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Chromo‐Fluorogenic Detection of Nitroaromatic Explosives by Using Silica Mesoporous Supports Gated with Tetrathiafulvalene Derivatives 下载免费PDF全文
Dr. Yolanda Salinas Dr. Marta V. Solano Rebecca E. Sørensen Dr. Karina R. Larsen Dr. Jess Lycoops Prof. Jan O. Jeppesen Prof. Ramón Martínez‐Máñez Dr. Félix Sancenón Dr. M. Dolores Marcos Prof. Pedro Amorós Dr. Carmen Guillem 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(3):855-866
Three new hybrid gated mesoporous materials ( SN3‐1 , SNH2‐2 , and SN3‐3 ) loaded with the dye [Ru(bipy)3]2+ (bipy=bipyridine) and capped with different tetrathiafulvalene (TTF) derivatives (having different sizes and shapes and incorporating different numbers of sulfur atoms) have been prepared. The materials SN3‐1 and SN3‐3 are functionalized on their external surfaces with the TTF derivatives 1 and 3 , respectively, which were attached by employing the “click” chemistry reaction, whereas SNH2‐2 incorporates the TTF derivative 2 , which was anchored to the solid through an amidation reaction. The final gated materials have been characterized by standard techniques. Suspensions of these solids in acetonitrile showed “zero release”, most likely because of the formation of dense TTF networks around the pore outlets. The release of the entrapped [Ru(bipy)3]2+ dye from SN3‐1 , SNH2‐2 , and SN3‐3 was studied in the presence of selected explosives (Tetryl, TNT, TNB, DNT, RDX, PETN, PA, and TATP). SNH2‐2 showed a fairly selective response to Tetryl, whereas for SN3‐1 and SN3‐3 dye release was found to occur with Tetryl, TNT, and TNB. The uncapping process in the three materials can be ascribed to the formation of charge‐transfer complexes between the electron‐donating TTF units and the electron‐accepting nitroaromatic explosives. Finally, solids SNH2‐2 and SN3‐1 have been tested for Tetryl detection in soil with good results, pointing toward a possible use of these or similar hybrid capped materials as probes for the selective chromo‐fluorogenic detection of nitroaromatic explosives. 相似文献
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《化学:亚洲杂志》2017,12(20):2670-2674
The development of easy and affordable methods for the detection of cyanide is of great significance due to the high toxicity of this anion and the potential risks associated with its pollution. Herein, optical detection of cyanide in water has been achieved by using a hybrid organic–inorganic nanomaterial. Mesoporous silica nanoparticles were loaded with [Ru(bipy)3]2+, functionalized with macrocyclic nickel(II) complex subunits, and capped with a sterically hindering anion (hexametaphosphate). Cyanide selectively induces demetallation of nickel(II) complexes and the removal of capping anions from the silica surface, allowing the release of the dye and the consequent increase in fluorescence intensity. The response of the capped nanoparticles in aqueous solution is highly selective and sensitive towards cyanide with a limit of detection of 2 μm . 相似文献
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Dr. Félix Sancenón Lluís Pascual Mar Oroval Dr. Elena Aznar Prof. Ramón Martínez-Máñez 《ChemistryOpen》2015,4(4):418-437
Silica mesoporous supports (SMSs) have a large specific surface area and volume and are particularly exciting vehicles for delivery applications. Such container-like structures can be loaded with numerous different chemical substances, such as drugs and reporters. Gated systems also contain addressable functions at openings of voids, and cargo delivery can be controlled on-command using chemical, biochemical or physical stimuli. Many of these gated SMSs have been applied for drug delivery. However, fewer examples of their use in sensing protocols have been reported. The approach of applying SMSs in sensing uses another concept—that of loading pores with a reporter and designing a capping mechanism that is selectively opened in the presence of a target analyte, which results in the delivery of the reporter. According to this concept, we provide herein a complete compilation of published examples of probes based on the use of capped SMSs for sensing. Examples for the detection of anions, cations, small molecules and biomolecules are provided. The diverse range of gated silica mesoporous materials presented here highlights their usefulness in recognition protocols. 相似文献
