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1.
《合成通讯》2013,43(9):1441-1445
1-R-4,6-Dinitroindoles 4–6 (R = H, Me, Ts) could be obtained from 2-picrylethanol 1 (readily available from TNT) via selective reduction of ortho-nitro group by N2H4/FeCl3 and subsequent treatment with TsCl, to yield a key intermediate 3. This intermediate was converted to the above mentioned indoles. 相似文献
2.
Synthesis of 1,2,3,4-tetrazine 1,3-dioxides annulated with 1,2,3-triazoles and 1,2,3-triazole 1-oxides 总被引:1,自引:0,他引:1
Alexey A. Voronin Victor P. Zelenov Aleksandr M. Churakov Yurii A. Strelenko Ivan V. Fedyanin Vladimir A. Tartakovsky 《Tetrahedron》2014
1,2,3,4-Tetrazine 1,3-dioxides annulated with 1,2,3-triazoles and 1,2,3-triazole 1-oxides have been synthesized by the reaction of 4-amino-5-(tert-butyl-NNO-azoxy)-2-R-2H-1,2,3-triazoles (R=Me, i-Pr, t-Bu) and their 1-oxides (R=H, Me, Et, i-Pr) with the HNO3/H2SO4/Ac2O system. Their thermal stability, spectroscopic, and X-ray properties have been studied. 相似文献
3.
Starosotnikov A. M. Kachala V. V. Lobach A. V. Vinogradov V. M. Shevelev S. A. 《Russian Chemical Bulletin》2003,52(8):1782-1790
A method for the synthesis of 1-aryl-3-formyl-4,6-dinitro-1H-indazoles by the reaction of picrylacetaldehyde with aryldiazonium salts followed by intramolecular cyclization of the resulting picrylglyoxal monoarylhydrazones was developed. Various 4,6-dinitro-1-phenyl-1H-indazoles substituted in position 3 were prepared via transformations involving the formyl group of 3-formyl-4,6-dinitro-1-phenyl-1H-indazole. 3-R-4,6-Dinitro-1-phenyl-1H-indazoles (R = CHO, CN, 1,3-dioxolan-2-yl) react regiospecifically with anionic O-, S-, and N-nucleophiles, in particular, with replacement of only the 4-NO2 group. Thus previously unknown 3-R-4-Nu-6-nitro-1-phenyl-1H-indazoles were synthesized (Nu is a nucleophile residue). 相似文献
4.
Abstract Molecular structures of the RbSCN complexes with N-(4′-hydroxy-3′,5′-diisopropylbenzyl)-monoaza-15-crown-5 ether (2-RbSCN) and N-(4′-hydroxy-3′,5′-di-tert-butylbenzyl)-monoaza-15-crown-5 ether (3-RbSCN) are reported. Crystal data (2-RbSCN) C24H39N2O5SRb, M = 553.11, monoclinic, space group P21, a = 9.835(4), b = 15.44(3), c = 18.563(6) Å, β = 99.58 (4), U = 2779(4) Å3, Z = 4, Dc = 1.322 gcm?3, v = 18.87 cm?1, R = 0.047, Rw = 0.049 for the 5339 independent reflections (of 5712 measured reflections) and 590 parameters. (3-RbSCN) C52H86N4 O10S2Rb2, M = 1162.32, triclinic, space group P21, a = 9.917(2), b = 24.644(6), c = 12.572(3), α = 89.38(2), γ = 96.13(2), γ = 89.34(2) Å, U = 3054(1) Å3, Z = 2, Dc = 1.264 g cm?3, μ = 17.20 cm?1, R = 0.051, R = 0.053 for the 6864 independent reflections (of 7201 measured reflections) and 316 parameters. The molecular structures of the RbSCN complexes with a series of N-(4-hydroxy-3′,5′-dialkylbenzyl)-monoaza-15-crown-5 ethers (1, 2 and 3) were systematically changed depending upon the size of the R groups at positions 3′ and 5′ in the side arm; 1 (R=Me), a polymer-like (1:1)n complex; 2 (R = i-Pr), a mixture of 1:1 complex and polymer-like (1:1)n complex; 3 (R = t-Bu), a dimeric 1:1 complex. 相似文献
5.
