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1.
The condensation of 1-benzyl-2-cyanocarbamoylmethylene-pyrrolidine with tetramethylurea diethylacetal and subsequent cyclization gave 1-benzyl-4-dimethyl-amino-6-chloro-7-cyano-5-azaindoline, for which nucleophilic substitution and dehydrogenation reactions are described. The reactivity of this product is compared with that of 1-benzyl-6-chloro-7-cyano-5-azaindoline.See [1] for Communication 58.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 215–220, February, 1981.  相似文献   

2.
Derivatives of some condensed systems that include furan rings were obtained by condensation of 1,4-benzoquinones with cyclic -diketones under the conditions of the Michael reaction. The structure of the methoxy derivatives of tetrahydrobenzofuran were established from the PMR spectra with the aid of europium(III) tris(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedionate). The location of the europium ion in the adduct of the lanthanide shift reagent (LSR) with the substrate was determined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 22–26, January, 1980.  相似文献   

3.
The electrophilic substitution reactions (nitration, bromination, acylation, and the Mannich and Vilsmeier reactions) of 1-benzyl-6-methoxy-7-cyano-5-azaindole and the nitration and Vilsmeier reaction of 6-hydroxy-5-azaindoline were studied.See [1] for Communication 60.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 356–360, March, 1982.  相似文献   

4.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, p. 857, June, 1991.  相似文献   

5.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 132–133, January, 1992.  相似文献   

6.
The synthesis of 2,3,5,6-tetrahydropyrrolo[3,2-c]pyrid-6-one was accomplished by rearrangement of 8H,1-cyano-8-dimethylaminomethylene-2,5,6,7-tetrahydropyrrolo[1, 2-c]pyrimidine. Pyrrolo[3,2-c]pyrimidine, 1,6-naphthyridine, and pyrimido[4,3-b]-azepine derivatives were synthesized on the basis of enamino dinitriles. The hydrolysis of 8H,1-cyano-8-dimethylaminomethylene-2,5,6,7-tetrahydropyrrolo[1,2-c]-pyrimidine in 50% CH3COOH leads to a pyrrolo[1,2-c]pyrido[4,3-d]pyrimidine derivative. A similar dipyrido[4,3-d-1,2-c]pyrimidine derivative was obtained from 1-cyano-9-dimethylaminomethylene-2,5,6,7,8,9-hexahydropyrido[1,2-c]pyrimidine under these conditions, and 3,4-dioxo-3,4,7,8,9,10-hexahydropyrido[1,2-c]pyrano[4,3-d]-pyrimidine was synthesized bytreatment with a 1 N solution of HCl.See [1] for Communication 34.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 518–522, April, 1982.  相似文献   

7.
N-substituted 1-benzyl-4-methyl-5-cyano-6-amino-7-azaindoles have been synthesized from the respective 1-benzyl-4-methyl-5-cyano-6-chloro(and 6-hydroxy)-7-azaindoles. The effect of the 5-cyano group on the oxidation-reduction processes accompanying nucleophilic replacement of chlorine in 6-chloro-7-azaindoles by primary and secondary amines has been considered. 7-Azaindoline compounds were dehydrogenated by chloranil to N-substituted 1-benzyl-4-methyl-5-cyano-6-amino-7-azaindoles.For communication 66, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 91–96, January, 1986.  相似文献   

8.
9.
Condensation of thiosemicarbazones of furfural, 3-(2-furyl)acrolein, as well as their 5-nitro derivatives with chloroacetone by boiling in alcohol or acetic acid gives the corresponding 4-methylthiazolyl-(2)hydrazones. 4-Methylthiazolyl-(2)-hydrazones of 5-nitro-2-acetylfuran and 5-nitro-2-furfurilydeneacetone can be prepared by condensing the corresponding thiosemicarbazones with chloroacetone by heating with glacial acetic acid containing fused sodium acetate.For Part IV see [1].  相似文献   

10.
A methoxyl group in the 4 and 6 positions has a passivating effect on the ability of the methyl group in monomethoxymethylpyrimidine derivatives to enter into azo coupling; at the same time, a methoxyl group in the 2 position does not have an appreciable effect on the activity of the methyl group because the conjugation effect of the methoxyl group in this position is less than in the 4 and 6 positions.See [1] for Communication XVIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1573–1574, November, 1970.  相似文献   

11.
12.
Treatment of diamides derived from α-amino acids with phosphorus pentasulfide or Lawesson's reagent was shown to provide a convenient method to prepare 5-aminothiazoles. By this method, in addition to mono-cyclic 5-aminothiazoles 19 , novel bicyclic 5-aminothiazole derivatives such as 4,5,6,7-tetrahydrothiazolo[5,4-b]pyridines 11 , 5,6,7,8-tetrahydro-4H-thiazolo[5,4-b]azepines 7 , 4,5,6,7,8,9-hexahydrothiazolo[5,4-b]azocine 16 and related compounds were prepared in moderate to good yields from simple diamides, suggesting the wide versatility of the method.  相似文献   

