SYNTHESIS OF 2,3-SUBSTITUTED QUI NOXALINE FROM α-KETOTHI OANI LI DE

A method of synthesis of quinoxaline by α-ketothioanilide ando-phenylenediamine is described in this paper.     

AN EFFICIENT SYNTHESIS OF DEOXOQINGHAOSU FROM DIHYDROQINGHAOSU

Deoxoqinghaosu,a more active antimalarial compound thanqinghaosu,was efficiently synthesized from the readily available dihydroqinghaosuwith a new reducing reagent BH_3NEt_3-Me_3SiCl.     

SYNTHESIS OF POLYESTER-POLYETHER MULTIBLOCK COPOLYMERS FROM POLYESTERS

A polymeric method was explored for the preparation of polyester-polyether multiblock copoly-mers using polyesters and polpethers as starting materials. The mechanism of the reaction and theeffect of the segment structure on it, the segment sequence of the block copolymers prepared havebeen studied. It has been shown that to the polymeric method the degree of compatibility betweenstarting polyester and polyether is of paramount importance, which determines not only the com-positional homogeneity of the block copolymers formed but also the success of the polymeric methodto get the block copolymers of the expected structure.     

SYNTHESIS OF α-AZIDO-2′-HYDROXYCHALCONES FROM CHALCONE DIBROMIDES WITH AZIDE ION

ABSTRACT

The reaction of the 2′-hydroxychalcone dibromides with azide ion was found to afford various products such as α-azido-2′-hydroxychalcones, flavones, aurones, isoxazoles or the parent chalcones depending on the substituent pattern of the substrate. Efficient transformation of α-azido-2′-hydroxychalcones to 3-amino-2-substituted chromones was also demonstrated.     

SYNTHESIS OF A NEW CHIRAL PHOSPHINE FROM DSORBITOL

ＳＹＮＴＨＥＳＩＳＯＦＡＮＥＷＣＨＩＲＡＬＰＨＯＳＰＨＩＮＥＦＲＯＭＤＳＯＲＢＩＴＯＬ￥ＡｎＬａｉＷＡＮＧ；ＸｉａｏＤｏｎｇＷＡＮＧ；ＳｈｉＪｉｅＬＵ；ＨｏｎｇＸｉａｎｇＦＵ；ＨａｎＱｉｎｇＷＡＮＧ（ＬａｎｚｈｏｕＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａ...     

ETEREOSPECIFIC SYNTHESIS OF α-D-FRUCTOFURANOSIDES——SYNTHESIS OF THE OLIGO-FRUCTAN DIASTEREOISOMERS

α-fructofuranosides were stereospecifically synthesized from2-O-Ac-1,3,4,6-O-tetra-benzoylfructose by employing TMSOTf as a catalyst.Meanwhile,one diastereoisomer derivative of sucrose and two of fructanoligomers were synthesized.The structure of all products were confirmed by~(13)C-NMR and ~1H-NMR spectra.     

STUDY OF Cu-Mu CATALYST FOR THE SYNTHESIS OF METHYL FORMATE AND METHANOL FROM SYNTHESIS GAS

将一种新型的ＣｕＭｎ催化剂用于由合成气合成甲酸甲酯和甲醇，该催化剂表现出良好的反应活性和甲酸甲酯选择性。考察了反应温度、合成气压力及催化剂制备方法等对合成甲酸甲酯和甲醇的反应活性及选择性的影响。在反应条件下，产物收率最高达６０．１０ｇ／（Ｌ·ｈ），产物甲酸甲酯的选择性很高。用ＢＥＴ、ＸＲＤ及ＸＰＳＡｕｇｅｒ等测试方法对催化剂的比表面、晶相组成以及铜、锰在催化剂中的价态进行了表征，并探讨了催化剂失活的原因。     

SYNTHESIS OF ALCOHOLS FROM HYDROGENATION OF CARBON DIOXIDE(Ⅲ)

The effects of catalyst preparation and reaction conditions on thecatalytic activity and selectivity for hydrogenation of carbon dioxide to alcoholsover zeolite supported bimetal catalyst were studied.The results showed that:(1)ethanol easily formed on the zeolite with larger pores and methanol did onthat with smaller pores;(2)when pH value of the ion exchange solution was10,the activity reached the maximum;(3)the optimum Cu/Ru mole ratio was3;(4)the influence of reation conditions such as temperature,pressure andH_2/CO_2 mole ratio on the topic reaction was greater.     

