共查询到20条相似文献,搜索用时 15 毫秒
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I. M. Sakhautdinov I. R. Batyrshin A. A. Fatykhov F. Z. Galin M. S. Yunusov 《Russian Journal of Organic Chemistry》2012,48(6):793-798
Dimeric compounds formed as a result of thermal oligomerization of methyl 4-(1,3-dioxo-2,3- dihydro-1H-isoindol-2-yl)buta-2,3-dienoate were identified. 相似文献
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1 INTRODUCTION Phthalimide and its derivatives are synthetic mate- rials, which are widely used as important chemical intermediates of biosensors[1] and many drugs such as Citalopran[2], luminal[3], Beta-Lactam[4] and the No. three generation quinolones[5], and they have been identified as active groups of some drugs and chemical luminescence reagents[6, 7]. Tert-butyl 4- [(E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1- butenyl] benzoate is an intermediate of a new type of insulin sen… 相似文献
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Masterova N. S. Ryabova S. Yu. Alekseeva L. M. Shashkov A. S. Chernyshev V. V. Granik V. G. 《Russian Chemical Bulletin》2009,58(9):1973-1980
Russian Chemical Bulletin - Reactions of 3-acetoxy-2-(2,2-dicyanovinyl)indole with hydrazine hydrate and methyl-and phenylhydrazines afforded new indolin-3-one derivatives, namely,... 相似文献
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D. Bevk M. Kmetic S. Recnik J. Svete L. Golic A. Golobic B. Stanovnik 《Chemistry of Heterocyclic Compounds》2001,37(12):1498-1510
Ethyl (Z)-2-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)-3-(dimethylamino)propenoate was prepared in one step from ethyl (2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)acetate and bis(dimethylamino)-tert-butoxymethane and treated with various amines and hydrazines to afford the corresponding amino substituted products. Reactions of the titled compound with N,N'-, C,N-, and C,O'-ambident nucleophiles in refluxing acetic acid furnished the corresponding fused pyrimidinones, quinolizinones, and pyranones. 相似文献
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Mallu Kiran Kumar Reddy Gundluru Mohan Sarva Santhisudha Cirandur Suresh Reddy 《Russian Journal of General Chemistry》2021,91(12):2506-2514
Russian Journal of General Chemistry - A series of structurally diverse and biologically potent diethyl [(substituted phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl]phosphonates has... 相似文献
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The title compound 3 was obtained during the rearrangement of isoxazol-5-yl hydrazine 1 to 1-aminopyrazolone 2 at 115°. X-ray analysis of the corresponding benzylidene derivative allowed us to achieve the structure assignment. 相似文献
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Long La-Sheng Tong Ye-Xiang Yang Shi-Ping Chen Xiao-Ming Ji Liang-Nian 《Transition Metal Chemistry》1999,24(4):440-444
The syntheses of two polydentate ligands comprising imidazole donors, 1,3-bis[(4-methyl-5-imidazol-1-yl) ethylideneamino]propan-2-ol (BIPO), 1,3-bis[(4-methyl-5-imidazol-1-yl)ethylideneamino]propane (BIP), and their copper(II) complexes [Cu(BIPO)(ClO4)(H2O)] (NO3) · H2O (1) and [Cu(BIP)(ClO4)](ClO4) · 2H2O (2) are reported. Single-crystal structural analyses show that (1) adopts an elongated octahedral geometry with the axial positions occupied by a perchlorate oxygen atom and an aqua ligand, while (2) adopts a distorted square-pyramidal geometry with the axial positions occupied by a perchlorate oxygen atom. Electronic spectra in aqueous solution indicate that both (1) and (2) adopt square-pyramidal geometry. Cyclic voltammetry in aqueous solution gives reduction waves at –0.07 and –0.08 V versus s.c.e. for (1) and (2), respectively. The low reduction potential and general reversibility of the redox reaction of (1) and (2) indicate that BIPO and BIP are flexible enough to stabilize both CuII and CuI forms of the complexes. 相似文献
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Kolyamshin O. A. Mitrasov Yu. N. Danilov V. A. Avruiskaya A. A. Pylchikova Yu. Yu. Savinova N. P. 《Russian Journal of General Chemistry》2021,91(1):34-39
Russian Journal of General Chemistry - The reaction of 2-[3(4)-nitrophenyl]-5,5-dichloromethyl-1,3-dioxanes with potassium 4-aminobenzoate in dimethylformamide gave... 相似文献
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Song Y Zhang L Huizhong Shi D Xie J Zhao G 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,70(4):943-952
The solid phase FT-IR and FT-Raman spectra of 1-[6-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-2-[(6-chloropyridin-3-yl)methylsulfanyl]-4-methyl-1,6-dihydropyrimidin-5-yl]ethanone (C25H21Cl3N4OS) were recorded in the region 4000-400 and 3500-100cm(-1), respectively. The vibrational spectra have been computed using density functional theory (B3LYP) and ab initio molecular orbital calculation (HF) with 6-31G(d, p) basis sets. A close agreement was achieved between the observed and calculated frequency by employing normal coordinate calculations. The observed and simulated spectra were found to be well comparable. 相似文献
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Alex F. C. Flores Juliana L. Malavolta Leandro M. Frigo Morgana Doneda Darlene C. Flores 《合成通讯》2013,43(10):1198-1204
We develop an efficient method to synthesize novel propionyl-spaced bisheterocyclic compounds. It entails cyclocondensation of 3-(5-trifluoromethyl-1H-pyrazol-3-yl)propanoyl hydrazide obtained from levulinic acid, with 1,1,1-trifluoro-4-methoxy-3-alken-2-ones proceeding regiospecifically to 1-[(5-trifluoromethyl-5-hydroxy-3-substituted-4,5-dihydro-1H-pyrazol-1-yl)-3-(5-trifluoromethyl-1H-pyrazol-3-yl)propan-1-one derivatives. 相似文献
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The title compound trans-4-[(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1H-pyra-zol-4-yl)methyleneamino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 (C28H23Cl2N5O2, Mr = 532.41) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1 with a = 8.9438(4), b = 11.6065(5), c = 14.2215(6) , α = 112.566(1), β = 92.324(2), γ = 102.91(1)o, V = 1315.65(10) 3, Z = 2, Dc = 1.344 g/cm3, μ(MoKα) = 0.282 mm-1, λ = 0.71073 , F(000) = 552, the final R = 0.0587 and wR = 0.1578 for 5071 observed reflections (I > 2σ(I)). X-ray analysis reveals that the product is a thermodynamically stable trans isomer. Intra-and intermolecular C(12)-H(12)···O(1) and C(28)-H(28)···O(1)#1 hydrogen bonds were observed in the title compound. 相似文献
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Xing Zhou LI Xian Ping DAI Jun Hai XIAO Song LI* Beijing Institute of Pharmacology & Toxicology Beijing School of pharmaceutical Engineering Shenyang Pharmaceutical University Shengyang 《中国化学快报》2005,16(9):1137-1139
For discovering novel small molecule inhibitors of transforming growth factor-β1(TGF-β1)type-I receptor(ALK5),we designed1,3,5-triaryl-4-hydroxyl-4,5-dihydro-1H-pyrazole(1)as target compound,mimic the structure of SB-431542which is a2-pyridyl substituted triarylimiazole inhibitor of ALK51.Racemic compound1showed moderate ALK5inhibitory activity in luciferase reporter assays[inhibition(%control):0.1umol/L8.79%;1umol/L19.05%].To investigate the influence of the absolute configuration of… 相似文献