HPTLC-Densitometric Analysis of Candesartan Cilexetil and Hydrochlorothiazide in Tablets

JPC – Journal of Planar Chromatography – Modern TLC - A simple, rapid and precise high-performance thin-layer chromatographic (HPTLC) method for analysis of candesartan cilexetil and...     

Simultaneous Densitometric Determination of Quinapril and Hydrochlorothiazide in the Combination Tablets

JPC – Journal of Planar Chromatography – Modern TLC - A new, simple, and accurate TLC method, using normal- and reversed-phase techniques and densitometric detection, has been developed...     

Stability-Indicating HPTLC Method for Simultaneous Estimation of Amlodipine Besylate,Hydrochlorothiazide and Olmesartan Medoxomil in Combined Tablet Dosage Forms

JPC – Journal of Planar Chromatography – Modern TLC -     

Simultaneous Densitometric TLC Analysis of Olmesartan Medoxomil and Hydrochlorothiazide in the Tablet Dosage Form

JPC – Journal of Planar Chromatography – Modern TLC - A simple, rapid, and selective densitometric thin-layer chromatographic (TLC) method has been established and validated for...     

Triarylborane-Appended Anils and Boranils: Solid-State Emission,Mechanofluorochromism, and Phosphorescence

Herein, the design, synthesis, optical properties, and mechanofluorochromism characteristics of a series of conjugates having covalently linked triarylborane (TAB) and anil/boranil units (TAB-anil: 1 a – 3 a and TAB-boranil: 1 – 3 ) are reported. The electronic interactions between TAB and anil/boranil in 1 a – 3 a and 1 – 3 were fine-tuned by changing the boryl moiety's position on the phenyl spacer connecting the BMes₂ (Mes=mesityl) and anil/boranil units. A boryl moiety at the meta position ( 1 a ) of the phenyl spacer stabilizes the enolic form (E-OH), whereas a boryl moiety at the para position ( 2 a and 3 a ) stabilizes the keto form (Z-NH) in the solid state. However, in solution 1 a , 2 a , and 3 a exhibit keto–enol tautomerism in both ground and excited states. Compounds 1 a – 3 a and 1 – 3 show red-shifted absorption compared with 4 a and 4 , which are devoid of TAB moieties, which indicate effective participation of an empty p orbital on the boron center in 1 a – 3 a and 1 – 3 . Compounds 1 and 2 showed fluorescence variations in response to external stimuli such as mechanical grinding. Long phosphorescence lifetimes of 18–46 ms were observed for compounds 1 – 3 . The observed optical properties of 1 a – 3 a and 1 – 3 are rationalized in the context of quantum mechanical calculations.     

Densitometric Determination of Naproxen,and of Naproxen Methyl Ester,its Impurity,in Pharmaceutical Preparations

JPC – Journal of Planar Chromatography – Modern TLC - A chromatographic–densitometric method has been established for identification and quantification of...     

Densitometric HPTLC Analysis of Juglone,Quercetin, Myricetin,Rutin, Caffeic Acid,and Gallic Acid in Juglans regia L.

JPC – Journal of Planar Chromatography – Modern TLC - Asensitive, selective, and precise high-performance thin-layer chromatography (HPTLC) method was developed for simultaneous...     

Isolation and Densitometric HPTLC Analysis of Rutin,Narcissin, Nicotiflorin,and Isoquercitrin in Caragana spinosa Shoots

JPC – Journal of Planar Chromatography – Modern TLC - Athin-layer chromatographic (TLC) method was used for the quantification of four dominant flavonoids (rutin, narcissin,...     

Thin-Layer Chromatographic Determination of Diazepam,Phenobarbitone, and Saccharin in Toddy Samples

JPC – Journal of Planar Chromatography – Modern TLC -     

Videodensitometric HPTLC Determination of Fleroxacin,Sparfloxacin, and Cinoxacin in Tablets

JPC – Journal of Planar Chromatography – Modern TLC - A new, simple, accurate, and rapid high-performance thin-layer chromatographic method has been developed for the determination of...     

Densitometric Determination of Omeprazole,Pantoprazole, and their Impurities in Pharmaceuticals

JPC – Journal of Planar Chromatography – Modern TLC - A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and...     

TLC Retention Behavior of Brodifacoum,Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents

JPC – Journal of Planar Chromatography – Modern TLC - The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and...     

