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Gary M. Coppola 《合成通讯》2013,43(9):995-1008
The synthesis of 1,2-dialkyl-3-phenyl-4-quinolinones (1) is readily accomplished by a low-temperature reaction of an N-alkylisatoic anhydride with the therraodynamic potassium enolate of phenyl-acetone. The reaction has also been extended to encompass the synthesis of the more complex 2-(3-hydroxy-propyl)-3-(4-fluorophenyl)-1-methyl-4(1H)-quinolinone (10). 相似文献
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Abstract Conformational behaviour of about 30 2-methoxy-2-oxo-1,2- oxaphospho l an-3-0 1 s containing various substituents was examined by 1H and 13C NMR. Vicinal coupling constants J(HCCH), J(HCCP), J(HCOP), J(CCOP) and J(CCCP) were employed in this study. Conformation of the 1,2-oxaphospholane ring is governed almost exclusively by substituents at C-3, C-4 and C-5, as we l l as by their orientation. The configuration of the P atom has little or no influence on conformation of the ring in diastsreomeric pairs. Strong preference of phenyl, methyl and substituted methyl groups to occupy the equatorial or pseudoequatoria l positions was observed for all but one compounds studied. In the cis-fused bicyclic syst ems conformat ionally rigid 6-membered rings forced the 1,2-oxaphospholane rings to adopt an enve l ope-l ike (E4) conformation. No influence of the p=o……HO-C-3 hydrogen bond on conformation of the 1,2-oxaphospholane ring was found. Preferred conformations for (2R, 3R, 4R)-3-(hydroxymethyI)-2-methoxy-2-oxo-1,2-oxaphospho lane-3,4-diol and its triacetate are shown below. 相似文献
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Sakram B. Madhu P. Sonyanaik B. Rambabu S. Ravi D. Kurumanna A. 《Russian Journal of General Chemistry》2018,88(6):1224-1227
Russian Journal of General Chemistry - A new methodology has been developed for the synthesis of novel 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylates from 2-aminonicotinaldehyde,... 相似文献
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The utility of commercially available, inexpensive 3-ethoxyacrylonitrile (1) as a precursor for the synthesis of 5-alkylcytosines was investigated. Metalation of 1 affords a 2-lithio derivative of sufficient stability to allow alkylation with allylic or benzylic bromides and primary iodides which are unbranched at the β-position. The alkylated derivatives are converted to 5-alkylcytosines in modest yield by exposure to sodium ethoxide and urea in ethanol. 相似文献
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sym-Triazine Derivatives. 2. Synthesis, Properties, and Structure of 2-Oxo-1,2-dihydro-sym-triazines
S. N. Mikhailichenko A. A. Chesniyuk V. E. Zavodnik S. I. Firgand L. D. Konyushkin V. N. Zaplishny 《Chemistry of Heterocyclic Compounds》2002,38(3):292-299
Previously unreported 2-oxo-1,2-dihydro-sym-triazines have been prepared and their alkylation reactions have been studied. It was found that, independently of the structure and nature of the substituent in positions 4 and 6 of the triazine ring or the structure of the alkyl halide used, the reaction occurs regioselectively at the oxygen atom. The stereostructure of the 2-oxo-1,2-dihydro-sym-triazines was investigated by X-ray analysis and it was shown that they exist as dimers in the crystalline state. 相似文献
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Daniel Barillier 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):251-255
Abstract Sulfurization of 2-acetoxy or 2-benzoyloxy-1,3-propanediones gives the corresponding 1,2-dithiolylium salts which are used as starting materials for preparation of 1,2-dithiolylium-4-olates. The reaction was studied under different conditions in order to obtain the best sulfurization yields. A new 3-p-dimethylaminophenyl-5-phenyl-1,2-dithiolylium-4-olate is also described. It is formed by nucleophilic attack on a 3-alkylthio substituted or a 5 unsubstituted position of a 1,2-dithiolylium ion by N, N-dimethylaniline. 相似文献
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Martinez M. G. Klimova-Berestneva T. Damian-Zea K. Meleshonkova N. N. Klimova E. I. 《Russian Journal of General Chemistry》2002,72(7):1132-1140
8-Acetyl-7-aryl-2-arylmethylene-8,9-diaza- and 4,8,9-triazabicyclo[4.3.0]non-9-enes react with4-phenyl-4,5-dihydro-3H-1,2,4-triazole-3,5-dione, following the ene addition pattern. Under similar conditons 7-aryl-2-arylmethylene-8-methyl-8,9-diazabicyclo[4.3.0]non-9-enes give rise to both mono- and polyadditionproducts. The product structures were studied by 1H and 13C NMR, IR, and UV spectroscopy and singlecrystal X-ray diffraction. 相似文献
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Chirkova Zh. V. Kabanova M. V. Makar’ina T. G. Filimonov S. I. Abramov I. G. 《Russian Journal of Organic Chemistry》2019,55(3):287-290
A three-step procedure has been developed for the synthesis of 2-oxo-2,3-dihydro-1H-imidazo-[1,2-a]indole-6,7-dicarbonitriles from substituted 2-amino-1-hydroxy-1H-indole-5,6-dicarbonitriles.
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The reaction of -nitroacetaldehyde with paraformaldehyde or aromatic aldehydes and ammonium acetate in acetic acid yielded 2-aryl-3,5-dinitro-1,2-dihydropyridines. Aromatic aldehydes, in an ethanol and acetic acid mixture, gave isomeric 3,5-dinitro-1,4-dihydropyridines in addition to 1,2-dihydropyridines. Physicochemical properties and reactivities of the compounds have been studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 64–70, January, 1993. 相似文献
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Russian Journal of Organic Chemistry - A green synthesis of 2-oxo-2H-chromene-3-carbonitriles has been carried out in one step by reacting 2-hydroxybenzaldehydes or 2-hydroxyacetophenones with... 相似文献
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1- and 1,3-substituted 3-oxo-2,3-dihydroisoquinolines 4 are obtained from ethyl 2-acylphenylacetates 3 and formamides. 相似文献
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