0.18 μm窄沟NMOS晶体管总剂量效应研究

为明确深亚微米NMOS器件抗辐照能力以及研究其加固措施, 本文对0.18 μm窄沟NMOS晶体管进行了⁶⁰Coγ总剂量辐射效应研究. 结果表明: 和宽沟器件不同, 阈值电压、跨导、漏源电导对总剂量辐照敏感, 此现象被称之为辐射感生窄沟道效应; 相比较栅氧化层, 器件隔离氧化层对总剂量辐照更敏感; 窄沟道NMOS器件阈值电压不仅和沟道耗尽区电荷有关, 寄生晶体管耗尽区电荷对其影响也不可忽略, 而辐照引起源漏之间寄生晶体管开启, 形成漏电通道, 正是导致漏电流、亚阈斜率等参数变化的原因. 关键词： 0.18μmm 窄沟NMOS晶体管 60Coγ辐照')" href="#">⁶⁰Coγ辐照 辐射感生窄沟道效应     

电光晶体调谐的外腔反馈半导体激光器

报道一种用电光晶体实现快速调谐和凋制激光频率的方法.在Littrow型外腔反馈半导体激光中插入LiNbO3晶体,利用LiNbO3晶体的电光效应,通过改变晶体电压来调节激光器的有效腔长,可以对激光频率进行快速的调谐和调制.采用该方法,自制外腔反馈半导体激光器的调谐频率可达到2 kHz,它的调谐范围为350 MHz,激光频率调谐系数约为1.06 MHz/V,用饱和吸收光谱观测频率调谐的效果.快速激光频率调制可以应用在稳频技术上,将外腔反馈半导体激光器调制在5～100 kHz频率下,均获得了87Rb原子D2线的饱和吸收光谱的色散信号,并实现了激光频率在饱和吸收峰上的长期稳定.     

Measurement and characterization of the frequency noise of a laser-diode-pumped single-frequency Tm-Ho:YAG laser

The frequency noise characteristics of a single-frequency 2.1-m Tm-Ho:YAG laser have been thoroughly investigated. From the measurement of the frequency noise spectral density, performed by means of an interferometric technique, a short-term laser linewidth of 550 kHz over 1-ms time interval has been obtained. The frequency stability, defined as the two sample standard deviation of the frequency fluctuations with dead time T, has been also evaluated, obtaining values ranging from 250 kHz to 2.5 MHz for T values between 1 and 100 ms over an observation time of 100 ns. It has been shown through a numerical analysis that a significant improvement is achievable, attaining a frequency stability of 25 kHz for T up to 100 ms, by using the Pound–Drever locking technique in connection with a roto-vibrational line of the HBr molecule.     

Frequency- and wavelength-modulation spectroscopies: Comparison of experimental methods using an AlGaAs diode laser

Low-wavelength modulation (1 kHz), high-wavelength modulation (100 MHz) and two-tone frequency modulation (390±5 MHz) spectroscopies are systematically compared by measuring the minimum detectable absorption achieved using an AlGaAs diode laser tuned on a third-overtone methane transition at 886 nm. From the S/N behavior has been extrapolated a minimum relative absorption (1 Hz of bandwidth) of 4.5(1)×10^–7 for the LMW, 9.7(3)×10^–8 for the HWM and 6.4(2)×10^–8 for the TTFM. In the LWM case the detection-limit value is represented by the laser amplitude 1/f excess noise, while for the high-frequency detection techniques this contribution is negligible with respect to other noise sources. These detection limits well agree with the calculated quantum limited values based on measured laser power, modulation index, noise figure of the electronic components, and other parameters of the apparatus.     

5-Aminolaevulinic acid enhances ultrasound-induced mitochondrial damage in K562 cells

Background

Ultrasound therapy is a new modality in the control of malignant cancers. The aim of the present study was to investigate the effect of 5-aminolaevulinic acid on the ultrasonic killing action in the cancer cells.

