Mathematical Modeling and Analysis of an Epidemic Model with Quarantine, Latent and Media Coverage

Epidemic models are very important in today''s analysis of diseases. In this paper, we propose and analyze an epidemic model incorporating quarantine, latent, media coverage and time delay. We analyze the local stability of either the disease-free and endemic equilibrium in terms of the basic reproduction number $\mathcal{R}_{0}$ as a threshold parameter. We prove that if $\mathcal{R}_{0}<1,$ the time delay in media coverage can not affect the stability of the disease-free equilibrium and if $\mathcal{R}_{0}>1$, the model has at least one positive endemic equilibrium, the stability will be affected by the time delay and some conditions for Hopf bifurcation around infected equilibrium to occur are obtained by using the time delay as a bifurcation parameter. We illustrate our results by some numerical simulations such that we show that a proper application of quarantine plays a critical role in the clearance of the disease, and therefore a direct contact between people plays a critical role in the transmission of the disease.     

总人口规模变化的年龄结构SEIR流行病模型的稳定性

运用泛函分析中的谱理论和非线性发展方程的齐次动力系统理论,讨论了总人口规模变化情况下的年龄结构的SEIR流行病模型．得到了与总人口增长指数λ*有关的再生数R0的表达式,证明了当R0<1时,系统存在唯一局部渐近稳定的无病平衡态;当 R0>1时,无病平衡态不稳定,此时存在地方病平衡态,并在一定条件下证明了地方病平衡态是局部渐近稳定的．     

Global dynamics of a reaction and diffusion model for an HTLV-I infection with mitotic division of actively infected cells

This paper is concerned with the global dynamics of a reaction and diffusion model for an HTLV-I infection with mitotic division of actively infected cells and CTL immune response. The well posedness of the proposed model is investigated. In the case of a bounded spatial domain, we establish the threshold dynamics in terms of the basic reproduction number $\mathcal{R}_0$ for the spatially heterogeneous model. Also, by means of different Lyapunov functions, the global asymptotic properties of the steady states for the spatially homogeneous model are studied. In the case of an unbounded spatial domain, there are no travelling wave solutions connecting the infection-free steady state with itself when $\mathcal{R}_0 < 1$. Finally, numerical simulations and conclusions are given.     

Dynamics of a Deterministic and Stochastic Susceptible-exposed-infectious-recovered Epidemic Model

We investigate a susceptible-exposed-infectious-recovered (SEIR) epidemic model with asymptomatic infective individuals. First, we formulate a deterministic model, and give the basic reproduction number $\mathcal{R}_{0}$. We show that the disease is persistent, if $\mathcal{R}_{0}>1$, and it is extinct, if $\mathcal{R}_{0}<1$. Then, we formulate a stochastic version of the deterministic model. By constructing suitable stochastic Lyapunov functions, we establish sufficient criteria for the extinction and the existence of ergodic stationary distribution to the model. As a case, we study the COVID-19 transmission in Wuhan, China, and perform some sensitivity analysis. Our numerical simulations are carried out to illustrate the analytic results.     

Boundedness of High Order Commutators of Riesz Transforms Associated with Schrödinger Type Operators

Let L_2=(-?)~2+ V~2 be the Schr?dinger type operator, where V■0 is a nonnegative potential and belongs to the reverse H?lder class RH_(q1) for q_1 n/2, n ≥5. The higher Riesz transform associated with L_2 is denoted by ■and its dual is denoted by ■. In this paper, we consider the m-order commutators [b~m, R] and [b~m, R*], and establish the(L~p, L~q)-boundedness of these commutators when b belongs to the new Campanato space Λ_β~θ(ρ) and 1/q = 1/p-mβ/n.     