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Ismael Otri Dr. Sameh El Sayed Serena Medaglia Prof. Ramón Martínez-Máñez Dr. Elena Aznar Dr. Félix Sancenón 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(15):3770-3774
A nanodevice based on mesoporous silica nanoparticles with rhodamine B in the pore framework, functionalized with carboxylates on the outer surface and capped with the cationic polymyxin B peptide, was used to selectively detect endotoxin in aqueous solutions with a limit of detection in the picomolar range. 相似文献
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Alessandro Agostini Dr. Laura Mondragón Dr. Andrea Bernardos Prof. Ramón Martínez‐Máñez Dr. M. Dolores Marcos Dr. Félix Sancenón Dr. Juan Soto Prof. Ana Costero Dr. Cristina Manguan‐García Prof. Rosario Perona Dr. Marta Moreno‐Torres Dr. Rafael Aparicio‐Sanchis Prof. José Ramón Murguía 《Angewandte Chemie (International ed. in English)》2012,51(42):10556-10560
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Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles 下载免费PDF全文
Cristina de la Torre Dr. Laura Mondragón Dr. Carmen Coll Alba García‐Fernández Dr. Félix Sancenón Prof. Ramón Martínez‐Máñez Prof. Pedro Amorós Dr. Mar Orzáez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(44):15506-15510
Excessive apoptotic cell death is at the origin of several pathologies, such as degenerative disorders, stroke or ischemia‐reperfusion damage. In this context, strategies to improve inhibition of apoptosis and other types of cell death are of interest and may represent a pharmacological opportunity for the treatment of cell‐death‐related disorders. In this scenario new peptide‐containing delivery systems (solids S1 ‐ P1 and S1 ‐ P2 ) are described based on mesoporous silica nanoparticles (MSNs) loaded with a dye and capped with the KKGDEVDKKARDEVDK ( P1 ) peptide that contains two repeats of the DEVD target sequence that are selectively hydrolyzed by caspase 3 ( C3 ). This enzyme plays a central role in the execution‐phase of apoptosis. HeLa cells electroporated with S1 – P1 are able to deliver the cargo in the presence of staurosporin (STS), which induces apoptosis with the consequent activation of the cytoplasmic C3 enzyme. Moreover, the nanoparticles S1 ‐ P2 , containing both a cell‐penetrating TAT peptide and P1 also entered in HeLa cells and delivered the cargo preferentially in cells treated with the apoptosis inducer cisplatin. 相似文献
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Shy‐Guey Wang Chia‐Wen Wu Prof. Kwunmin Chen Prof. Victor S.‐Y. Lin Prof. 《化学:亚洲杂志》2009,4(5):658-661
Three orientations to choose from : 2D hexagonal organically functionalized mesoporous silica nanoparticles with tunable mesochannel orientation (straight, helical, and radial mesochannels) were synthesized through a simple addition of various amounts of ureidopropyltrimethoxylsilane (UDPTMS) in the condensation of tetraorthosilicate (TEOS) in aqueous solution.
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Hexametaphosphate‐Capped Silica Mesoporous Nanoparticles Containing CuII Complexes for the Selective and Sensitive Optical Detection of Hydrogen Sulfide in Water 下载免费PDF全文
Sameh El Sayed Dr. Michele Milani Prof. Maurizio Licchelli Prof. Ramón Martínez‐Máñez Dr. Félix Sancenón 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(19):7002-7006
CuII‐macrocycle functionalized hexametaphosphate‐capped silica mesoporous nanoparticles have been prepared and used for the selective and sensitive detection of hydrogen sulfide in aqueous environments. The possibility of using different metal complexes combined with different capping anions and choice of different dyes or other sensing molecules as indicators makes this new protocol highly appealing for the preparation of new sensing systems for sulfide detection in different environments. 相似文献
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Frontispiece: Hexametaphosphate‐Capped Silica Mesoporous Nanoparticles Containing CuII Complexes for the Selective and Sensitive Optical Detection of Hydrogen Sulfide in Water 下载免费PDF全文
Sameh El Sayed Dr. Michele Milani Prof. Maurizio Licchelli Prof. Ramón Martínez‐Máñez Dr. Félix Sancenón 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(19)
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Jie Zhu Huixiang Wang Lei Liao Lingzhi Zhao Liang Zhou Meihua Yu Prof. Yunhua Wang Prof. Baohong Liu Prof. Chengzhong Yu 《化学:亚洲杂志》2011,6(9):2332-2338
Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti‐cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs. 相似文献
