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The sponges Raspailia pumila and ramosa (Demospongiae, Tetractinomorpha, Axinellida) from the North-East Atlantic are shown to contain a series of novel long-chain enol ethers of glycerol where the enol ether C?C bond is conjugated, in sequence, to both an acetylenic and an olefinic bond. Polar extracts give raspailynes hydroxylated at their (1Z5Z)-1,5-alkadien-3-ynyl chain, like raspailyne Al ( = (+)-(S)-3-[((1Z,5Z)-16-hydroxy-hexadeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; (+ 2 ) and isoraspailyne A ( = (+)-3-[((1Z,5Z)-17-hydroxyocta-deca-1,5-dien-3-ynyl)oxy]-1,2-[propanediol; (+)- 3 ). Less polar extracts give 3 different types of raspailynes not hydroxylated at the chain. Raspailynes of the first type have either the (1Z,5Z)-configuration in a linear chain such as raspailyne B2 (( = (?)-(s)-3-[((1Z,5Z)-trideca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; (?)-4), raspailyne Bl ( = (?)-3-[((1Z,5Z)-tetradeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol;(?)- 5 ), and raspailyne B ( = 3-[((1Z,5Z)-pentadeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 6 ) or the (1Z,5Z)-pentadeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 6 )or the (1Z,5Z)-configuration in a chain ending with an isopropyl group, like isoraspailyne Bl ( = 3-[((1Z,5Z)-12-methyltrideca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 7 ) and isoraspailyne B ( = 3-[((1Z,5Z)-13-methyltetradeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 8 ). Raspailynes of the second type have the (1Z,5E)-configuration, like isoraspailyne Bla ( =3-[((1Z,5E)-tetradeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 9 ) and isoraspailyne Ba ( = 3-[((1Z,5E)-13-methyltetradeca-1,5-dien-3-ynyl)oxy]-1,2-propanediol; 10 ). Raspailynes of the third type have the (1E,5Z)-configuration, like isoraspailyne Blb ( = 3-[((1E,5Z)-tetradeca-1,5-dien-3-ynyl)oxy]-1,2,-propanediol; 11 ). The (S)-configuration for (+)- 1 ,((+)- 2 , and (?)- 4 is derived from chemical correlations. 相似文献
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Catalytic conversion of unsaturated alcohols to their corresponding aldehydes and ketones with nonacarbonyl diiron in benzene at 40–50 C are performed efficiently in high yields. The efficient preparation of some enol ethers and also preperation of a few esters from their corresponding unsaturated ethers and esters are also performed by this method. 相似文献
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N-乙酰乙酰基吡咯为有机合成上有用的起始原料和中间体。例如,可能作为合成Carbapenam类β-内酰胺化合物的原料。1977年,Wang Nam-Chiang和And- 相似文献
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Acylation of (3H,5H)-tetrahydrothiophene-2,4-dione (thiotetronic acid) with acetyl, propionyl, and valeryl chlorides followed by O-C isomerization in the presence of 4-dimethylaminopyridine or acetone cyanohydrin gave rise to 3-acetyl, 3-propanoyl, and 3-pentanoyl derivatives of thiotetronic acid. The reaction of 3-acylthiotetronic acids with diazomethane afforded enol methyl ethers at the endocyclic keto groups. The subsequent reaction of these enol ethers with allylamine, benzylamine, and p-anisidine occurs along the mechanism of vinylog substitution providing the corresponding endocyclic enamino derivatives. 相似文献
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Zheldakova T. A. Budnikova M. V. Rubinov D. B. 《Russian Journal of Organic Chemistry》2003,39(2):235-241
The reaction of 3-acetyl-6,6-dimethyltetrahydrothiopyran-2,4-dione with diazomethane furnishes a mixture of 3-acetyl-6,6-dimethyl-4-methoxy-5,6-dihydro-2H-thiopyran-2-one and 3-acetyl-6,6-dimethyl- 2-methoxy-5,6-dihydro-2H-thiopyran-4-one in 2:3 ratio, whereas in reaction with dimethyl sulfate in the presence of potassium carbonate forms a mixture of the same products in 9:1 ratio. In both reactions the overall yield of ethers amounts to 50%. Treating of regioisomeric enol methyl ethers with pyrrolidine, o-toluidine, and allylamine provides the corresponding endocyclic enaminodiketones. 相似文献
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Talsi V. P. Evdokimov S. N. Shatsauskas A. L. 《Russian Journal of Organic Chemistry》2019,55(2):161-167
Russian Journal of Organic Chemistry - The NMR spectra of several heterocyclic compounds synthesized at Omsk universities revealed manifestation of a diasteomerism at a large (up to fifteen bonds)... 相似文献
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Using Bi2(SO4)3 as the catalyst and TMSCl as the additive, a wide variety of aldehydes, ketones, and acetals were smoothly condensed with aryl ethers at room temperature to provide the corresponding diarylmethanes and triarylmethanes selectively in good to excellent yields. 相似文献
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Yu. A. SIMONOV E. LUBOCH J. F. BIERNAT N. V. BOLOTINA V. E. ZAVODNIK 《Journal of inclusion phenomena and macrocyclic chemistry》1997,28(1):17-32
Sodium iodide complexes of 13-membered azo-(I)and azoxycrown ethers (II) have been synthesized. Compound I[Na(L1 trans)2]IH2O is triclinic witha = 11.53(2), b = 15.74(2), c = 19.17(2) Å, = 98.93(9), = 105.51(9), = 89.20(9) deg.; Z = 4, space groupP1. Compound II [Na(L2)2]I is orthorhombic witha = 12.451(2), b = 13.796(3), c = 18.667(4)Å; Z = 4, space group P212121. In bothcomplexes the cation is coordinated tochain oxygen atoms and to one nitrogen atom of the azoor azoxy unit. The ability of bothligands to form complexes in relation to thegeometry of the azo or azoxy subunit of themacrocycle is discussed. 相似文献