Separation,Identification, and Quantitative Analysis of the Epimers of Cefaclor by TLC-Densitometry

JPC – Journal of Planar Chromatography – Modern TLC - The epimers of cefaclor have been separated, identified, and analyzed quantitatively by TLC. The stationary phase was silica gel 60...     

Simultaneous RP-LC Determination of Losartan Potassium, Ramipril, and Hydrochlorothiazide in Pharmaceutical Preparations

A simple, rapid, and precise reversed-phase high-performance liquid chromatographic method has been developed for simultaneous determination of losartan potassium, ramipril, and hydrochlorothiazide. The three drugs were separated on a 150 mm × 4.6 mm i.d., 5 μm particle, Cosmosil C₁₈ column. The mobile phase was 0.025 m sodium perchlorate–acetonitrile, 62:38 (v/v), containing 0.1% heptanesulphonic acid, pH adjusted to 2.85 with orthophosphoric acid, at a flow rate of 1.0 mL min⁻¹. UV detection was performed at 215 nm. The method was validated for linearity, accuracy, precision, and limit of quantitation. Linearity, accuracy, and precision were acceptable in the ranges 35–65 μg mL⁻¹ for losartan, 1.75–3.25 μg mL⁻¹ for ramipril, and 8.75–16.25 μg mL⁻¹ for hydrochlorothiazide.     

Simultaneous Determination of Marmin,Skimmianine, Umbelliferone,Psoralene, and Imperatorin in the Root Bark of Aegle Marmelos by High-Performance Thin-Layer Chromatography

JPC – Journal of Planar Chromatography – Modern TLC - Aegle marmelos (Rutaceae) has gained traditional therapeutic importance owing to their coumarins (umbelliferone, psoralene, marmin,...     

Reversed-Phase Pressurized Planar Electrochromatography and Planar Chromatography of Acetylsalicylic Acid,Caffeine, and Acetaminophen

JPC – Journal of Planar Chromatography – Modern TLC - We have investigated the use of pressurized planar electrochromatography (PPEC) and planar chromatography (TLC) for reversed-phase...     

Synthesis of Novel Chromene,Pyridine, Pyrazole,Pyrimidine, and Imidazole Derivatives via One‐pot Multicomponent Reaction

New series of chromenes 2 – 4 , pyridines 5 – 8 , and pyranopyrazoles 9a,b were synthesized via one‐pot multicomponent reaction of 4‐tosyloxybenzaldehyde ( 1 ) and malononitrile with phenols, amines or hydrazines, and ethyl acetoacetate, respectively. Compound 9a was reacted with acetic anhydride, formic acid, or formamide to afford N ‐acetyl derivative 10 and pyrazolopyranopyrimidines 11 – 13 , respectively. Imidazole derivatives 14 and 15a – d were obtained by multicomponent reaction between compound 1 with ammonium acetate and benzil or aromatic amines in (1:2:1) or (1:1:1:1) ratio, respectively. The structures of new compounds were elucidated by elemental and spectral analyses.     

A New TLC Method for Quantification of Paraquat,Diquat, Difenzoquat,Mepiquat and Chloromequat in Water

JPC – Journal of Planar Chromatography – Modern TLC - We report improved separation of the highly toxic contact herbicides paraquat, diquat, difenzoquat, mepiquat, and chloromequat by...     

Thin-Layer Chromatographic Separation of Cadaverine and Ornithine,and Spectrophotometric Quantification

JPC – Journal of Planar Chromatography – Modern TLC -     

Mononuclear Tetraamineplatinum(II) Complexes: Synthesis,Anticancer Activity,DNA Binding,and Cellular Uptake

The synthesis of three bis[(tert‐butoxy)carbonyl]‐protected (tetramine)dichloroplatinum complexes 2a – c of formula cis‐[PtCl₂(LL)] and of their cationic deprotected analogs 3a – c and their evaluation with respect to in vitro cytotoxicity, intramolecular stability, DNA binding, and cellular uptake is reported. The synthesis comprises the complexation of K₂[PtCl₄] with di‐N‐protected tetramines 1a – c to give 2a – c and subsequent acidolysis, yielding 3a – c . The cytotoxicity of the complexes is in direct relation to the length of the polyamine. Complexes 3a – c display a significant higher affinity for CT DNA as well as for cellular DNA in A2780 cells than cisplatin.