染料在聚甲基丙烯酸甲酯/溶胶-凝胶复合玻璃中的发光行为与聚甲基丙烯酸甲酯和溶胶-凝胶玻璃二者的基质性质有关,同时由于固体基质中分子发生聚集的可能性降低,荧光强度相对于同浓度溶液增强,稳定性提高. 相似文献
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Xingxing Lu Huan Xu Xiaoming Zhang Tengda Sun Yufan Lin Yongheng Zhang Honghong Li Xuesheng Li Xinling Yang Hongxia Duan Yun Ling 《Molecules (Basel, Switzerland)》2022,27(18)
Neonicotinoids are important insecticides for controlling aphids in agriculture. Growing research suggested that neonicotinoid insecticides are a key factor causing the decline of global pollinator insects, such as bees. Flupyrimin (FLP) is a novel nicotinic insecticide with unique biological properties and no cross-resistance, and is safe for pollinators. Using FLP as the lead compound, a series of novel compounds were designed and synthesized by replacing the amide fragment with a sulfonamideone. Their structures were confirmed by 1H NMR, 13C NMR and HRMS spectra. Bioassay results showed that compound 2j had good insecticidal activity against Aphis glycines with an LC50 value of 20.93 mg/L. Meanwhile, compound 2j showed significantly lower acute oral and contact toxicity to Apis mellifera. In addition, compound 2j interacted well with the protein in insect acetylcholine binding protein (AChBP). The molecular docking on honeybee nicotinic acetylcholine receptor (nAChR) indicated that the sulfonamide group of compound 2j did not form a hydrogen bond with Arg173 of the β subunit, which conforms to the reported low bee-toxicity conformation. In general, target compound 2j can be regarded as a bee-friendly insecticide candidate. 相似文献
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K.M. Pietrusiewicz M. Zabłocka W. Wisniewski 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):263-266
Abstract A large variety of structurally diversified optically active phosphine oxides can be derived from a single readily available homochiral (-)-S-methylphenylvinylphosphine oxide through elaboration of its versatile vinyl functionality. 相似文献