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In the presence of one equivalent of boron trifluoride etherate, organolithium compounds cause the ring cleavage reactions of tetrahydrofurans and tetrahydropyran to give the corresponding long-chain alcohols in moderate yields. These reactions are highly regioselective for unsymmetric cyclic ethers. 相似文献
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Khalilova Y. A. Faizullina L. Kh. Valeev F. A. 《Russian Journal of Organic Chemistry》2019,55(8):1088-1092
Russian Journal of Organic Chemistry - The addition of lithium enolates and TMS ethers of cyclohexanone and cyclododecanone to levoglucosenone in the presence of Lewis acids was studied. It was... 相似文献
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Silver‐Catalyzed Oxidative Coupling of Aniline and Ene Carbonyl/Acetylenic Carbonyl Compounds: An Efficient Route for the Synthesis of Quinolines 下载免费PDF全文
An efficient silver‐mediated coupling of aniline with ene carbonyl/acetylenic carbonyl compounds for the synthesis of quinolines is reported. The transformation is effective for a broad range of substrates, thus enabling the expansion of substituent architectures on the heterocyclic framework. The electronic properties of the substituents on the amine have been investigated. It was found that molecules with both electron‐donating and electron‐withdrawing substituents were suitable substrates for this transformation, and the expected products were obtained in moderate to excellent yields. The use of a single catalytic system to mediate chemical transformations in a synthetic operation is important for the development of new atom‐economic strategies and this strategy is efficient in building complex structures from simple starting materials in an environmentally benign fashion. 相似文献
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Rahman Hosseinzadeh Mahmood Tajbakhsh Farhad Ramzanian-Lehmali Marzieh Sadatshahabi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2279-2283
Deprotection of trimethylsilyl ethers to their parent aldehydes and ketones in high yields has been carried out using 2,6-dicarboxypyridinium fluorochromate under mild conditions. 相似文献
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Takanari Matsutani Dr. Takashi Sakuramoto Kento Okabayashi Prof. Mamoru Tobisu Prof. Toshiyuki Moriuchi 《European journal of organic chemistry》2023,26(14):e202201410
Oxovanadium(V)-catalyzed deoxygenative coupling reaction of allyl alcohols with trimethylsilyl enol ethers was demonstrated to afford γ,δ-unsaturated carbonyl compounds in one-step. The catalytic deoxygenative coupling reaction of allyl alcohols proceeded smoothly with both aromatic and aliphatic trimethylsilyl enol ethers. This catalytic deoxygenative coupling system could be applied to the deoxygenative coupling reaction of benzyl alcohols with trimethylsilyl enol ethers, providing the corresponding carbonyl compounds. Furthermore, a gram-scale catalytic synthesis of the γ,δ-unsaturated carbonyl compound was successfully performed to validate the scalability of this catalytic deoxygenative coupling reaction. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - Rapid analysis by coupling HPTLC with bioluminescence and mass spectrometry enables very fast response to bioactive substances in... 相似文献
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HussniA. Muathen 《Helvetica chimica acta》2003,86(1):164-168
A new mild and efficient method for aromatic halogenation with a wide variety of halides in the presence of sodium bismuthate NaBO3 in AcOH is reported. Metal halides of groups Ia, IIa, IIIa, IVa, Va, and the first row of transition elements are suitable for this method. 相似文献
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Various types of trimethylsilyl and tert-butyldimethylsilyl ethers of primary and secondary benzylic alcohols could be selectively converted to their corresponding carbonyl compounds with MnO2 in the presence of AlCl3 in good to excellent yields. 相似文献
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Catalytic Oxidative Deformylation of Polyethylene Glycols with the Participation of Molecular Oxygen
The kinetics of oxidation of diethylene glycol, triethylene glycol, and polyethylene glycols (PEGs) with molecular weights ranging from 400 to 2000 in the presence of Cu(II) ions and bases was studied. It was found that ethylene glycols can be oxidized by molecular oxygen in anhydrous media in a temperature range of 30–60°C at anomalouosly high rates which are higher than the rates of chain-radical PEG autoxidation by several orders of magnitude. Only terminal hydroxyl groups were subjected to oxidation. The reaction occurs with the cleavage of a C–C bond and results in the formation of formic acid and a PEG with the number of –(CH2CH2O)– groups lower than that in the parent compound by unity. The rate and selectivity of PEG oxidation were found to strongly depend on the molecular weight of the polymer; from diethylene glycol to PEG 2000, the specific rate of oxidation increased by a factor of 60 in terms of terminal hydroxyl groups. An oxidation mechanism was suggested, which involves the formation of ternary complexes [Cu2+···A–···O2], which undergo further degradation by a many-electron concerted mechanism to form formic acid and, probably, an unstable hemiacetal {RO–CH2OH}. The rapid oxidative degradation of the latter leads to the formation of PEG with a lower molecular weight. 相似文献