Lipschitz Estimates for Commutators of $N$-Dimensional Fractional Hardy Operators

In this paper, it is proved that the commutator$\mathcal{H}_{β,b}$ which is generated by the $n$-dimensional fractional Hardy operator $\mathcal{H}_β$ and $b\in \dot{Λ}_α(\mathbb{R}^n)$ is bounded from $L^P(\mathbb{R}^n)$ to $L^q(\mathbb{R}^n)$, where $0<α<1,1相似文献   

Ext_F-投射生成子与Ext_F-内射余生成子

设A是Abel范畴,F是Ext_A~1(-,-):A~(op)×A→A的加法子双函子.首先研究了Ext_(F-)投射生成子与Ext_F-内射余生成子的同调性质,其次引入了W_F-Gorenstein模的概念.特别地,证明了如果重复W_F-Gorenstein模的定义程序将不会产生新的模类.最后,统一并推广了许多参考文献中的结论.     

The dynamic behavior of deterministic and stochastic delayed SIQS model

In this paper, we present the deterministic and stochastic delayed SIQS epidemic models. For the deterministic model, the basic reproductive number $R_{0}$ is given. Moreover, when $R_{0}<1$, the disease-free equilibrium is globally asymptotical stable. When $R_{0}>1$ and additional conditions hold, the endemic equilibrium is globally asymptotical stable. For the stochastic model, a sharp threshold $\overset{\wedge }{R}_{0}$ which determines the extinction or persistence in the mean of the disease is presented. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. Numerical simulations are also conducted in the analytic results.     

Boundedness of the Cesàro Operator in Hardy Spaces

The Ces\aro operator $\mathcal{C}_{\alpha}$ is defined by \begin{equation*} (\mathcal{C}_{\alpha}f)(x) = \int_{0}^{1}t^{-1}f\left( t^{-1}x \right)\alpha (1-t)^{\alpha -1}\,dt~, \end{equation*} where $f$ denotes a function on $\mathbb{R}$. We prove that $\mathcal{C}_{\alpha}$, $\alpha >0$, is a bounded operator in the Hardy space $H^{p}$ for every $0 < p \leqq 1$.     

Stability of a delayed SIRS epidemic model with a nonlinear incidence rate

In this paper, an SIRS epidemic model with a nonlinear incidence rate and a time delay is investigated. By analyzing the corresponding characteristic equations, the local stability of an endemic equilibrium and a disease-free equilibrium is discussed. By comparison arguments, it is proved that if the basic reproductive number R₀<1, the disease-free equilibrium is globally asymptotically stable. If R₀>1, by means of an iteration technique, sufficient conditions are derived for the global asymptotic stability of the endemic equilibrium.     

On the Analytical Approach of Codimension-Three Degenerate Bogdanov-Takens (B-T) Bifurcation in Satellite Dynamical System

In this paper, we have conducted parametric analysis on the dynamics of satellite complex system using bifurcation theory. At first, five equilibrium points $\mathcal{E}_{0,1,2,3,4}$ are symbolically computed in which $\mathcal{E}_{1,3}$ and $\mathcal{E}_{2,4}$ are symmetric. Then, several theorems are stated and proved for the existence of B-T bifurcation on all equilibrium points with the aid of generalized eigenvectors and practical formulae instead of linearizations. Moreover, a special case $\alpha_{2}=0$ is observed, which confirms all the discussed cases belong to a codimension-three bifurcation along with degeneracy conditions.     

Assessing the impact of the environmental contamination on the transmission of Ebola virus disease (EVD)