Kanupriya Sharma Nandu Bala Sharma Anirudh Singh 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2735-2744
Equimolar reactions of BuSn(OPri)3 with diethanolamines, RN(CH2CH2 OH) 2 (abbreviated as RdeaH2, where R = H or Me), afford dimeric isopropoxo-bridged six-coordinate butyltin(IV) complexes [{Bu(η3-Rdea)Sn(μ-OPri)}2] (R = H ( 1 ), Me ( 2 )). Interactions between BuSn(OPri)3 and diethanolamines (RdeaH2) in a 1:2 molar ratio yield monomeric derivatives of the type [BuSn(Rdea)(RdeaH)] (R = H ( 3 ), R = Me ( 4 )). These homometallic complexes on 1:1 reactions with an appropriate metal alkoxide form monomeric heterobimetallic complexes of the type [BuSn (Rdea)2 {M(OR′)n}] (R = H, M = Al, R′ = Pri, n = 2 ( 5 ); R = H, M = Ti, R = Pri, n = 3 ( 6 ); R = H, M = Zr, R′ = Pri, n = 3 ( 7 ); R = Me, M = Al, R′ = Pri, n = 2 ( 8 ); R = Me, M = Ti, R′ = Pri, n = 3 ( 9 ); R = Me, M = Ge, R′ = Et, n = 3 ( 10 )). The driving force behind this work was (i) to explore the utility of homometal complexes ( 1 ) –( 4 ) in assembling a metal alkoxide fragment via a condensation reaction and (ii) to gain insights into the structures of new compounds by NMR spectral data. All of these derivatives have been characterized by elemental analysis, spectroscopic (IR, NMR; 1H, 27Al, and 119Sn) studies, and molecular weight measurements. 119Sn NMR spectral studies indicate that both the homometallic ( 3 ) and ( 4 ) and heterobimetallic ( 5 ) – ( 9 ) complexes exist in a solution in an equilibrium of six- and five-coordinated tin(IV) species. 相似文献
6.
Flash vacuum pyrolysis (FVP) of tert-butylthiosulfinic acid S-tert-butylester, t-BuS(O)St-Bu, at a temperature of 500 °C and a pressure of 0.07 hPa leads to the formation of tert-butylthiosulfoxylic acid, t-BuSSOH ( 1 ), and 2-methylpropene as byproduct. 1 has been identified in the gas phase by its IR absorption bands at ν(OH) = 3598 cm–1, δ(SOH) = 1149 cm–1 and ν(SO) = 718 cm–1. At higher temperatures (700 °C) the elimination of a second mole of 2-methylpropene and the shift of ν(SO) to higher wavenumbers (750 cm–1) indicate the formation of 1-oxatrisulfane, HSSOH. Different sulfenic acids RSOH (R = Me, i-Pr, t-Bu) were synthesized by FVP in order to study the influence of the substituent R on the vibrational wavenumbers ν(OH), ν(SO) and δ(SOH) observed in the gas phase. The strongest effect results for δ(SOH) leading to a decrease by 6 wavenumbers if the methyl group is substituted by a tert-butyl group. The assignment of the experimental wavenumbers has been supported by theoretical values obtained from ab initio calculations at the MP2(fc)/6-311G** level. Furthermore, the theoretical studies show that of all compounds RS2OR′ (R = R′ = H, Me; R = Me (H), R′ = H (Me)) the unbranched chain isomers RSSOR′ are energetically favored over the branched chain isomers. Relaxed potential energy surface scans at the MP2(fc)/6-311G** level have been carried out to study the rotational isomers of the branched molecules RS(Y)XR′ (R = R′ = H, Me; R = Me (H), R′ = H (Me); X = O (S), Y = S (O)). Of the three conformations (+)syn-clinal, (–)syn-clinal, and anti-periplanar resulting from molecular model considerations only the two latter ones correspond to local minima on the calculated potential curve. The (–)syn-clinal conformation is slightly favored for all other constitutional isomers except for HS(O)SH and MeS(O)SH, which prefer the anti-periplanar conformation. 相似文献
7.