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Chitosan‐Capped Mesoporous Silica Nanoparticles as pH‐Responsive Nanocarriers for Controlled Drug Release 下载免费PDF全文
Herein, we present a straightforward synthesis of pH‐responsive chitosan‐capped mesoporous silica nanoparticles (MSNs). These MCM‐41‐type MSNs could be used as nanocapsules to accommodate guest molecules. Subsequently, (3‐glycidyloxypropyl)trimethoxysilane was grafted onto the surface of the MSNs, which served as a bridge to link between MSNs and chitosan, which is ubiquitous in nature and commercially available. Owing to the pH‐responsive and biocompatible features of chitosan, the loading and release of an anti‐cancer drug, doxorubicin hydrochloride, were carried out in vitro, in which the composite chitosan‐capped MSNs (CS‐MSNs) showed excellent environmental response. As the pH value of the media decreased, the degree of drug release correspondingly increased. Moreover, thanks to the perfect biocompatibility of chitosan, the CS‐MSNs exhibited lower cytotoxicity than that of the naked MSNs in an MTT assay. In addition, the in vitro kill potency against MCF‐7 breast‐cancer cells was enhanced over time, as well as with increasing concentration of the drug‐loaded CS‐MSNs. These results indicate that CS‐MSNs are promising candidates for pH‐responsive drug delivery in cancer therapy. 相似文献
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复合介孔二氧化硅膜是近十年来发展起来的一种具有独特孔中孔结构的新型膜材料。该材料以多孔膜(无机多孔膜或者有机多孔膜)为硬模板,以表面活性剂为结构导向剂,通过溶胶-凝胶等方法将介孔二氧化硅材料组装在多孔膜的孔道中制备而成。由于其具有不同于传统介孔二氧化硅膜材料的一些独特结构和性能,并在分离、吸附和催化等领域具有广泛的应用前景,引起了人们广泛的关注。本文主要就复合介孔二氧化硅膜的制备方法,特别是近几年内其在纳滤、纳米材料的模板合成、酶的固定、传感器、反应器以及药物释放等方面最新的应用研究进展进行论述,同时对这类新型的复合介孔二氧化硅膜材料在合成和应用方面存在的问题进行了分析和总结,并对其发展前景作了展望。 相似文献
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Direct Assembly of Mesoporous Silica Functionalized with Polypeptides for Efficient Dye Adsorption 下载免费PDF全文
Yi‐Syuan Lu Dr. Bishnu Prasad Bastakoti Dr. Malay Pramanik Dr. Victor Malgras Prof. Yusuke Yamauchi Prof. Shiao‐Wei Kuo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(3):1159-1164
Herein, we introduce a new polypeptide‐functionalized mesoporous silica template fabricated from a biodegradable poly(ethylene oxide‐b‐?‐caprolactone) (PEO‐b‐PCL) diblock copolymer and a poly(tyrosine) (PTyr) biopolymer. The crystallization behavior of the PEO‐b‐PCL diblock copolymer changes after blending, but the secondary structure of PTry remains stable. After selective solvent extraction in THF, the PEO‐b‐PCL is removed, but PTyr remains within the silica matrix due to its different solubility. Fourier‐transform IR spectroscopic analysis (FTIR), thermal gravitometry analysis (TGA), small‐angle X‐ray scattering (SAXS), and X‐ray diffraction (XRD) studies confirm the retention of PTyr to form a polypeptide‐functionalized mesoporous material. The adsorption of methylene blue hydrate (MB) from aqueous solution into the polypeptide‐functionalized mesoporous silica is investigated, thus revealing that the nanocomposite exhibits a high adsorption capacity relative to pure silica due to hydrogen‐bonding interactions between the hydroxy phenolic group of PTyr and the N‐containing aromatic ring from MB. 相似文献
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Cathepsin‐B Induced Controlled Release from Peptide‐Capped Mesoporous Silica Nanoparticles 下载免费PDF全文
Cristina de la Torre Laura Mondragón Carmen Coll Félix Sancenón María D. Marcos Ramón Martínez‐Máñez Pedro Amorós Mar Orzáez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(47):15309-15314
New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM‐41 supports loaded with safranin O ( S1‐P ) or doxorubicin ( S2‐P ) containing a molecular gate based on a cathepsin B target peptidic sequence were synthesized. Solids were designed to show “zero delivery” and to display cargo release in the presence of cathepsin B enzyme, which selectively hydrolyzed in vitro the capping peptide sequence. Controlled delivery in HeLa, MEFs WT, and MEFs lacking cathepsin B cell lines were also tested. Release of safranin O and doxorubicin in these cells took place when cathepsin B was active or present. Cells treated with S2‐P showed a fall in cell viability due to nanoparticles internalization, cathepsin B hydrolysis of the capping peptide, and cytotoxic agent delivery, proving the possible use of these nanodevices as new therapeutic tools for cancer treatment. 相似文献