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1.
IntroductionOrganophosphoruscompoundsarewidelyusedasin secticides ,herbicidesandfungicides .Inviewofthepos sibleinfluenceoffluorinesubstitutiononthebiologicalactivityoforganophosphoruscompoundswehaveturnedourattentiontothestudyofthesynthesisandbiologica… 相似文献
2.
De Cai FU Feng Ming CHU Zong Ru GUO 《中国化学快报》2005,16(10):1305-1308
The fourth generation cephalosporin cefepime I exhibited potent antibacterial activity with board antibacterial spectrum1,2.Based on the structure of cefepime,we synthesized its analogs Ia having fluoro atom at the aminothiazolyl oxime moiety at the7-position of the cephem nucleus,and Ib possessing1-(2-fluoroethyl)pyrrolidium methyl group at the3-position.It was reported that cephalosporin derivatives with a quaternary ammonium moiety at the3-position of the cephem nucleus,showed enhanced ant… 相似文献
3.
JIN Gui-Yu WU Hai-Kun NI Yin-Hai Institute of Elemento-Organic Chemistry Nankai University Tianjin 《有机化学》1993,(3)
α-bromo tert-butylmethyl ketone and 3-substituted 2,2-dimethylcyclopropane carbonylchloride react with phosphites to give the phosphonates 1 and 4 respectitvly. The bromination of 1 isdescribed. 相似文献
4.
N. K. Gusarova A. O. Sutyrina E. A. Matveeva I. V. Sterkhova V. I. Smirnov B. A. Trofimov 《Doklady Chemistry》2018,478(1):5-8
Direct phosphorylation of α-methylstyrene dimer with red phosphorus in KOH/DMSO superbasic system has provided the preparation of 4-methyl-2,4-diphenylpentylphosphonous acid (heating at 105°C for 3 h) or tris(4-methyl-2,4-diphenylpentyl)phosphine oxide (microwave irradiation, 15 min) in 21 and 38% yield, respectively. 相似文献
5.
Abstract The lithium phosphide tetrahydrofurane complexes 1 react with phosphinic acid chlorides (2) to yield diphosphenes (4), possessing a tri- and a quinquevalent phosphorus atom; the diphosphane oxides 3 are regarded to be intermediate steps of the transformation. 相似文献
6.
Nguyen Ngoc-Hong Pham Duc Dung Le Thi-Thanh-Van Nguyen Thi-Anh-Tuyet Huynh Dinh-Long Duong Thuc-Huy Sichaem Jirapast 《Chemistry of Natural Compounds》2021,57(6):1038-1041
Chemistry of Natural Compounds - Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid (1a–1b, 2a–2b, and 3a–3c) were synthesized to study their... 相似文献
7.
A. K. Khalafallah N. A. A. El-Kanzi H. A. Soleiman M. Younis 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2483-2503
A series of some fused and spiro heterocyclic compounds such as pyrazolines, isoxazolines, pyrimidines, β-lactams, and thiazolidinone derivatives incorporating compounds 3, 6a–d, 7a–d, 9a–c, 10a–c, 11a–c, 12a–c, and 13a–c have been synthesized by a cycloaddition and cyclocondensation reaction of monochloroacetyl chloride, mercaptoacetic acid, hydrazines, hydroxylamine, urea, and thiourea with the prepared 5a–d and 8a–c. 相似文献
8.
Dr. Jörn Bruns Prof. Dr. Henning A. Höppe Dr. Michael Daub Prof. Dr. Harald Hillebrecht Prof. Dr. Hubert Huppertz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(36):7966-7980
Borosulfates are oxoanionic compounds consisting of condensed sulfur- and boron-centered tetrahedra. Hitherto, they were mostly achieved from solvothermal syntheses in SO3-enriched sulfuric acid, or from reactions with the superacid H[B(HSO4)4]. The crystal structures are very similar to those of the corresponding class of silicates and their substitution variants, especially regarding the typical structural motif of corner-sharing tetrahedra. However, the borosulfates are supposed to be even more versatile, because (BO3) units might also be part of the anionic network. The following article deals with detailed reports on the different synthesis strategies, the crystal chemistry of borosulfates in comparison to silicates, and their hitherto identified properties. 相似文献
9.
Centella asiatica, as known as Pegagan was previously reported to have anti-hyperglycemic effects in animal diabetic model rats. However, its α-glucosidase activity in vitro assay not yet reported. Our goal in this study is to isolate and identify active compounds as α-glucosidase inhibitor and antioxidant from aqueous ethanol 70% (v/v) extract of C. asiatica. The extract was partitioned by n-hexane, EtOAc, and n-butanol sequentially. Among the fractions tested, EtOAc fraction was showed the highest antioxidant and α-glucosidase inhibitory activities with an IC50 values of 45.42 and 73.17 μg/mL, respectively. The antioxidant activity was conducted by determination of DPPH radical scavenging activity, whereas α-glucosidase inhibitory activity was determined against yeast α-glucosidase. Furthermore, isolation of the ethyl acetate extract yielded two active compounds, which were identified as kaempferol (1) and quercetin (2). Both of the compounds showed good yeast α-glucosidase inhibitory activity with IC50 values of 16.50 and 21.61 μg/mL, respectively. In addition those compounds also could scavenge DPPH radical activity with IC50 values of 9.64 and 11.97 μg/mL, respectively. Due to its ability in reducing α-glucosidase activity and scavenging free radical activity, the C. asiatica appears to be a potential as a good resource for future development of antioxidant and antidiabetic drug. 相似文献
10.