G. V. Bozhenkov V. A. Savosik L. I. Larina L. V. Klyba E. R. Zhanchipova A. N. Mirskova G. G. Levkovskaya 《Russian Journal of Organic Chemistry》2008,44(7):1014-1023
2-Chlorovinyl alkyl ketones react with alkylhydrazines to give mixtures of 1-R-3-R′- and 1-R-5-R′-pyrazoles: The 1-R-3-R′-pyrazoles form through the heterocyclization of 2-chlorovinyl ketone alkylhydrazones whereas in the heterocyclization into 1-R-5-R′-pyrazoles N 1-alkyl-N 2-(2-acylvinyl)hydrazines are involved. The regiospecific heterocyclization of 2-chloro-and 2,2-dichlorovinyl ketones with arylhydrazines and also of 2,2-dichloro(bromo)vinyl trifluoromethyl ketones with C alkylhydrazines into pyrazoles and 5-chloro(bromo)-pyrazoles proceeds through a stage of haloenones hydrazones formation. The study of the structure of the obtained 1-alkyl-3(5)-alkylpyrazoles by means of two-dimenaional 1H and 13C NMR spectroscopy and GC-MS method made it possible to assign the proton and carbon signals of isomeric pyrazoles and to establish the diagnostic ions for the pair of 1,3-and 1,5-isomers. 相似文献
8.
F. Bonati A. Burini B.R. Pietroni M. Felici 《Journal of organometallic chemistry》1984,273(2):275-281
Reaction of LAuCl with various pyrazol-5-ones and alkali in homogeneous or heterogeneous medium has given several 1-R-3-R′-4(LAu)2-pyrazol-5-one derivatives (R = H, phenyl, p-bromophenyl, tosyl, methyl; R′ = methyl, trifluoromethyl; L = Ph3P or Et3P). In the case of 1-aryl-5-methylpyrazol-3-one 1-aryl-2-triphenylphosphinegold-5-methylpyrazol-3-one, a compound with an AuN bond is formed. The scope, limitation, and characteristic of the auration reaction are discussed. 相似文献
9.
Treatment of Ru3(CO)12 with salicylaldimines [2-HOC6H4-CH?=N–C6H4-4-R] [R?=?Me; Cl; Br; OMe; CF3] in refluxing toluene gave three novel binuclear ruthenium carbonyl complexes {[µ-?2-2-OC6H4-CH=N-C6H4-4-R)][µ-?2-2-CH2-OC6H4][µ-?-NH-C6H4-4-R]}Ru2(CO)4 [R?=?Me (1), Cl (2), Br (3)] and three mononuclear carbonyl complexes [2-OC6H4-CH=N-C6H4-4-R][2-OC6H4-CH2NH-C6H4-4-R]Ru(CO)2 [R?=?Me (4), OMe (5), CF3 (6)], respectively. The structures of 1–6 were fully characterized using IR and NMR spectroscopy, elemental analysis and single-crystal X-ray diffraction. These results suggest that the substituent group on the phenyl of salicylaldimine has a significant effect on the structure of the Ru complex.
相似文献10.
The synthesis,structure, and ethylene polymerization of dimeric salicylaldiminato titanium complexes
《Journal of Coordination Chemistry》2012,65(20):3652-3660
A series of dimeric titanium complexes bearing salicylaldiminates, [4-R-6-tBu-2-(CH=NnBu)C6H2OTiCl2(µ-Cl)]2 [R?=?H (1); R?=?tBu (2); R?=?NO2 (3)], have been synthesized in high yield (>90%) by the reaction of corresponding 4-R-6-tBu-2-(CH=NnBu)C6H2OSiMe3 with TiCl4. The molecular structure of 2 has been confirmed by single-crystal X-ray diffraction analysis. When activated with methylaluminoxane, these complexes exhibit good catalytic activity for ethylene polymerization. 相似文献
11.