Materials/methods

The K562 cells as a cancer cell model were subjected to investigate the effect of 5-aminolaevulinic acid (5-ALA) on the ultrasonic killing action, in which the 5-ALA concentration was 2 mM and the ultrasound exposure was 15 s at the intensity of 0.46 W/cm² and the frequency of 1.7 MHz. Cytotoxicity was investigated 24 h after ultrasound exposure using the trypan blue exclusion test. Ultrastructural cell morphology and mitochondrial changes were observed using transmission electron microscopy (TEM). Mitochondrial membrane potential (ΔΨm) was evaluated using Rhodamine 123 assay.

Results

The death rates of the K562 cells in the controls including sham radiation and 5-ALA treatment alone were 1.81 ± 0.13%, 1.27 ± 0.20%, respectively. Those in ultrasound radiation alone and 5-ALA-ultrasound treatment were 12.61 ± 2.63%, 46.87 ± 4.09%, respectively. There were significant differences between 5-ALA-ultrasound treatment, ultrasound radiation alone and the controls (P < 0.05). TEM showed that the mitochondria expanding and some vacuoles were found in the ultrasound-treated cells. After the treatment of ultrasound and 5-ALA together some cells presented typical characteristics of apoptotic cells, such as nuclear condensation and crescent formation. Mitochondria of the cells were damaged more seriously than those treated by ultrasound alone, there were obvious swollen mitochondria and mitochondria in which cristae were almost perfectly disappeared, and more vacuolar mitochondria were founded. Mitochondrial membrane potential (ΔΨm) was more significantly collapsed when the K562 cells were exposed to 2 mM 5-ALA for 4 h and then 0.46 W/cm² irradiation of ultrasound than ultrasound radiation alone.

Conclusion

5-ALA pretreatment significantly enhanced the cytotoxicity of ultrasound radiation in K562 cells. The damage of mitochondria structure and function might be an important cause of cell death in K562 cells induced by the treatment of ultrasound radiation and 5-ALA together.     

Internal pulse-code modulation of a 0.6328 μm He-Ne laser at 150 Mbit s−1

Pulse-code modulation of a 0.6328m He-Ne laser by simultaneous mode-locking and coupling modulation is achieved at a bit-rate of 150 Mbits^–1 using a single modulation element. Both modelocking techniques, loss modulation and phase modulation are used and compared. The phase of the output signal is stabilized by means of a phase-locked loop. The influence of the coupling modulation on the resonator energy causes a time-dependent decrease of the output signal amplitude. This effect can be compensated by controlling the coupling voltage. A calculation of the maximum available bitrate for a 2 mm bore He-Ne laser tube is given.     

高功率微波对毫米波引信耦合效应分析

针对高功率微波对毫米波引信的前门耦合效应问题,利用电磁仿真软件对某型毫米波调频连续波引信模型进行辐照试验,并与引信前端限幅电路结合进行联合仿真。在此基础上,继续设计正交试验,对信号参数影响水平进行分析。通过仿真试验发现,在高功率微波信号频率和引信工作频率对准的情况下,辐照场强峰值为60 kV/m时,天线末端耦合电压最大可达188 V;当辐照场强峰值为40 kV/m时,改变辐照信号特征参数,发现长脉宽信号更容易导致限幅器的热击穿效应;信号上升时间会影响天线末端耦合电压波形复杂程度,当信号峰值、脉宽一定时,上升时间为5 ns的输入信号导致的尖峰泄漏电压约为5.94 V,而当上升时间为0.1 ns时,尖峰泄漏电压为18.4 V,并且限幅电路更快达到饱和状态;通过正交试验发现,信号上升时间对尖峰泄漏峰值电压的影响最大,信号峰值对其的影响次之。     