This paper deals with the following biological question: how influential is the environmental contamination on the transmission of EVD? Based on the works in (Bibby et al., Environ Sci Technol Lett 2:2–6, 2015; Leroy et al., Nature 438: 575–576, 2005; World Health Organization. Unprecedented number of medical staff infected with Ebola), we design a new mathematical model to address this question by assessing the effect of the Ebola virus contaminated environment on the dynamical transmission of EVD. The formulated model captures two infection pathways through both direct human-to-human transmission and indirect human-to-environment-to-human transmission by incorporating the environment as a transition and/or reservoir of Ebola viruses. We compute the basic reproduction number \({\mathcal {R}}^{env}_0\) for the model with environmental contamination and prove that the disease-free equilibrium is globally asymptotically stable (GAS) whenever \({\mathcal {R}}^{env}_0 \le 1\). When \({\mathcal {R}}^{env}_0 > 1\), we show that the said model has a unique endemic equilibrium which is GAS. Similar results hold for the free environmental contamination sub-model (without the incorporation of the indirect transmission). More precisely, for the latter model, calculate the corresponding basic reproduction number \({\mathcal {R}}^{h}_0\) and establish the GAS of the disease-free and endemic equilibria, whenever \({\mathcal {R}}^{h}_0 \le 1\) and \({\mathcal {R}}^{h}_0 > 1\), respectively. At the endemic level, we show that the number of infected individuals for the full model with the environmental contamination is greater than the corresponding number for the free environmental contamination sub-model. In conjunction with the inequality \({\mathcal {R}}^{h}_0 < {\mathcal {R}}^{env}_0\), our finding suggests a negative answer to the biological question under investigation, i.e. the contaminated environment plays a detrimental role on the transmission dynamics of EVD by increasing the endemic level and/or the severity of the outbreak. Therefore, it is natural to implement a control strategy which aim at reducing the severity of the disease by providing adequate hygienic living conditions, educate populations at risk to follow rigorously those basic hygienic conditions as well as ask them avoid contact with suspected contaminated objects. Further, we perform numerical simulations to support the theory.     

Global Well-Posedness and Asymptotic Behavior for the 2D Subcritical Dissipative Quasi-Geostrophic Equation in Critical Fourier-Besov-Morrey Spaces

In this paper, we study the subcritical dissipative quasi-geostrophic equation. By using the Littlewood Paley theory, Fourier analysis and standard techniques we prove that there exists $v$ a unique global-in-time solution for small initial data belonging to the critical Fourier-Besov-Morrey spaces $ \mathcal{F} {\mathcal{N}}_{p, \lambda, q}^{3-2 \alpha+\frac{\lambda-2}{p}}$. Moreover, we show the asymptotic behavior of the global solution $v$. i.e., $\|v(t)\|_{ \mathcal{F} {\mathcal{N}}_{p, \lambda, q}^{3-2 \alpha+\frac{\lambda-2}{p}}}$ decays to zero as time goes to infinity.     

Quadratic derivative nonlinear Schrödinger equations in two space dimensions

We study the global in time existence of small classical solutions to the nonlinear Schrödinger equation with quadratic interactions of derivative type in two space dimensions $\left\{\begin{array}{l@{\quad}l}i \partial _{t} u+\frac{1}{2}\Delta u=\mathcal{N}\left( \nabla u,\nabla u\right),&;t >0 ,\;x\in {\bf R}^{2},\\ u\left( 0,x\right) =u_{0} \left( x\right),&;x\in {\bf R}^{2}, \end{array}\right.\quad\quad\quad\quad\quad\quad (0.1)$ where the quadratic nonlinearity has the form ${\mathcal{N}( \nabla u,\nabla v) =\sum_{k,l=1,2}\lambda _{kl} (\partial _{k}u) ( \partial _{l}v) }We study the global in time existence of small classical solutions to the nonlinear Schr?dinger equation with quadratic interactions of derivative type in two space dimensions