RESEARCH AND DEVELOPMENT OF FUEL ALCOHOL SYNTHESIS FROM SYNGAS

The research and development of catalyst preparation and catalytic technology for fuel alcohol synthesis from syngas have been conducted. The laboratory research work includes the investigation on the effects of preparation method, the composition and K2O content on the catalyst performance. The influences of reaction temperature, pressure, GHSV and feed composition on higher alcohols synthesis have also been investigated. On the basis of laboratory results, the catalysts have been further tesied in micro-pilot reactor under the industrial condition to investigate the effects of commercial preparation of catalyst, the reactor scaling up and (he use of industrial coal based syngas on the fuel alcohol ( mixture of methanol and higher alcohols ) synthesis. The catalyst stability has been tested by a 1000 h continuous operation. These provide the fundamental for further commercial plant design.     

PREPARATION OF THE CATALYST FOR DIRECT SYNTHESIS OF DIMETHYL ETHER FROM SYNTHESIS GAS BY BIHYDROLYSIS PRECIPITATION

ＰＲＥＰＡＲＡＴＩＯＮＯＦＴＨＥＣＡＴＡＬＹＳＴＦＯＲＤＩＲＥＣＴＳＹＮＴＨＥＳＩＳＯＦＤＩＭＥＴＨＹＬＥＴＨＥＲＦＲＯＭＳＹＮＴＨＥＳＩＳＧＡＳＢＹＢＩＨＹＤＲＯＬＹＳＩＳＰＲＥＣＩＰＩＴＡＴＩＯＮ￥ＬｉＪｉｎｌｕ；ＺｈａｎｇＸｕｅｇｏｎｇ（Ｓｔａ...     

HIGH YIELD SYNTHESIS OF α-ALKOXYPHOSPHONIUM SALTS AND α-ALKOXYPHOSPHONATES

Abstract

The recent work of Ley et al. ¹ on α-alkoxyphosphorane compounds from cyclic enolethers has prompted us to report our findings in this area. In addition to cyclic enol ethers we have studied the acyclic case as well as the use of phosphite in place of triphenylphosphine. Using this approach we have prepared alkoxy-as well as 5-and 6-membered oxyheterocyclic phosphonium salts and phosphonates in high yield.     

STUDIES ON THE SYNTHESIS OF NOVEL ISONUCLEOSIDE FROM D-GLUCOSE

ＳＴＵＤＩＥＳＯＮＴＨＥＳＹＮＴＨＥＳＩＳＯＦＮＯＶＥＬＩＳＯＮＵＣＬＥＯＳＩＤＥＦＲＯＭＤ－ＧＬＵＣＯＳＥ￥ＨｏｎｇＷｕＹＵ；ＬｉｎｇＴａｉＭＡ；ＬｉＨｅＺＨＡＨＧ（ＳｃｈｏｏｌｏｆＰｈａｒｍａｃｅｕｔｉｃａｌＳｃｉｅｎｃｅｓＢｅｉｊｉｎｇＭｅｄｉ...     

SYNTHESIS OF 11 α-HYDROXY-AND 11β-CHLORO-ARTEMISININ

11α-Hydroxy-and 11β-chloro-artemisinin have been prepared from artemisinin     

STRUCTURAL ELUCIDATION AND SYNTHESIS OF ASTERBATANOSIDE A FROM ASTER BATANFENSIS

ＳＴＲＵＣＴＵＲＡＬＥＬＵＣＩＤＡＴＩＯＮＡＮＤＳＹＮＴＨＥＳＩＳＯＦＡＳＴＥＲＢＡＴＡＮＯＳＩＤＥＡＦＲＯＭＡＳＴＥＲＢＡＴＡＮＦＥＮＳＩＳ￥ＹｕＳＨＡＯ；ＹｕｎＬｏｎｇＬＩａｎｄＢｉｎｇＮａｎＺＨＯＵ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＭａｔ...     