相位调制信号对窄线宽光纤放大器线宽特性和受激布里渊散射阈值的影响

高功率窄线宽光纤放大器的输出功率主要受限于受激布里渊散射(SBS)效应,通过相位调制进行线宽展宽可以有效抑制SBS效应.基于窄线宽光纤放大器中的SBS动力学模型,研究了正弦信号、白噪声信号和伪随机编码信号(PRBS)对窄线宽光纤放大器光谱特性与SBS阈值的影响.研究发现,采用不同信号进行相位调制时,调制频率和调制深度等参数对调制后激光光谱的谱线间隔、谱线数目与光谱平整度的影响存在较大差异,进而影响放大器的线宽特性和SBS阈值.通过对比分析,给出了调制信号的类型选择和参数优化原则,能够为窄线宽光纤放大器的相位调制系统设计提供参考.     

All-optical modulation at 1.3 μm wavelength in the inGaAsP/InP system

All-optical, normal-to-surface modulation in InGaAsP epitaxial layers, lattice matched to InP, is investigated. Close to the gap wavelength of 1.3 m a transmission increase under optical excitation is observed. A modulation depth of 34% is achieved for 0.8 mW pump power at 790 nm wavelength. The modulation frequency is limited by excess carrier lifetime. A 3 dB frequency of 80 MHz is achieved with a 10 dB decrease at 400 MHz. A lateral electric field enlarges the bandwidth but decreases the modulation depth. For weak excitation the experiments are well described in terms of direct electronic transitions between parabolic bands or in terms of simple band filling. The devices are well suited for parallel optical data processing.     

Enhancing electrooptic modulators using modulation instability

As electronic operating frequencies increase toward the terahertz regime, new electrooptic modulators capable of low‐voltage high‐frequency operation must be developed to provide the necessary optical interconnects. This Letter presents a new concept that exploits modulation instability to compensate for the intrinsically weak electrooptic effect, χ⁽²⁾. Simulations demonstrate more than 50 times enhancement of electrooptic effect at millimeter wave frequencies leading to a substantial reduction in the required modulation voltage.

     

Widely tunable narrow-linewidth nanosecond optical parametric generator with self-injection seeding

This paper reports a widely tunable narrow-linewidth nanosecond optical parametric generator (OPG) with a pulse-repetition rate of 10 kHz. The OPG consists of a 55-mm-long periodically poled lithium niobate crystal with a domain period of 29.5 m. At an average pump power of 2.0 W the OPG emitted 0.33 W of signal power and 0.17 W of idler power. The wavelength and spectral width of the OPG are controlled by self-injection seeding. For this purpose, a small fraction of the OPGs pulsed signal radiation is used as seed radiation for the next OPG pulse. In order to overlap in time the seed pulse with the succeeding pump pulse, the seed pulse is delayed by a 22-km-long single-mode fiber. For narrowing the spectrum of the seeded OPG output, the seed radiation is spectrally filtered by a tunable fiber Fabry–Perot interferometer (FFPI). The OPG signal radiation could be tuned from 1547 to 1605 nm by changing the OPGs crystal temperature and by tuning simultaneously the FFPI. The corresponding idler wave tuned from 3157 to 3413 nm. Within the whole tuning range, the linewidth of the signal wave was less than 185 MHz. Compared to the 240-GHz linewidth of the free-running OPG, the linewidth of the seeded OPG is thus narrowed by more than three orders of magnitude. By tuning the FFPI, continuous wavelength tuning has been demonstrated within the gain spectrum of the OPG over a range of 820 GHz. PACS 42.65.Yj; 42.79.Nv; 42.79.Qx     

A total internal reflection device using KTN

A total internal reflection diffraction device has been constructed using a quadratic electro-optic material (KTN). This device exhibits a best zero order extinction voltage of 40 V, and a capacitance of 630 pf at room temperature (20° C above Curie temperature). Useful modulation is achieved with coarse gratings (0.4 mm pitch at 0.63m) and mildly striated material can often be used.     