$\left\{{l@{\quad}l}i \partial _{t} u+\frac{1}{2}\Delta u=\mathcal{N}\left( \nabla u,\nabla u\right),&t >0 ,\;x\in {\bf R}^{2},\\ u\left( 0,x\right) =u_{0} \left( x\right),&x\in {\bf R}^{2}, \right.\quad\quad\quad\quad\quad\quad (0.1)$\left\{\begin{array}{l@{\quad}l}i \partial _{t} u+\frac{1}{2}\Delta u=\mathcal{N}\left( \nabla u,\nabla u\right),&t >0 ,\;x\in {\bf R}^{2},\\ u\left( 0,x\right) =u_{0} \left( x\right),&x\in {\bf R}^{2}, \end{array}\right.\quad\quad\quad\quad\quad\quad (0.1)      15. Relations between different types of spectra and spectral characterizations      Bolis Basit  Hans Günzler 《Semigroup Forum》2008,76(2):217-233 In the study of the asymptotic behaviour of solutions of differential-difference equations the -spectrum has been useful, where and implies Fourier transform , with given , φ∈L ∞(ℝ,X), X a Banach space, (half)line. Here we study and related concepts, give relations between them, especially weak Laplace half-line spectrum of φ, and thus ⊂ classical Beurling spectrum = Carleman spectrum =  ; also  = Beurling spectrum of “φ modulo ” (Chill-Fasangova). If satisfies a Loomis type condition (L U ), then countable and uniformly continuous ∈U are shown to imply ; here (L U ) usually means , indefinite integral Pf of f in U imply Pf in (the Bohl-Bohr theorem for = almost periodic functions, U=bounded functions). This spectral characterization and other results are extended to unbounded functions via mean classes , ℳ m U ((2.1) below) and even to distributions, generalizing various recent results for uniformly continuous bounded φ. Furthermore for solutions of convolution systems S*φ=b with in some we show . With these above results, one gets generalizations of earlier results on the asymptotic behaviour of solutions of neutral integro-differential-difference systems. Also many examples and special cases are discussed.      16. 单位方体上沿曲面的振荡积分在Sobolev空间上的有界性      赵俊燕 《数学年刊A辑(中文版)》2017,38(4):405-418 研究了欧氏空间R~2中单位方体Q~2=[0,1]~2上沿曲面(t,s,γ(t,s))的振荡奇异积分算子T_(α,β)f(u,v,x)=∫_(Q~2)f(u-t,v-s,x-γ(t,s))e~(it~(-β_1)s~(-β_2))t~(-1-α_1)s~(-1-α_2)dtds从Sobolev空间L_τ~p(R~(2+n))到L~p(R~(2+n))中的有界性,其中x∈R~n,(u,v)∈R~2,(t,s,γ(t,s))=(t,s,t~(P_1)s~(q_1),t~(p_2)s~(q_2),…,t~(p_n)s~(q_n))为R~(2+n)上一个曲面,且β_1α_1≥0,β_2α_20.这些结果推广和改进了R~3上的某些已知的结果.作为应用,得到了乘积空间上粗糖核奇异积分算子的Sobolev有界性.      