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1.
Krivonogov V. P. Sivkova G. A. Belaya E. A. Greben'kova N. V. Kozlova G. G. Abdrakhmanov I. B. Spirikhin L. V. Mannapova R. T. 《Russian Journal of Organic Chemistry》2003,39(5):723-726
Reactions of 1,3-bis(3-chloro-2-hydroxypropyl)uracil, 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracil, 1,3-bis(3-chloro-2-hydroxypropyl)-5-hydroxy-6-methyluracil, and 1,3-bis(3-chloro-2-hydroxypropyl)-5-fluorouracil with 2-amino-4-methylthiobutanoic acid (methionine) were studied for the first time. 相似文献
2.
Mirza Arfan Yawer Stefanie Reim Ehsan Ullah Inam Iqbal Helmut Reinke Peter Langer 《Tetrahedron》2007,63(51):12562-12575
A variety of 4-chlorophenols, 10-chloro-7-hydroxy-6H-benzo[c]chromen-6-ones, and 4-chloro-1-hydroxy-9H-fluoren-9-ones were prepared by formal [3+3] cyclizations of 1,3-bis(silyloxy)-1,3-dienes with 2-chloro-3-(silyloxy)alk-2-en-1-ones. 相似文献
3.
Treatment of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha-chlorocarboxylic acid chlorides resulted in chemo- and regioselective formation of 6-chloro3,5-dioxo esters, which were regioselectively converted into functionalised 3(2H)furanones. Chemo- and regioselective condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha-chloroacetic dimethyl acetal afforded 6-chloro-5-methoxy-3-oxo esters, which could be regio- and stereoselectively transformed into 2-alkylidene-4-methoxytetrahydrofurans. 相似文献
4.
The 1,3-dipolar cycloaddition of 1,2-dithiole-3-thiones with alkynes to form 1,3-dithioles is one of the most studied reactions in this class of polysulfur-containing heterocycles. Nucleophilic substitution of chlorine atoms in dimethyl 2-(1,2-dichloro-2-thioxoethylidene)-1,3-dithiole-4,5-dicarboxylate, which was obtained by addition one molecules of DMAD to 4,5-dichloro-3H-1,2-dithiole-3-thione, led to a series of 2-chloro-2-(1,3-dithiol-2-ylidene)ethanethioamides. Cycloaddition reaction of 2-chloro-2-(1,3-dithiol-2-ylidene)ethanethioamides with activated alkynes led to the unexpected formation of 2-(thiophen-3(2H)-ylidene)-1,3-dithioles via new intermediate, 1-(1,3-dithiol-2-ylidene)-N-phenylethan-1-yliumimidothioate. Structure of dimethyl 2-(4,5-bis(methoxycarbonyl)-2-(phenylimino)thiophen-3(2H)-ylidene)-1,3-dithiole-4,5-dicarboxylate was finally proven by single crystal X-ray diffraction study. Optimized reaction conditions and a mechanistic rationale for the 1,3-dipolar cycloaddition of novel intermediate are presented. 相似文献
5.
Krivonogov V. P. Kozlova G. G. Belaya E. A. Sivkova G. A. Spirikhin L. V. Abdrakhmanov I. B. Plechev V. V. 《Russian Journal of Organic Chemistry》2004,40(3):417-420
6-Methyluracil sodium salt reacts with 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracils in DMF, yielding products of alkylation at the nitrogen atom in position 3 of the uracil ring. 相似文献
6.
L. M. Potikha A. R. Turelik V. A. Kovtunenko 《Chemistry of Heterocyclic Compounds》2009,45(10):1184-1189
Bromination of 1,3-bis(aryl)-2-buten-1-ones by N-bromosuccinimide in anhydrous carbon tetrachloride gives Z-1,3-bis(aryl)-4-bromo-2-buten-1-ones.
The effect of the nature of substituent in the benzene ring on the course of a reaction with nucleophiles has been studied.
Heating an alcohol solution of these ketones (Ar = 4-MeOC6H4, 4-ClC6H4) in the presence of acid or in the presence of base (Ar = Ph) gave 2,4-bis(aryl)furans. Treatment of 1,3-bis(aryl)-4-bromo-2-buten-1-ones
with thioacetamide gave 2,4-bis(aryl)thiophenes. The oxidation of the halo-substituted dypnones with H2O2/NaOH gave (3-bromomethyl-3-aryl-2-oxiranyl)(aryl)methanones. The reaction of halo-substituted dypnones with aryl hydrazines
gave 1,3,5-triaryl-1,6-dihydropyridazines or 1,3,5-triarylpyridazinium bromides depending on the structure of the reagents. 相似文献
7.
The cyclocondensation of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with 1,3-bis(silyloxy)-1,3-butadienes provides a convenient synthesis of benzo[c]chromen-6-ones. 相似文献
8.
A variety of 2-arylthio-4-methoxybenzoates are regioselectively prepared by TiCl4-mediated [3+3] cyclocondensations of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 3-oxo-orthoesters. Unsubstituted 2-(arylthio)benzoates were prepared by Me3SiOTf-catalyzed cyclization of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 1,1,3,3-tetramethoxypropane. The TiCl4-mediated cyclization of 3-arylthio-1-trimethylsilyloxy-1,3-butadienes with 1,1-bis(methylthio)-1-en-3-ones results in regioselective formation of 2-arylthio-6-(methylthio)benzoates. 相似文献
9.