Faraday effect on the Rb <Emphasis Type="Italic">D</Emphasis> <Subscript>1</Subscript> line in a cell with a thickness of half the wavelength of light

The rotation of the radiation polarization plane in a longitudinal magnetic field (Faraday effect) on the D₁ line in atomic Rb vapor has been studied with the use of a nanocell with the thickness L varying in the range of 100–900 nm. It has been shown that an important parameter is the ratio L/λ, where λ = 795 nm is the wavelength of laser radiation resonant with the D₁ line. The best parameters of the signal of rotation of the radiation polarization plane have been obtained at the thickness L = λ/2 = 397.5 nm. The fabricated nanocell had a large region with such a thickness. The spectral width of the signal reached at the thickness L = 397.5 nm is approximately 30 MHz, which is much smaller than the spectral width (≈ 500 MHz) reached with ordinary cells with a thickness in the range of 1–100 mm. The parameters of the Faraday rotation signal have been studied as functions of the temperature of the nanocell, the laser power, and the magnetic field strength. The signal has been reliably detected at the laser power P_L ≥ 1 μW, magnetic field strength B ≥ 0.5 G, and the temperature of the nanocell T ≥ 100°C. It has been shown that the maximum rotation angle of the polarization plane in the longitudinal magnetic field is reached on the F_g = 3 → F_e = 2 transition of the ⁸⁵Rb atom. The spectral profile of the Faraday rotation signal has a specific shape with a sharp peak, which promotes its applications. In particular, Rb atomic transitions in high magnetic fields about 1000 G are split into a large number of components, which are completely spectrally resolved and allow the study of the behavior of an individual transition.     

无人机定位系统辐照干扰失效全过程与机理分析

定位系统是无人机核心单元中的电磁敏感环节,是无人机电磁防护的重点部位。为了分析电磁干扰效应机理与失效过程,以典型自组装无人机定位系统为目标,通过电磁拓扑模型分析干扰耦合方式,分析不同耦合路径下辐照干扰耦合机理和作用机制。采用GPS增强转发系统在电波暗室内为无人机系统提供正常动态工作环境,并依据标准开展微波辐照干扰效应试验,通过无人机系统固件中的日志记录功能,结合地面站监测实时状态,实现无人机定位系统电磁干扰效应全过程动态特征数据记录与故障机理分析。试验结果表明:无人机接收天线耦合干扰主要发生在定位系统最大接收带宽（200 MHz）之内;线缆耦合干扰主要在1 GHz以下的频段内且在171 MHz和511 MHz附近达到最大值;PCB电路耦合干扰主要在1.24 GHz以上频段,耦合电压波动性随着干扰信号频率增加而变强。     

Two‐Wave CO2 Laser with Loss Modulation in Both Channels

The nonlinear dynamics of a twowave CO₂ laser with continuous pumping by an electric discharge and loss modulation in both channels is investigated theoretically. In modulation of losses with the same frequencies it is possible, by changing the shift of the phases of modulating signals, to monitor simply enough the amplitude, form, duration, and depth of modulation and also the repetition rate of radiation. Depending on the shift of phases, the maximum response can be concentrated in the lowfrequency region or propagate also to the region of high frequencies. If losses in both channels are modulated with different frequencies, a change in the relationship between these frequencies predominantly leads to a change in the shape, magnitude, and structure of response in the lowfrequency region of the amplitudefrequency characteristic (AFCh). In the highfrequency region of the amplitudefrequency characteristic, beginning from the peaks of the doubling of the vibration period, where inphase modes of radiation are implemented, the response virtually does not change. Similar regularities are observed on change in the shift of phases.     

Flux Capacitors and the Origin of Inertia

The explanation of inertia based on Mach's principle is briefly revisited and an experiment whereby the gravitational origin of inertia can be tested is described. The test consists of detecting a small stationary force with a sensitive force sensor. The force is presumably induced when a periodic transient Mach effect mass fluctuation is driven in high voltage, high energy density capacitors that are subjected to 50 kHz, 1.3 kV amplitude voltage signal, and threaded by an alternating magnetic flux of the same frequency. An effect of the sort predicted is shown to be present in the device tested. It has the expected magnitude and depends on the relative phase of the Mach effect mass fluctuation and the alternating magnetic flux as expected. The observed effect also displays scaling behaviors that are unique to Mach effects. Other tests for spurious signals suggest that the observed effect is real.     