17. Regularity in Capacity and the Dirichlet Laplacian      Markus Biegert  Mahamadi Warma 《Potential Analysis》2006,25(3):289-305 Given an open set in , we prove that every function in is zero everywhere on the boundary if and only if is regular in capacity. If in addition is bounded, then it is regular in capacity if and only if the mapping from into is injective, where denotes the Perron solution of the Dirichlet problem. Let be the set of all open subsets of which are regular in capacity. Then one can define metrics and on only involving the resolvent of the Dirichlet Laplacian. Convergence in those metrics will be defined to be the local/global uniform convergence of the resolvent of the Dirichlet Laplacian applied to the constant function . We prove that the spaces and are complete and contain the set of all open sets which are regular in the sense of Wiener (or Dirichlet regular) as a closed subset.      18. 一列连续函数的遍历优化      陈阳洋  赵云 《数学年刊A辑(中文版)》2013,34(5):589-598 设$T:X\rightarrow X$是紧度量空间$X$上的连续映射, $\mathcal{F}=\{f_n\}_{n\geq 1}$是$X$上的一族连续函数. 如果 $\mathcal{F}$是渐近次可加的, 那么$\sup\limits_{x\in \mathrm{Reg}(\mathcal{F},T)}\lim\limits_{n\rightarrow\infty}\frac 1 n f_n (x)=\sup\limits_{x\in X} \limsup\limits_{n\rightarrow\infty}\frac 1 n f_n (x) =\lim\limits_{n\rightarrow\infty}\frac 1 n \max\limits_{x\in X}f_n (x)=\sup\{\mathcal{F}^*(\mu):\mu\in\mathcal{M}_T\}$, 其中$\mathcal{M}_T$表示$T$-\!\!不变的Borel概率测度空间, $\mathrm{Reg}(\mathcal{F},T)$ 表示函数族$\mathcal{F}$的正规点集, $\mathcal{F}^*(\mu)=\lim\limits_{n\rightarrow\infty}\frac 1 n \int f_n \mathrm{d}\mu$. 这把Jenkinson, Schreiber 和 Sturman 等人的一些结果推广到渐近次可加势函数, 并且给出了次可加势函数从属原理成立的充分条件, 最后给出了 一些相关的应用.      19. Strong Solutions of Stochastic Differential Equations with Coefficients in Mixed-Norm Spaces      Ling  Chengcheng  Xie  Longjie 《Potential Analysis》2022,56(2):227-265 Potential Analysis - In this article we study stability properties of $g_{_{\mathcal {O}}}\!$ , the standard Green kernel for $\mathcal {O}$ an open regular set in $\mathbb {R}^{d}$ . In d ≥...      20. 具有边界控制的线性Timoshenko型系统的指数稳定性      杜燕  许跟起 《系统科学与数学》2008,28(5):554-575 研究多孔弹性材料在实际应用中的稳定性问题.多孔物体的动力学行为由线性Timoshenko型方程描述,这样的系统一般只是渐近稳定但不指数稳定,假定系统在一端简单支撑,另一端自由,在自由端对系统施加边界反馈控制,讨论闭环系统的适定性和指数稳定性.首先,证明了由闭环系统决定的算子A是预解紧的耗散算子、生成C0压缩半群,从而得到了系统的适定性.进一步通过对系统算子A的本征值的渐近值估计,得到算子谱分布在一个带域,相互分离的,模充分大的本征值都是A的简单本征值.通过引入一个辅助算子A0,利用算子A0的谱性质以及算子A与A0之间的关系,得到了A的广义本征向量的完整性以及Riesz基性质.最后利用Riesz基性质和谱分布得到闭环系统的指数稳定性.