Charge Effects in PCP Pincer Complexes of NiII bearing Phosphinite and Imidazol(i)ophosphine Coordinating Jaws: From Synthesis to Catalysis through Bonding Analysis
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Dr. Boris Vabre Dr. Yves Canac Dr. Christine Lepetit Dr. Carine Duhayon Prof. Remi Chauvin Prof. Davit Zargarian 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(48):17403-17414
This contribution reports on a new family of NiII pincer complexes featuring phosphinite and functional imidazolyl arms. The proligands RPIMCHOPR′ react at room temperature with NiII precursors to give the corresponding complexes [(RPIMCOPR′)NiBr], where RPIMCOPR=κP,κC,κP‐{2‐(R′2PO),6‐(R2PC3H2N2)C6H3}, R=iPr, R′=iPr ( 3 b , 84 %) or Ph ( 3 c , 45 %). Selective N‐methylation of the imidazole imine moiety in 3 b by MeOTf (OTf=OSO2CF3) gave the corresponding imidazoliophosphine [(iPrPIMIOCOPiPr)NiBr][OTf], 4 b , in 89 % yield (iPrPIMIOCOPiPr=κP,κC,κP‐{2‐(iPr2PO),6‐(iPr2PC4H5N2)C6H3}). Treating 4 b with NaOEt led to the NHC derivative [(NHCCOPiPr)NiBr], 5 b , in 47 % yield (NHCCOPiPr=κP,κC,κC‐{2‐(iPr2PO),6‐(C4H5N2)C6H3)}). The bromo derivatives 3–5 were then treated with AgOTf in acetonitrile to give the corresponding cationic species [(RPIMCOPR)Ni(MeCN)][OTf] [R=Ph, 6 a (89 %) or iPr, 6 b (90 %)], [(RPIMIOCOPR)Ni(MeCN)][OTf]2 [R=Ph, 7 a (79 %) or iPr, 7 b (88 %)], and [(NHCCOPR)Ni(MeCN)][OTf] [R=Ph, 8 a (85 %) or iPr, 8 b (84 %)]. All new complexes have been characterized by NMR and IR spectroscopy, whereas 3 b , 3 c , 5 b , 6 b , and 8 a were also subjected to X‐ray diffraction studies. The acetonitrile adducts 6 – 8 were further studied by using various theoretical analysis tools. In the presence of excess nitrile and amine, the cationic acetonitrile adducts 6 – 8 catalyze hydroamination of nitriles to give unsymmetrical amidines with catalytic turnover numbers of up to 95. 相似文献
12.
Jens Mahnke Andreas Zanin Wolf-Walther du
Mont Frank Ruthe Peter G. Jones 《无机化学与普通化学杂志》1998,624(9):1447-1454
The New P -Phosphanylphosphaalkene 1-Bis(trimethylsilyl)methylidene-2,2-diisopropyldiphosphane: First Reactions at its P=C and P–P Bonds (Me3Si)2C=PCl ( 1 ) reacts with the trichlorosilylphosphanes RR′PSiCl3 (R and R′ = t-Bu or i-Pr) providing the new P-dialkylphosphanylphosphaalkenes (Me3Si)2C=P–P-i-Pr2 ( 2 ) and (Me3Si)2C=P–P(t-Bu)(i-Pr) ( 3 ) as well as the known (Me3Si)2C=P–P-t-Bu2 ( 4 ). The P=C double bond of 2 can be protected reversibly by a [2 + 4]-cycloaddition with cyclopentadiene resulting in the formation of a P-phosphanyl-phosphanorbornene derivative 5 . The [2 + 4]-cycloaddition of 2 with 2,3-dimethylbutadiene provides the cyclic diphosphane 6 . Reactions of 2 with sulfur and selenium were followed by 31P and 77Se nmr: Chalcogen insertion into the P–P bond leads to the products (Me3Si)2C=P–X–P-i-Pr2 9 a (X = S) and 9 b (X = Se). Subsequent σ3λ3 → σ4λ5 oxidation steps of 9 a with S and of 9 b with Se lead to compounds (Me3Si)2C=P–X–P(=X)-i-Pr2 10 a (X = S) and 10 b (X = Se), which contain phosphinic acid functions with the phosphaalkene moieties attached to S or Se. 10 a and 10 b were not isolated in a pure state. However, trapping 10 b from an enriched solution by [2 + 4]-cycloaddition with cyclopentadiene allowed the isolation of the P-diseleno-phosphinato-phosphanorbornene 12 . The constitution of new compounds 2 , 3 , 5 , 6 and 12 was confirmed by elemental analyses, nmr and mass spectra. The structures of cycloadducts 5 and 6 were determined by X-ray diffraction analysis. 相似文献
13.
《Journal of Coordination Chemistry》2012,65(1):75-85
The reaction of [Ru(OH2)2(RaaiR′)2]2+ [RaaiR′ = 1-alkyl-2-(arylazo)imidazole, p-R–C6H4–N=N–C3H2–NN(1)–R′, R=H (1), Me (2), Cl (3); R′ = Me (a), Et (b), CH2Ph (c)] with 8-quinolinol (HQ) in acetone solution followed by the addition of NH4PF6 afforded violet, mixed ligand complexes of composition [Ru(Q)(RaaiR′)2](PF6). The structure of [Ru(Q)(MeaaiMe)2](PF6) (2a) has been confirmed by X-ray diffraction studies. Solution electronic spectra exhibit a strong MLCT band at 560–580?nm in MeCN. Cyclic voltammogrames show a Ru(III)/Ru(II) couple at 1.0–1.1?V versus SCE along with three successive ligand reductions. The electronic properties are correlated with EHMO results. 相似文献
14.