The heating of perfluoro-3,3-diethylindan-1-one with SbF5 at 180°C after treatment of the reaction mixture with anhydrous HF afforded perfluoro-1,3-dimethyl-4-ethylisochromen, and after hydrolysis, perfluoro-1,3-dimethyl-4-ethyl-1H-isochromen-1-ol. The latter under the action of NaHCO3 converted into 5,6,7,8-tetrafluoro-1,3-bis(trifluoromethyl)-1H-isochromen-1-ol. Both isochromenols reacted with SOCl2 gave the corresponding polyfluoro-1-chloro-1H-isochromens. On dissolving isochromenols in CF3SO3H and isochromens in SbF5 perfluoro-1,3-dimethyl-4-ethylisochromenyl and 5,6,7,8-tetrafluoro-1,3-bis(trifluoromethyl)isochromenyl cations were generated which by hydrolysis were converted into the corresponding isochromenols. 相似文献
10.
E. G. Mesropyan G. B. Ambartsumyan A. A. Avetisyan A. S. Galstyan I. R. Arutyunova 《Russian Journal of Organic Chemistry》2005,41(1):67-69
1-Phenoxy-3-piperidinopropan-2-ol, 1-(5-methyl-1,3-benzothiazol-2-ylsulfanyl)-3-phenoxypropan-2-ol, 1-(2-hydroxy-3-phenoxypropyl)azepan-2-one, 1,1′-(6-chloro-1,3-benzothiazol-2-ylimino)bis(3-phenoxypropan-2-ol), 1-(1,3-benzothiazol-2-ylsulfanyl)-3-phenoxypropan-2-ol, 1,1′-(piperazine-1,4-diyl)bis(3-phenoxypropan-2-ol), and 1,3-bis(2-hydroxy-3-phenoxypropyl)barbituric acid were synthesized by condensation of 1,2-epoxy-3-phenoxypropane with the corresponding amines and thiols.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 70–72.Original Russian Text Copyright © 2005 by Mesropyan, Ambartsumyan, Avetisyan, Galstyan, Arutyunova. 相似文献
11.
Vergil Percec James H. Wang Shigeru Okita 《Journal of polymer science. Part A, Polymer chemistry》1991,29(12):1789-1800
This article describes the synthesis and the cation-radical polymerization (Scholl reaction) of 1,3-bis[4-(1-naphthoxy) benzoyl] benzene ( 6 ) and 1,4-bis[4-(1-naphthoxy) benzoyl]- benzene ( 7 ) initiated by FeCI3. This polymerization produced poly(ether ether ketone ketone)s (PEEKK) of number average molecular weight (M?n) up to 5400 g/mol. The synthesis of bis[4-(1-naphthoxy) phenyl] methane ( 8 ), 1,3-bis[4-(1-napthoxy) phenylmethyl] benzene ( 9 ), and 1,4-bis[4-(1-naphthoxy) phenylmethyl] benzene ( 10 ) are also described. Polyethers of M?n up to 15400 g/mol at a FeCl3/monomer molar ratio of 2/1 were obtained. An increased polymerizability of the monomers 9 and 10 containing two CH2 groups versus that of the corresponding monomers containing two carbonyl groups ( 6 and 7 ) was observed. This enhanced polymerizability was explained based on the increased nucleophilicity of monomers 9 and 10 . 相似文献
12.
Viktor O. Iaroshenko Alina Bunescu Lutz Domke Dmitri V. Sevenard Vyacheslav Ya. Sosnovskikh 《Journal of fluorine chemistry》2011,132(7):441-449
A formal [3+3] cyclocondensation of 1,3-bis(silyl enol ethers) with the little-known 4,4-dimethylthio-1,1,1-trifluorobut-3-en-2-one was studied. In contrast to 4,4-dimethoxy-1,1,1-trifluorobut-3-en-2-one, this α-oxoketene dithioacetal reacts with 1,3-bis(trimethylsilyloxy)-1,3-butadienes in the presence of TiCl4 to give mainly 6-methylthio-4-(trifluoromethyl)salicylates via 1,2-addition. The scope and limitations of the reaction are discussed. 相似文献
13.
R. Abele E. Abele K. Rubina O. Dzenitis P. Arsenyan I. Shestakova A. Nesterova I. Domracheva J. Popelis S. Grinberga E. Lukevics 《Chemistry of Heterocyclic Compounds》2002,38(7):867-872
We have developed a two-step method for synthesis of 3-(hetarylthio)-1-propynyl(trimethyl)silanes from thiols in a phase-transfer catalysis system HCCCH2Br-solid K2CO3-18-crown-6-toluene followed by reaction with n-BuLi-Me3SiCl in ether or THF. We have observed that 3-[1,3-bis(trimethylsilyl)-2-propynyl]thioindole displays high cytotoxicity in HT-1080 and MG-22A tumor cell lines. 相似文献
14.