Relations between different types of spectra and spectral characterizations

In the study of the asymptotic behaviour of solutions of differential-difference equations the -spectrum has been useful, where and implies Fourier transform , with given , φ∈L ^∞(ℝ,X), X a Banach space, (half)line. Here we study and related concepts, give relations between them, especially weak Laplace half-line spectrum of φ, and thus ⊂ classical Beurling spectrum = Carleman spectrum =  ; also  = Beurling spectrum of “φ modulo ” (Chill-Fasangova). If satisfies a Loomis type condition (L _U ), then countable and uniformly continuous ∈U are shown to imply ; here (L _U ) usually means , indefinite integral Pf of f in U imply Pf in (the Bohl-Bohr theorem for = almost periodic functions, U=bounded functions). This spectral characterization and other results are extended to unbounded functions via mean classes , ℳ ^m U ((2.1) below) and even to distributions, generalizing various recent results for uniformly continuous bounded φ. Furthermore for solutions of convolution systems S*φ=b with in some we show . With these above results, one gets generalizations of earlier results on the asymptotic behaviour of solutions of neutral integro-differential-difference systems. Also many examples and special cases are discussed.     

单位方体上沿曲面的振荡积分在Sobolev空间上的有界性

研究了欧氏空间R~2中单位方体Q~2=[0,1]~2上沿曲面(t,s,γ(t,s))的振荡奇异积分算子T_(α,β)f(u,v,x)=∫_(Q~2)f(u-t,v-s,x-γ(t,s))e~(it~(-β_1)s~(-β_2))t~(-1-α_1)s~(-1-α_2)dtds从Sobolev空间L_τ~p(R~(2+n))到L~p(R~(2+n))中的有界性,其中x∈R~n,(u,v)∈R~2,(t,s,γ(t,s))=(t,s,t~(P_1)s~(q_1),t~(p_2)s~(q_2),…,t~(p_n)s~(q_n))为R~(2+n)上一个曲面,且β_1α_1≥0,β_2α_20.这些结果推广和改进了R~3上的某些已知的结果.作为应用,得到了乘积空间上粗糖核奇异积分算子的Sobolev有界性.     

Regularity in Capacity and the Dirichlet Laplacian

Given an open set in , we prove that every function in is zero everywhere on the boundary if and only if is regular in capacity. If in addition is bounded, then it is regular in capacity if and only if the mapping from into is injective, where denotes the Perron solution of the Dirichlet problem. Let be the set of all open subsets of which are regular in capacity. Then one can define metrics and on only involving the resolvent of the Dirichlet Laplacian. Convergence in those metrics will be defined to be the local/global uniform convergence of the resolvent of the Dirichlet Laplacian applied to the constant function . We prove that the spaces and are complete and contain the set of all open sets which are regular in the sense of Wiener (or Dirichlet regular) as a closed subset.     

一列连续函数的遍历优化

设$T:X\rightarrow X$是紧度量空间$X$上的连续映射, $\mathcal{F}=\{f_n\}_{n\geq 1}$是$X$上的一族连续函数. 如果 $\mathcal{F}$是渐近次可加的, 那么$\sup\limits_{x\in \mathrm{Reg}(\mathcal{F},T)}\lim\limits_{n\rightarrow\infty}\frac 1 n f_n (x)=\sup\limits_{x\in X} \limsup\limits_{n\rightarrow\infty}\frac 1 n f_n (x) =\lim\limits_{n\rightarrow\infty}\frac 1 n \max\limits_{x\in X}f_n (x)=\sup\{\mathcal{F}^*(\mu):\mu\in\mathcal{M}_T\}$, 其中$\mathcal{M}_T$表示$T$-\!\!不变的Borel概率测度空间, $\mathrm{Reg}(\mathcal{F},T)$ 表示函数族$\mathcal{F}$的正规点集, $\mathcal{F}^*(\mu)=\lim\limits_{n\rightarrow\infty}\frac 1 n \int f_n \mathrm{d}\mu$. 这把Jenkinson, Schreiber 和 Sturman 等人的一些结果推广到渐近次可加势函数, 并且给出了次可加势函数从属原理成立的充分条件, 最后给出了 一些相关的应用.     

Strong Solutions of Stochastic Differential Equations with Coefficients in Mixed-Norm Spaces

Potential Analysis - In this article we study stability properties of $g_{_{\mathcal {O}}}\!$ , the standard Green kernel for $\mathcal {O}$ an open regular set in $\mathbb {R}^{d}$ . In d ≥...     

具有边界控制的线性Timoshenko型系统的指数稳定性

研究多孔弹性材料在实际应用中的稳定性问题.多孔物体的动力学行为由线性Timoshenko型方程描述,这样的系统一般只是渐近稳定但不指数稳定,假定系统在一端简单支撑,另一端自由,在自由端对系统施加边界反馈控制,讨论闭环系统的适定性和指数稳定性.首先,证明了由闭环系统决定的算子A是预解紧的耗散算子、生成C0压缩半群,从而得到了系统的适定性.进一步通过对系统算子A的本征值的渐近值估计,得到算子谱分布在一个带域,相互分离的,模充分大的本征值都是A的简单本征值.通过引入一个辅助算子A0,利用算子A0的谱性质以及算子A与A0之间的关系,得到了A的广义本征向量的完整性以及Riesz基性质.最后利用Riesz基性质和谱分布得到闭环系统的指数稳定性.