Elise Duhamel Alpar Pöllnitz Adina Stegarescu Prof. Dr. Anca Silvestru 《无机化学与普通化学杂志》2011,637(10):1355-1360
Redistribution reactions between diorganodiselenides of type [2‐(R2NCH2)C6H4]2Se2 [R = Et, iPr] and bis(diorganophosphinothioyl disulfanes of type [R′2P(S)S]2 (R = Ph, OiPr) resulted in the hypervalent [2‐(R2NCH2)C6H4]SeSP(S)R′2 [R = Et, R′ = Ph ( 1 ), OiPr ( 2 ); R = iPr, R′ = Ph ( 3 ), OiPr ( 4 )] species. All new compounds were characterized by solution multinuclear NMR spectroscopy (1H, 13C, 31P, 77Se) and the solid compounds 1 , 3 , and 4 also by FT‐IR spectroscopy. The crystal and molecular structures of 3 and 4 were determined by single‐crystal X‐ray diffraction. In both compounds the N(1) atom is intramolecularly coordinated to the selenium atom, resulting in T‐shaped coordination arrangements of type (C,N)SeS. The dithio organophosphorus ligands act monodentate in both complexes, which can be described as essentially monomeric species. Weak intermolecular S ··· H contacts could be considered in the crystal of 3 , thus resulting in polymeric zig‐zag chains of R and S isomers, respectively. 相似文献
15.
J. F. J. Engbersen A. Koudijs H. C. Der Van Plas 《Journal of heterocyclic chemistry》1982,19(6):1281-1283
Treatment of an aqueous solution of chromone, the detergent sodium dodecylbenzenesulfonate, silver nitrate and an alkanoic acid, with ammonium peroxydisulfate gives 2-R-chromone [R = i-C3H7 (47%), R = t-C4H9 (65%) and R = 1-adamantyl (78%)]. In addition 2-R-4-chromanone [R = i-C3H7 (40%), R = t-C4H9 (5%) and R-1-adamantyl (10%)] is formed. It is proposed that the reaction involves as intermediate the relatively stable 2-R-4-chromanon-3-yl radical and that the detergent has a micellar catalytic activity on the free radical alkylation process. 相似文献
16.
From Dibismuthenes to Three‐ and Two‐Coordinated Bismuthinidenes by Fine Ligand Tuning: Evidence for Aromatic BiC3N Rings through a Combined Experimental and Theoretical Study
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Iva Vránová Dr. Mercedes Alonso Dr. Rabindranath Lo Dr. Robert Sedlák Dr. Roman Jambor Prof. Aleš Růžička Prof. Frank De Proft Prof. Pavel Hobza Dr. Libor Dostál 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(47):16917-16928
The reduction of N,C,N‐chelated bismuth chlorides [C6H3‐2,6‐(CH?NR)2]BiCl2 [where R=tBu ( 1 ), 2′,6′‐Me2C6H3 ( 2 ), or 4′‐Me2NC6H4 ( 3 )] or N,C‐chelated analogues [C6H2‐2‐(CH?N‐2′,6′‐iPr2C6H3)‐4,6‐(tBu)2]BiCl2 ( 4 ) and [C6H2‐2‐(CH2NEt2)‐4,6‐(tBu)2]BiCl2 ( 5 ) is reported. Reduction of compounds 1 – 3 gave monomeric N,C,N‐chelated bismuthinidenes [C6H3‐2,6‐(CH?NR)2]Bi [where R=tBu ( 6 ), 2′,6′‐Me2C6H3 ( 7 ) or 4′‐Me2NC6H4 ( 8 )]. Similarly, the reduction of 4 led to the isolation of the compound [C6H2‐2‐(CH?N‐2′,6′‐iPr2C6H3)‐4,6‐(tBu)2]Bi ( 9 ) as an unprecedented two‐coordinated bismuthinidene that has been structurally characterized. In contrast, the dibismuthene {[C6H2‐2‐(CH2NEt2)‐4,6‐(tBu)2]Bi}2 ( 10 ) was obtained by the reduction of 5 . Compounds 6 – 10 were characterized by using 1H and 13C NMR spectroscopy and their structures, except for 7 , were determined with the help of single‐crystal X‐ray diffraction analysis. It is clear that the structure of the reduced products (bismuthinidene versus dibismuthene) is ligand‐dependent and particularly influenced by the strength of the N→Bi intramolecular interaction(s). Therefore, a theoretical survey describing the bonding situation in the studied compounds and related bismuth(I) systems is included. Importantly, we found that the C3NBi chelating ring in the two‐coordinated bismuthinidene 9 exhibits significant aromatic character by delocalization of the bismuth lone pair. 相似文献
17.
