5,7,12,14-Tetramethyldimethoxybenzo[b,i][1,4,8,11]tetraazacyclodecine,a new tumoricidal pseudo-porphyrin

The title compound, a mixture of two isomers differing in the position of a methoxy substituent in one benzene ring, was obtained in a Ni-templated synthesis directly as a water soluble dihydrochloride of the free base. The cyclic voltametry study indicated that in a neutral solution the reduction and oxidation are irreversible one electron processes, the latter leading to cation radical undergoing polymerization, a process followed by deposition of a film on the electrode. In 1,2-dichloroethane the cation radical is oxidized to a dication, both species being much less stable than those originating from meso-tetraphenylporphyrin. The title compoud at 2.5 × 10^?5 M in Tris buffer showed a 50% inhibition of the growth of malignant melanoma cells as compared to a 44% inhibition shown by a water soluble meso-monomethoxy-tris(N-methylpyridinium)porphyrin. The exposure to light for 30 minutes at 2.5 times smaller concentration increased the inhibition caused by the pseudo-porphyrin from 9% to 49%.     

Reaction of 2,3-dichloro-1,4-naphthoquinone with dithiooxamide. Synthesis of dibenzo[b,i]thianthrene-5,7,12,14-tetrone

The reaction of 2,3-dihalogeno-1,4-naphthoquinone with dithiooxamide gave dibenzo[b,i]thianthrene-5,7,12,14-tetrone in high yield but not 2,2′-bis(naphtho[2,3-d]thiazole-4,9-dione) which was previously reported. A similar reaction of 3,4-dichloro-N-phenylmaleimide with dithiooxamide also gave the corresponding sulfur heterocycles but not the reported bisthiazole.     

离子液体中13-芳基-5,7,12,14-四氢二苯并[b, i]氧杂蒽5,7,12,14(13H)-四酮衍生物的绿色高效合成

在离子液体[bmim+][BF4-]中高产率的合成了一系列13-芳基-5,7,12,14-四氢二苯并[b, i]氧杂蒽-5,7,12,14(13H)-四酮类化合物。该反应操作步骤简单,离子液体易于与产物分离,并且离子液体可以循环使用。     

Synthesis, characterization and crystal structure of a 6,8,15,17-tetramethyldibenzo [b,i] (1,4,8,11)tetraaza (14)-annulene yttrium (III) complex

In this study, the sandwich complex of tmtaa, Y(tmtaa) (Htmtaa)·2THF (H₂tmtaa=6,8,15,17-tetramethyldibenzo [b,i] , respectively. The distances of the yttrium to the planes of the 4 nitrogen atoms for tmtaa and Htmtaa are 1.44 (2) and 1.51 (2) Å, respectively.     

A rapid and efficient method for the synthesis of 14H-dibenzo[α.j]xanthenes,aryl-5H-dibenzo[b.i]xanthene-5,7,12,14-(13H)-tetraone and 1,8-dioxooctahydroxanthenes by acidic ionic liquid

<正>Various xanthenes have been synthesized by the condensation ofβ-naphthol,2-hydroxynaphthalene-1,4-dione or dimedone with various aldehydes in the presence of trifluoroacetic acid as catalyst in 1,1,3,3-N,N,N′,N′-tetramethylguanidinium trifluoroacetate (TMGT) ionic liquid within 1 h at 75℃.     

The synthesis of benzo[b]phenanthro[d]thiophenes and anthra[b]benzo[d]thiophenes

The synthesis of benzo[b]phenanthro[2, 3-d]thiophene ( 5 ), benzo[b]phenanthro[4, 3-d]thiophene ( 6 ), benzo-[b]phenanthro[2, 1-d]thiophene ( 9 ), benzo[b]phenanthro[3, 2-d]thiophene ( 14a ), anthra[1, 2-b]benzo[d]thiophene ( 24 ), anthra[2, 3-b]benzo[d]thiophene ( 29 ) and anthra[2, 1-b]benzo[d]thiophene ( 30 ) is described as well as the preparation of 13-methylbenzo[b]phenanthro[3, 2-d]thiophene ( 14b ).     

六元瓜环与磺基水杨酸主客体配合物的晶体结构

合成了六元瓜环与磺基水杨酸主客体配合物,并测定了其单晶结构.晶体结构表明六元瓜环包结了3个水分子,磺基水杨酸位于六元瓜环的外侧,且与水分子通过氢键与六元瓜环相连,瓜环之间通过端口的羰基O原子、磺基水杨酸以及水分子间的氢键作用形成一维超分子.     

Dipole moments of phenyl,benzo, and benzo[b]thiopheno derivatives of thiophene; 1, 4-dithiin,and thianthrene and their sulfones

The dipole moments of a series of phenyl, benzo-, and benzo[b]thiopheno-derivatives of thiophene, 1,4-dithiin, and thianthrene have been determined. An increase in the dipole moments of the phenyl derivatives of thiophene with an increase in the number of phenyl groups is connected with the existence of conjugation between the thiophene and benzene rings, a quantitative evaluation of the nature of which is given. It is suggested that the structure of the 1, 4-dithiin ring is close to coplanar.