An effective method of synthesizing polyaromatic hydrocarbons with high selectivity was developed through our research work on the photocoupling reactions between several haloaromatic hydrocarbons and aromatic compounds. The structures of polyaromatic hydrocarbons synthesized were determined by IR, UV, ~1H NMR, MS and elemental analysis, and the crystal structure of 3-(1-naphthyl)-coumarin was established by an crystallographic analysis. Further study of the regioselectivity, orientational effect of substituents, solvent effect, sensitizing and quenching effect supported the proposed mechanism of this type of reaction involving election transfer process under excited triplet state. 相似文献
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12.
8, 8-Dimethyl-5, 6, 7,8-tetrahydrophenanthrene-3, 4-dione (3) and 8, 8-dimethyl-2- ( 1-hydroxy ethyl) -5,6, 7, 8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell fine as assayed by in vitro MTT method. 相似文献
13.
Yong An ZHANG Ke Zhong LIU Deng Yuan WANG Yu Zhu WANG Liang Jian QU Chang Jin ZHU 《中国化学快报》2006,17(7):895-898
Sodium ion channels, acetylcholine esterase and neurotransmitter receptors in insect neurons and skeletal muscles are often made as target by practical neurotoxic pesticides. But insects can create resistance after using a pesticide for a long time. So th… 相似文献
14.
Fei DENG Fu Jun ZHANG Ming ZHAO Yi Ping WANG Jin Sheng ZHANG 《中国化学快报》2006,17(9):1177-1180
It has been considered that the lipid peroxidition damage was involved in aging and pathological disorders. Some phases of atherosclerosis, neuronal ceroid lipofuscinosis, intermittent claudication, oxygen toxicity, and liver injury caused by orotic acid, ethanol, phosphorous or chlorinated hydrocarbons have been discussed in relation to lipid peroxidion1-3. We found that a series of unique 4,5-secoditerpenoidal compounds isolated from the medicinal plant Salvia prionitis showed various bioact… 相似文献
15.
Chromophores are the center piece of second order nonlinear optical (NLO) materials. The common chromophore consists of a Donor-Bridge-Acceptor structure. Donors and acceptors are connected by a bridge and together they make a fully conjugated system. Based on our previously synthesized novel acceptors [1], we have synthesized a large number of high electro-optic chromophores. In this paper, we report four general types of chromophore that were synthesized during the last few years in our l… 相似文献
16.
Zakharov S. V. Nuriazdanova G. Kh. Garifzyanov A. R. Galkin V. I. Cherkasov R. A. 《Russian Journal of General Chemistry》2004,74(6):873-881
-Aminophosphoryl compounds of the phosphonate, phosphine oxide, and ,-bis(phosphine oxide) series and some of their thiophosphoryl analogs were synthesized. Potentiometric measurements of the pKa of the conjugate acids revealed an insignificant effect of variation of substituents on the phosphorus, nitrogen, and -carbon atoms on the basicity of the phosphorylated amines. The latter are weak bases. Organophosphorus groups decrease the basicity of the amines by almost 5 pK
a units. The role of the hydrophobic effect and intramolecular H-bonding in the obtained substances was discussed. 相似文献
17.
Michael A. Pudovik Alexander R. Burilov Irina L. Nikolaeva Yana A. Drozdova Dmitriy V. Cherepashkin Alexei A. Barulin 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):219-222
Abstract Phosphorylation and silylation of α -mercaptooarbonyl compounds have been investigated. A novel type of 1.4 S-O migration trimethylsilyl and P(III) groups has been discovered. The thiophosphite-thiophosphonate rearrangement when exposed to oxygen as well as heterocyclization with the formation of 1,3,2-oxathiaphospholenes and 1,3,2-oxathiasilalenes were also found. Some regularities of these processes and the properties of heterocycles synthesized have also been brought out. 相似文献
18.
Ling Guang QIU * An Jian XIE Yu Hua SHEN* School of Chemistry Chemical Engineering Anhui University Hefei Institute of Solid State Physics Chinese Academy of Sciences Hefei 《中国化学快报》2003,14(6):653-656
Gemini surfactants, which contain two hydrophilic groups and two hydrophobic groups in the molecule, are considered as a new generation of surfactants. These surfactants are about 3 orders of magnitude more efficient at reducing surface tension and more than 2 orders of magnitude more efficient at forming micelles than conventional surfactants1. During recent years, many gemini surfactants have been synthesized, and a considerable number of investigations have been reported on their unusua… 相似文献
19.
A series of 1-glycosyl-2-glycosylthiopyrimidine (4), annelated pyrimidine derivatives, pyrazolo[3,4-d]-pyrimidine (8), ditetrazolo[1,5-a;1‘,5‘-c]pyrimidine (9), 2,9a,10-triazaanthracene (12), thieno[2,3-d]pyrimidine (14),9-thia-1,3,5,7-tetraazafluorene-8-one (15), 7-oxa-9-thia-1,3,5-triazafluorene-8-one (16), 5-oxa-9-thia-1,3-diaza-fluorene (21a and 21b) derivatives have been synthesized via a sequence of heterocyclization reactions of suitably functionalized 6-[5-(4-bromophenyl)oxazol-4-yl]-1,2,3,4-tetrahydro-2-thioxo-4-oxopyrimidine-5-carbonitrile (2) with different electrophiles and nucleophiles. The new compounds were prepared with the objective to study their pharmacological properties. 相似文献
20.
Synthesis and Cleavage Activity of Artifical Minic Polypeptides 总被引:2,自引:0,他引:2
Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li Feng CAO Yu Fen ZHAO 《中国化学快报》2006,17(9):1197-1200
Natural product distamycin and netropsin are polyamide containing three N-methyl- pyrrole (Py) moieties. They have ability to binding to the minor groove of A·T-rich sequences of double–helical DNA. Thus, much attention has been attracted to the synthes… 相似文献