DEVELOPMENT OF CATALYSTS FOR SYNTHESIZING DIMETHYL ETHER FROM SYNTHESIS GAS

IntroductionAsmorcandmorcuscsarcfoundinindustn'andci\'ilIifc\"ithdimcth\Icthcr(D\1l:).tllccompoundisrccci\'ingmorcattc11tiontl1anc\'CrBcsidcsthccol1\'c11tiol1al\\a\ofproduclngDMEb}'dch\'drationofmctllanoI*tI1cproccssofdlrccts}'nthcslzlngDMEfrol11s}'llthcsisgas(s}'ngas)\\asproposcda11dl1asbccnstudicdfort\"c11t}}'carsl1lTopsoccombincdthlstcchnlqtlc\\'lththcproccssofDMEcon\'CrslontofucIlnthcirpiIotplantandconcIudcdthath1c\\I1olcproccss\\ouldbc11lorccfficicnti11cconom\'tl1a11son1cothcrtccI…     

SYNTHESIS AND PROPERTIES OF IER FROM 2—HYDROXYETHYL METHACRYLATE

This paper introduced the synthesis and properties of IER based on 2-hydroxyethyl methacrylate.The derivatives containing DEAE-,CM-,SO3H groups were prepared and their uses in biochemistry were studies.     

SYNTHESIS AND PROPERTIES OF IER FROM 2 - HYDROXYETHYL METHACRYLATE

This paper introduced the synthesis and properties of IER based on 2-hydrox-yethyl methacrylate. The derivatives containing DEAE-, CM-, -SO3H groups were prepared and their uses in biochemistry were studied.     

STRUCTURE ELUCIDATION AND SYNTHESIS OF CONISELIN FROM CONISELIUM VAGINATUM THELL

ＳＴＲＵＣＴＵＲＥＥＬＵＣＩＤＡＴＩＯＮＡＮＤＳＹＮＴＨＥＳＩＳＯＦＣＯＮＩＳＥＬＩＮＦＲＯＭＣＯＮＩＳＥＬＩＵＭＶＡＧＩＮＡＴＵＭＴＨＥＬＬＰｉｎｇＹｕＤＩＮＧ；ＲｕｏＹｕｎＣＨＥＮ；ＤｅＤｕａｎＹＵＩｎｓｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅｄｉｃａ...     

AN EFFICIENT SYNTHESIS OF ALIPHATIC α-ORGANOTHIO ALDOXIME

The importance of the aliphatic α-organothio aldoxime compound 3 in the preparation of various pesticides is well established. Molecules comprising the α-organothio oxime moiety have been reported to exhibit insecticidal,nematocidal,miticidal activities.^[1-2] In the synthesis of the compound 3,the chlorination of the corresponding aliphatic aldoxime 1 is the key step.In conventional methods, the aliphatic aldoxime 1 is chlorinated by chlorine,then the resulting hydroxime acid chloride 2 is treated with sodium alkyl mercaptide to obtain the desired compounds 3^[3]. Although free Cl₂ is the most common chlorinating agent,it is laborious to determine the accurate amount that has been absorbed,and the high reactivity of Cl₂ always leads to side reactions. In connection with an our ongoing research project, we require an efficient and simple method for the synthesis of the compound 3.An improved synthesis process according to the following scheme is reported in this paper.     

SYNTHESIS AND TRANSFORMATIONS OF OPTICALLY ACTIVE α-PHOSPHORYL SULPHOXIDES

Abstract

As part of a continuing studies of α-phosphoryl sulphoxides, racemic dimethylphosphorylmethyl p-tolyl sulphoxide (1) was prepared and resolved into optical isomers. Sulphoxide (+)-1 with the R chirality at sulphur was synthesized stereospecifically by treatment of (?)-menthyl p-tolylsulphinate with dimethylphosphorylmethyllithium. This communication describes some transformations of optically active 1.