By reaction of Z-3-(2-naphthyl)-3-chloro-2-propenal with semicarbazide hydrochloride and thiosemicarbazide the corresponding semicarbazone and thiosemicarbazone were obtained that underwent a heterocyclization into a pyrazole system with elimination of amide moieties and with migration of the naphthyl fragment into the position 4 of the pyrazole ring. The alkylation of 4-(2-naphthyl)pyrazole synthesized with 2-nitropentachloro-1,3-butadiene afforded 1,1-bis[4-(2-naphthyl)-pyrazol-1-yl]-2-nitrotrichloro-1,3-butadiene.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 5, 2005, pp. 753–755.Original Russian Text Copyright © 2005 by Vashkevich, Potkin, Kozlov. 相似文献
15.
Yu. A. Sayapin E. A. Gusakov Zyong Ngia Bang I. O. Tupaeva V. N. Komissarov I. V. Dorogan V. V. Tkachev S. M. Aldoshin V. I. Minkin 《Russian Chemical Bulletin》2013,62(2):480-491
A reaction of substituted 2-(quinolin-2-yl)-1,3-tropolones with POCl3 leads to the new3-chloro-2-(quinolin-2-yl)tropone derivatives. New 2-(4-arylaminoquinolin-2-yl)-3-aryl-aminocyclohepta-2,4,6-trien-1-ones and 2-[4-morpholino(piperidino)quinolin-2-yl]-3-aryl-aminocyclohepta-2,4,6-trien-1-ones were obtained by nucleophilic substitution reaction of the halogen atom in 2-(4-chloroquinolin-2-yl)-3-chlorotropones and 3-chloro-2-[4-morpholino-(piperidino)quinolin-2-yl]tropones. Molecular structures of 3-chloro-2-(quinolin-2-yl)tropone and 3-arylamino-2-(quinolin-2-yl)tropone were established by X-ray diffraction analysis. Energy and structural characteristics of isomers of 3-arylamino-2-(quinolin-2-yl)tropones in the gas phase and in solution were calculated by the density functional theory method (PBE0/6-31G**). 相似文献
16.
Functionalized amino- and nitro-substituted biaryls and dibenzo[b,d]pyrid-6-ones (6(5H)-phenanthridinones) were prepared by [3+3]cyclocondensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with nitro-substituted 1-aryl-1-silyloxy-1-en-3-ones and subsequent hydrogenation. 4-Nitro- and 4-aminophenols were prepared based on formal [3+3] cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-ethoxy-2-nitro-2-en-1-ones. 相似文献
17.
M. Zh. Ovakimyan A. S. Pogosyan M. L. Movsisyan M. G. Indzhikyan 《Russian Chemical Bulletin》2010,59(3):560-564
Basic hydrolysis of 1,4-bis(triphenylphosphonio)buta-1, 3-diene dichloride with 10% NaOH gave isomeric 4-diphenylphosphoryl-4-phenylbut-1(2)-enes
and 1-diphenylphosphoryl-1-phe-nylbuta-1, 3-diene, the products of anionotropic migration of a phenyl group from the P atom
to the α-position. Hydrolysis with Na2CO3 afforded only the diene product. In both cases, triphe-nylphosphine and triphenylphosphine oxide were isolated as secondary
products. Dehydro-chlorination of 2-chloro-1,4-bis(triphenylphosphonio)but-2-ene dibromide with triphenylphosphine was proposed
as a new convenient route to 1,4-bis(triphenylphosphonio)buta-1,3-diene dibromide. 相似文献
18.
The domino, Michael-retro-Michael-aldol, reaction of 2,4-bis(trimethylsilyloxy)penta-1,3-diene with 3-formylchromones afforded 4-(2-hydroxybenzoyl)-2-acetylphenols, which were transformed into 6-(2-hydroxybenzoyl)chromones. The Me3SiOTf-mediated condensation of the latter with 1,3-bis(silyl enol ethers) and subsequent domino ‘retro-Michael-aldol-lactonization’ reaction afforded 7-hydroxy-2-(2-hydroxybenzoyl)benzo[c]chromen-6-ones. 相似文献
19.
Obaid-Ur-Rahman Abid Muhammad Nawaz Nasim Hasan Rama Peter Langer 《Tetrahedron letters》2010,51(4):657-7025
The [4+2] cycloaddition of 1-ethoxy-2-chloro-1,3-bis(trimethylsilyloxy)-1,3-diene with dimethyl acetylenedicarboxylate (DMAD) afforded dimethyl 4-chloro-3,5-dihydroxyphthalate. Site-selective Suzuki-Miyaura reactions of its bis(triflate) provide a convenient approach to 3,5-diaryl-4-chlorophthalates containing two different aryl groups. 相似文献
20.
Stefanie Reim Ibrar Hussain Zafar Ahmed Alexander Villinger 《Tetrahedron letters》2008,49(33):4901-4904
The reaction of 2-chloro-1,3-bis(trimethylsilyloxy)-1,3-butadienes with various electrophiles allows a convenient synthesis of chlorinated molecules which are not readily available by other methods. 相似文献