Microwave spectroscopy of cold rubidium atoms

The effect of microwave radiation on the resonance fluorescence of a cloud of cold ⁸⁵Rb atoms in a magnetooptical trap is studied. The radiation frequency was tuned near the hyperfine splitting frequency of rubidium atoms in the 5S ground state. The microwave field induced magnetic dipole transitions between the magnetic sublevels of the 5S (F=2) and 5S (F=3) states, resulting in a change in the fluorescence signal. The resonance fluorescence spectra were recorded by tuning the microwave radiation frequency. The observed spectra were found to be substantially dependent on the transition under study and the frequency of a repump laser used in the cooling scheme.     

光声光谱技术在多组分气体浓度探测中的应用

CO和CH_4气体作为判断变压器运行状态的故障气体,对其浓度的探测在变压器维护中具有重要意义.为了准确探测变压器运行过程中产生的CH_4和CO气体浓度,本文利用光声光谱技术,设计了一套基于宽带光源的多组分气体探测系统,和共振型光声系统相比,该系统中所用的非共振型光声池体积小,易加工,池内各处信号强度相同,降低了对声学信号探测器的安装要求.系统的性能通过对CO和CH_4气体的探测进行评估.首先,从理论上分析了信号强度与调制频率呈反比,然后根据宽带光声系统在不同调制频率下的响应,确定系统的最佳调制频率为22 Hz.在最佳调制频率下,根据温度与待测气体光声信号的关系,对光声信号进行温度补偿,消除温度变化对光声信号的影响,进一步提高了系统的稳定性.最后,通过不同浓度的CH_4和CO气体对系统进行标定.实验表明,温度补偿前后,光声信号随温度的漂移分别为0.023 23V/℃和8.383 48×10~(-5) V/℃,通过对不同浓度CH_4和CO气体的探测,系统的线性度分别达到0.995和0.998 4.在一个大气压下,积分时间为1s时,宽带光声探测系统对CO和CH_4气体的探测极限浓度能够达到1μL/L.该系统成本低,线性度好,探测灵敏度符合国标对变压器维护过程中CO和CH_4气体的探测要求.     

Dual-high-frequency ultrasound excitation on microbubble destruction volume

Objective and motivation

The goal of this work was to test experimentally that exposing air bubbles or ultrasound contrast agents in water to amplitude modulated wave allows control of inertial cavitation affected volume and hence could limit the undesirable bioeffects.

Methods

Focused transducer operating at the center frequency of 10 MHz and having about 65% fractional bandwidth was excited by 3 μs 8.5 and 11.5 MHz tone-bursts to produce 3 MHz envelope signal. The 3 MHz frequency was selected because it corresponds to the resonance frequency of the microbubbles used in the experiment. Another 5 MHz transducer was used as a receiver to produce B-mode image. Peak negative acoustic pressure was adjusted in the range from 0.5 to 3.5 MPa. The spectrum amplitudes obtained from the imaging of SonoVue^TM contrast agent when using the envelope and a separate 3 MHz transducer were compared to determine their cross-section at the - 6 dB level.

Results

The conventional 3 MHz tone-burst excitation resulted in the region of interest (ROI) cross-section of 2.47 mm while amplitude modulated, dual-frequency excitation with difference frequency of 3 MHz produced cross-section equal to 1.2 mm.

Conclusion

These results corroborate our hypothesis that, in addition to the considerably higher penetration depth of dual-frequency excitation due to the lower attenuation at 3 MHz than that at 8.5 and 11.5 MHz, the sample volume of dual-frequency excitation is also smaller than that of linear 3-MHz method for more spatially confined destruction of microbubbles.