《Journal of Coordination Chemistry》2012,65(5):776-780
Fe2(CO)9 and R2P(S)P(S)R2 (R = Et, n-Pr, n-Bu, Ph) react to form two types of cluster complexes Fe3(CO)9(μ3-S)2 (1), Fe2(CO)6(μ-SPR2)2 (2A)–(2D), [2A, R = Et; 2B, R = n-Pr; 2C, R = n-Bu; 2D, R = Ph]. The complexes result from phosphorus–phosphorus bond scission; in the former sulfur abstraction has also occurred. The complexes have been characterized by elemental analyses, FT-IR and 31P-[1H]-NMR spectroscopy and mass spectrometry. 相似文献
18.
Sergey M. Ivanov 《Journal of heterocyclic chemistry》2021,58(6):1371-1378
Reactions of 2-(6-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-3(2H)-ylidene)-3-oxo-3-R-propanenitriles (R = t-Bu, Ad-1) with tert-butyl bromoacetate gave the corresponding N(2), C(5)O bis-alkylation products. Treatment of the latter with t-BuLi, in the case of R = t-Bu, led to intramolecular condensation at the exocyclic nitrile group. However, in the case of R = Ad-1, the condensation with the sterically more hindered carbonyl group was observed to give diastereomerically pure 8-cyanopyrrolo[1,2-b][1,2,4]triazine-6-carboxylate derivatives. The structures of the isolated products were confirmed by spectral methods and X-ray single-crystal diffraction. 相似文献
19.
Enantiomerically pure and sterically-varied 2-organylapoisopinocampheylboranes (RapBH2; R=Me, IpcBH2; R=Et, EapBH2; Pr, PraBH2; i-Bu, i-BapBH2; R=Ph, PapBH2; and R=i-Pr, i-PraBH2) were prepared from their corresponding 2-organylapopinenes (2-R-apopinenes; R=Me, Et, Pr, i-Bu, Ph, and i-Pr) and the relative efficiency of these reagents for the asymmetric hydroboration of representative prochiral alkenes compared. With the exception of Ph, the results reveal simple relationships between the steric requirements of the groups R (Me, Et, Pr, i-Bu, Ph, and i-Pr) in these reagents and the moderate to excellent enantioselectivities achieved in the asymmetric hydroboration of six representative prochiral alkenes, such as 2-methyl-1-butene, cis-2-butene, trans-2-butene, 2-methyl-2- butene, 1-methyl-1-cyclopentene, and 1-methyl-1-cyclohexene. 相似文献
20.
《Journal of Coordination Chemistry》2012,65(14):2369-2387
New organotin(IV) carboxylates, R2SnL2 (R=n-Bu: 1), R2Sn(Cl)L (R=n-Bu: 2), and R3SnL (R=Me: 3; n-Bu: 4; Ph: 5) have been synthesized by stirring 5-chloro-2-hydroxybenzoic acid HL with KOH and R2SnCl2 (R=n-Bu)/R3SnCl (R=Me, n-Bu, Ph) in methanol at room temperature. The complexes along with ligand have been characterized by FTIR, (1H, 13C) NMR, EI-MS, and single-crystal XRD crystallography. FTIR data indicated bidentate coordination of carboxylate. NMR data suggested six- or five-coordinate geometry of organotin(IV) carboxylates. Single-crystal XRD of 1 demonstrated skew-trapezoidal geometry around the tin center, with the basal plane occupied by four oxygens and the two butyl groups lying in distorted axial position. Complexes 1, 2, and 5 exhibited interaction with SS-DNA (salmon sperm) and suggests intercalating mode of binding. The complexes displayed significant antimicrobial activities against bacterial and fungal strains as compared to free ligand. The hemolytic activity of the complexes was lower compared to Triton-X 100 (positive control, 100% lysis) and higher than phosphate-buffered saline (negative control, 0% lysis). Complex 4 was the most potent inhibitor of bacterial/fungal growth. 相似文献