13.
10-Hydroxy-5H-dibenzo(a,i)phenoxazin-5-one and its 6-chloro derivative - condensed derivatives of resorufin, simultaneously containing in the molecule linearly and angularly condensed benzene rings - were synthesized. Their spectral-luminescent properties were investigated.  相似文献   

14.
Condensation of 4-chloro-2-oxo-2H-chromene-3-carbonitrile with selected heteroarylamines in acetonitrile containing a catalytic amount of triethylamine, followed by intramolecular cyclization, gave the new coumarin derivatives with yields ranging from 43 % to 78 %. The novel compounds were subjected to acid hydrolysis giving the corresponding oxo derivatives in 66–70 % yield. The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses.  相似文献   

15.
The intramolecular heterocyclization of 2-benzazolylmercaptoalkyl diazomethyl ketones under the influence of acidic agents leads to 1,3-thiazino[2,3-b]benzim-idazole, 1,3-thiazino[2,3-b]benzothiazolium, and 1,3-thiazino[2,3-b]benzoxazolium systems. Under similar conditions 2-quinolylmercaptoalkyl diazomethyl ketones form 1,3-thiazino[2,3-a]quinolinium systems.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 635–639, May, 1984.  相似文献   

16.
The Beirut reaction of 5,6-difluorobenzofuroxan with 1,3-diketones, β-ketoesters, and amides produces 6,7-difluoroquinoxaline 1,4-dioxides. The condensation of 2-ethoxycarbonyl-6,7-difluoro-3-methylquinoxaline 1,4-dioxide is studied. Fluorinated furo[3,4-b]- and pyrrolo[3,4-b]quinoxaline 4,9-dioxides are synthesized and further functionalized by nucleophilic substitution of fluorine and reduction of the N-O bond. Dedicated to Professor Henk van der Plas on his 70th birthday. Ural's State Technical University, Ekaterinburg 62002, Russia; e-mail: azine@htf.rcupi.e-burg.su. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 520–531, April, 1999.  相似文献   

17.
A number of 5- and 7-azaindolines were oxidized to the corresponding azaindoles by means of activated manganese dioxide. The dependence of the ease of dehydrogenation of 5- and 7-azaindolines by activated manganese dioxide on their oxidation potentials is demonstrated.See [1] for communication 56.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 375–378, March, 1979.  相似文献   

18.
Levoglucosenone, the ,ß-unsaturated ketone obtained by the pyrolysis of cellulose, reacts with NH-azoles in the presence of bases. In this process not only normal Michael adducts are formed, but in some cases their hydrates (gem-diols) are also formed. In all cases the addition proceeds stereospecifically and with good yields. 3-Nitro-s-triazole, 3-nitro- and 4-nitropyrazoles, 3-methyl-4-nitropyrazole, 5-nitrotetrazole, 4,5-dicarbomethoxy-v-triazole, 3,4-dinitropyrazole, 3(5)-methylpyrazole, pyrazole, and imidazole have been studied in this reaction. All of the adducts are characterized by NMR- and IR-spectroscopy.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1135–1140, June, 1994.  相似文献   

19.
Levoglucosenone reacts with α-aminoazoles to yield azolo[1,5-a]pyrimidine systems fused with a carbohydrate fragment. The reaction oocurs much more smoothly than in the case of other α,β-unsaturated ketones. The reactions of levoglucosenone with β-dicarbonyl compounds (dimedone, barbituric acid) in the presence of a base results in the pyran ring closure, which has never been observed earlier in reactions of β-dicarbonyl compounds with α,β-unsaturated ketones under the conditions of basic catalysis. The structures of products were established by IR and NMR spectroscopy. For Part 3, see Ref. 1. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 553–558, March, 1997.  相似文献   

20.
Treatment of the ammonium (I) or benzylammonium salt of 2,6-dihydroxy-3-(-hydroxyethyl)-4-methyl-5-cyanopyridine (II) with a mixture of benzylamine and phosphorus pentoxide yielded 2-benzylamino-3-(-hydroxyethyl)-4-methyl-5-cyano-6-hydroxypyri-dine (III), which, when heated with phosphorus oxychloride, is converted to 1-benzyl-4-methyl-5-cyano-6-hydroxy-7-azaindoline (IV). The products of thermal fragmentation of II with benzylamine were studied by the method of chromato-mass spectrometry. In addition to compound III, N,N-dibenzylurea (V) and the dibenzylamide of malonic acid (VI) were preparatively isolated from the reaction products. The cyclization of I and II to 4-methyl-6-hydroxy-2,3-dihydro-7-azabenzofuran (VII) and 4-methyl-5-cyano-6-hydroxy-2,3-dihydro-7-azabenzofuran (VIII) was carried out. Heating VIII with benzylamine at 200–210°C led to compound III.For communication 64, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1105–1109, August, 1984.  相似文献   

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